Clinical trials: Interleukin-6
Obesity, Metabolic Syndrome
The Predictive Role of Preoperative Pentraxin-3 (PTX3) in Metabolic and Inflammatory Outcomes After Roux-en-Y Gastric Bypass
This study evaluated the prognostic value of preoperative pentraxin-3 (PTX3) levels in predicting weight loss, inflammatory resolution (CRP, IL-6), and metabolic improvements (HOMA-IR) following Roux-en-Y gastric bypass in…
- Conditions
- Obesity, Metabolic Syndrome, Insulin Resistance, Inflammation
- Trial name
- PTX3-BYPASS (NCT07241741)
- Testing
- Biomarker Stratification by PTX3
- Volunteers
- 23 people
- Sponsor
- Istanbul University
Rheumatoid Arthritis, Periodontitis
Consequences of Anti-interleukin 6 Immunotherapy Treatment for Rheumatoid Arthritis on Periodontium
Rheumatoid arthritis and periodontitis are two inflammatory diseases that share many pathophysiological similarities as some inflammatory mediators like TNF-alpha, IL-1, Il-6, Il-17, Il-12 et Il-17, RANK-L, or OPG The most severe…
- Trial name
- ParoPAR (NCT01806974)
- Testing
- oral exam and
- Where
- 2 sites in France
- Volunteers
- 16 people
- Sponsor
- Nantes University Hospital
Endometriosis
Relaxin, Matrix Metalloproteinase-2 and Interleukin-6 in Women With Chronic Pelvic Pain
In our study, by evaluating the serum and vaginal-peritoneal fluid levels of Relaxin, Matrix Metalloproteinase-2 and Interleukin-6 in women over 35 years of age with chronic pelvic pain, the investigators aimed to reveal their…
- Trial name
- NCT06628479
- Testing
- interleukin, enzyme, hormone
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Interleukin 6
Assessment of Licorice Extract as an Adjunctive Therapy to Mechanical Debridement in Stage II Periodontitis
To assess the clinical effectiveness of the locally delivered licorice extract as an adjunctive therapy to mechanical debridement in stage II periodontitis patients.
- Trial name
- NCT07422883
- Testing
- Mechanical debridement will be performed for 20 stage II periodontitis patients followed by local application of licorice gel., Mechanical Debridement
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Preoperative Anxiety, Cytokines
Effect of Preoperative Anxiety on Fetus in Pregnant Women
In the preoperative period, 60-80% of the patients had anxiety symptoms. This rate increases even more during pregnancy. There are a number of studies examining the role of anxiety symptoms on fetal outcome, but the mechanisms…
- Trial name
- NCT04226573
- Testing
- Preoperative anxiety levels
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bozok University
Migraine, Tension-Type Headache
Salivary Inflammatory Markers in Tension Type Headache and Migraine
Data role of salivary inflammatory markers in migraine and Tension Type headache (TTH) are lacking. Τhe investigators studied whether headache attacks are associated with changes in C reactive protein (CRP), Interleukin -1β and…
- Trial name
- SalHead (NCT03727672)
- Where
- Greece
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Arrhythmogenic Right Ventricular Dysplasia
Local Inflammation in Arrhythmogenic Right Ventricular Cardiomyopathy
The understanding of ARVC pathophysiology remains incomplete. Several clues indicate that disease progression is mediated through inflammation.
- Trial name
- LI-ARVC (NCT05209776)
- Testing
- Peripheral immunological assessment on venous blood, Immunological assessment carried out on intracardiac material
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Toulouse
Aneurysm, Cerebral
Lidocaine and Perioperative Cytokine Levels in Blood and Cerebrospinal Fluid in Cerebral Aneurysm Patients
Cerebral aneurysm surgery has significant mortality and morbidity rate. Inflammation plays a key role in the pathogenesis of intracranial aneurysms, their rupture, subarachnoid haemorrhage and neurologic complications.
- Trial name
- NCT03823482
- Testing
- Lidocaine
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- Clinical Hospital Centre Zagreb
Procedural Pain
Intravenous Magnesium Sulfate for Post-Endoscopic Symptoms After Upper Gastrointestinal Endoscopy With Biopsy
This randomized placebo-controlled clinical trial evaluated whether intravenous magnesium sulfate reduces esophageal symptoms after upper gastrointestinal endoscopy (UGIE) with biopsy in adult patients.
- Trial name
- NCT07816848
- Testing
- Magnesium sulfate (MgSO4) infusion, 0.9 % sodium chloride
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Hasanuddin University
Metabolism in Adipose Tissue
Interleukin-6 Secretion in Adipose Tissue Following Sprint Exercise
Low volume sprint exercise training has been shown to reduce body fat despite small total energy expenditure (for ref see Gillen and Gibala 2014). IL-6 has been shown to increase adipose tissue lipolysis in vitro.
- Trial name
- NCT04566354
- Testing
- Repeated 30-s sprint exercise
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
COPD, COPD (Chronic Obstructive Pulmonary Disease)
Probiotics in COPD: Effects on Symptoms, Lung Function, and Inflammation
The goal of this randomized, placebo controlled, double-blind clinical trial is to find out whether a probiotic supplement can help adults with chronic obstructive pulmonary disease (COPD) breathe better and better control their…
- Conditions
- COPD, COPD (Chronic Obstructive Pulmonary Disease), Probiotic, Probiotic Supplement
- Trial name
- NCT07339280
- Testing
- Probiotic Capsule
- Where
- 5 sites in Croatia
- Volunteers
- 60 people
- Sponsor
- University Hospital of Split
Coronary Disease, Myocardial Infarction
ASSessing the Effect of Anti-IL-6 Treatment in Myocardial Infarction: The ASSAIL-MI Trial
The main goal of this study is to evaluate the ability of a single administration of tocilizumab to reduce myocardial damage in patients presenting with an acute ST-segment elevation myocardial infarction (STEMI).
