Clinical trials: Interstitial Liquid
Diabetes Care
Investigation of a Sub-Conjunctival Insert
The study is intended to evaluate a non-invasive method of glucose measurement in diabetics. The medical device that is evaluated consists on a sensor-insert which is placed under the conjunctiva of the eye of diabetic patients…
- Trial name
- NCT00999856
- Testing
- GOMIS and Photometer
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- EyeSense GmbH
Healthy Volunteers
Minimally Invasive Sensing of Beta-lactam Antibiotics
This study is an in-house feasibility study of a microneedle biosensor developed within Imperial College London.
- Trial name
- MISBL (NCT03847610)
- Testing
- Phenoxymethyl Penicillin, Microneedle array
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Skin Massage
Exploring the Cutaneous Immune Response to Skin Massage in Early Life
This project aims to study whether regular skin massage in babies induces cutaneous inflammation and whether this inflammatory response is amplified in those receiving daily (vs bi-weekly or no) skin massage over an 8 week…
- Trial name
- CUTIE (NCT07228728)
- Testing
- Skin Massage with Product
- Where
- United Kingdom
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- King's College London
Breast Carcinoma
Contrast-Enhanced Ultrasound Scan for the Estimation of Tissue Pressure in Patients With Breast Cancer
This clinical trial studies the use of contrast-enhanced ultrasound (CEUS) in estimating tissue pressure in patients with breast cancer. Diagnostic procedures, such as CEUS, may help estimate tissue pressure noninvasively.
- Trial name
- NCT04721886
- Testing
- Ultrasonsgraphy, Perflutren Lipid Microcpheres, Contrast - Enhanced Ultrasound
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Thomas Jefferson University
Chronic Fatigue Syndrome, Fibromyalgia
Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
The purpose of this study is: 1. To identify specific set of proteins in the cerebrospinal fluid (fluid surrounding the brain and the spinal cord), that are believed to be seen in Chronic fatigue syndrome (CFS) patients, but not…
- Conditions
- Chronic Fatigue Syndrome, Fibromyalgia, Gulf War Illness, Multiple Chemical Sensitivity
- Trial name
- NCT00810329
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Lung Transplantation
Development a Method to Extract Antibiotic Concentration From Interstitial Lung and Epithelial Lining Fluid.
Infections are critical factors for the survival of critically ill patients. A serious problem is the high variability of antibiotic concentrations in critically ill patients.
- Trial name
- ALF (NCT03970265)
- Testing
- extraction of ELF and ILF from explanted lung tissue; meropenem concentration in ELF and ILF; ELF on postoperative day 1-5 when bronchoscopy is performed within clinical routine.
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Pneumonitis
Single-cell Sequencing of BLF to Guide the Treatment of Radiation Pneumonitis or Immune Checkpoint Inhibitor Pneumonitis
A multicenter, exploratory clinical research, to map the radiation or immune checkpoint inhibitor pneumonitis in patients with alveolar lavage single-celled map.
- Trial name
- NCT05455034
- Testing
- single-cell sequencing
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xinqiao Hospital of Chongqing
Colloid Osmotic Pressure
Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma
The purpose of this study is to evaluate a method of sampling interstitial fluid from subcutaneous sewn wicks.
- Trial name
- NCT01044979
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Colloid Osmotic Pressure
Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma in Healthy and Sick Children
The purpose of this study is to measure colloid osmotic pressure in interstitial fluid and plasma in healthy children under two years, in asphyxiated babies and in children undergoing heart surgery.
- Trial name
- NCT01044940
- Where
- Norway
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Hyperglycemia, Hypotension
Feasibility of Using the "CGM GUARDIAN 2" Interstitial Fluid Glucose Measurement System in Intensive Care Medicine
Glycemic imbalances are very common in shock patients admitted to intensive care units. A blood glucose control every 2 hours is routinely performed in patients requiring insulin therapy.
- Conditions
- Hyperglycemia, Hypotension, Shock, Septic
- Trial name
- GALI (NCT04910841)
- Testing
- CGM GUARDIAN 2
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Feasibility Study of Blood Glucose Monitoring With the Non-invasive Medical Device D-Base
This study aims to evaluate the feasibility of monitoring the blood glucose values by measuring the glucose in the interstitial fluid of the skin on the wrist of subjects with diabetes mellitus type 1 and 2.
- Trial name
- NCT05169034
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Diamontech AG
Diabetes Mellitus, Type 2
ApoB48 Metabolism in Plasma and Interstitial Fluid
Postprandial increases in the levels of atherogenic chylomicron remnant lipoprotein particles have long been considered a presumable risk factor for the development of atherosclerosis with time, also in normolipidemic subjects.
- Trial name
- NCT03921203
- Where
- Sweden
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Sepsis, Diastolic Dysfunction
Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients
Sepsis is one of the most challenging conditions with an exceptionally high mortality rate. Diastolic Dysfunction is common in septic patients and has been found to be associated with mortality.
- Conditions
- Sepsis, Diastolic Dysfunction, Lung Edema, Fluid Overload
- Trial name
- NCT03768752
- Where
- Germany
- Volunteers
- 83 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Adherence, Medication, Opioid Use Disorder
Assessing Dose Taken in Opioid Use Disordered Patients With an Electrochemical Sensor
CARI Health aims to develop a methadone dose taken sensor that provides real-time data on interstitial fluid (ISF) levels that could be used as a methadone adherence monitor for daily doses.
- Trial name
- NCT05998876
- Testing
- Remote Medication Monitor (RMM) - Prototype, Daily Methadone Dose
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cari Health Inc.
Colloid Osmotic Pressure
Measurement of Colloid Osmotic Pressure in Plasma and Interstitial Fluid in Children
The purpose of this study is to identify normal values of colloid osmotic pressure in interstitial fluid and plasma in healthy children between 2 and 10 years.
- Trial name
- NCT01044641
- Where
- Norway
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Diagnostic Technics, Neurological
Measuring Fluid Flow in the Brain Using Alcohol and MRI in Healthy Participants
Intracranial interstitial fluid (ISF) flow is crucial for adequate clearance of extracellular waste products from the brain parenchyma.
- Trial name
- NCT04608292
- Testing
- Single-voxel MRS, Multi-voxel MRSI, Magnetization Transfer Imaging
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Critical Illness, Metabolism Disorders
Blood-Interstitial Fluid Glucose Gap
Metabolic monitoring is fundamental to guiding nutritional therapy in critically ill patients. Although indirect calorimetry is the established gold standard for measuring resting energy expenditure, its routine clinical use is…
- Trial name
- NCT07240103
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Chinese Medical Association
No Condition, Healthy Individuals
Microneedle-based ISF Sampling Technique
This clinical investigation aims to evaluate the performance and safety of the PELSA system, a hollow microneedle-based medical device designed for the collection of dermal interstitial fluid (dISF) from human skin.
- Trial name
- MIST (NCT07882225)
- Testing
- PELSA System
- Where
- Germany
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Ascilion AB
Cushing Syndrome, Primary Aldosteronism
Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Improved Management of Adrenal Disorders
The goal of this project is to provide novel technology that will pave the way from the present single-point (analogue) endocrinology towards continuous cortisol and aldosterone monitoring with full time resolution.
- Conditions
- Cushing Syndrome, Primary Aldosteronism, Adrenal Insufficiency
- Trial name
- NCT06980753
- Testing
- Participants will use the biossensor for 48 h
- Where
- Brazil
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Hydrocephalus
Crystallization of LA and Adjuvant Mixtures in Cerebrospinal Fluid
Different mixtures of local anesthetics or local anesthetics with adjuvants that are known to precipitate in vitro are tested in human cerebrospinal fluid (CSF).
- Trial name
- NCT07442929
- Where
- Austria
- Volunteers
- 2 people
- Sponsor
- Medical University Innsbruck