Clinical trials: Interstitial Liquid
Obesity, Type 2 Diabetes Mellitus
The Influence of Fatty-Acids on Systemic and Subcutaneous Cytokines
This is a mono-center randomized controlled trial to be performed in the Center of Medical Research (ZMF) at Medical University Graz and is composed by one screening visit (V1) and two study visits (V2 and V3).
- Trial name
- TNF4 (NCT00708266)
- Testing
- Openflow microperfusion catheter, Intralipid 20%, 0.9% Saline Solution
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Effectiveness and Safety Study of the Next-Generation DexCom™ SEVEN® Continuous Glucose Monitoring System
The purpose of this study is to evaluate the safety and effectiveness of the next-generation DexCom SEVEN Continuous Glucose Monitoring System (SEVEN.2 System) when worn for up to 7-days by subjects >18 years-old with diabetes…
- Trial name
- NCT00722241
- Where
- 3 sites in United States
- Volunteers
- 53 people
- Sponsor
- DexCom, Inc.
Inflammation, Vasculitis
Analysis of Bronchial Tissue and Fluid in Patients With Wegener's Granulomatosis
This study will collect fluid and tissue samples from the bronchi (air passages to the lungs) of patients with Wegener's granulomatosis for laboratory examination.
- Conditions
- Inflammation, Vasculitis, Wegener's Granulomatosis
- Trial name
- NCT00001541
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lung Diseases, Interstitial
Nebulized Human Amniotic Fluid in Patients With Interstitial Lung Disease
This is a Phase I, pilot clinical trial designed to evaluate the safety and exploratory efficacy of nebulized diluted amniotic fluid, Matrix (HAF-Matrix) in adults with interstitial lung disease (ILD).
- Trial name
- HAF ILD (NCT07372989)
- Testing
- Matrix
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Maule Stem Cell Research Institute, Inc.
Pulmonary Edema
Pulmonary Function at High-Altitude
Based on the findings of decreased vital capacity, decreased FEV1 and increased closing volume after ascent to high altitude, some investigators suggest the presence of a subclinical high altitude pulmonary edema (HAPE).
- Trial name
- NCT00604227
- Testing
- Hypoxic Exposure
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Cryptogenic Organizing Pneumonia, Idiopathic Interstitial Pneumonias
Screening Microorganism of Cryptogenic Mechanical Pneumonia Through Next Generation Sequencing to Lung Tissue Fluid
The etiology of cryptogenic organizing pneumonia (COP)was not clear, but previous studies have shown that in some patients, some pathogen could be detected in bronchoalveolar lavage fluid (BALF), and may be one of the causes of…
- Trial name
- COPandNGS (NCT04511884)
- Testing
- Next-generation sequencing
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Healthy
Study of Dermal Interstitial Fluid Collection With a Vacuum-Assisted Microneedle Device
This study evaluates the collection of dermal interstitial fluid using a vacuum-assisted microneedle device in healthy adult volunteers.
- Trial name
- MAP (NCT07867028)
- Testing
- Vacuum-Assisted Microneedle Device
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sharon Pitteri
Heart Defects, Congenital, Hypoplastic Left Heart Syndrome
Fluid Balance in Children Undergoing Fontan Surgery
This project will evaluate fluid balance and edema formation in children with congenital heart disease in need of a surgical procedure, The Fontan procedure.
- Trial name
- NCT02306057
- Testing
- Pre BCPC, Pre TCPC, BCPC surgery
- Where
- Norway
- Volunteers
- 39 people
- Sponsor
- Oslo University Hospital
Biomarkers, Acute Kidney Injury
Vancomycin Exposure and Biomarker Tracking Using Real-time Monitoring of Interstitial Fluid
The goal of this observational study is to understand whether a wearable sensor (the Nutromics Sensor Device) can accurately measure drug and biomarker levels in the fluid just under the skin (interstitial fluid), instead of…
- Conditions
- Biomarkers, Acute Kidney Injury, Sepsis
- Trial name
- VENTURE (NCT07893223)
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Nutromics
Opioid Use Disorder
Assessment of Methadone and Buprenorphine in Interstitial Fluid
The purpose of this research is to determine if common medications for opioid use disorder (i.e., buprenorphine/naloxone, buprenorphine, methadone) and their metabolites (norbuprenorphine [a metabolite of buprenorphine]…
- Trial name
- NCT05546229
- Testing
- Microneedle based interstitial fluid collection
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Cari Health Inc.
Dengue Fever, Children
New Tools for Predicting Capillary Leak Shock During Dengue Fever
Evaluate the prognostic value of different methods (Osmometry / clinical-biological score) compared to the occurrence of capillary leak shock during dengue fever.
- Conditions
- Dengue Fever, Children, Adults
- Trial name
- PrediDengue (NCT04422782)
- Testing
- For each routine sample, an additional tube will be collected to measure the osmotic pressure in the blood and urine
- Where
- France
- Volunteers
- 342 people
- Sponsor
- Centre Hospitalier de Cayenne
Cardiovascular Diseases
Biomarkers in Dermal Interstitial Fluid for Early Diagnosis and Follow-up of Cardiovascular Diseases
Sampling of dISF and blood plasma for qualitative measurements.
- Trial name
- BIO-ISF-CVD (NCT06632353)
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Ascilion AB
Cervical Cancer
Predictive Assays In Cervix Cancer
The experiments outlined in this proposal will compare a number of currently available techniques for assessing hypoxia and interstitial fluid pressures in patients with cervix cancer.
- Trial name
- NCT01181375
- Testing
- Tumour Biopsies and Blood Sampling
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University Health Network, Toronto
Type 1 Diabetes
Investigation of Correlation Between Concentrations of Glucose in Blood and Interstitial Fluid in Type 1 Diabetics
This is a mono-centre trial performed at the Center for Clinical Research at the Medical University Graz. There will be a screening information and a study visit.In the study visit arterialized venous blood glucose values will be…
- Trial name
- NCT00499954
- Testing
- Microdialysis, Guardian RT, Glucoday S
- Where
- Austria
- Volunteers
- 16 people
- Sponsor
- Medical University of Graz
Glioblastoma
Effect of Salovum® on Pressure, Oxygen and Inflammation in Glioblastoma
The objective of this clinical trial is to investigate the effects of Salovum®, an egg yolk powder enriched with the endogenous protein antisecretory factor, in participants undergoing diagnostic biopsies for suspected…
- Trial name
- AFGBMBiop (NCT07364786)
- Testing
- Salovum
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Peter Siesjö
Cava-pulmonary Anastomosis
Surgical Site Infection Study
The purpose of this study is to investigate the pharmacokinetics of cefazolin using both plasma and microdialysate sampling methods in children with single ventricle physiology undergoing their second palliation procedure.
- Trial name
- SSI (NCT01449669)
- Volunteers
- 14 people
- Sponsor
- Children's Hospital of Philadelphia
Critical Illness
Continuous Glucose Monitoring With a Subcutaneous Sensor During Critical Illness and Surgery
We hypothesize that measurements of interstitial fluid (ISF) glucose by the FreeStyle Navigator (Abbot Diabetes Care), a continuous glucose monitoring system, will correlate with blood glucose (BG) values in surgical and ICU…
- Trial name
- NCT00694473
- Testing
- Freestyle Navigator
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Massachusetts General Hospital
Diabetes, Healthy
A Trial Investigating the Relationship Between Pharmacodynamic and Interstitial Concentration for Insulin Detemir and Human Insulin
This study is conducted in Europe. The aim of this study is to estimate the relationship between pharmacodynamic and interstitial pharmacokinetic steady state following intravenous (i.v.) administration of insulin detemir and…
- Trial name
- NCT02162407
- Testing
- insulin detemir, human soluble insulin
- Where
- Austria
- Volunteers
- 13 people
- Sponsor
- Novo Nordisk A/S
Coronary Artery Bypass, Coronary Artery Bypass Graft
A Single Centre Study Comparing Continuous Interstitial Fluid Lactate Detection to Standard Measurements of Lactate in Patients Undergoing Elective Coronary Artery Bypass Graft Surgery and/or Valve Replacement.
The main goal of this study is to see if a wearable device can reliably track changes in lactate levels in the body. We\'ll compare the device\'s readings to standard blood tests to ensure accuracy.
- Conditions
- Coronary Artery Bypass, Coronary Artery Bypass Graft, Coronary Artery Bypass Graft Surgery (CABG), Valve Replacement
- Trial name
- CONTINUUM LINT (NCT06602336)
- Testing
- Continuous Lactate Monitoring Device
- Where
- United Kingdom
- Volunteers
- 61 people
- Sponsor
- Queen Mary University of London
IDIOPATHIC PULMONARY FIBROSIS
The Role of Gastric Content Microaspirations in the Pathogenesis of Idiopathic Pulmonary Fibrosis
The pathogenesis of idiopathic pulmonary fibrosis (IPF) is debatable. Looking for an insult to lung parenchyma that generates the pathogenesis of the disease is challenging.
- Trial name
- NCT01714934
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center