Clinical trials: Interventions
Healthy
The Absorption of Bioactive Berberine in Human
Berberine from medicinal plants has therapeutic activities against multiple chronic diseases. But its absorption rate is very low.
- Trial name
- NCT03438292
- Testing
- Berberine, TPGS emulsified berberine, Quillaja extract emulsified berberine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Florida
Other Instability of Joint, Shoulder Region, Strain of Shoulder Muscle (Disorder)
The Effects of Muscle Characteristics on the Control of Shoulder Complex During Functional Movements
The movement control of shoulder joint relies not only on the glenohumeral joint, but also the critical contributions from scapulothoracic joint.
- Conditions
- Other Instability of Joint, Shoulder Region, Strain of Shoulder Muscle (Disorder), Movement Disorders
- Trial name
- NCT04176692
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tzu Chi University
Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture
Altering Bone Microarchitecture and Mechanics by Off-label Pharmaceutical Intervention Following an Acute Knee Injury
The purpose of this study is to assess if a zoledronic acid injection can alter the trajectory of joint degeneration following an acute anterior cruciate ligament (ACL) injury.
- Conditions
- Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Injuries, Osteo Arthritis Knee
- Trial name
- ZAPOA (NCT05204836)
- Testing
- Zoledronic Acid Injection
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of Calgary
Early Childhood Development in HIV-Exposed Children
Evaluation of an Early Childhood Development Intervention for HIV-Exposed Children in Cameroon
There is substantial evidence that early childhood development (ECD) programming can improve child health and development outcomes.
- Trial name
- NCT03195036
- Testing
- Home-based ECD services
- Where
- Cameroon
- Volunteers
- 230 people
- Sponsor
- Duke University
Hepatitis C, Liver Inflammation
Treatment of HOsPitalised Inpatients for Hepatitis C (TOPIC): Therapeutic Intervention Enhancing Care Linkage in People Who Inject Drugs
This study will evaluate the proportion of patients achieving confirmed SVR12 (undetectable HCV RNA at time point 12 weeks plus post treatment commencement) in patients hospitalised for IRID (injecting related infectious…
- Conditions
- Hepatitis C, Liver Inflammation, Liver Cirrhoses
- Trial name
- TOPIC (NCT03981211)
- Testing
- Glecaprevir/Pibrentasvir 100 MG-40 MG Oral Tablet, Sofosbuvir 400 MG + Glecaprevir/Pibrentasvir 100 MG-40 MG Oral Tablet
- Where
- 7 sites in Australia
- Volunteers
- 21 people
- Sponsor
- Kirby Institute
Acupuncture, Mild Traumatic Brain Injury
Acupuncture for Mild Traumatic Brain Injury：A Functional Magnetic Resonance Imaging Study
The overall goal of this study is to examine if acupuncture intervention can reduce the post-concussion symptom (PCS), and affective and cognitive complaints among mild traumatic brain injury (TBI).
- Conditions
- Acupuncture, Mild Traumatic Brain Injury, MRI
- Trial name
- NCT02868671
- Testing
- acupuncture
- Where
- China
- Volunteers
- 66 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Obesity
A School-based Gardening Obesity Intervention for Low-income Minority Children
The investigators recently completed an NIH R21 grant, which was a randomized controlled trial (RCT) to test the effects of a gardening, nutrition, and cooking program in 375 low-income Hispanic students living in Los Angeles.
- Trial name
- NCT02668744
- Testing
- Intervention
- Where
- 16 sites in United States
- Volunteers
- 3,302 people, healthy volunteers welcome
- Sponsor
- Jaimie N. Davis
Substance Abuse, Drug Addiction
Integrating Mindfulness-Based Skills Training Into Brief Outpatient Treatment for Substance Abusing Youth
The proposed study will evaluate the clinical effectiveness of integrating mindfulness-based skills training into a standardized brief group intervention for youth (ages 16 to 24) identified as having problematic substance use.
- Trial name
- NCT00244699
- Testing
- MI Alone or Plus Mindfulness-Based Skills Training
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Addiction and Mental Health
HIV
Using Cultural Ceremonies to Reduce Intimate Partner Violence and HIV Transmission
Violence against women (VAW), the most extreme manifestation of the unequal power balance between women and men, is a major global public health concern.
- Trial name
- NCT02311699
- Testing
- Intervention to reduce IPV and HIV
- Where
- Ethiopia
- Volunteers
- 6,800 people, healthy volunteers welcome
- Sponsor
- Abdul Latif Jameel Poverty Action Lab
Preventive Health Services, Health Communication
Patients Engaged in Prevention: Enhancing Outreach to Increase Patient Engagement in Diabetes Prevention
This study examines whether a health message that includes a self-affirmation intervention (where people reflect on values that are important to them) increases acceptance of the message and encourages people to take steps to…
- Trial name
- PEP (NCT03550066)
- Testing
- Values affirmation, No affirmation
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Substance Use Disorder, Motivation
Stop&Go: an Intervention Program to Promote Healthy and Active Lifestyles Among Patients With Substance Use Disorders
Stop\&Go is an intervention program aimed at promoting a healthy and physically active lifestyle for patients requiring inpatient detoxification treatment. The program includes two different phases.
- Trial name
- NCT03055351
- Testing
- Stop&Go Intervention
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
COVID-19
Short-time Intervention in Post-Covid Syndrome Syndrome (SIPCOV): A Pragmatic Randomised Controlled Trial
The present study is a 2-arm pragmatic randomised controlled trial (RCT) in which 310 patients who suffer from post-Covid syndrome are randomised to either a short-time outpatient-based rehabilitation program (the intervention)…
- Trial name
- SIPCOV (NCT05196451)
- Testing
- Rehabilitation based on CBT principles
- Where
- Norway
- Volunteers
- 314 people
- Sponsor
- University Hospital, Akershus
Alcohol Dependence, Alcohol Abuse
A Smartphone Based Intervention for the Prevention of Relapse in Alcohol Dependence
The rate of relapse following an inpatient alcohol rehabilitation program has been around 50% for a number of years. Offered treatments mainly focus on conscious and controllable aspects of behaviour, but research has found that…
- Conditions
- Alcohol Dependence, Alcohol Abuse, Alcohol Use Disorder
- Trial name
- SPIRA (NCT03952429)
- Testing
- Anti Alcohol App with Active Cognitive Bias, Inactive Cognitive Bias Modification
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Salus Klinik Lindow
Frailty
Development of a Frailty Risk Prediction Model and Preliminary Evaluation of a Risk-stratified Social Robot-assisted Intervention in Middle-aged and Older Spousal Caregivers
Background With population ageing accelerating worldwide, long-term care needs are rising, and family caregivers have become an essential yet often under-recognised component of care systems.
- Trial name
- NCT07740031
- Testing
- Virtual social robot-assisted intervention, Wait-list control group
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Health Knowledge, Attitudes, Practice
Effect of a Nutritional Education Intervention in Female Athletes
This cluster randomized controlled trial aimed to evaluate the effect of a nutritional education intervention on sports nutrition knowledge, dietary intake, and body composition in adolescent female handball players.
- Trial name
- ATHENEA (NCT07460102)
- Testing
- Nutritional education program
- Where
- Spain
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Andreu Farran-Codina
HIV Infections
Alternative Stress Management Approaches in HIV Disease
The overall purpose of the proposed study is to determine whether three short-term stress management interventions along with booster strategies will improve and sustain improvements in psychosocial functioning, quality of life…
- Trial name
- NCT00029237
- Testing
- Cognitive-behavioral relaxation (Positively Living), Spiritual growth group, Focused Tai Chi
- Where
- United States
- Volunteers
- 392 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
ST Elevation Myocardial Infarction
Long-term Clinical Outcomes of intraVascular Ultrasound-guided vs Angiography-guided Primary pErcutaneous Intervention in Patients With Acute ST Segment Elevated Myocardial Infarction
To examine the impact of IVUS guidance on clinical outcomes in the patient with Acute ST Segment Elevated Myocardial Infarction.
- Trial name
- LOVEinSTEMI (NCT04063345)
- Testing
- IVUS-guided PCI, Angiography-guided PCI
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Alcohol Intoxication
Biphasic Effects of Acute Alcohol Intoxication on Bystander Intervention
The goal of this experimental study is to examine the effect of alcohol, gender, and bystander attitudes on bystander barriers and sexual violence intervention among young adult men and women (age 21-20).
- Trial name
- NCT05701865
- Testing
- Alcohol Intoxication- Ascending Limb, Alcohol Intoxication- Descending Limb, No Alcohol Control
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cardiac Diseases Requiring Surgery
Investigating the Related Factors and Outcome of Kinesiophobia and the Effects of Multidimensional Interventions in Cardiac Surgery Patients
The primary objective of this two-year research project is to investigate the status of activity fear, its related factors, and prognosis in cardiac surgery patients in the first year.
- Trial name
- NCT06625892
- Testing
- the multidimensional interventions
- Where
- Taiwan
- Volunteers
- 245 people
- Sponsor
- Ai-Ling Chang
Any Non-traumatic Musculoskeletal Condition
Testing a Brief Reassurance Message Before a Musculoskeletal Clinic Visit
The goal of this clinical trial is to learn if a brief, reassuring pre-visit message affects patients' expectations and planned follow-up care in adults with common musculoskeletal conditions.
- Trial name
- NCT07330492
- Testing
- Nudge intervention
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Texas at Austin
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