Clinical trials: Intervention Phase
Obstetric Labor Complications, Vacuum Extraction; Failure, Affecting Fetus or Newborn
Comparison of Prevention and Appropiate Obstetric Interventions for Prolonged Second Stage Labor at Term Pregnancies During Vaginal Delivery
Randomized Control Trial for Comparison of Prevention and Appropiate Obstetric Interventions for Prolonged Second Stage Labor at Term Pregnancies During Vaginal Delivery.
- Conditions
- Obstetric Labor Complications, Vacuum Extraction; Failure, Affecting Fetus or Newborn, Complicated Labour/Delivery Livebirth
- Trial name
- NCT04888871
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
End Stage Renal Disease, Depression
Music Therapy and Dialysis: A Pilot Investigation Into the Effectiveness of Patient-Selected Music Interventions on Physiological, Psychological, and Quality-of-Life Outcomes
The objective of this study is to determine the effect of music therapy during dialysis on: depression, anxiety, quality of life, blood pressure, heart rate, medication compliance, compliance with dialysis treatment, number of…
- Conditions
- End Stage Renal Disease, Depression, Anxiety, Major Depressive Disorder
- Trial name
- NCT03925168
- Testing
- Music therapy
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Tulane University
Heart Failure, Heart-assist Devices
PCORI-1310-06998 Trial of a Decision Support Intervention for Patients and Caregivers Offered Destination Therapy Heart Assist Device
The left ventricular assist device (LVAD) is growing rapidly among people dying from end-stage heart failure who are unable to get a heart transplant.
- Trial name
- DECIDE-LVAD (NCT02344576)
- Testing
- DT LVAD Decision Support Intervention
- Where
- 6 sites in United States
- Volunteers
- 445 people
- Sponsor
- University of Colorado, Denver
Sleep Onset Latency
Circadian Light Exposure Adjustment for Restfulness
Many young children are exposed to light int he evening hours before bedtime. Children's biological clocks are highly sensitive to evening light exposure, which can delay the timing of the clock and make it harder to fall asleep.
- Trial name
- CLEAR (NCT07391852)
- Testing
- Amber Tinted Glasses, Clear Glasses, Smart Lightbulbs
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Arizona
Diagnostic Techniques and Procedures, Clinical Laboratory Techniques
Clinical Validation of an Artificial Intelligence System for the Interpretation of Laboratory Test Results Combined With a Structured Medical History
This study evaluates a certified artificial intelligence (AI) based software system that automatically interprets laboratory test results in combination with a structured, dynamically generated medical history questionnaire.
- Conditions
- Diagnostic Techniques and Procedures, Clinical Laboratory Techniques, Triage
- Trial name
- LTC-VALID (NCT07810491)
- Testing
- AI-based laboratory result interpretation software
- Where
- 2 sites in Poland
- Volunteers
- 899 people
- Sponsor
- Labplus Sp. z o.o.
Colorectal Cancer, Colo-rectal Cancer
ctDNA-guided Surveillance for Stage III CRC, a Randomized Intervention Trial
IMPROVE-IT2 is a randomized multicenter trial comparing the outcomes of ctDNA guided post-operative surveillance and standard-of-care CT-scan surveillance.
- Conditions
- Colorectal Cancer, Colo-rectal Cancer, ctDNA, Gastro-Intestinal Disorder
- Trial name
- NCT04084249
- Testing
- ctDNA-analysis, Intensified Follow-up Schedule
- Where
- 10 sites in Denmark
- Volunteers
- 359 people
- Sponsor
- Claus Lindbjerg Andersen
Prostate Cancer (Diagnosis), Prostate Cancer Stage IV
High Cardiovascular Risk Intervention With Cardio-Oncology Consultation for Prostate Cancer Following Androgen Receptor Pathway Inhibitor (ARPI) Therapy (Heart-Safe)
In patients with prostate cancer (PC), cardiovascular disease (CVD) causes significant morbidity and is the second leading cause of death.
- Conditions
- Prostate Cancer (Diagnosis), Prostate Cancer Stage IV, CV Risk
- Trial name
- NCT07223385
- Testing
- Cardio-Oncology Referral, Notification to PCP/General Cardiologist
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Cedars-Sinai Medical Center
Spina Bifida; Fetus, Myelomeningocele
Cryopreserved Human Umbilical Cord as a Meningeal Patch in Fetoscopic Spina Bifida Repair
The objective is to test the efficacy of a laparotomy-assisted fetoscopic surgical approach to cover spina bifida spinal cord developmental defects using cryopreserved human umbilical cords (NEOX Cord 1K®) as a meningeal and skin…
- Conditions
- Spina Bifida; Fetus, Myelomeningocele, Myeloschisis
- Trial name
- HUC-FICS (NCT06042140)
- Testing
- NEOX Cord 1K applied fetoscopically
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston
Substance Use, Substance Use Disorders
Peer-Delivered Behavioral Activation for Methadone Adherence - Pilot Phase
The purpose of this study is to evaluate the feasibility and effectiveness of a peer-led, brief, behavioral intervention to improve adherence to medication for opioid use disorder (MOUD) among low-income, minoritized individuals…
- Conditions
- Substance Use, Substance Use Disorders, Opioid-use Disorder, Peer Delivered
- Trial name
- HEAL Together (NCT04248933)
- Testing
- Peer-Delivered Behavioral Activation (Peer Activate)
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Maryland, College Park
TBI (Traumatic Brain Injury)
Cognitive Support Technology for Postsecondary Students With Traumatic Brain Injuries
This study will fill important knowledge gaps in the availability of best practices that use innovative methods to integrate the cognitive and vocational needs of students with TBI who will be transitioning from 2- and 4-year…
- Trial name
- NCT05054855
- Testing
- : Cognitive Support Technology (CST)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kent State University
Coronavirus Disease 2019 (COVID-19)
Non-Interventional Enhanced Active Surveillance Study of Adults Vaccinated With AZD1222
This is a Phase IV real-world, observational, non-interventional, prospective cohort study of adults vaccinated with AZD1222. The purpose of this study is to assess the safety and tolerability of AZD1222 in adults vaccinated in…
- Trial name
- COVID-19 (NCT04877743)
- Testing
- None (Observational study)
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Anesthesia, Dental
Study of NV-101 for Efficacy, Pharmacodynamics, and Safety in Dental Patients Undergoing Maxillary Procedures
This Phase 3 clinical study is designed as a multicenter, randomized, blinded, controlled study to evaluate the efficacy, pharmacodynamics, and safety of NV-101 administered as a submucosal injection following completion of a…
- Trial name
- NCT00309335
- Testing
- Phentolamine Mesylate (NV-101)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Novalar Pharmaceuticals, Inc.
End Stage Renal Disease on Dialysis
Survey and Reduction of Mortality in Peridialysis Uremic Patients Via Intervention of Risk Factors
In patients with non-dialysis-dependent end stage kidney disease (ESKD) the common transition of care to renal replacement therapy is dialysis.
- Trial name
- SURVIVOR (NCT04088526)
- Testing
- intervention group
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- Shanghai Changzheng Hospital
Head Neck Cancer, Swallowing Disorders
Swallowing Intervention During Radiochemotherapy on Head and Neck Cancer
General Objective: To evaluate the swallowing results of speech pathologist rehabilitation of advanced oropharynges, larynx and hypopharynx cancer patients during neoadjuvant chemotherapy and radiotherapy concomitant to…
- Trial name
- Swallowing-1 (NCT02075385)
- Testing
- pre, during and pos-treatment swallowing exercises
- Where
- Brazil
- Volunteers
- 94 people
- Sponsor
- Barretos Cancer Hospital
Disease or Disorder
The da Vinci Single Port Robotic System for Use in Abdominal and Pelvic Surgical Procedures
This phase II trial test the effectiveness and safety of a single-port robotic device (the da Vinci single port [SP]1098) for use in abdominal and pelvic surgeries.
- Trial name
- NCT05672368
- Testing
- Robot-Assisted Surgery
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- City of Hope Medical Center
Prostate Cancer
Androgen Deprivation Therapy in Treating Patients With Prostate Cancer
RATIONALE: Androgens can cause the growth of prostate cancer cells. Androgen deprivation therapy may stop the adrenal glands from making androgens.
- Trial name
- NCT00110162
- Testing
- antiandrogen therapy, releasing hormone agonist therapy, orchiectomy
- Where
- 20 sites in Australia, New Zealand
- Volunteers
- 2,000 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Vaccination
P3+ Intervention Phase
This study will address vaccine uptake both for pregnant women and for their children, through 20 months of age, to test the hypothesis that exposure to the P3+ intervention package will increase the likelihood a pregnant woman…
- Trial name
- NCT02898688
- Testing
- Control Site, Intervention Site, Patient-level Control Group
- Where
- 23 sites in United States
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- Emory University
Eczema
A Study of the Medicine Called Abrocitinib in Children 6 to Less Than 12 Years of Age With Moderate-to-Severe Eczema
This research study is being conducted to find out if the test medicine, abrocitinib, improves eczema and is safe for children 6 to <12 years of age who have moderate-to-severe eczema.
- Trial name
- NCT06807268
- Testing
- Abrocitinib
- Where
- 47 sites in United States, China and 6 more
- Volunteers
- 150 people
- Sponsor
- Pfizer
Breast Cancer
Diagnostic Procedures in Women With Locally Advanced Breast Cancer Who Are Receiving Chemotherapy Before Breast Cancer Surgery
RATIONALE: Comparing results of diagnostic procedures performed before, during, and after chemotherapy may help doctors predict a patient's response to treatment and help plan the most effective treatment.
- Trial name
- NCT00033397
- Testing
- biopsy, magnetic resonance imaging, radiomammography
- Where
- 5 sites in United States
- Volunteers
- 360 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Musculoskeletal Cancers
Trial Evaluating Hypnosis Using Virtural Reality vs Standard Pain Management During Musculoskelettal Biopsy
The primary objective of this trial is to evaluate the benefit of the virtual reality technology in the pain management for patients having a radio-guided musculoskeletal biopsy indication
- Trial name
- REVENRI (NCT03418597)
- Testing
- Deep local anesthesia + Virtual reality, Deep local anesthesia alone
- Where
- France
- Volunteers
- 99 people
- Sponsor
- Centre Leon Berard
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