Clinical trials: Interstitial Cystitis/Bladder Pain Syndrome
Interstitial Cystitis, Bladder Diseases
Analysis of Expression of Nitric Oxide Syntheses and Their Functional Role in Human Urothelium
Painful bladder syndrome (PBS)/interstitial cystitis (IC) may be due to the actions of nitric oxide (NO) in the bladder tissue. NO is a gaseous substance with a very short half-life, synthesized by a group of NO-synthase-enzymes…
- Conditions
- Interstitial Cystitis, Bladder Diseases, Urinary Incontinence
- Trial name
- NCT00253006
- Testing
- Tissue examination for protein- and mRNA-expression of NO
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Copenhagen University Hospital at Herlev
Prostatitis, Chronic Prostatitis
Microbiome of Urologic Chronic Pelvic Pain Syndrome
This research is being done to learn more about the bacteria that live in the genito-urinary tract in subjects with urologic chronic pelvic pain syndrome (UCPPS).
- Conditions
- Prostatitis, Chronic Prostatitis, Interstitial Cystitis, Painful Bladder Syndrome
- Trial name
- NCT03027076
- Testing
- Genitourinary Specimen Collection, Collect midstream urine samples
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Interstitial Cystitis, Painful Bladder Syndrome
Pilot Study of Percutaneous Posterior Tibial Nerve Stimulation for the Treatment of IC/PBS
In 2014, the American Urological Association updated it management algorithm for Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS). As the algorithm progresses, interventions become increasingly invasive and morbid.
- Trial name
- NCT02550561
- Testing
- Posterior Tibial Nerve Stimulation
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Overactive Bladder, Bladder Pain Syndrome
Migraine Medication Effects on Urinary Symptoms
A prospective observational cohort trial to study the effects of CGRP inhibitors (CGRPi) on lower urinary tract symptoms (LUTS) and bladder/pelvic pain.
- Conditions
- Overactive Bladder, Bladder Pain Syndrome, Migraine Disorders, Overactive Bladder Syndrome
- Trial name
- NCT06212661
- Testing
- Ubrogepant, Rimegepant, Atogepant
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The Cleveland Clinic
Urologic Chronic Pelvic Pain Syndrome (UCPPS), Interstitial Cystitis
EPPIC: Easing Pelvic Pain Interventions Clinical Research Program
The EPPIC (Easing Pelvic Pain Interventions Clinical Research Program) study evaluates an ultra-brief, 4 session cognitive behavioral pain treatment transdiagnostic in design for urologic chronic pain syndrome (UCPPS) with…
- Conditions
- Urologic Chronic Pelvic Pain Syndrome (UCPPS), Interstitial Cystitis, Bladder Pain Syndrome, Chronic Prostatitis
- Trial name
- EPPIC (NCT05127616)
- Testing
- Minimal Contact-Cognitive Behavior Therapy, Patient Education/Support
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- State University of New York at Buffalo
Painful Bladder Syndrome, Interstitial Cystitis
Prospective Trial Comparing Intravesical Chondroitin Sulphate 2% and DMSO in the Treatment of PBS/Interstitial Cystitis
Painful bladder syndrome/interstitial cystitis (PBS/IC)is a disease of unknown origin with a significant impact on the quality of life.
- Trial name
- NCT04268810
- Testing
- Bladder instillations
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- National Multiple Sclerosis Center
Bladder Pain Syndrome, Interstitial Cystitis
Acupuncture First for IC/BPS
The goal of this clinical trial is to learn if acupuncture in addition to behavioral changes can better treat in women with bladder pain syndrome (also known as interstitial cystitis) that have not received other treatments.
- Trial name
- NCT06366269
- Testing
- Acupuncture, Behavioral management, Physical therapy
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University Hospitals Cleveland Medical Center
Interstitial Cystitis, Bladder Pain Syndrome
The Female Microbiome in Patients Undergoing Bladder Instillation Therapy
The underlying pathophysiology for BPS/IC is currently an active area of research. There is speculation that there may be alteration in the bladder and vaginal microbiome that contributes to the symptomatology of BPS/IC, however…
- Conditions
- Interstitial Cystitis, Bladder Pain Syndrome, Microbial Colonization
- Trial name
- NCT05414305
- Testing
- Heparin & Alkalinized Lidocaine Bladder Instillation
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Walter Reed National Military Medical Center
Bladder Pain Syndrome
fMRI for BPS: A Descriptive Study of Findings and Symptoms
The goal of this observational study is to investigate the relationship between functional magnetic resonance imaging (fMRI) findings of the brain and symptom presentation in patients with bladder pain syndrome (BPS).
