Clinical trials: Interstitial Liquid, active
Cervix Neoplasms
Cervix: Hypoxia, Interstitial Fluid Pressure and GSH Levels
The aim of this study is to measure the oxygen content and interstitial fluid pressure in cervix cancer patients. Tumour oxygen content and internal pressure of tumours may be an important factor that influences the effectiveness…
- Trial name
- NCT00188539
- Testing
- Pre-treatment tumour oxygen measurements (under anesthesia)
- Where
- Canada
- Volunteers
- 346 people
- Sponsor
- University Health Network, Toronto
Biomarkers, Acute Kidney Injury
Vancomycin Exposure and Biomarker Tracking Using Real-time Monitoring of Interstitial Fluid
The goal of this observational study is to understand whether a wearable sensor (the Nutromics Sensor Device) can accurately measure drug and biomarker levels in the fluid just under the skin (interstitial fluid), instead of…
- Conditions
- Biomarkers, Acute Kidney Injury, Sepsis
- Trial name
- VENTURE (NCT07893223)
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Nutromics
Breast Cancer
Proteomics and Radiomics Research of Breast Cancer Markers in Tissue, Interstitial Fluid and Serum
The current study is a case control study involving comparisons of tissue interstitial fluid from breast cancer and adjacent non-cancerous tissue as well as that from benign breast lesion and its adjacent non-diseased tissue for…
- Trial name
- NCT01042548
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Pittsburgh
Hyperglycemia, Hypotension
Feasibility of Using the "CGM GUARDIAN 2" Interstitial Fluid Glucose Measurement System in Intensive Care Medicine
Glycemic imbalances are very common in shock patients admitted to intensive care units. A blood glucose control every 2 hours is routinely performed in patients requiring insulin therapy.
- Conditions
- Hyperglycemia, Hypotension, Shock, Septic
- Trial name
- GALI (NCT04910841)
- Testing
- CGM GUARDIAN 2
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Eczema, Atopic Dermatitis
Cutaneous Biomarkers in Atopic Eczema Using a Non-Invasive Micro-Suction Device in Babies
This project aims to establish whether an adapted extraction device is tolerable and will be able to measure chemical signals in baby's ISF.
- Conditions
- Eczema, Atopic Dermatitis, Atopic Eczema
- Trial name
- CARE (NCT07228962)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King's College London
Healthy
Study of Dermal Interstitial Fluid Collection With a Vacuum-Assisted Microneedle Device
This study evaluates the collection of dermal interstitial fluid using a vacuum-assisted microneedle device in healthy adult volunteers.
- Trial name
- MAP (NCT07867028)
- Testing
- Vacuum-Assisted Microneedle Device
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sharon Pitteri
Coronary Artery Bypass, Coronary Artery Bypass Graft
A Single Centre Study Comparing Continuous Interstitial Fluid Lactate Detection to Standard Measurements of Lactate in Patients Undergoing Elective Coronary Artery Bypass Graft Surgery and/or Valve Replacement.
The main goal of this study is to see if a wearable device can reliably track changes in lactate levels in the body. We\'ll compare the device\'s readings to standard blood tests to ensure accuracy.
- Conditions
- Coronary Artery Bypass, Coronary Artery Bypass Graft, Coronary Artery Bypass Graft Surgery (CABG), Valve Replacement
- Trial name
- CONTINUUM LINT (NCT06602336)
- Testing
- Continuous Lactate Monitoring Device
- Where
- United Kingdom
- Volunteers
- 61 people
- Sponsor
- Queen Mary University of London
Sepsis, Sepsis Bacterial
A Validation Study of the Lab Clasp Device: A Point of Care Sepsis Risk Monitor
The overall purpose of this study is to demonstrate the usability of a clinical-grade device in the form of a finger clasp similar to a pulse oximeter for monitoring lactate values, by comparing its performance in reading…
- Conditions
- Sepsis, Sepsis Bacterial, Lactate Blood Increase, Infectious Disease
- Trial name
- NCT04796285
- Testing
- Lab Clasp
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
No Condition, Healthy Individuals
Microneedle-based ISF Sampling Technique
This clinical investigation aims to evaluate the performance and safety of the PELSA system, a hollow microneedle-based medical device designed for the collection of dermal interstitial fluid (dISF) from human skin.
- Trial name
- MIST (NCT07882225)
- Testing
- PELSA System
- Where
- Germany
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Ascilion AB
Epidermis, Ultraviolet Exposure
A Clinical Study to Evaluate the Efficacy and SPF of Two Test Materials According to an Adaptation of the Guidelines of the FDA Sunscreen Drug Products for Over-the-Counter Human Use
Approximately 70 subjects (35 subjects per light and dark group) will be enrolled in this clinical study (to complete with a minimum of 10 subjects per skin type (I-VI) to assess the effects of known UV Radiation dosage on light…
- Trial name
- NCT07789639
- Testing
- Hybrid sunscreen, Chemical sunscreen, No sunscreen
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Good Molecules, LLC
Lung Diseases, Interstitial
Nebulized Human Amniotic Fluid in Patients With Interstitial Lung Disease
This is a Phase I, pilot clinical trial designed to evaluate the safety and exploratory efficacy of nebulized diluted amniotic fluid, Matrix (HAF-Matrix) in adults with interstitial lung disease (ILD).
- Trial name
- HAF ILD (NCT07372989)
- Testing
- Matrix
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Maule Stem Cell Research Institute, Inc.
Cardiovascular Diseases
Biomarkers in Dermal Interstitial Fluid for Early Diagnosis and Follow-up of Cardiovascular Diseases
Sampling of dISF and blood plasma for qualitative measurements.
- Trial name
- BIO-ISF-CVD (NCT06632353)
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Ascilion AB
Cervical Cancer
Predictive Assays In Cervix Cancer
The experiments outlined in this proposal will compare a number of currently available techniques for assessing hypoxia and interstitial fluid pressures in patients with cervix cancer.
- Trial name
- NCT01181375
- Testing
- Tumour Biopsies and Blood Sampling
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University Health Network, Toronto
Pneumonitis
Single-cell Sequencing of BLF to Guide the Treatment of Radiation Pneumonitis or Immune Checkpoint Inhibitor Pneumonitis
A multicenter, exploratory clinical research, to map the radiation or immune checkpoint inhibitor pneumonitis in patients with alveolar lavage single-celled map.
- Trial name
- NCT05455034
- Testing
- single-cell sequencing
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xinqiao Hospital of Chongqing
Skin Massage
Exploring the Cutaneous Immune Response to Skin Massage in Early Life
This project aims to study whether regular skin massage in babies induces cutaneous inflammation and whether this inflammatory response is amplified in those receiving daily (vs bi-weekly or no) skin massage over an 8 week…
- Trial name
- CUTIE (NCT07228728)
- Testing
- Skin Massage with Product
- Where
- United Kingdom
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- King's College London
Glioblastoma
Effect of Salovum® on Pressure, Oxygen and Inflammation in Glioblastoma
The objective of this clinical trial is to investigate the effects of Salovum®, an egg yolk powder enriched with the endogenous protein antisecretory factor, in participants undergoing diagnostic biopsies for suspected…
- Trial name
- AFGBMBiop (NCT07364786)
- Testing
- Salovum
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Peter Siesjö
Diagnostic Technics, Neurological
Measuring Fluid Flow in the Brain Using Alcohol and MRI in Healthy Participants
Intracranial interstitial fluid (ISF) flow is crucial for adequate clearance of extracellular waste products from the brain parenchyma.
- Trial name
- NCT04608292
- Testing
- Single-voxel MRS, Multi-voxel MRSI, Magnetization Transfer Imaging
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Alcohol Intoxication
Development of LabPatch-alcohol as a Noninvasive Skin Patch to Detect Blood Alcohol Concentrations
This study is designed to test LabPatch-alcohol, a wearable, non-invasive biosensor Band-Aid like patch that is designed to detect real-time changes in interstitial alcohol concentrations in human subjects.
- Trial name
- NCT03242161
- Testing
- LabPatch-alcohol
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Cushing Syndrome, Primary Aldosteronism
Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Improved Management of Adrenal Disorders
The goal of this project is to provide novel technology that will pave the way from the present single-point (analogue) endocrinology towards continuous cortisol and aldosterone monitoring with full time resolution.
- Conditions
- Cushing Syndrome, Primary Aldosteronism, Adrenal Insufficiency
- Trial name
- NCT06980753
- Testing
- Participants will use the biossensor for 48 h
- Where
- Brazil
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital