Clinical trials: Intervention Study
Counterpulsation, Angina Pectoris
Effectiveness of ECP Therapy in Stable Angina Pectoris Patients
External Counterpulsation (ECP) is a non-invasive therapy using pressured cuff that is performed on patients with refractory stable angina pectoris to relieve symptoms and increase quality of life.
- Trial name
- NCT04873687
- Testing
- External Counter Pulsation (ECP) therapy
- Where
- Indonesia
- Volunteers
- 84 people
- Sponsor
- Universitas Padjadjaran
Bronchiolitis
Montelukast in Acute RSV Bronchiolitis
There is evidence of inflammatory mechanisms in RSV bronchiolitis with increased cysteinyl-leukotrienes (cys-LT). Recently, specific cys-LT receptor antagonists - montelukast (Singulair©) approved for use in infants as granule…
- Trial name
- NCT00524693
- Testing
- Montelukast
- Volunteers
- 51 people
- Sponsor
- Ziv Hospital
Mixed Hemorrhoids
A Multi Center Clinical Trial of Rph With the Simplified Milligan-Morgan Surgery on Treatment of Mixed Hemorrhoids
Simplified Milligan-Morgan is a surgical option which was improved and developed by Professor He,well-known traditional Chinese doctor from Hunan province,based on Milligan-Morgan.RPH is a new therapy for hemorrhoid following the…
- Trial name
- RPHSMMH (NCT02306421)
- Testing
- RPH with the simplified Milligan-Morgan, PPH with the simplified Milligan-Morgan, RPH
- Where
- 12 sites in China
- Volunteers
- 3,000 people
- Sponsor
- The Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine
Forward Head Posture
The Effect of Different Exercises on Craniovertebral Angle in Individuals With Forward Head Posture
Forward head posture (FHP) is a prevalent postural misalignment commonly attributed to prolonged exposure to poor ergonomic conditions and insufficient physical activity.
- Trial name
- NCT06947421
- Testing
- McKenzie Exercise, Standard Neck Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Bahçeşehir University
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8
Radiation Therapy Boost Before Surgery for the Treatment of Non-metastatic Breast Cancer
This phase II trial investigates the safety of delivering a part (boost) of radiation treatment before breast surgery in treating patients with breast cancer that has not spread to other places in the body (non-metastatic).
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8
- Trial name
- NCT04871516
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Radiation Boost
- Where
- 11 sites in United States
- Volunteers
- 103 people
- Sponsor
- Rutgers, The State University of New Jersey
Screening Compliance
A Multilevel Intervention to Improve Uptake of Gastrointestinal Cancer Screening: a Cluster Randomized Clinical Trial
This study is a cluster randomized controlled trial aimed at evaluating the effectiveness of a multi-level intervention strategy in improving adherence to gastrointestinal cancer screening.
- Trial name
- NCT06830304
- Testing
- Multi-level Education and Navigation Program for Gastrointestinal Cancer Screening, Health education
- Where
- China
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Chongqing University Cancer Hospital
Hemophilia A
A Clinical Study to Evaluate the Effects of NXT007 Compared to Emicizumab Prophylaxis in People With Hemophilia A
The purpose of this study is to evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of NXT007 prophylaxis compared with emicizumab prophylaxis in people age 12 years and older with severe or moderate congenital…
- Trial name
- ZEBRHA 2 (NCT07416604)
- Testing
- NXT007, Emicizumab
- Where
- 59 sites in United States, Argentina and 20 more
- Volunteers
- 360 people
- Sponsor
- Hoffmann-La Roche
FSHD1, FSHD2
Longitudinal Study on Diaframmatic Ultrasound in FSHD Patients
The goal of this prospective, longitudinal, single-center study is to describe respiratory function in patients affected by FSHD at baseline and after one year using both diaphragmatic ultrasound and pulmonary function test.
- Trial name
- NCT06078852
- Testing
- Diaphragmatic ultrasound, Pulmonary function test
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Polyps, Colon Preparation
Comparison Between Asymmetric And Standard Split-Dose Regimen For Bowel Preparation
We aimed to compare the efficacy for bowel cleansing of a split-dose regimen with a low morning dose of PEG solution (Asymmetric; 25% of the dose is given on the day of the procedure and 75% of the dose is given on the day…
- Trial name
- NCT03146052
- Testing
- PEG-4000 added with citrates and simethicone (PEG-CS) plus Bisacodyl
- Where
- Italy
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- ASST Rhodense
Feasibility
Newly Diagnosed With Inflammatory Arthritis - a Self-management Intervention (NISMA)
Even though medical treatment has improved within the last 10-15 years, patients with inflammatory arthritis (IA) still experience reduced quality of life, depression, anxiety, changes in family roles, work life, and social…
- Trial name
- NCT06063252
- Testing
- NISMA
- Where
- Denmark
- Volunteers
- 23 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Takayasu Arteritis
Use of MRI and PET for Assessing Disease Activity in Takayasu's Arteritis
Assessing disease activity in people with Takayasu's arteritis is difficult, as most people with the disease do not exhibit visible, measurable symptoms.
