Clinical trials: Internal Limiting Membrane
Retinal Detachment
Internal Limiting Membrane Flaps for Coexistent Macular Hole and Retinal Detachment
Purpose: To evaluate the logical surgical approaches in closing macular holes in eyes of proliferative diabetic retinopathy with retinal detachment
- Trial name
- ILMFCMHRDPDR (NCT03618498)
- Testing
- ILM flaps insertion techniques or free ILM flaps.
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Changhua Christian Hospital
Macular Holes, High Myopia
Effects of Macular Buckle Versus Vitrectomy on Macular Hole and Macular Detachment in Highly Myopic Eyes
Full-thickness macular Hole associated with macular detachment is a one of the maculopathies of high myopia. There is controversy in the primary treatment for this situation.
- Conditions
- Macular Holes, High Myopia, Macular Detachment
- Trial name
- NCT03433547
- Testing
- Buckle, Vitrectomy, Limbal paracentesis
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Idiopathic Epimacular Membrane
Prospective, Single-blind Study Assessing the Benefit/Risk Ratio of Internal Limiting Membrane (ILM) Peeling During Epimacular Membrane (EMM) Surgery (Peeling)
The epimacular membrane (EMM) is a degenerative condition associated with age, with a variable impact on vision. Treatment is surgery based and consists of a vitrectomy followed by a peeling of the epimacular membrane using a…
- Trial name
- Peeling (NCT02146144)
- Testing
- ILM Peeling
- Where
- 6 sites in France
- Volunteers
- 213 people
- Sponsor
- Nantes University Hospital
Retinal Detachment, Surgery
Internal Limiting Membrane Flap in the Management of Retinal Detachment Due to Paracentral Retinal Breaks
To describe the technique and outcomes of using either inverted or free internal limiting membrane flap in the management of retinal detachment due to paracentral retinal breaks.
- Trial name
- NCT03707015
- Volunteers
- 9 people
- Sponsor
- San Ni Chen
Retinoschisis, Macular Detachment
Effects of Macular Buckle Versus Vitrectomy on Macular Schisis and Macular Detachment in Highly Myopic Eyes
Macular schisis associated with macular detachment is a one of the complications of high myopia. There is controversy in the primary treatment for this situation.
- Conditions
- Retinoschisis, Macular Detachment, High Myopia
- Trial name
- NCT03023800
- Testing
- Macular buckling, Vitrectomy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sun Yat-sen University
Macular Holes, Retina Detachment
Comparison of Vitrectomy Without Internal Limiting Membrane Peeling Versus Inverted ILM Flap Technique for Macular Hole Retinal Detachment in Highly Myopic Eyes
The aim of this study was to determine whether inverted ILM peeling technique could contribute to high reattachment and closure rates after vitrectomy in patients with myopic macular hole retinal detachment (MHRD) in comparison…
- Trial name
- NCT04011007
- Testing
- vitrectomy with or without inverted ILM flap technique
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- University of Alexandria
Vitrectomy
Vitrectomy for Branch Retinal Vein Occlusion
To evaluate the long term outcomes of pars plana vitrectomy (PPV), with and without internal limiting membrane (ILM) peeling, in eyes with persistent macular edema secondary to branch retinal vein occlusion (BRVO).
- Trial name
- NCT00685490
- Testing
- Vitrectomy w/o ILM peeling for macular edema with BRVO
- Where
- Japan
- Volunteers
- 70 people
- Sponsor
- Shinjo Ophthalmologic Institute
Retinal Detachment, Proliferative Vitreoretinopathy
Internal Limiting Membrane Peeling in Retinal Detachment Surgery
Despite advances in surgical techniques over the recent decades, proliferative vitreoretinopathy (PVR) remains the main obstacle to successful rhegmatogenous retinal detachment (RRD) repair, accounting for nearly 75% of all…
- Trial name
- IMPURITY (NCT05538156)
- Testing
- Control group, Intervention group
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Macular Holes
Comparative Study of Decellularized Human Amniotic Membrane Hydrogel and Inverted Internal Limiting Membrane Flap in Idiopathic Large Macular Holes
The human amniotic membrane (hAM) patch, introduced by Rizzo et al. in 2018, showed a 100% anatomical success rate for large or failed macular holes over a 6-month follow-up.
- Trial name
- MACROHOLE (NCT06433284)
- Testing
- 25-gauge pars plana vitrectomy with inverted flap technique and SF6 tamponade, 25-gauge pars plana vitrectomy with complete internal limiting membrane peeling with amniotic membrane hydrogel filling and SF6 tamponade
- Where
- Thailand
- Volunteers
- 26 people
- Sponsor
- Walailak University
Proliferative Vitreoretinopathy
Outcomes of Extensive Brilliant Blue G-Assisted Internal Limiting Membrane Peeling in Proliferative Vitreoretinopathy
The aim of this study is to report outcomes of pars plana vitrectomy (PPV) in retinal detachment (RD) accompanied with proliferative vitreoretinopathy (PVR) after extensive Brilliant Blue G-Assisted internal limiting membrane…
- Trial name
- ILM (NCT04490876)
- Testing
- 3D Pars Plana Vitrectomy associated with Extensive Brilliant Blue G-Assisted ILM Peeling Method
- Where
- Argentina
- Volunteers
- 14 people
- Sponsor
- Centro Oftalmológico Dr Charles
Macular Hole
Outcomes of Macular Hole Surgery With Inverted Flap With vs Without Post op Posturing With SF6 in Macular Hole More Than 400 Micrometres
This study evaluated the outcomes of surgery for large full-thickness macular holes measuring more than 400 micrometres using the inverted internal limiting membrane flap technique with sulphur hexafluoride (SF6) gas tamponade.
- Trial name
- NCT07787390
- Testing
- Macular Hole Surgery With Inverted Internal Limiting Membrane Flap and SF6 Gas Tamponade, Face-Down Postoperative Positioning, No Face-Down Postoperative Positioning
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Lahore General Hospital
Macular Holes
Clinical Research on the Effect of Different Extents of Internal Limiting Membrane Peeling on Macular Hole Closure and Visual Acuity
Observing and describing the surgical effects of different extents of internal limiting membrane peeling combined with internal limiting membrane insertion for macular hole
- Trial name
- NCT03805763
- Testing
- Large extent of ILM Peeling, Small extent of ILM Peeling
- Volunteers
- 60 people
- Sponsor
- Wenzhou Medical University
Epiretinal Membrane, Internal Limiting Membrane Wrinkling
Fovea ERM After Fovea-sparing ILM Peeling
To report cases who had received previous fovea-sparing internal limiting peeling membrane and developed secondary fovea epiretinal membrane contraction
- Trial name
- NCT04445142
- Testing
- fovea-sparing internal limiting membrane peeling
- Where
- Taiwan
- Volunteers
- 3 people
- Sponsor
- Changhua Christian Hospital
Myopic Traction Maculopathy
Ultrastructure Analysis of Excised Internal Limiting Membrane in Eyes of Highly Myopia With Myopic Traction Maculopathy
The excised ILM from 7 eyes of 7 patients with MTM including 7 eyes with macular retinoschisis and 4 eyes with foveal detachment but without any retinal break underwent vitrectomy with induction of posterior vitreous detachment…
- Trial name
- NCT02528058
- Testing
- Vitrectomy with internal limiting membrane peeling
- Where
- Japan
- Volunteers
- 7 people
- Sponsor
- Kyorin University
Macular Holes
PEELED INTERNAL LIMITING MEMBRANE REPOSITION
Macular hiatus (MH) refers to a tissue defect in the photoreceptor cell layer of the inner boundary membrane of the optic disc in the macular region.
- Trial name
- NCT06359548
- Testing
- Peeled ILM Reposition, ILM Peeling
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Diabetic Retinopathy Visually Threatening
Internal Limiting Membrane Peeling in Proliferative Diabetic Retinopathy
Subject/Participant Groups: Study Group: Subjects undergo internal limiting membrane (ILM) peeling during vitrectomy for the indication of tractional retinal detachment Control Group: Subjects do not undergo ILM peeling during…
- Trial name
- NCT04380064
- Testing
- ILM Peeling, No ILM Peeling
- Where
- Mexico
- Volunteers
- 200 people
- Sponsor
- Rush Eye Associates
Retinal Detachment
Peeling of the Internal Limiting Membrane During Primary Vitrectomy for Retinal Detachment Repair
Primary vitrectomy for retinal detachment repair is one of the current methods for surgical treatment of retinal detachment. Additional peeling of the internal limiting membrane (ILM) was reported to successfully prevent…
- Trial name
- NCT07438210
- Testing
- ILM-Peeling, No Peeling
- Where
- Austria
- Volunteers
- 21 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Idiopathic Epiretinal Membranes
Clinical Evaluation of With or Without Internal Limiting Membrane Peeling for Idiopathic Epiretinal Membrane Surgery: A Randomized Controlled Trial
Idiopathic epiretinal membrane (ERM) is an age-related degenerative retinal condition. One of the primary treatment approaches is vitrectomy combined with epiretinal membrane peeling.
- Trial name
- NCT07142785
- Testing
- Epiretinal membrane peeling, Epiretinal membrane peeling combined with internal limiting membrane peeling
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Macular Hole
Effects of Different Area of Internal Limiting Membrane Peeling (ILM) Peeling on Anatomical Outcomes in Macular Hole Surgery
The purpose of this study is to determine the effects of two different internal limiting membrane (ILM) peeling area on anatomical closure outcomes after macular hole surgery measured by optical coherence tomography (OCT).
- Trial name
- NCT02930369
- Testing
- ILM peeling surgery
- Volunteers
- 128 people
- Sponsor
- Peking University People's Hospital
Macular Holes
Extent of ILM Removal and Its Impact on Outcomes of MH Surgery
Eligible patients who were scheduled for surgery for idiopathic macular hole (MH) were equally randomized to small extent group or large extent group depending on the extent of internal limiting membrane (ILM) to be removed.
- Trial name
- NCT02010138
- Testing
- small-extent peeling, large-extent peeling
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Samsung Medical Center