Clinical trials: Internal Disorders
Sleep Apnea, Obstructive, Larynx
Accuracy of the Sensory Test Using the Laryngopharyngeal Endoscopic Esthesiometer in Obstructive Sleep Apnea
This is a prospective double blinded randomized crossover controlled trial aiming at validating the measurement of laryngopharyngeal mechanosensitivity in patients with suspected OSA using a recently developed laryngopharyngeal…
- Conditions
- Sleep Apnea, Obstructive, Larynx, Sensory Disorder
- Trial name
- NCT03109171
- Testing
- Laryngopharyngeal sensory test
- Where
- 2 sites in Colombia
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Fundación Neumologica Colombiana
Obstructive Sleep Apnea
A Study of Sex Differences in Neurocirculatory Control
The purpose of this study is to investigate potential sex differences in neurocirculatory control of blood pressure in patients with untreated obstructive sleep apnea (OSA).
- Trial name
- NCT06261034
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Primary Insomnia
Polysomnography Study of MK-6096 in Participants With Primary Insomnia (MK-6096-011)
This was a cross-over, polysomnography (PSG) study to test the safety, tolerability and effectiveness of different doses of MK-6096 in the treatment of participants with primary insomnia.
- Trial name
- NCT01021852
- Testing
- MK-6096
- Volunteers
- 326 people
- Sponsor
- Merck Sharp & Dohme LLC
Hypertension, Insomnia
Sleep Quality and Mechanisms of Cardiovascular Risks in Adults With Hypertension
The objective of this study is to elucidate the potential mechanisms responsible for the increased risk of cardiovascular disease among patients with hypertension and comorbid insomnia.
- Trial name
- NCT04009447
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I)
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Duke University
Sleep Apnea, Obstructive
Upper Airway Toning for Improve the Compliance of CPAP
The obstructive sleep apnoea/hypopnoea syndrome (OSAHS) is a breathing disorder which happens at night and consists of the interruption of airflow for more than five seconds.
- Trial name
- NCT01936038
- Testing
- CPAP, Upper Airway Toning for Improve the Compliance of CPAP
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Fisiolistic
Sleep-disordered Breathing
Sleep and Breathing in the General Population - Chemical Stimuli
Central sleep apnea (CSA) is a common condition and its treatment remains elusive. The focus of this proposal is to identify the role of the physiologic path involving cortical arousals in CSA by decreasing arousal frequency…
- Trial name
- NCT04720547
- Testing
- Zolpidem, No Treatment
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Sleep Apnea, Stroke
Positional Therapy After Stroke
Stroke is the leading cause of adult disability and the third leading cause of death in the United States. Unfortunately, there are few therapies that have been proven to improve stroke outcome.
- Trial name
- NCT01047709
- Testing
- Positional therapy including the use of a special pillow
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Michigan
Hypertension,Essential, Obstructive Sleep Apnea
A Cardiosleep Research Program on Obstructive Sleep Apnea, Blood Pressure Control and Maladaptive Myocardial Remodeling
The objective of this proposal is to evaluate whether mandibular advancement device (MAD) is non-inferior to continuous positive airway pressure (CPAP) in the treatment of obstructive sleep apnea (OSA) and blood pressure…
- Trial name
- CRESCENT (NCT04119999)
- Testing
- Mandibular Advancement Device, Continuous Positive Airway Pressure
- Where
- Singapore
- Volunteers
- 321 people
- Sponsor
- National University of Singapore
Sleep Apnea, Obstructive
Correlation Between Preeclampsia and Positive for Obstructive Sleep Apnea Screening Test: STOPBANG Questionnaire
The purpose of this study is to find the correlation between high risk OSA (obstructive sleep apnea) patient, based on Stop-bang screening tool and preeclampsia
- Trial name
- NCT02800798
- Testing
- Preeclampsia positive
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Ramathibodi Hospital
Relapsing Remitting Multiple Sclerosis, Sleep Initiation and Maintenance Disorders
Eszopiclone for Improving Sleep in Multiple Sclerosis (MS)
The purpose of this study is to determine if people with multiple sclerosis (MS) and fatigue have disrupted sleep, as was suggested in previous studies, and whether treating the disruptions of sleep improves the fatigue.
- Conditions
- Relapsing Remitting Multiple Sclerosis, Sleep Initiation and Maintenance Disorders, Fatigue
- Trial name
- NCT00594087
- Testing
- eszopiclone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Vermont
Obstructive Sleep Apnea, Metabolic Syndrome
Prevalence of Metabolic Syndrome in Obstructive Sleep Apnea (OSA) and Effect of Treatment With Continuous Positive Airway Pressure (Auto-CPAP) on Metabolic Syndrome
Metabolic syndrome is a constellation of risk factors for cardiovascular disease. The prevalence of metabolic syndrome in persons with obstructive sleep apnea syndrome (OSAS) is known to be very high, about 70%.
- Trial name
- NCT00694616
- Testing
- AutoSet Spirit, Modified-AutoSet Spirit
- Where
- India
- Volunteers
- 90 people
- Sponsor
- All India Institute of Medical Sciences
Sleep Disorders, Insomnia
A Multidimensional Health Perspective: Analysis of the Effects of Yoga Intervention on Sleep Disorders in Older Adults
This randomized controlled trial aims to evaluate the impact of a structured yoga intervention on multidimensional health outcomes in older adults with sleep disturbances.
- Conditions
- Sleep Disorders, Insomnia, Aging, Yoga
- Trial name
- NCT07061158
- Testing
- Structured Yoga Course Intervention
- Where
- China
- Volunteers
- 73 people
- Sponsor
- Beijing Sport University
Insomnia, Breast Cancer
PERSONAL - Sleep In Breast Cancer
Sleep is essential for human function, immunity, and well-being. In the general population, sleep disturbance and insomnia cause significant health problems and impact on the quality of life of many individuals.
- Trial name
- NCT05093426
- Testing
- Stage 2 Digital sleep diary app
- Where
- United Kingdom
- Volunteers
- 226 people
- Sponsor
- Closed Loop Medicine
Chronic Insomnia
Hyper-Arousal in Chronic Primary Insomnia
The purpose of this study is to determine whether individuals with chronic insomnia disorder have a higher degree of physiologic arousal (resulting in their trouble sleeping) than good sleepers.
- Trial name
- NCT02048878
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Obstructive Sleep Apnea
Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic
Patients who have obstructive sleep apnea (OSA) frequently stop breathing while they sleep. They often develop high blood pressure. We are not sure what drug is best to treat the high blood pressure.
- Trial name
- guanhctz (NCT02699125)
- Testing
- Guanfacine, Hydrochlorothiazide
- Volunteers
- 41 people
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea
Comparison of Two Oral Myofunctional Reeducation Methods for Children With Obstructive Sleep Apnea
Myofunctional therapy has been shown to be effectively reduce symptoms of paediatric sleep apnea. As the effectiveness of reeducation relies on parental involvement and child's compliance, the investigator's research question was…
- Trial name
- PERSIST-B (NCT03061019)
- Testing
- Oral Myofunctional Therapy with exercices, Oral Myofunctional Therapy with soft oral appliance
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Université de Montréal
Epilepsy, Status Epilepticus
De-identified UNMH EEG Corpus Database Creation With Fully De-identified Clinical Information
This proposal outlines the steps required for the creation of a pilot database of EEG recordings and de-identified medical records from patients internally referred within the UNMH Comprehensive Epilepsy Center.
- Conditions
- Epilepsy, Status Epilepticus, Seizures
- Trial name
- NCT05140265
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- University of New Mexico
Sleep Disturbance, Sleep Disorder
Efficacy of a Sleep Hygiene Toolkit for Patients in ARU
Sleep Hygiene Study Abstract: INTRODUCTION Sleep is integral to the health of a person and can have multifaceted contributions to a person including their physical, cognitive, and psychosocial well-being.
- Conditions
- Sleep Disturbance, Sleep Disorder, Insomnia, Critical Illness Myopathy
- Trial name
- NCT05541692
- Testing
- Sleep Hygiene Toolkit
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Narcolepsy, Narcolepsy 1
'A Profile of Physical Performance Variables in an Out-patient Adult Population With Narcolepsy'
Narcolepsy is a sleep disorder characterised by excessive daytime sleepiness and significantly impacts quality of life. People with narcolepsy demonstrate many potential barriers to being physically active, such as sleepiness and…
- Conditions
- Narcolepsy, Narcolepsy 1, Narcolepsy Type 1, Narcolepsy With Cataplexy
- Trial name
- NCT04419792
- Testing
- Assessment of physical performance variables
- Where
- Ireland
- Volunteers
- 70 people
- Sponsor
- University of Dublin, Trinity College
Obstructive Sleep Apnea
Face of Sleepiness
The purpose of this pilot study is to find out whether successful treatment of obstructive sleep apnea makes people look less sleepy, for example by reducing swelling or dark circles under the eyes.
- Trial name
- Face (NCT01060436)
- Testing
- CPAP or BiPAP machines
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan