Clinical trials: Intermittent Explosive Disorder
Intermittent Explosive Disorder
A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder
This study will compare the medications fluoxetine (Prozac®) and divalproex (Depakote®) for the treatment of aggressive behavior in individuals with Intermittent Explosive Disorder (IED).
- Trial name
- NCT00078754
- Testing
- Fluoxetine, Divalproex
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Chicago
Intermittent Explosive Disorder, Childhood Aggression
Intuniv vs Placebo in the Treatment of Childhood Intermittent Explosive Disorder
Children with explosive aggression are often rejected by their peers, placed in special classroom, and contribute to family discord. When psychotherapy and family therapy is unsuccessful, medications are often used.
- Conditions
- Intermittent Explosive Disorder, Childhood Aggression, Oppositional Defiant Disorder, Attention Deficit Disorder
- Trial name
- NCT02048241
- Testing
- Parent Management Training, Intuniv
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- New York State Psychiatric Institute
Intermittent Explosive Disorder
Effect of Nitrous Oxide on Aggression.
The goal of this experimental medicine clinical trial is to test the hypothesis that nitrous oxide inhalation will result in a change in neurocircuit function in healthy controls and in individuals with impulsive aggressive…
- Trial name
- NCT06118567
- Testing
- Nitrous oxide, Room Air
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Oppositional Defiant Disorder, Conduct Disorder
Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone.
This study was developed in order to assess the effects of risperidone (Risperdal) as compared with placebo on cognitive-motor performance (attention, memory, and hand steadiness) and body movements.
- Conditions
- Oppositional Defiant Disorder, Conduct Disorder, Attention Deficit/Hyperactivity Disorder (ADHD), Intermittent Explosive Disorder
- Trial name
- NCT00399698
- Testing
- Risperdal
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ohio State University
Psychotic Disorders, Antisocial Personality Disorder
Efficacy of a Triptan in the Treatment of Hostility and Aggression Among Convicts With a Psychiatric Treatment Order
In a double blind randomized clinical trial with cross-over design, treatment using naratriptan will be compared to placebo within a group of 30 convicts with psychiatric disorders such as psychosis or psychopathy with repeated…
- Conditions
- Psychotic Disorders, Antisocial Personality Disorder, Impulse Regulation Disorder, Intermittent Explosive Disorder
- Trial name
- NCT00282165
- Testing
- naratriptan
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- UMC Utrecht
Anger, Intermittent Explosive Disorder
A Pilot Study Comparing the Efficacy of Group Versus Individual Anger Management in Subjects With IED
The purpose of this study is to see how different forms of "Anger Management" compare in reducing anger and impulsive aggressive symptoms in people.
- Trial name
- NCT00127400
- Testing
- anger management therapy
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Chicago
Anger, Intermittent Explosive Disorder
Psychotherapy for Intermittent Explosive Disorder
The goal of this study is to examine the effectiveness two forms of psychotherapy (also known as "talk therapy" ) for individuals with anger and aggression problems.
- Trial name
- NCT00667212
- Testing
- Cognitive Behavioral Therapy, Supportive Psychotherapy
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Chicago
Anger, Intermittent Explosive Disorder
Maladaptive Anger Treatment
From a psychoevolutionary perspective, anger is a universal emotion that can serve the function of making us aware of wrongdoing and motivating us to undo/correct the wrongdoing.
- Conditions
- Anger, Intermittent Explosive Disorder, Emotional Distress, Aggression
- Trial name
- NCT06275607
- Testing
- Cognitive Behavioral Affective Therapy, Emotional Discussion
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas at San Antonio
Alcohol Use Disorder, Intermittent Explosive Disorder
Neural Correlates During Alcohol Intoxication
Alcohol intoxication is responsible for a large proportion of violent crime/assault and personal injury in our society. While a number of variables have been associated with alcohol-related aggression, high trait aggression and…
- Trial name
- NCT06118580
- Testing
- Alcohol (Ethanol)
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Intermittent Explosive Disorder
Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Intermittent Explosive Disorder
This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate AVP-786 for the treatment of Intermittent Explosive Disorder (IED).
- Trial name
- NCT03420222
- Testing
- AVP-786
- Where
- 9 sites in United States
- Volunteers
- 10 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Intermittent Explosive Disorder
Safety, Tolerability and Activity of SRX246 in Adults With Intermittent Explosive Disorder
This study is designed to explore the safety and tolerability, and to compare the activity of SRX246 against placebo, in adults with Intermittent Explosive Disorder (IED).
- Trial name
- AVN009 (NCT02055638)
- Testing
- SRX246
- Where
- 7 sites in United States
- Volunteers
- 97 people
- Sponsor
- Azevan Pharmaceuticals
Intermittent Explosive Disorder
Pimavanserin and Aggression and Social Cognition.
The investigators are studying how certain drugs can reduce anger outbursts in people with anger problems. In this study the investigators seek to determine if a single 34 mg (two 17 mg tablets) oral dose of the 5-HT2a receptor…
- Trial name
- NCT05895513
- Testing
- Pimavanserin 34 mg
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Intermittent Explosive Disorder
A Cognitive Bias Modification RCT for Aggression
This randomized controlled trial will test a computerized cognitive bias modification program (CBM) to treat attention and interpretive biases in patients with primary aggression.
- Trial name
- NCT04819230
- Testing
- Cognitive Bias Modification, Cognitive Bias Control
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Temple University
Intermittent Explosive Disorder
Inflammatory Challenge in Human Aggression.
The goal of this clinical trial is to explore the differences in behavioral and cytokine response to a low dose infusion of endotoxin (vs.
- Trial name
- LPSS (NCT06665074)
- Testing
- Endotoxin (E. coli O:113, Reference Endotoxin)
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Major Depressive Episode (MDE), Major Depressive Disorder (MDD)
LHC-CIDI-5 in Hong Kong
The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12…
- Conditions
- Major Depressive Episode (MDE), Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD), Suicidal Ideation
- Trial name
- NCT06804525
- Testing
- CIDI-5, LHC-CIDI-5
- Where
- Hong Kong
- Volunteers
- 2,500 people
- Sponsor
- The University of Hong Kong