Clinical trials: Intervention Phase
Healthy
A Study Exploring the Use of Challenge Agents in Healthy Volunteers - Intervention Specific Appendix
The purpose of this study is to characterize the disruption of intestinal barrier as a result of indomethacin challenge in healthy volunteers using an orally administered lactulose-mannitol test.
- Trial name
- NCT04821323
- Testing
- Indomethacin, Lactulose-mannitol
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Melanoma, Melanoma (Skin)
Clinical Outcomes and Biomarkers in Patients With Stage 0-IV Melanoma in Real Clinical Practice
Prospective non-interventional study of clinical outcomes and biomarkers in patients with stage 0-IV skin melanoma in real clinical practice
- Conditions
- Melanoma, Melanoma (Skin), Melanoma, Uveal, Melanoma Stage IV
- Trial name
- ISABELLA (NCT05402059)
- Testing
- surgery (any volume) and / or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines
- Where
- Russia
- Volunteers
- 1,570 people
- Sponsor
- MelanomaPRO, Russia
Anxiety Disorder, Worry
Cognitive-Behavioral Intervention for Worry, Uncertainty, and Insomnia for Cancer Survivors
This randomized clinical trial studies a cognitive-behavioral intervention to treat worry, uncertainty, and insomnia in cancer survivors.
- Conditions
- Anxiety Disorder, Worry, Uncertainty, Sleep Disorders
- Trial name
- FOCUS (NCT01929720)
- Testing
- Cognitive-behavioral therapy for worry, uncertainty & insomnia
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Substance Abuse
Brief Interventions for Drop-out Re-engagement
We will evaluate a series of interventions intended to help individuals who drop out of substance abuse treatment re-engage in order to improve treatment outcome.
- Trial name
- NCT00350571
- Testing
- brief (behavioral therapy), Drop out re-engagement motivational intervention, standard care follow up
- Where
- 2 sites in United States
- Volunteers
- 299 people
- Sponsor
- Yale University
Anemia, Renal Insufficiency, Chronic
A Prospective Interventional Study Assessing the Clinical and Operational Effectiveness of Transitioning From Mircera to Daprodustat for the Treatment of Anemia in End Stage Kidney Disease
Investigator-initiated, interventional, prospective study to assess the clinical and operational effectiveness of daprodustat in adult patients receiving in center hemodialysis or peritoneal home dialysis who are transitioning…
- Conditions
- Anemia, Renal Insufficiency, Chronic, Renal Anemia
- Trial name
- ROQ-IT (NCT05951192)
- Testing
- Daprodustat
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- USRC Kidney Research
Osteoarthritis, Knee, Diabetic Neuropathic Pain
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-state addenda (DSA) and intervention-specific appendices (ISAs).
- Conditions
- Osteoarthritis, Knee, Diabetic Neuropathic Pain, Chronic Low-back Pain
- Trial name
- CPMP (NCT05986292)
- Testing
- LY3016859 ISA, LY3556050 ISA, LY3526318 ISA
- Where
- 64 sites in United States, Puerto Rico
- Volunteers
- 10,000 people
- Sponsor
- Eli Lilly and Company
Cognitive Decline
Exercise Adherence and Cognitive Decline: Phase 2
The purpose of this study is to conduct a test of a goals-based program to help people exercise more. This program was designed for individuals aged 45-65 from the Black community.
- Trial name
- MOVE (NCT07127965)
- Testing
- Goal Setting and Exercise Intensity Intervention
- Where
- 2 sites in United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Breast Cancer, Colorectal Cancer
The Active After Cancer Trial (AACT)
This study is being done to determine whether a telephone-based counseling intervention can help survivors of breast and colorectal cancer increase their weekly physical activity.
- Trial name
- AACT (NCT00548236)
- Testing
- Telephone-Based exercise intervention
- Where
- 9 sites in United States
- Volunteers
- 120 people
- Sponsor
- Dana-Farber Cancer Institute
Dental Caries in Children, Early Childhood Caries
Effect of Optimized Behavioural Intervention Using The Multi-Phase Optimization Strategy (MOST).
In the current study, MOST approach is proposed, to engineer an oral health behavior modification intervention, to increase the engagement of mothers in brushing their pre-school children's teeth.
- Trial name
- NCT04923581
- Testing
- Oral Health Behavioral Interventions
- Where
- 2 sites in Egypt
- Volunteers
- 128 people
- Sponsor
- Merna Ihab
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Coronavirus Disease 2019 (COVID-19)
A Study to Learn About the Medicine Called Nirmatrelvir Used in Combination With Ritonavir in People With Weakened Immune Systems or at Increased Risk for Poor Outcomes Who Are Hospitalized Due to Severe COVID-19
A Study to Learn About the Medicine Called Nirmatrelvir Used in Combination With Ritonavir in People with Weakened Immune Systems or at Increased Risk for Poor Outcomes who are Hospitalized Due to Severe COVID-19
- Conditions
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Coronavirus Disease 2019 (COVID-19), Immunocompromised, Hospitalization
- Trial name
- EPIC-HOS (NCT05545319)
- Testing
- Nirmatrelvir, Ritonavir
- Where
- 11 sites in United States, Bulgaria
- Sponsor
- Pfizer
Breast Cancer
A Study to Learn About Vepdegestrant When Given With PF-07220060 to People With Advanced or Metastatic Breast Cancer.
The purpose of this study is to learn about the safety and effects of giving vepdegestrant along with PF-07220060. Vepdegestrant is studied to see if it can be a possible treatment for advanced metastatic breast cancer.