- Trial name
- NCT00744952
- Where
- 5 sites in United States, Canada
- Volunteers
- 26 people
- Sponsor
- Peter Merkel
Stroke, Acute Ischemic Stroke
Trial of pRehospital Intervention With trAditional Chinese Medicine for Acute strokE
The main purpose of this trial is to observe whether Xingnaojing, intravenously administered within 24 hours of symptom onset on pre-hospital emergency ambulance, improves the Early neurological deterioration of acute stroke at 3…
- Conditions
- Stroke, Acute Ischemic Stroke, Acute Intracranial Hemorrhage
- Trial name
- TRACE (NCT04275349)
- Testing
- Xingnaojing injection within 24 hours of symptom onset
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Dongzhimen Hospital, Beijing
Chikungunya Fever
Resistance Exercise Program on the Functionality of Individuals With Chikungunya Fever
Common symptoms of chikungunya fever are persistent arthritis and arthralgia, such symptoms can lead to impairment in functionality.
- Trial name
- NCT03702348
- Testing
- Resistance exercise
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal de Pernambuco
Acne Vulgaris
A Efficacy and Safety of Duac™Compared With Clindamycin Phosphate Gel in the Treatment of Mild to Moderate Acne Vulgaris
This is a multicentre, randomized, assessor-blind, comparator-controlled evaluation of the efficacy, safety, and tolerability of Duac™Once Daily Gel and clindamycin phosphate gel in the topical treatment of mild to moderate…
- Trial name
- NCT01915732
- Testing
- Duac™Once Daily Gel, 1% clindamycin phosphate gel
- Where
- 24 sites in China
- Volunteers
- 1,018 people
- Sponsor
- GlaxoSmithKline
Papulopustular Rosacea
Safety, Efficacy and Pharmacokinetics of Rifaximin in Patients With Moderate-to-severe Papulopustular Rosacea
Rosacea is a common chronic inflammatory relapsing-remitting skin condition almost exclusively affecting the central area of the face and the eyes.
- Trial name
- NCT05150587
- Testing
- Rifaximin
- Where
- 38 sites in United States
- Volunteers
- 216 people
- Sponsor
- Alfasigma S.p.A.
Functional Movement Disorder
CBT Training for Cognitive Reappraisal as an Intervention for Patients With Functional Tremor - an EEG Study
The aim of this psychological study is to evaluate the effect of a cognitive behavioral therapy (CBT) intervention aimed at improving cognitive reappraisal on (1) Clinical and Self-Rated Health according to Patient Global…
- Trial name
- NCT06022393
- Testing
- Cognitive Reappraisal, Reflection
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Oxidative Stress
Taurine as a Possible Anti-aging Therapy?
Among the strategies that can improve the body's ability to counteract oxidative stress, the use of nutritional antioxidants has been investigated.
- Trial name
- NCT05149716
- Testing
- Taurine
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Early Stage Glottic Squamous Cell Carcinoma With Poor Differentiation
Role of Radiotherapy in T1-T2N0M0 Glottic Carcinoma With Poor Differentiation
There remains no uniform treatment modality for glottic laryngeal carcinoma. Current clinical guidelines broadly recommend surgery or radiotherapy as single-modality treatment for early-stage glottic laryngeal carcinoma.
- Trial name
- NCT07781098
- Testing
- Radiation: intensity modulated radiotherapy (IMRT)
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ovarian Cancer
Pembrolizumab With Chemotherapy in Front Line Advanced Ovarian, Primary Peritoneal and Fallopian Tube Cancer
This study is designed to assess the therapeutic efficacy and toxicity of the combination chemotherapy Paclitaxel and Carboplatin with Pembrolizumab in patients with advanced ovarian cancer.
- Trial name
- MITO28MaNGOov4 (NCT03410784)
- Testing
- Pembrolizumab, Paclitaxel, Carboplatin
- Where
- 13 sites in Italy
- Volunteers
- 72 people
- Sponsor
- National Cancer Institute, Naples
Blood Pressure
Health Effects of Indoor Air Filtration in Healthy Chinese Adults
This study aims to detect serum metabolite changes, as well as other health indicators with the intervention of air purifiers on a randomized, crossover, double-blind trial.
- Trial name
- NCT02712333
- Testing
- Air Purifiers
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fudan University