Clinical trials: Intervention Studies
Arrhythmia
Prevention of Arrhythmia Device Infection Trial (PADIT)
The goal of the study is to compare whether a center-wide policy of incremental antibiotic therapy will reduce CIED infection rate compared to a policy of conventional antibiotic prophylaxis in high-risk patients undergoing…
- Trial name
- NCT01628666
- Testing
- Incremental, Conventional
- Where
- Canada
- Volunteers
- 12,814 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Depression, Anxiety, Palliative Care
Problem-Solving Therapy for Cancer Caregivers in Outpatient Palliative Care
This study is a randomized clinical trial of a problem-solving therapy intervention for family caregivers of individuals with cancer receiving outpatient palliative care.
- Conditions
- Depression, Anxiety, Palliative Care, Caregivers, Cancer
- Trial name
- NCT04867122
- Testing
- Problem-Solving Therapy, Attention-matched Control, In-depth interviews
- Where
- 3 sites in United States
- Volunteers
- 532 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Necrotic Pulp
Effect of Irrigation With Antibiotic-containing Solutions on Postoperative Pain and Intra-canal Bacteria
The aim of this study is to compare the degree of postoperative pain and the antimicrobial effect in terms of bacterial count reduction after using co-amoxiclav-clindamycin solution versus MTAD and sodium hypochlorite irrigating…
- Trial name
- NCT04035070
- Testing
- co-amoxiclav-clindamycin solution, MTAD, 2.5% sodium hypochlorite
- Where
- Egypt
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Cairo University
Alveolar Bone Loss
Effectiveness in Limiting the Need to Elevate the Maxillary Sinus
The aim of the present study is to evaluate the effectiveness of different alveolar preservation procedures performed at the time of extraction of the first or second upper molar in avoiding a maxillary sinus elevation or at…
- Trial name
- SO-GHI (NCT03357705)
- Testing
- alveolar ridge preservation with synthetic bone, alveolar ridge preservation with bovine collagen
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- International Piezosurgery Academy
Evaluate the Immediate Loading Implants in All on 4 Cases Using Conversion Denture and OT Bridge System
Splinted and Unsplinted OT Bridge Systems in Screw Retained Implant Restoration
Evaluation of Bone level changes around dental implants in All on 4 cases with immediate loading using conversion denture and OT Bridge system either splinted or not
- Trial name
- OTBS (NCT05031156)
- Testing
- Splinting of OT Bridge system
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cairo University
Transpalatal Arch (TPA), Oral Health Related Quality of Life (OHRQoL)
Comparing Clinical Application of Innovatedly Made Transpalatal Arch (TPA) From 3D Reconstructed Model and Conventionally Made TPA
Trans-palatal Arch or TPA is an intra oral device that is occasionally used in conjunction of orthodontic fixed appliance treatment. It has two main types, the fixed or removable TPA.
- Conditions
- Transpalatal Arch (TPA), Oral Health Related Quality of Life (OHRQoL), Oral Health Impact Profile Short Version 14 (OHIP 14), Orthodontic Pain
- Trial name
- NCT03755622
- Testing
- Conventional Transpalatal Arch (TPA), Transpalatal Arch (TPA) fabricated from 3D reconstructed model
- Where
- Malaysia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Alzheimer Disease
Pharmacokinetic Properties of Idalopirdine (Lu AE58054) in Subjects With and Without Impaired Kidney Function
The purpose of this study is to evaluate the pharmacokinetics properties of idalopirdine following multiple dosing in patients with renal impairment and compare to those in healthy subjects
- Trial name
- NCT02340195
- Testing
- Idalopirdine (Lu AE58054) 60 mg
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Opaque Bottles, Conventional, Clear Bottles
Opaque Bottle Study
The proposed research aimed to conduct an intervention study assessing the effect of feeding mode (clear versus opaque bottle) on the quality and outcome of infant feeding interactions.
- Trial name
- NCT03711370
- Testing
- Clear Bottle, Opaque Bottle
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- California Polytechnic State University-San Luis Obispo
COPD
Inflammation in COPD and the Effect of Nicotinamide Riboside
The aim of this study is to investigate if nicotinamide riboside can reduce the airways inflammation associated with chronic obstructive pulmonary disease (COPD) in patients aged 60 or older.