- Trial name
- NCT06206837
- Testing
- vepdegestrant, PF-07220060
- Where
- 58 sites in United States, Belgium and 6 more
- Volunteers
- 71 people
- Sponsor
- Pfizer
Periodontitis
Nd:YAG Laser Versus Diode Laser Assisted New Attachment Procedure (Lanap) in the Management of Stage II Periodontitis
Aim of the study was to assess and compare the clinical and microbiological changes following Laser assisted new attachment procedure (LANAP®) using diode 940 nm versus ND:YAG 1064 nm, and to compare the outcome to conventional…
- Trial name
- NCT06509412
- Testing
- LANAP surgical protocol using ND:YAG 1064 laser, LANAP surgical protocol using diode 940 laser, Scaling and root planing (SRP)
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Nada Shaban
Pacemaker, Implantable Cardioverter-Defibrillators
Enhancing Knowledge Implantable Cardioverter-Defibrillators (ICDs)
The specific aims of the patient intervention are to: 1. increase patient knowledge about pacemakers (PM) and implantable cardioverter-defibrillators (ICDs) 2. help patients to identify if their PM or ICD has been interrogated 3.
- Trial name
- NCT00822965
- Testing
- Questionnaires, Phone Interviews, Educational Packet
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- M.D. Anderson Cancer Center
Autism Spectrum Disorder
Virtual Reality Intervention for Skill Acquisition Support in Autism Spectrum Disorder (ASD)
A Randomized Controlled Phase II study to assess the efficacy of Floreo VR (Virtual reality) Building Social Connections as treatment for social skills in children with Autism Spectrum Disorder (ASD)
- Trial name
- NCT05791071
- Testing
- Floreo VR Building Social Connections
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Floreo, Inc.
Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease
For Patients With Myocardial Infarction and Multiple Vessel: Testing if Ultrasound (UFR) Can Guide All Needed Treatment in One Procedure, Avoiding a Return Hospital Visit for a Second Operation.
Brief Summary The Purpose of the Study : The purpose of this study is to find a safe and reliable "one-stop" solution for treating heart attack patients who have multiple blocked arteries.
- Conditions
- Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease, ACS (Acute Coronary Syndrome), ST Elevation Myocardial Infarction (STEMI)
- Trial name
- ACT-EVOLVE (NCT07264881)
- Testing
- IVUS-based Fractional Flow Reserve (UFR), Invasive Coronary Physiology Measurement (FFR/RFR/IMR), Cardiac Magnetic Resonance (CMR)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Plaque Psoriasis
Efficacy and Safety of Tildrakizumab 100 Milligrams (mg) in Participants With Moderate-Severe Chronic Plaque Psoriasis and Its Impact on Their Quality of Life (TRIBUTE)
The main aim of the study is to evaluate the efficacy, safety and impact on the health-related quality of life (HRQoL) in participants with moderate-to-severe chronic plaque psoriasis who are treated with tildrakizumab 100…
- Trial name
- TRIBUTE (NCT04229836)
- Testing
- Tildrakizumab 100 mg Solution for Injection
- Where
- 39 sites in Italy, Spain
- Volunteers
- 178 people
- Sponsor
- Almirall, S.A.
Major Depressive Disorder
Goal Achievement After a Change to Vortioxetine in Adults With Major Depressive Disorder
The purpose of this study is to determine the effectiveness of treatment with vortioxetine on participant goal achievement after a change in antidepressant medication for the treatment of major depressive disorder (MDD).
- Trial name
- NCT02972632
- Testing
- Vortioxetine
- Where
- 25 sites in United States
- Volunteers
- 123 people
- Sponsor
- Takeda
Stage IIA Pancreatic Cancer, Stage IIB Pancreatic Cancer
Palliative Care in Improving Quality of Life in Patients With Newly Diagnosed Pancreatic Cancer
This pilot clinical trial studies a palliative care program in improving the quality of life of patients with newly diagnosed pancreatic cancer.
- Conditions
- Stage IIA Pancreatic Cancer, Stage IIB Pancreatic Cancer, Stage III Pancreatic Cancer, Stage IV Pancreatic Cancer
- Trial name
- NCT02307539
- Testing
- Psychosocial Assessment and Care, Palliative Therapy, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- City of Hope Medical Center
Facial Wrinkles (Nasolabial Folds)
A Study to Determine Safety & Efficacy of Autologous Human Platelet Lysate (HPL) in Facial Wrinkles(Nasolabial Folds)
This is a multicentre, open label, pilot study to evaluate safety and efficacy of Autologous Human Platelet Lysate (HPL) in subjects with Facial Wrinkles (Nasolabial Folds). The study is being conducted at 2 centers in India.
- Trial name
- NCT01644461
- Testing
- Autologous Human Platelet Lysate
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Kasiak Research Pvt. Ltd.
Type 2 Diabetes Mellitus (T2DM)
Quinoa Improves Glycolipid Metabolism and Glucose Fluctuation Based on β-Cell Function in Early-stage Type 2 Diabetes
The goal of this clinical trial is to explore whether quinoa diet can improve glycolipid metabolism and glucose fluctuations in patients with early-stage type 2 diabetes mellitus (T2DM) and observe its impact on islet β-cell…
- Trial name
- QIGMAGFBOβFIET (NCT07329231)
- Testing
- Quinoa-based foods
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Qilu Hospital of Shandong University
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