Clinical trials: Intervention Phase
Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease
For Patients With Myocardial Infarction and Multiple Vessel: Testing if Ultrasound (UFR) Can Guide All Needed Treatment in One Procedure, Avoiding a Return Hospital Visit for a Second Operation.
Brief Summary The Purpose of the Study : The purpose of this study is to find a safe and reliable "one-stop" solution for treating heart attack patients who have multiple blocked arteries.
- Conditions
- Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease, ACS (Acute Coronary Syndrome), ST Elevation Myocardial Infarction (STEMI)
- Trial name
- ACT-EVOLVE (NCT07264881)
- Testing
- IVUS-based Fractional Flow Reserve (UFR), Invasive Coronary Physiology Measurement (FFR/RFR/IMR), Cardiac Magnetic Resonance (CMR)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Cardiac Rehabilitation, Physical Activity
Using a mHealth Intervention to Promote Physical Activity in Phase III Cardiac Rehabilitation Clients
In this study, the investigators will implement a pilot project of using activity tracker (i.e., Fitbit) with phase III CR clients.
- Trial name
- NCT05795036
- Testing
- mHealth 1, mHealth 2
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- AdventHealth University
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8
Culturally Based Brief Expressive Writing Intervention for the Improvement of Health in Chinese Immigrant Stage 0-III Breast Cancer Survivors, Writing to Heal Study
This clinical trial studies the effect of a culturally based brief expressive writing intervention in improving the health of Chinese immigrant stage 0-III breast cancer survivors.
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8
- Trial name
- NCT04754412
- Testing
- Behavioral, Psychological or Informational Intervention, Best Practice, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- M.D. Anderson Cancer Center
Type 2 Diabetes Mellitus, Cardiovascular Autonomic Dysfunction
Nurse-Led Self-Management and Breathing Intervention in Type 2 Diabetes
Brief Summary This study evaluated the effect of a structured nurse-led home-based self-management and paced-breathing intervention on cardiovascular autonomic function and blood pressure among adults with type 2 diabetes…
- Trial name
- NCT07847177
- Testing
- Structured Nurse-Led Home-Based Self-Management and Paced-Breathing Program
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Aziza Ibrahim Mohamed
Breast Cancer, Anatomic Stage I Breast Cancer AJCC v8
Piloting Y-AMBIENT: A Quality of Life Intervention for Young African American Breast Cancer Survivors
The purpose of this two-arm pilot RCT is to evaluate processes and preliminary outcomes of a targeted QOL intervention vs. an attention control among young AA survivors post-treatment for early (I-II) \& late (III) stage breast…
- Conditions
- Breast Cancer, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8
- Trial name
- NCT05452681
- Testing
- Educational Intervention, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Alabama at Birmingham
Plaque Psoriasis
Long-Term Treatment Effect With Tildrakizumab in Participants With Plaque Psoriasis
The purpose of this study is to evaluate the psoriasis disease control over time in participants who had received Tildrakizumab for at least the last 5 years and have discontinued it and to describe blood and skin inflammatory…
- Trial name
- MODIFY (NCT04339595)
- Testing
- Tildrakizumab
- Where
- 3 sites in Poland
- Volunteers
- 47 people
- Sponsor
- Almirall, S.A.
Renal Failure Chronic Contrast Induced
Effect of a Pre-interventional Diet on Renal Function After Administration of Contrast Agent in Patients at Risk
The aim of this study is to assess the effect of a diet prior to administration of contrast agent in terms of a preventive procedure which leads to an attenuation of the contrast-induced nephropathy (CIN).
- Trial name
- CR_KMN (NCT01879839)
- Testing
- Diet
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University of Cologne
COVID-19
A Study to Learn About the Study Medicines (Nirmatrelvir Plus Ritonavir) in People Aged 12 Years or Older With COVID-19 and a Compromised Immune System
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called Nirmatrelvir/Ritonavir) for the possible treatment of COVID-19.
- Trial name
- NCT05438602
- Testing
- Nirmatrelvir, Ritonavir
- Where
- 84 sites in United States, Australia and 7 more
- Volunteers
- 158 people
- Sponsor
- Pfizer
Malaria
Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA)
The BOHEMIA program consists of a combination of studies organized around a central community prevention mass drug administration protocol and four sub-studies (i.e.; social science, entomology, health economics, and…
- Trial name
- BOHEMIA (NCT04966702)
- Testing
- Albendazole Pill, Ivermectin Pill, Ivermectin Injectable Product
- Where
- 2 sites in Kenya, Mozambique
- Volunteers
- 48,145 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Breast Cancer
An Internet-based Psychosexual Intervention for Couples Following Treatment for Breast Cancer
Diagnosis and treatment of breast cancer often leads to lower levels of sexual desire, decreased sexual arousal, painful intercourse, and difficulties achieving orgasm, and thus adversely impacts sexual functioning and intimacy.