- Trial name
- NCT06294951
- Testing
- fMRI
- Where
- China
- Volunteers
- 120 people
- Sponsor
- RenJi Hospital
Interstitial Cystitis, Bladder Pain Syndrome
The CBD-IC Randomized Controlled Trial: Evaluation of Hemp Cannabidiol SuppositoRies for Pain and Urinary SymptOms in INterstitial Cystitis (CHRONIC)
This study seeks to exploit bladder cannabidiol receptors as a therapeutic drug target by conducting a double-masked, placebo-controlled randomized trial evaluating the effects of vaginal hemp cannabidiol (CBD) suppositories on…
- Trial name
- CHRONIC (NCT04349930)
- Testing
- Cannabidiol vaginal suppository
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of New Mexico
Cystitis, Interstitial, Painful Bladder Syndrome
A Study to Determine the Role of Toll-like Receptor-4 Expression in Patients With Interstitial Cystitis/Bladder Pain Syndrome
This is a prospective pilot study, with a recruitment goal of 60 patients. Patients who are female, above the age of 18, and with a diagnosis of IC/BPS based on clinical criteria and O'Leary Sant ICPI and ICSI scores undergoing…
- Trial name
- NCT02868775
- Testing
- cystoscopy, bladder hydrodistention and bladder biopsy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Philadelphia Urosurgical Associates
Interstitial Cystitis, Levator Spasm
A Multidisciplinary, Multimodal Bundled Care Approach to Chronic Pelvic Pain
The goal of this clinical trial is to compare two different treatment patterns in patients with chronic bladder pain. The main questions the investigators are seeking to answer is if bladder pain improves before and after…
- Conditions
- Interstitial Cystitis, Levator Spasm, Bladder Pain Syndrome
- Trial name
- NCT05658874
- Testing
- Multimodal Bundle Drugs, Operative Cystoscopy, Behavioral health consultation/therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Jocelyn Fitzgerald
Interstitial Cystitis, Bladder Pain Syndrome
Engage 24: Evaluation of the Safety and Effectiveness of URG101 in Subjects With Interstitial Cystitis/Bladder Pain Syndrome
The purpose of this study is to determine if the combination product (URG101) is safe and effective versus its individual components (Heparin Sodium and Lidocaine Hydrochloride) for the treatment of Interstitial Cystitis/Bladder…
- Trial name
- NCT02591199
- Testing
- URG101, Lidocaine, Heparin
- Where
- 11 sites in United States
- Volunteers
- 91 people
- Sponsor
- Urigen
Painful Bladder Syndrome
Sensory Processing in Subjects With Painful Bladder Syndrome
The purpose of this study is to determine if clinically relevant subsets exist in patients meeting the diagnosis of Painful Bladder Syndrome (PBS).
- Trial name
- NCT00903643
- Testing
- Physical examination
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Interstitial Cystitis, Chronic Prostatitis
Microbiomes of Pelvic Pain
This research study seeks to provide more insight as to how the microbiome affects or is affected by conditions causing chronic pelvic pain such as Interstitial Cystitis (IC), Chronic Prostatitis/Chronic Pelvic Pain Syndrome…
- Conditions
- Interstitial Cystitis, Chronic Prostatitis, Chronic Pelvic Pain Syndrome, Lower Urinary Tract Symptoms
- Trial name
- NCT01738464
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Interstitial Cystitis/Bladder Pain Syndrome
Study of V117957 in Interstitial Cystitis/Bladder Pain Syndrome
The purpose of this study is to evaluate the safety, tolerability and efficacy of V117957 in subjects with interstitial cystitis/bladder pain syndrome, compared to placebo.
- Trial name
- NCT06285214
- Testing
- V117957
- Where
- 24 sites in United States
- Volunteers
- 47 people
- Sponsor
- Imbrium Therapeutics
Gastrointestinal Diseases, Chronic Pain
Web-Based Survey of Pain, Stress and Complementary and Alternative Medicine
The investigators are inviting people with fibromyalgia, IBS, interstitial cystitis, chronic pain, and other chronic and recurring conditions to sign up and participate in a year-long Internet-based survey to study the…
- Conditions
- Gastrointestinal Diseases, Chronic Pain, Stress, Anxiety
- Trial name
- PROCAIM (NCT00740233)
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Interstitial Cystitis, Bladder Pain Syndrome
Clinical Trial Comparing Two Bladder Instillations for IC/BPS
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a condition that results in long-term bladder and pelvic pain. IC/BPS affects women more often than men. How the disorder develops is not completely known.
- Trial name
- NCT03463915
- Testing
- Bladder instillation WITH triamcinolone acetonide, Bladder instillation WITHOUT triamcinolone acetonide
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Olivia Cardenas-Trowers, M.D.
Interstitial Cystitis, Bladder Pain Syndrome
Efficacy and Safety of 2 Doses of AQX-1125 in Subjects With Interstitial Cystitis / Bladder Pain Syndrome
This study evaluates the effects of two doses of oral AQX-1125 on bladder pain and other urinary symptoms in subjects with interstitial cystitis/bladder pain syndrome.
- Conditions
- Interstitial Cystitis, Bladder Pain Syndrome, Painful Bladder Syndrome, Chronic Interstitial Cystitis
- Trial name
- LEADERSHIP 301 (NCT02858453)
- Testing
- AQX-1125 100 mg, AQX-1125 200 mg
- Where
- 120 sites in United States, Belgium and 10 more
- Volunteers
- 433 people
- Sponsor
- Aquinox Pharmaceuticals (Canada) Inc.
Painful Bladder Syndrome, Interstitial Cystitis
Acupuncture for Female IC/PBSyndrome and Its Effect on the Urinary Microbiome: A Randomized Controlled Trial
The investigators central hypothesis is that women with Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) will benefit from acupuncture compared with sham treatment and acupuncture responders will have a differential…
- Trial name
- NCT02232282
- Testing
- standard acupuncture treatment
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Loyola University