- Trial name
- ICON (NCT04990869)
- Testing
- Nicotinamide Riboside
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Tetanus
Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Recombinant Human Anti-Tetanus Toxin Monoclonal Antibody Injection
A Randomized, Double-blind, Controlled, Dose-escalation Phase I Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Single Intramuscular Injection of Recombinant Human Anti-tetanus…
- Trial name
- NCT07149454
- Testing
- Recombinant Human Anti-Tetanus Toxin Monoclonal Antibody Injection, Human Tetanus Immunoglobulin
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Lanzhou Institute of Biological Products Co., Ltd
Healthy
A Clinical Trial in Healthy Participants to Learn How Itraconazole Affects MK-2828 Levels and How MK-2828 Affects Midazolam Levels (MK-2828-007)
The main goals of this study are: To learn what happens to one dose of MK-2828 in a healthy person's body over time when it is taken with itraconzole To learn what happens to one dose of midazolam in a healthy person's body over…
- Trial name
- NCT07435194
- Testing
- MK-2828, Itraconazole, Midazolam
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Dental Diseases
Repair of Proximal Restoration Resin Bulk Fill. Clinical Trial
Bulk Fill" (RBF) composite resins (RC) has been on the market, with the main advantage of being applied in a single layer, faster and easier than a conventional RC.
- Trial name
- NCT05013866
- Testing
- Repair resin composite proximal
- Where
- Chile
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Andres Bello
Cognitive Function, Fatigue
A Clinical Trial to Evaluate the Effects of a Supplement on Cognitive Function and Energy Levels
This study evaluates the effects of Artah's Cellular Hydration electrolyte supplement on cognitive function and energy levels in healthy adults aged 25-60 who experience mild to moderate fatigue, brain fog, or related symptoms.
- Conditions
- Cognitive Function, Fatigue, Energy Levels, Mental Clarity
- Trial name
- NCT07755475
- Testing
- Cellular Hydration Supplement
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Artah Nutrition Limited
Moderate-to-severe Inflammatory Bowel Disease
A Study to Evaluate the Safety of SHR-7590 in Chinese Healthy Participants and in Patients With Moderate-to-severe Inflammatory Bowel Disease
This Phase I first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of SHR-7590 via subcutaneous or intravenous administration in Chinese healthy participants and patients with…
- Trial name
- NCT07758101
- Testing
- SHR-7590
- Where
- China
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Healthy
Pharmacokinetic-Pharmacodynamic Relationship of Metformin in Healthy Volunteers
Two doses of metformin with 12 hour interval low dose group (375/250 mg) high dose group (1000/1000mg)
- Trial name
- NCT02712619
- Testing
- Metformin
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Alcohol Consumption
Pilot Study of a Computer-Based Intervention for Alcohol Misuse in the Emergency Department
Alcohol misuse amongst youth is a significant clinical and public health problem. The Emergency Department (ED) is an important setting for the treatment of alcohol-related problems as it is often the first point of contact…
- Trial name
- NCT01146665
- Testing
- Computer-based PAF
- Where
- 3 sites in Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Tooth Whitening
Investigation of the Instant Tooth Whitening Effect of a Silica Toothpaste Containing Blue Covarine
The study investigates the effect of toothbrushing with a toothpaste containing blue covarine compared to a control toothpaste without blue covarine on tooth color.
- Trial name
- NCT03760367
- Testing
- Blue covarine toothpaste, Control toothpaste
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sinus Floor Augmentation, Maxillary Sinus Floor Elevation
Evaluation of Lateral Sinus Floor Elevation Using Xenograft Versus L-PRF Block Combined With Xenograft
Rehabilitation of the posterior maxilla with dental implants is frequently complicated by insufficient residual bone height resulting from alveolar ridge resorption and maxillary sinus pneumatization.
- Conditions
- Sinus Floor Augmentation, Maxillary Sinus Floor Elevation, Sinus Lift, Xenograft
- Trial name
- NCT07677007
- Testing
- Lateral sinus lift with Xenograft Alone, Lateral sinus lift using L-PRF Block + Xenograft
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Cervical Cancer
Immunogenicity and Safety Study of NBP615 in Healthy Female
This was a randomized, double-blind, active-controlled, phase I/II clinical trial to enroll 200 healthy female including 80 healthy adult aged 19 to 26 years and 120 adolescents aged 9 to 13 years.
- Trial name
- NCT04453241
- Testing
- NBP615, Gardasil
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- SK Bioscience Co., Ltd.
Overweight, Obesity
Impact of Active and Healthy Families
The purpose of this study is to evaluate the impact of the 10-week Active and Healthy Families (AHF) intervention on body mass index (BMI) in Latino youth aged 5-12 years.
- Trial name
- AHF (NCT02044705)
- Testing
- Active and Healthy Families
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
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