- Trial name
- IPSIC (NCT01881022)
- Testing
- Psychosexual Intervention
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Stable Coronary Artery Disease
Intracoronary Stenting and Antithrombotic Regimen: Lesion Platelet Adhesion as Selective Target of Endovenous Revacept
The main objective is to evaluate the efficacy and safety of treatment with 2 doses (80 and 160 mg) of Revacept versus placebo in patients with stable coronary artery disease undergoing PCI.
- Trial name
- ISAR-PLASTER (NCT03312855)
- Testing
- Revacept 80 mg, Revacept 160 mg
- Where
- 8 sites in Germany
- Volunteers
- 334 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Endothelial Dysfunction
Stair Climbing Outcomes in Cardiac Rehabilitation Exercise
This study will evaluate the effect of brief, intermittent stair climbing exercise on key cardiovascular and metabolic markers of health in individuals completing a cardiac rehabilitation program.
- Trial name
- SCORE (NCT03235674)
- Testing
- High-intensity stair climbing exercise
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
End Stage Renal Disease
PMR vs MM for Patients on Hemodialysis
Background: Hemodialysis is considered as an effective therapy to remove harmful waste from the body and to improve the quality of life in patients suffering from end-stage renal disease (ESRD).
- Trial name
- NCT06625125
- Testing
- Mindfulness-based intervention, Progressive muscle relaxation
- Where
- Jordan
- Volunteers
- 159 people
- Sponsor
- Jordan University of Science and Technology
Metastatic Melanoma Naive to Immune Therapy in Metastatic Setting
Analysis of the Modulation of the Tumor Microenvironment by MK-3475 (Pembrolizumab) Using a Systems Biology Approach (PEMSYS)
This is a monocentric, prospective, interventional and translational phase II study. Metastatic melanoma (mMEL) patients who are naive to immune therapy in the metastatic setting, and for whom an anti-Programmed Cell Death-1…
- Trial name
- NCT03534635
- Testing
- Pembrolizumab, Pembrolizumab - additional treatment
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Breast Cancer Stage I, Breast Cancer Stage II
Novel Social Media Intervention For Older Br CA Patients
The number of patients 60 and older with breast cancer is increasing as our population ages. Despite the fact that the majority of breast cancers occur in patients 60 and over, these patients are consistently under-represented in…
- Conditions
- Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer Stage III
- Trial name
- NCT02639208
- Testing
- PatientsLikeMe (PLM)
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Dana-Farber Cancer Institute
Prediabetic State
mHealth Intervention to Prevent Type 2 Diabetes Mellitus (Phase II Study)
The aim of this study is to develop and evaluate a low intensity, multifaceted, digital health intervention to prevent T2DM based on: i) the use of a system comprising mobile health (mHealth) technology integrated with electronic…
- Trial name
- preDIABETEXT (NCT05110625)
- Testing
- preDIABE-TEXT, Online Education
- Where
- Spain
- Volunteers
- 365 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Spinal Muscular Atrophy
A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy
The primary objective of the study is to examine the clinical efficacy of nusinersen (ISIS 396443) administered intrathecally (IT) to participants with infantile-onset with infantile-onset spinal muscular atrophy (SMA).
- Trial name
- ENDEAR (NCT02193074)
- Testing
- nusinersen
- Where
- 31 sites in United States, Australia and 11 more
- Volunteers
- 122 people
- Sponsor
- Biogen
Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
Phase 1 Study of the Litx™ BPH System in Patients With Lower Urinary Tract Symptoms (LUTS) Due to Benign Prostatic Hyperplasia (BPH)
This is a phase 1 study to evaluate the safety and effectiveness of using the Litx™ BPH System in patients with LUTS due to benign prostatic hyperplasia (BPH).
- Trial name
- NCT00709488
- Testing
- Talaporfin sodium, Placement of device in prostate urethra, Transurethral illumination with light emitting diodes (Litx™ BPH Device)
- Where
- 6 sites in United States
- Volunteers
- 12 people
- Sponsor
- Light Sciences Oncology
Migraine
A Phase II Study of NB001 for Acute Migraine Treatment
The goal of this observational study is to Evaluate the Efficacy and Safety of NB001 for the Acute Treatment of Migraine in Adult patients diagnosed with migraine.
- Trial name
- Channel (NCT07577050)
- Testing
- Four tablets of NB001
- Volunteers
- 120 people
- Sponsor
- Chinese PLA General Hospital
Colorectal Cancer, Quality of Life
RESPONSE: Colorectal Cancer Survivors' Follow-up Care - Now Digital and Need-based
Over the last decades, the 3-year recurrence rates for patients with stage I and II colorectal cancer have decreased to just 5% and 12%.
- Conditions
- Colorectal Cancer, Quality of Life, Survivorship
- Trial name
- RESPONSE (NCT06614647)
- Testing
- Recurrence monitoring with circulating tumor DNA (ctDNA) as a high risk biomarker, Monitoring for late adverse effects with electronic patient reported outcome measures (ePROMs), Systematic treatment of organ-specific late effects and/or biopsychosocial late effects
- Where
- 9 sites in Denmark
- Volunteers
- 400 people
- Sponsor
- University of Aarhus
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