Clinical trials: Interleukin-6
Obesity, Healthy
IL-6 Regulation of Substrate Metabolism and Influence of Obesity
The aim of the study is to investigate the effects of blocking IL-6 signaling with tocilizumab on lipid, glucose and protein metabolism during rest and exercise in healthy and obese humans.
- Trial name
- NCT03967691
- Testing
- Tocilizumab infusion, Saline 0.9%
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Preoperative Anxiety, Cytokines
Effect of Preoperative Anxiety on Fetus in Pregnant Women
In the preoperative period, 60-80% of the patients had anxiety symptoms. This rate increases even more during pregnancy. There are a number of studies examining the role of anxiety symptoms on fetal outcome, but the mechanisms…
- Trial name
- NCT04226573
- Testing
- Preoperative anxiety levels
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bozok University
Periodontitis, Gingivitis
Evaluation of Salivary Biomarker Levels in Individuals With Different Periodontal Conditions
In order to determine the pathogenesis of chronic inflammatory diseases, the levels of various cytokines are examined in tissues and fluids taken from the body.
- Conditions
- Periodontitis, Gingivitis, Periodontal Health
- Trial name
- NCT06558136
- Testing
- Saliva obtaining
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Oral Potentially Malignant Disorders, Oral Lichen Planus
Salivary IL-8 and Serum IL-6 as Biomarkers for Oral Potentially Malignant Disorders in Smokers and Never-Smokers
The goal of this observational study is to learn whether two inflammatory proteins, interleukin-8 (IL-8) measured in saliva and interleukin-6 (IL-6) measured in blood serum, can help distinguish adults with oral potentially…
- Conditions
- Oral Potentially Malignant Disorders, Oral Lichen Planus, Oral Leukoplakia, Oral Squamous Cell Carcinoma
- Trial name
- NCT07915570
- Testing
- Salivary IL-8 and Serum IL-6 Measurement
- Where
- Egypt
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Interleukin 6
Assessment of Licorice Extract as an Adjunctive Therapy to Mechanical Debridement in Stage II Periodontitis
To assess the clinical effectiveness of the locally delivered licorice extract as an adjunctive therapy to mechanical debridement in stage II periodontitis patients.
- Trial name
- NCT07422883
- Testing
- Mechanical debridement will be performed for 20 stage II periodontitis patients followed by local application of licorice gel., Mechanical Debridement
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Major Depressive Disorder
Neutralizing Interleukin (IL)-6
The proposed study aims to establish the feasibility and safety of subcutaneous tocilizumab, a monoclonal antibody (mAb) against interleukin (IL)-6 receptor, in adults with Major Depressive Disorder (MDD) and evidence of…
- Trial name
- NCT07493317
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Rheumatoid Arthritis
Acute Response to Exercise in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the joints, causing pain, edema, physical disability and poor quality of life.
- Trial name
- NCT04927546
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Migraine, Tension-Type Headache
Salivary Inflammatory Markers in Tension Type Headache and Migraine
Data role of salivary inflammatory markers in migraine and Tension Type headache (TTH) are lacking. Τhe investigators studied whether headache attacks are associated with changes in C reactive protein (CRP), Interleukin -1β and…
- Trial name
- SalHead (NCT03727672)
- Where
- Greece
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
COVID-19, Adrenal Insufficiency
Assessment of Diurnal Salivary Cortisol Production in COVID-19
In the year of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic several studies have focused on the effect of the COVID-19 on the adrenal cortex, demonstrating conflicting results.
