Clinical trials: Internal Radiation
Prostate Cancer
The Effect of Radiation on Semen Quality and Fertility in Men With Prostate Cancer
Many younger men are diagnosed with prostate cancer. These patients are often choosing radiation therapy as their primary treatment.
- Trial name
- NCT00496249
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Prostate Cancer, Radiotherapy Side Effect
Ultra Hypofractionnated Radiotherapy With HDR Brachytherapy Boost.
Phase 1-2 study, comparing ultra-hypofractionnated (UH) to a moderately hypofractionnated (MH) radiation therapy, with image guided HDR prostate brachytherapy.
- Conditions
- Prostate Cancer, Radiotherapy Side Effect, Hypofractionation, Brachytherapy
- Trial name
- HYPO-5 (NCT05786742)
- Testing
- grade and compare reported side effects between groups
- Where
- Canada
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Intrinsic Aging of Skin, Skin Wrinkling
Study of Intradermal Injections of RCS-01 in Male and Female Subjects
The primary purpose of this study is to assess the safety profile of RCS-01 injections as compared to placebo injections. This study will also measure the impact these injections will have on skin markers related to aging through…
- Conditions
- Intrinsic Aging of Skin, Skin Wrinkling, Solar Degeneration of Skin
- Trial name
- NCT02391935
- Testing
- RCS-01
- Where
- Germany
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- RepliCel Life Sciences, Inc.
Breast Cancer
Internal Mammary Lymph Nodes Irradiation in High-risk Breast Cancer After Neoadjuvant Chemotherapy
The aim of this study is to explore the impact of internal mammary nodal irradiation on disease-free survival in high-risk breast cancer patients (ypN+or supra/subclavicular lymph node positive) after neoadjuvant chemotherapy.
- Trial name
- NCT06559696
- Testing
- internal mammary nodal irradiation, No internal mammary node irradiation
- Where
- China
- Volunteers
- 722 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Hand Massage
The Effect of the Hand Massage A Women Undergoing Brachytherapy
Background Gynecologic cancers are among the ten most common cancers among women. During brachytherapy, women can have pain and situational anxiety due to the treatment.
- Trial name
- NCT05937607
- Testing
- Hand massage
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Cervix Uteri Cancer
Clinical Response and Toxicity of Hypo-fractionated Chemoradiotherapy in Cervix Cancer
Uterine cervix cancer can be treated definitively with concurrent chemoradiation (external beam radiotherapy and chemotherapy) followed by high dose rate brachytherapy.
- Trial name
- NCT04831437
- Testing
- Hypofractionated EBRT, Standard EBRT
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Gynecologic Cancer
Evaluation of a Brachytherapy Discharge Education Program to Improve Patient Care
Although brachytherapy is an effective treatment modality for gynecological cancer, a significant proportion of patients develop late treatment-related vaginal toxicity, negatively impacting their quality of life and limiting…
- Trial name
- BrachDEP (NCT04707937)
- Testing
- Online education, Regular standard of care education
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Breast Cancer, Fatigue
Using Pranayama and Deep Breathing Exercises to Reduce Cancer-Related Fatigue and Insomnia During Radiotherapy
The study aims to evaluate the effectiveness of pranayama and deep breathing exercise in reducing fatigue and insomnia in patients receiving radiotherapy due to breast cancer.
- Conditions
- Breast Cancer, Fatigue, Insomnia
- Trial name
- NCT04441827
- Testing
- breathing exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KTO Karatay University
Prostate Cancer
PD-L1-expressing Regulatory T Cells in Localized Prostate Cancer Patients Undergoing Iodine-125 Permanent Brachytherapy
Immunotherapy is currently revolutionizing the field in oncology. However, prostate cancer is poorly responsive to immune checkpoint inhibition.
- Trial name
- NCT04369508
- Testing
- permanent brachytherapy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Brachytherapy, Complementary Approaches
The Effect of Acupressure on Patients Receiving Brachytherapy
This study aimed to use acupressure to reduce anxiety in gynecologic cancer patients receiving brachytherapy. It was also aimed to investigate the effects of acupressure on anxiety, pain, and vital signs.
- Conditions
- Brachytherapy, Complementary Approaches, Gynecological Cancers
- Trial name
- NCT06531551
- Testing
- The group to which Acupressure will be applied in each fraction
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Locally Advanced Cervical Carcinoma
Evaluation of Ultraaccelerated High Dose Rate Intrauterine Interventional Radiotherapy
To evaluate the degree of acute and long-term intestinal, urinary and vaginal toxicity, and the impact on sexual activity of an accelerated fractionation of high dose rate interventional radiotherapy (IRT-HDR) in patients with…
- Trial name
- EROS3 (NCT06398938)
- Testing
- Interventional Radiotherapy
- Where
- Italy
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Prostate Cancer
Prophylactic Vs. Therapeutic Use of Uroxatrol in Men Undergoing Brachytherapy
To asess the efficacy of Uroxatrol, an alpha blocker in men undergoing prostate brachytherapy to treat prostate cancer, and whether the use of Uroxatrol in advance of the brachytherapy is better or not than starting it on the day…
- Trial name
- NCT00201630
- Testing
- Uroxatrol (drug)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- New York Prostate Institute
Insomnia, Anxiety
Evaluation of Physiological Effects Induced by Low Level Light Irradiation on the Acupoints of the Hand
The goal of this clinical trial is to determine if low-level laser therapy (LLLT) and LED-based low-level light therapy (LLLT) are effective in inducing relaxation and improving sleep quality and anxiety levels in individuals…
- Conditions
- Insomnia, Anxiety, Acupuncture, Low-level Laser Therapy
- Trial name
- Acupuncture (NCT07190417)
- Testing
- LEDs and laser light
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Prostate Cancer
Hemiablative Focal Brachytherapy Pilot Study
Whole gland LDR brachytherapy has been a well established modality of treating low risk prostate cancer. Treatment in a focal manner has the advantages of reduced toxicity to surrounding organs.
- Trial name
- NCT02643511
- Testing
- Transperineal template guided mapping biopsy, multiparametric MRI, Hemiablative Focal Brachytherapy
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- St George Hospital, Australia
Cervical Cancer
Development & Validation of Utilities for Health States Relevant to Cervical Cancer Patients
Purposes of this study: 1) To define comprehensive set of descriptive health states related to treatment of cervical cancer (e.g.
- Trial name
- NCT00788216
- Testing
- Discussion & scoring of health states related to the treatment of cervical cancer
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duke University
Insomnia
Effect of Low Level Light Irradiation on Insomniacs' Meridians During the First Sleep Cycle.
Introduction In the past, it was found that stimulating the meridians and acupoints with low-level light often had a good effect.
- Trial name
- NCT05426226
- Testing
- laser acupuncture
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Internal Radiation, Advanced Hepatocellular Carcinoma
Targeted Internal Radiation Therapy in Advanced HCC Patients.
The aim of this study is to evaluate the 131I-chTNT-1/B treatment effect and safety of individual therapy using randomized controlled study, in order to acquire the evidence of evidence-based medicine and create a new program of…
- Trial name
- NCT02724267
- Testing
- 131I-chTNT-1/B
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Prostate Cancer
Assessing Radio-hybrid Prostate Specific Membrane Antigen (rhPSMA-7.3) (18F) in Healthy Volunteers and Subjects With Prostate Cancer
A Phase 1, Open-label Study to Assess Safety, Biodistribution, and Internal Radiation Dosimetry of rhPSMA-7.3 (18F) Injection in Healthy Volunteers, and to Assess Safety and Investigate the Imaging Characteristics in Subjects…
- Trial name
- NCT03995888
- Testing
- rhPSMA-7.3 (18F) Injection
- Where
- Finland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Blue Earth Diagnostics
Prostatic Neoplasm
Pd-103 Dose De-Escalation for Early Stage Prostate Cancer: A Prospective Randomized Trial
The purpose of this study is to determine the most appropriate radiation implant dose for palladium-103 monotherapy. Radiation dose is related to potential cure.
- Trial name
- NCT00247312
- Testing
- Pd-103
- Where
- 2 sites in United States
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- Schiffler Cancer Center
Healthy Subjects (HS)
A Study to Evaluate the Safety, Biodistribution, Internal Radiation Dosimetry, and Effective Dose of DaTSCAN™ Ioflupane (123I) Injection in Chinese Healthy Volunteers.
This is a phase 1, single-centre, single-group, nonrandomized, noncomparative, open-label, single-dose study to evaluate the safety, biodistribution, internal radiation dosimetry, and effective dose of DaTSCAN™ ioflupane (123I)…
- Trial name
- NCT04564092
- Testing
- DaTSCAN™ Ioflupane (123I) Injection
- Where
- China
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- GE Healthcare