Clinical trials: Internal Limiting Membrane
Macular Edema Due to Diabetes Mellitus, Vitreous Hemorrhage
Comparison of Restoration in Vitreous Hemorrhage Patients With DME After or Not Removing Inner Limiting Membrane
This study is conducted to compare the anti-VEGF effect and visual function in vitreous hemorrhage patients with diabetic macular edema after pars plana vitrectomy with inner limiting membrane peeling or not
- Trial name
- NCT05529589
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ophthalmopathy
Single Superior ILM/ERM Flap for the FTMH.
In this study, the investigators will make the only upper flap either from the internal limiting membrane or from the epiretinal membrane to cover the full thickness macular hole.
- Trial name
- NCT05494242
- Testing
- Surgical intervention
- Where
- Iraq
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Omer Othman Abdullah
C11.768.740
Internal Limiting Membrane and Macular Hole
Observational study of Internal Limiting Membrane peeled in macular Hole surgery and studied by Transmission electronic Microscopy (TEM) and Optical Coherence Tomography (OCT) findings in closed holes.
- Trial name
- NCT03799575
- Testing
- Transmission Electron Microscopy analysis
- Where
- Portugal
- Volunteers
- 10 people
- Sponsor
- Hospital de Santa Maria, Portugal
Macular Hole, Proliferative Diabetic Retinopathy
Macular Hole in Diabetic Retinopathy
Macular hole in proliferative diabetic retinopathy with fibrovascular proliferation may have unique features. Internal limiting membrane peeling facilitates hole closure only in cases with shallow macular detachment.
- Trial name
- NCT00737074
- Where
- Taiwan
- Volunteers
- 23 people
- Sponsor
- National Taiwan University Hospital
Macular Holes
Full-Thickness Macular Hole Surgery: A Comparison of Ten Techniques
This study compares ten modern vitreoretinal surgical techniques for full-thickness macular hole repair. Participants will be randomly assigned to one of the surgical approaches during pars plana vitrectomy, using stratified…
- Trial name
- FTMH-10 (NCT07606404)
- Testing
- Pars Plana Vitrectomy (PPV)-Based Macular Hole Surgery, Autologous Platelet-Rich Plasma (PRP), Human Amniotic Membrane (hAM) Graft
- Where
- Kazakhstan
- Volunteers
- 120 people
- Sponsor
- Kazakh Eye Research Institute
Proliferative Diabetic Retinopathy
OCT and OCT-A Afer Diabetic Vitrectomy in PDR
Detection of any structural or vascular changes at the macula after Pars Plana Vitrectomy ( PPV ) in cases with complicated proliferative diabetic retinopathy ( PDR )
- Trial name
- NCT05938491
- Testing
- OCT and OCT-A
- Volunteers
- 30 people
- Sponsor
- Assiut University
Macular Holes
Macular Hole Surgery With and Without Internal Limiting Membrane Peeling：A Systematic Review and Meta-analysis
Since Kelly and Wendel first reported successful closure of idiopathic macular holes (MH) by vitrectomy in 1991, many surgical modifications have been made to improve the anatomical and visual outcomes of this surgery.
- Trial name
- NCT01687829
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Yifan Feng
Macular Hole Retinal Detachment
Inverted Internal Limiting Membrane Flap Technique for Macular Hole Retinal Detachment in Highly Myopic Eyes
To evaluate efficacy of vitrectomy with inverted internal limiting membrane (ILM) flap technique for macular hole retinal detachment (MHRD) in highly myopic eyes, and to demonstrate postoperative clinical course of MHRD after…
- Trial name
- NCT02896972
- Testing
- Vitrectomy
- Volunteers
- 32 people
- Sponsor
- Kyorin University
High Myopia, Macular Holes
High Myopia Macular Hole and Retinal Detachment Treated With Double ILM Flaps
From July 2015 to December 2015, clinical record of 8 consecutive cases of macular hole with retinal detachment in high myopia treated with combined inverted and free ILM flap insertion into the hole were retrospectively…
- Conditions
- High Myopia, Macular Holes, Retinal Detachment
- Trial name
- NCT03174639
- Testing
- Inverted and free ILM insertion
- Volunteers
- 8 people
- Sponsor
- National Taiwan University Hospital
Diabetic Retinopathy, Macular Edema
PPV With Internal Limiting Membrane Peeling for Treatment-Naïve DME
Treatment-naïve subjects with center-involved diabetic macular edema undergoing pars plana vitrectomy with internal limiting membrane peeling will have similar visual outcomes but better anatomical outcomes compared to subjects…
- Trial name
- NCT03660345
- Testing
- PPV/MP, Intravitreal injection
- Where
- Mexico
- Volunteers
- 11 people
- Sponsor
- Rush Eye Associates
Idiopathic Macular Hole
ILM Inverted Flap Size in Macular Hole
In the current study, the investigators described the results of a randomized, comparative clinical trial that was conducted to study the impact of the size of internal limiting membrane (ILM) inverted flap on rate and timing of…
- Trial name
- NCT04683276
- Testing
- pars plana vitrectomy with ILM inverted flap
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Mansoura University
Idiopathic Macular Hole
Indocyanine Green or Trypan Blue for Delamination of the Internal Limiting Membrane in Macular Hole Surgery
To evaluate the anatomical and visual outcomes after vitrectomy and internal limiting membrane (ILM) peeling with indocyanine green (ICG) or trypan blue (TB) for idiopathic macular hole repair in a prospective randomized trial.
- Trial name
- NCT00419185
- Testing
- Delamination of the Internal limiting membrane
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Luebeck
Macular Hole, Macular Hole Surgery
No Endotamponade for Macular Hole Repair: the NEMAR Study
Full-thickness macular hole (MH) is a common sight threatening macular condition with a prevalence of 3.3 per 1000 individuals. Prompt surgical repair of MH is imperative in preventing irreversible vision loss from MH as the…
- Trial name
- NEMAR (NCT06908824)
- Testing
- Conventional surgery, ILM flap with no gas tamponade
- Where
- 3 sites in Hong Kong, Poland and 1 more
- Volunteers
- 180 people
- Sponsor
- Chinese University of Hong Kong
Vitrectomy, Macular Pucker
Assessing the Efficacy and Safety fo DEXTENZA, Sustained Release Dexamethasone 0.4 mg Insert(s) for the Treatment of Pain, Inflammation, and Cystoid Macular Edema Following 27 Gauge Vitrectomy With Internal Limiting Membrane Peel for the Treatment of Retinal Edema Associated With Macular Pucker.
Assessing the efficacy and safety of DEXTENZA, sustained release dexamethasone 0.4 mg inserts following 27 gauge vitrectomy with internal limiting membrane peel
- Conditions
- Vitrectomy, Macular Pucker, Retinal Edema
- Trial name
- NCT04501367
- Testing
- Dexamethasone Intracanalicular Insert, 0.4 mg, Prednisone acetate 1%
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kovach Eye Institute
Diffuse Diabetic Macular Edema
Vitrectomy Without Internal Limiting Membrane Removal in the Treatment of Diffuse Diabetic Macular Edema: a Comparative Kenalog Vs Bevacizumab Intravitreal Injection Vs Control Study
Diabetic macular edema is the most common cause of visual loss among patients with diabetic retinopathy. Pars plana vitrectomy has been reported to be effective for the treatment of diabetic macular edema.
- Trial name
- NCT00600301
- Testing
- Triamcinolone Acetonide and Bevacizumab
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Full Thickness Macular Hole
Inverted Flap Versus Internal Limiting Membrane Peeling in Small Full Thickness Macular Holes
Primary outcome: difference of microperimetry retinal sensitivity after primary vitrectomy for idiopathic full thickness macular holes with inverted flap technique versus internal limiting membrane (ILM) peeling technique…
- Trial name
- NCT04498624
- Testing
- inverted flap, peeling internal limiting membrane (ILM)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Turin, Italy
Retinal Perforations
Evaluation of a New Surgical Technique for Macular Hole Which Was Not Closed After a Previous Surgery
Macular hole is an infrequent retinal pathology (2 to 4/1000) which most often affects people aged over 60, and twice common in women than men. The vast majority of cases are idiopathic.
- Trial name
- ILMT (NCT02946372)
- Testing
- internal limiting membrane transplantation (ILMT)
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
Macular Pucker, Macular Hole
Brilliant Blue Versus Indocyanine Green
A study of non-inferiority design comparing brilliant blue and indocyanine green as intraoperative dye in macular pucker and macular hole.
- Conditions
- Macular Pucker, Macular Hole, Vitreoretinal Surgery
- Trial name
- NCT01083004
- Testing
- Indocyanine green, Brilliant blue arm
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Cologne
Macular Holes, Retinal Detachment
A Study of a New Surgical Treatment of Macular Hole Retinal Detachment in High Myopia
This study evaluates the surgical outcomes of inverted internal limiting membrane insertion combined with air tamponade in the treatment of macular hole retinal detachment (MHRD) in high myopia, and also to compare the treatment…
- Conditions
- Macular Holes, Retinal Detachment, High Myopia
- Trial name
- NCT03383731
- Testing
- Group 1, Group 2
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Retinal Detachment Rhegmatogenous, ILM Peeling
1ry Versus 2ry ILM Peeling in RD
Patients with uncomplicated rhegmatogenous retinal detachment will be recruited. All eyes will underwent 23G PPV with silicon oil tamponade. The eyes will be classified into two groups according to the timing of ILM peeling.
- Trial name
- NCT07346560
- Testing
- Primary ILM peeling, Secondary ILM peeling
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University