- Conditions
- COVID-19, Adrenal Insufficiency, Adrenal Hyperfunction
- Trial name
- NCT04988269
- Testing
- Blood sampling, Saliva sampling
- Where
- Greece
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Periodontal Health, Gingivitis
Salivary and GCF Biomarkers in Periodontal Health, Gingivitis and Periodontitis
This observational cross-sectional study aims to compare the levels of irisin, interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-α) in saliva and gingival crevicular fluid (GCF) among individuals…
- Conditions
- Periodontal Health, Gingivitis, Periodontitis
- Trial name
- NCT07881406
- Testing
- Clinical periodontal examination, ELISA-based biomarker analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Athletic Performance, Physical Endurance
Event-Specific Adaptations to CrossFit and Running-Based HIIT in Elite Distance Runners at Moderate Altitude
The goal of this clinical trial is to compare the effects of two high-intensity training programs on physical performance and physiological adaptations in elite male middle- and long-distance runners aged 25 to 35 years who live…
- Conditions
- Athletic Performance, Physical Endurance, Altitude Training Adaptation, Aerobic Capacity
- Trial name
- NCT07675577
- Testing
- Running-Based High-Intensity Interval Training (HIIT), CrossFit-Based High-Intensity Training (CF)
- Where
- Iran
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sistan and Baluchestan
Pain, Postoperative
Pecs Block vs Local Infiltration in Mastectomy
Studied the comparison between PECS II block and LIA on pain intensity, opioid requirements, RNL, and postoperative IL-6 levels in MRM patients.
- Trial name
- PBLIM (NCT06451705)
- Testing
- PECS II block, LIA
- Where
- Indonesia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Lumbar Posterior Decompression
Thoracolumbal Interfascial Plane Block Versus Erector Spinae Plane Block for Lumbar Posterior Decompression Stabilization
This study aimed to found out The Comparison Of Perioperative Analgesia Effectiveness Between Thoracolumbal Interfascial Plane Block with Erector Spinae Plane Block In Lumbar Posterior Decompression and Stabilization.
- Trial name
- NCT04951024
- Testing
- Thoracolumbar interfacial plane (TLIP) Block, Erector Spinae Plane (ESP) Block
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Autoantibodies, Interleukin-6
Characterization of Natural IL-6 Inhibition in Healthy Individuals
The aim of the project is to investigate whether or not there are any difference in cardiometabolic outcomes in individuals with high or low levels of c-aAb against interleukin-6 (IL-6).
- Trial name
- FIDI (NCT05867524)
- Testing
- Oral Glucose Tolerance Test, Cycling test
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Oxidative Stress, Inflammation
PsP Ganoderma Lucidum Supplementation and Biomarker Changes in Smokers
The goal of this randomized controlled clinical trial is to evaluate whether polysaccharide peptide (PsP) supplementation from Ganoderma lucidum can modulate biomarkers of oxidative stress, inflammation, nicotine exposure, and…
- Conditions
- Oxidative Stress, Inflammation, Cigarette Smoking
- Trial name
- PSPGL (NCT07316400)
- Testing
- PsP
- Where
- Indonesia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Brawijaya
Obesity, Periodontitis
Chemerin and Interleukin-6 Levels of Gingival Crevicular Fluid in Obese Individuals Following Periodontal Treatment
The objective in this case-control intervention study, therefore, was to explore the effect of nonsurgical periodontal therapy on the GCF levels of chemerin and IL-6 in patients with chronic periodontitis in order to determine…
- Trial name
- NCT02660814
- Testing
- Non-surgical periodontal treatment, Gingival crevicular fluid collection
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Umut BALLI
Analgesia, Surgical Procedure, Unspecified
TLIP Block Versus Modified TLIP Block for Posterior Decompression and Stabilization Surgery
This study aimed to compare the analgesia effectivity of TLIP and modified TLIP block in Posterior Lumbar Decompression and Stabilization Surgery Perioperatively.
- Trial name
- NCT05104203
- Testing
- Thoracolumbar Interfascial Plane block, Modified Thorcolumbar Interfascial Plane block
- Where
- Indonesia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Healthy, Glucagon Resistance
Interplay Between Interleukin-6 and Glucagon in the Regulation of Human Amino Acid and Protein Homeostasis
The goal of this proof-of-concept study is to learn if interleukin-6 changes the effect of glucagon in healthy volunteers. The main question it aims to answer is: Does IL-6 influence how effectively glucagon lowers the…
- Conditions
- Healthy, Glucagon Resistance, Amino Acid Change
- Trial name
- IGLU (NCT06721910)
- Testing
- Tocilizumab
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland