Clinical trials: Intervention Phase
Malignant Melanoma
Safety and Efficacy Study of Pembrolizumab (MK-3475) Combined With Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Advance Melanoma (MK-7902-003/E7080-G000-312/LEAP-003)
The purpose of this study is to assess the safety and efficacy of pembrolizumab (MK-3475) combined with lenvatinib (MK-7902/E7080) compared to pembrolizumab alone (with placebo for lenvatinib) as first-line treatment in adults…
- Trial name
- NCT03820986
- Testing
- Pembrolizumab, Lenvatinib
- Where
- 119 sites in United States, Australia and 16 more
- Volunteers
- 674 people
- Sponsor
- Merck Sharp & Dohme LLC
Hemophilia
Safety and Efficacy of FVIIa to Prevent Excessive Bleeding in Hemophilia Patients With Inhibitors Undergoing Major Surgery
This is an interventional, prospective, international, multicenter, single-arm, Phase 3, and sequential efficacy and safety study in adolescents and adults with congenital hemophilia A or B with inhibitors to factor VIII (FVIII)…
- Trial name
- SCOPE HIM (NCT05695391)
- Testing
- Coagulation Factor VIIa (Recombinant)
- Where
- 15 sites in United States, Malaysia and 4 more
- Volunteers
- 2 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
End Stage Renal Disease
Survival on Peritoneal Dialysis (PD) Versus Hemodialysis (HD) in China
Primary Objective: The primary objective is to prospectively assess and compare survival in subjects with End Stage Renal Disease (ESRD) randomized to Peritoneal Dialysis (PD) or Hemodialysis (HD) treatment.
- Trial name
- NCT01413074
- Testing
- Peritoneal Dialysis treatment, Hemodialysis treatment
- Where
- 7 sites in China
- Volunteers
- 416 people
- Sponsor
- Vantive Health LLC
Prostate Carcinoma, Recurrent Prostate Carcinoma
Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial
This phase II trial compares the effect of time-restricted eating (TRE) and glucagon-like peptide-1 (GLP1) receptor agonists (RA), semaglutide and tirzepatide, to an American Heart Association (AHA) heart healthy diet (HHD)…
- Trial name
- NCT07202247
- Testing
- Antiandrogen Therapy, Behavioral Intervention, Biospecimen Collection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- City of Hope Medical Center
Peripheral Artery Disease
Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities
The purpose of study was to test whether rivaroxaban added to standard of care treatment, when compared to placebo, had the potential to reduce the incidence of the clinical events related to the clots and complications of the…
- Trial name
- VOYAGER PAD (NCT02504216)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939)
- Where
- 532 sites in United States, Argentina and 32 more
- Volunteers
- 6,564 people
- Sponsor
- Bayer
Cardio Vascular Disease, Obesity & Overweight
Support Your Heart, Phase 1
This is a pilot feasibility study designed to establish the feasibility and acceptability of the "Support Your Heart" (SYH) study's phone-based protocols regarding AHA's LE8, social isolation, loneliness, and stress.
- Conditions
- Cardio Vascular Disease, Obesity & Overweight, Physical Activity, Sleep
- Trial name
- SYH (NCT07623733)
- Testing
- Support Your Heart
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- George Washington University
End Stage Renal Disease on Dialysis
Study on the Influence of Dyadic Psychoeducational Intervention on Patients With Maintenance Hemodialysis
This study aims explored the effectiveness of dual psychological intervention strategies in improving the quality of life of MHD patients based on the theoretical guidance of double ABC-X model.
- Trial name
- MHD (NCT06203730)
- Testing
- dyadic psychological intervention strategy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Jiangsu Taizhou People's Hospital
Urinary Incontinence, Overactive Bladder
A Safety and Efficacy Study of BOTOX® (Botulinum Toxin Type A) in Patients With Urinary Incontinence Due to Neurogenic Detrusor Overactivity or Overactive Bladder in India
This is a Post-Marketing Surveillance study in India to evaluate safety and efficacy of BOTOX® (Botulinum Toxin Type A) in the treatment of patients with urinary incontinence due to neurogenic detrusor overactivity or overactive…
- Trial name
- NCT02590250
- Testing
- botulinum toxin Type A
- Where
- 12 sites in India
- Volunteers
- 250 people
- Sponsor
- Allergan
Pelvic Organ Prolapse, Stage II-III
Clinical Performance of GYNECARE PROSIMA* Pelvic Floor Repair System for Symptomatic Pelvic Organ Prolapse
The purpose of this study is to evaluate the safety and effectiveness of the GYNECARE PROSIMA* Pelvic Floor Repair System as a Device in Women with Symptomatic Pelvic Organ Prolapse.
- Trial name
- NCT01396122
- Testing
- Procedure: GYNECARE PROSIMA* Pelvic Floor Repair System
- Where
- 25 sites in China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
ANCA-IgG-positive ANCA Associated Vasculitis
Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis
The goal of this phase I/II clinical trial is to investigate anti-CD 19 chimeric antigen receptor T cell (CAR-T cell) therapy in patients with antineutrophil cytoplasmic antibodies (ANCA) immunoglobulin (IgG) positive ANCA…
- Trial name
- IDEAL (NCT06590545)
- Testing
- KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy
- Volunteers
- 8 people
- Sponsor
- David Simon
Colorectal Cancer
Pedometer Intervention and Health Effects for Sedentary Colorectal Cancer Patients During Adjuvant Chemotherapy
Colorectal cancer is one of the most common cancers in Denmark, annually 4,200 men and women are diagnosed and approx. 2000 patients die of their colorectal cancer.
- Trial name
- NCT02522520
- Testing
- Pedometer intervention, Pedometer + hospital based intervention, Omron Walking Style pro. 20
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Osteoarthritis (OA) of the Knee, ACL Reconstruction
Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns in Pre-stage Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction
Osteoarthritis (OA) is a condition that causes pain and stiffness in the joints, often due to injuries like torn ligaments. Even after surgery, these injuries can lead to long-term joint problems.
- Trial name
- PROTO-WP4 (NCT06596824)
- Testing
- Training intervention
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Human Papillomavirus, High-Grade Squamous Intraepithelial Lesions
Safety and Efficacy Study of TVGV-1 Vaccine to Treat HPV Induced Cervical HSIL
The purpose of this research study is to test the safety and effectiveness of the investigational study vaccine, called TVGV-1. The study will test the vaccine in women with high grade HPV cervical infection.
- Trial name
- NCT02576561
- Testing
- TVGV-1, GPI-0100
- Where
- 11 sites in United States
- Volunteers
- 10 people
- Sponsor
- THEVAX Genetics Vaccine
Colorectal Cancer Stage II, Colorectal Cancer Stage III
Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors
This phase III trial evaluates whether a web-based intervention called Current Together after Cancer (CTAC) works to increase the number of patients with surgically removed (resected) colorectal cancer who receive surveillance…
- Trial name
- NCT07018869
- Testing
- Intervention website access, Control website access, Interview
- Where
- 384 sites in United States, Guam and 1 more
- Volunteers
- 1,057 people, healthy volunteers welcome
- Sponsor
- SWOG Cancer Research Network
Ischemic Stroke, Acute Stroke
Aerobic Exercise Training in Acute Ischaemic Stroke
Stroke is a leading cause of adult disability in the UK. There are few treatment options that improve long-term disability outcomes after stroke.
- Conditions
- Ischemic Stroke, Acute Stroke, Cerebrovascular Accident
- Trial name
- ATAS (NCT04742686)
- Testing
- Aerobic exercise training
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Sheffield Hallam University
Breast Cancer
An Internet-based Psychosexual Intervention for Couples Following Treatment for Breast Cancer
Diagnosis and treatment of breast cancer often leads to lower levels of sexual desire, decreased sexual arousal, painful intercourse, and difficulties achieving orgasm, and thus adversely impacts sexual functioning and intimacy.
- Trial name
- IPSIC (NCT01881022)
- Testing
- Psychosexual Intervention
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Hypochondroplasia
Interventional Study of Vosoritide for the Treatment of Children With Hypochondroplasia
The intent and design of this Phase 3 study is to assess vosoritide as a therapeutic option for the treatment of children with hypochondroplasia (HCH).
- Trial name
- CANOPY-HCH-3 (NCT06455059)
- Testing
- Vosoritide
- Where
- 23 sites in United States, Australia and 7 more
- Volunteers
- 80 people
- Sponsor
- BioMarin Pharmaceutical
Dental Anesthesia, Anesthesia, Local
Study of OraVerse® for Safety and Efficacy in Pediatric Dental Patients
The purpose of this study is to determine whether OraVerse is safe and effective for the reversal of dental anesthesia in children 2 to 5 years of age weighing at least 10 kg.
- Conditions
- Dental Anesthesia, Anesthesia, Local, Anesthesia, Reversal
- Trial name
- NCT01474382
- Testing
- OraVerse
- Where
- 7 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Novocol Pharmaceutical of Canada, Inc.
Hemorrhage, Urgent Surgery
Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure
This is a multi-center, open-label, prospective single-arm study of reversal of the antiplatelet effects of ticagrelor with bentracimab (PB2452) in patients who present with uncontrolled major or life-threatening bleeding or who…
- Conditions
- Hemorrhage, Urgent Surgery, Invasive Procedure
- Trial name
- REVERSE-IT (NCT04286438)
- Testing
- Bentracimab (PB2452) Infusion
- Where
- 68 sites in United States, Austria and 11 more
- Volunteers
- 226 people
- Sponsor
- SFJ Pharmaceuticals, Inc.
Hemodialysis, End Stage Renal Disease Requiring Hemodialysis
Pharmacist-led Intervention on Hemodialysis Patients' Therapy Adherence
A parallel-group, cluster-randomized, controlled trial designed to evaluate if hemodialysis patients benefit from BCT. The study includes two groups: usual care and pharmacist-led intervention groups.
- Trial name
- NCT06744738
- Testing
- Pharmacist led behavioral change technique
- Where
- Iraq
- Volunteers
- 72 people
- Sponsor
- Thuraya Safaa Ibrahim
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