Clinical trials: Interleukin-6
COVID-19 Respiratory Infection
Dynamics of Markers of Infection and Inflammation in Hospitalized Coronavirus Disease 2019 (COVID-19) Patients
Patients requiring admission to the hospital due to a moderate and severe COVID-19 infection may differ in their ability to respond to viral infection and to eliminate viral load.
- Trial name
- NCT04887623
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Hradec Kralove
Sepsis, Cytokine Storm
Effect of Cytosorb on Blood Levels of Inflammatory Biomarkers of Sepsis.
Background: There is still an evident need for useful biomarkers and effective therapeutic approaches regarding the challenging management of sepsis.
- Trial name
- NCT04226430
- Testing
- Cytokine aphaeresis
- Volunteers
- 34 people
- Sponsor
- University of Gaziantep
Recurrent Ovarian Cancer
Feasibility of the Combination of Chemotherapy (Carbo/Caelyx or Carbo/Doxorubicin) With Tocilizumab (mAb IL-6R) and Peg-Intron in Patients With Recurrent Ovarian Cancer
The purpose of this interventional study is to determine the feasibility to combine standard chemotherapy (Carbo/Caelyx or doxorubicin) for recurrent ovarian cancer with immunotherapy (Tocilizumab and Peg-Intron).
- Trial name
- PITCH (NCT01637532)
- Testing
- tocilizumab and interferon alpha 2-b, Carboplatin and Caelyx or doxorubicin
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Leiden University Medical Center
Subarachnoid Hemorrhage, Stroke
Clinical, Pharmacological and Molecular Effects of IV and Oral Acetaminophen in Adults With aSAH
This study compares the bioavailability of IV and PO acetaminophen in both blood and the cerebrospinal fluid (CSF) of patients following subarachnoid hemorrhage.
- Trial name
- aSAH (NCT02549716)
- Testing
- IV acetaminophen, Oral acetaminophen
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Milton S. Hershey Medical Center
Chronic Periodontitis, Diabetes Mellitus
Chemerin and IL-6 Levels in Diabetes and Periodontitis
The aims of the present study were to determine the gingival crevicular fluid (GCF) chemerin and interleukin-6 (IL-6) levels and to analyse the relationship between chemerin and IL-6 in periodontal health and in chronic…
- Trial name
- NCT02596581
- Testing
- non-surgical periodontal treatment
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Rheumatoid Arthritis
Efficacy and Safety of CDP6038 in Patients With Rheumatoid Arthritis With an Unsuccessful Response to Anti-Tumor Necrosis Factor (Anti-TNF) Therapy
The purpose of this study is to evaluate the safety, efficacy, pharmacokinetics, and immunogenicity of CDP6038 treatment in adult subjects with active rheumatoid arthritis who have had an inadequate response to anti-tumor…
- Trial name
- NCT01242488
- Testing
- CDP6038, Tocilizumab (Actemra or RoActemra)
- Where
- 82 sites in United States, Belgium and 1 more
- Volunteers
- 221 people
- Sponsor
- UCB Pharma
Colorectal (Colon or Rectal) Cancer, Inflammation
Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery
Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta).
- Trial name
- NCT06272461
- Testing
- Lidocaine IV, Ketamine Injectable Solution
- Where
- Tunisia
- Volunteers
- 50 people
- Sponsor
- University Tunis El Manar
Coronary Syndrome
Identification of Biomarkers in Subjects With Coronary Syndrome (PLAQUE Study)
The study will to test the levels of innovative biomarkers, such as miRNAs, in the blood of subjects underwent to angioplasty procedure according to standard clinical practice.
- Trial name
- PLAQUE (NCT06103357)
- Testing
- blood sample collection
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Periodontal Diseases
Hepcidin Levels in Periodontal Health and Disease
Periodontal disease refers to inflammatory disease of the periodontium caused by the host and/or pathogenic microorganisms. Anti-inflammatory and pro-inflammatory cytokines play a role in the periodontal inflammation process.
- Trial name
- NCT03789565
- Testing
- Biomarker test
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bulent Ecevit University
Brain Diseases, Ischemic Stroke
Interleukin-6 Receptor Inhibition for Symptomatic Intracranial Atherosclerosis
IRIS-sICAS is a multicenter, randomized, double-blind, placebo-controlled clinical trialis a multicenter, randomized, double-blind, placebo-controlled clinical trial, to assess the safety and efficacy of tocilizumab injection in…
- Conditions
- Brain Diseases, Ischemic Stroke, Ischemia, Stroke
- Trial name
- IRIS-sICAS (NCT06447701)
- Testing
- Tocilizumab, NaCl 0.9% 100ml
- Volunteers
- 486 people
- Sponsor
- Zhujiang Hospital
Indolent Systemic Mastocytosis
Safety and Efficacy of Subcutaneous Sarilumab in Improving the Quality of Life in People With Indolent Systemic Mastocytosis
Background: Mast cells help the body fight disease and heal wounds. People with indolent systemic mastocytosis (ISM) make too many mast cells. This causes pain, tiredness, digestive problems, and other symptoms.