- Trial name
- ASSAIL-MI (NCT03004703)
- Testing
- Tocilizumab, Sodium chloride 0.9%
- Where
- 3 sites in Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Multiple Sclerosis
Evaluating of the Effect of Fingolimod With Fish Oil on Relapsing-Remitting Multiple Sclerosis Patients
This study evaluates the effect of adding fish oil to Fingolimod on some serum cytokines in patients with Relapsing-Remitting Multiple Sclerosis.
- Trial name
- NCT02939079
- Testing
- Fingolimod, Fish Oil
- Volunteers
- 50 people
- Sponsor
- Isfahan University of Medical Sciences
Rheumatoid Arthritis
Open-label Study to Assess the Safety and Efficacy of CDP6038 (Olokizumab) in Patients Who Completed RA0056
The purpose of this study is to evaluate the long term safety and tolerability of CDP6038 (olokizumab) treatment in adult subjects with active rheumatoid arthritis who completed study RA0056 (NCT01242488).
- Trial name
- NCT01296711
- Testing
- CDP6038 (olokizumab)
- Where
- 55 sites in United States, Belgium and 1 more
- Volunteers
- 190 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Preterm Premature Rupture of Membranes (PPROM)
TAILORED Therapeutic Regime in Patients With Preterm Premature Rupture Of Membranes to Prolong Pregnancy, Improve Maternal and Neonatal Outcomes, and Reduce Antibiotic Burden
The goal of this clinical trial is to learn whether tailoring antibiotic and steroid treatment based on a lab result (interleukin-6, or IL-6) from amniotic fluid can help safely prolong pregnancy in people with preterm premature…
- Trial name
- TAILORED-PROM (NCT07107477)
- Testing
- Tailored antibiotic and steroid therapy based on the IL-6 value in amniotic fluid obtained by amniocentesis in patients with premature rupture of membranes, Antenatal steroids administration, Neuroprotection
- Where
- 3 sites in Czechia
- Volunteers
- 138 people
- Sponsor
- The Central and Eastern European Gynecologic Oncology Group
Severe Sepsis, Acute Respiratory Failure
Effect of Different Electric Muscle Stimulation in Patients With Severe Sepsis and Respiratory Failure
Rationale : Electric muscle stimulation reduced critical-illness related weakness in patients with severe sepsis and septic shock. But optimal protocol of the stimulation in unknown.
- Conditions
- Severe Sepsis, Acute Respiratory Failure, Muscle Hypotonia, Inflammation
- Trial name
- NCT01895647
- Testing
- EMS
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Mackay Memorial Hospital
Covid19 Positive Patients
Role of Interleukin-6 and Procalcitonin as Novel Inflammatory Biomarkers in Evaluating COVID 19 Disease Severity - an Experience at CMH Quetta
Serum Interleukin-6 and Procalcitonin of 100 consenting COVID 19 positive patients from April 2020 - May 2021 were assessed at Pathology department CMH Quetta and the results were correlated with severity of lung involvement on…
- Trial name
- NCT04945811
- Testing
- Interlukein 6 and procalcitonin serum levels
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- FARAH AFZAL
Melanoma, Unresectable Melanoma
Interleukin-6 Receptor Inhibitor Sarilumab in Combination With Ipilimumab, Nivolumab and Relatlimab in Patients With Unresectable Stage III or Stage IV Melanoma
This study will evaluate how safe the study drug is, how well patients tolerate it, how it works in the body, and the disease's response to the drug.
- Trial name
- NCT05428007
- Testing
- Sarilumab, Ipilimumab Injection, Nivolumab/Relatlimab
- Where
- 4 sites in United States
- Volunteers
- 105 people
- Sponsor
- NYU Langone Health
Burnout Syndrome, Neutrophil-Lymphocyte Ratio
Music Therapy on Neutrophyl Lymphocytes Ratio, Interleukin 6 and Interleukin 10 Levels of Burnout Syndrome
Burnout Syndrome (BOS) can be defined as a state of stress both physically and psychically due to the burden and stressor of high work. The prevalence of BOS in health workers varies between 25-75% globally.
- Conditions
- Burnout Syndrome, Neutrophil-Lymphocyte Ratio, Interleukin-6, Interleukin-10
- Trial name
- NCT05750160
- Testing
- music therapy
- Where
- Indonesia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Acute Hypoxemic Respiratory Failure
Interleukin-6 Guided Treatment With Dexamethasone or Tocilizumab in Patients Hospitalized With Acute Respiratory Symptoms - a Feasibility Study
Acute hypoxemic respiratory failure (AHRF) happens when the lungs are unable to absorb enough oxygen. The bloodstream is deprived of oxygen which can eventually lead to more severe conditions like multi-organ failure (MOF) and…
- Trial name
- IDENTIFY (NCT07334379)
- Testing
- Tocilizumab (Actemra®), Dexamethasone
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Lorenzo delSorbo