- Trial name
- NCT03770273
- Testing
- sarilumab
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Rheumatoid Arthritis
Study to Assess Safety and Efficacy of Anti-Interleukin 6-receptor (IL6R) Nanobody in Rheumatoid Arthritis (RA) Patients
The purpose of this study is to determine whether the ALX-0061, a Nanobody targeting the receptor for interleukin 6 (IL6R), is safe and effective after single or multiple administrations to patients with rheumatoid arthritis…
- Trial name
- NCT01284569
- Testing
- ALX-0061
- Where
- 7 sites in Czechia, Hungary and 1 more
- Volunteers
- 65 people
- Sponsor
- Ablynx, a Sanofi company
Exercise Physiology, Cardiorespiratory Fitness
IL-6 and Cortisol Responses to Cycling Exercise
This study aimed to investigate salivary interleukin-6 (IL-6) and cortisol responses following short-term and long-term cycling exercise in team athletes with different cardiorespiratory fitness levels.
- Conditions
- Exercise Physiology, Cardiorespiratory Fitness, Interleukin-6, Cortisol
- Trial name
- NCT07681362
- Testing
- Wingate Anaerobic Cycling Test, YMCA Submaximal Cycling Test
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Systemic Inflammatory Response Syndrome, Coronary Artery Bypass Grafting
Immunomodulation of EA-230 Following On-pump Coronary Artery Bypass Grafting (CABG)
EA-230 is a newly developed synthetic compound with anti-inflammatory properties, it is a linear tetrapeptide derived from the human chorionic gonadotropin hormone (hCG).
- Trial name
- EASI (NCT03145220)
- Testing
- EA-230
- Where
- Netherlands
- Volunteers
- 180 people
- Sponsor
- Radboud University Medical Center
Stem Cell Transplantation
Investigating Cytokine Genes of Stem Cell Donors
This study seeks to investigate the factors that may account for the differences in the way a stem cell recipient s immune system works after a transplant.
- Trial name
- NCT00353821
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Apical Periodontitis
Accuracy of PoCT to ELISA by Detecting Human IL-6 in Teeth with Apical Periodontitis
To compare the diagnostic agreement of human IL-6 chairside PoCT to ELISA in apical periodontitis undergoing endodontic therapy which could be clinically helpful to monitor the healing of periapical tissues enabling the clinician…
- Trial name
- PoCT ELISA (NCT06701266)
- Testing
- Point of Care Test
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- Manipal University College Malaysia
Suicide, Attempted, Suicidal Ideation
Biomarkers as Predictors of Suicidal Risk in Adolescents
Suicide is one of the most devastating events in society at all levels. The primary goal of this study is to predict suicide in adolescents at risk.
- Conditions
- Suicide, Attempted, Suicidal Ideation, Suicidal Intention, Suicide
- Trial name
- NCT03014518
- Testing
- Clinical assessments and blood samples; follow-up for 12 mos, Clinical assessments and blood samples; no 12mo follow-up
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Multiple Myeloma
A Study to Compare CNTO 328 (Anti-IL-6 Monoclonal Antibody) and VELCADE-Melphalan-Prednisone (VMP) With VMP Alone in Previously Untreated Multiple Myeloma Patients
The purpose of this study is to evaluate safety and effectiveness of CNTO 328 (siltuximab) when it is administered together with velcade-melphalan-prednisone (VMP) in comparison with VMP alone in participants with multiple…
- Trial name
- NCT00911859
- Testing
- Siltuximab11 mg/kg, Siltuximab 8.3 mg/kg or 11 mg/kg, Velcade (bortezomib)
- Where
- 37 sites in United States, Australia and 9 more
- Volunteers
- 118 people
- Sponsor
- Janssen Research & Development, LLC
Sepsis Newborn
The Effect of Melatonin as an Adjuvant Therapy for Preterm Neonates With Sepsis
The goal of this clinical trial is to assess the effect of melatonin on MDA serum, IL-6, IL-8 levels, ANC, and sepsis score in preterm neonates with sepsis.
- Trial name
- NCT06191523
- Testing
- Control Group, Treatment Group
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Universitas Sebelas Maret
Type 2 Diabetes Mellitus, Ischemic Heart Disease
Effects of Vildagliptin/Metformin Combination on Markers of Atherosclerosis, Thrombosis, and Inflammation in Diabetics With Coronary Artery Disease
The purpose of this study is to demonstrate that combined vildagliptin-metformin therapy is associated with clinically significant reductions in biological markers of inflammation, pro-thrombogenicity, and atherosclerosis as…
- Trial name
- VAAST (NCT01604213)
- Testing
- Metformin plus vildagliptin, Metformin only
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center