Clinical trials: Intervertebral Disc Herniation
Lumbar Disc Herniation, Pain
The Spatiotemporal Gait Parameters in LDH Patient
The aim of this study was to assessment on the interaction of spatial and temporal gait parameters and gait asymmetry in patients with Lumbar Disc Herniation (LDH) before and 15 days after surgery.
- Trial name
- NCT04409548
- Testing
- All of the spatial and Temporal Gait parameters
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Marmara University
Lumbar Disc Herniation, Radiculopathy Lumbar
Quantitative Sensory Testing and PET/CT Scanning in Assessment of Surgical Outcome for Lumbar Disc Herniation
Patients with lumbar disc herniation suffer from pain and morbidity. Surgical intervention can be a quick and effective relief, however some individuals experience less favorable outcome.
- Trial name
- PET-Pain (NCT03894943)
- Testing
- PET/CT scan, Quantitative Sensory Testing
- Volunteers
- 61 people
- Sponsor
- Spine Centre of Southern Denmark
Pain, Opioid Use
Comparison of Quadratus Lumborum Block Types
This study will compare the quality of analgesia and reduction of opioid use, between standard of care and two groups of local anesthetic blocks in different location in the quadratus lumborum plane, for postoperative pain…
- Conditions
- Pain, Opioid Use, Lumbar Disc Herniation
- Trial name
- NCT04588389
- Testing
- Ropivacaine injection Location 1, Ropivacaine injection Location 2, Multimodal Pharmacological Management
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Massachusetts, Worcester
Herniated Disc, Low Back Pain
Efficacy of PLDD Versus ESI in the Treatment of Lumbar Radicular Pain
The most common cause of lumbar radicular pain is intervertebral disc herniation with or without pressure on the nerve root, which leads to inflammation and pain.
- Trial name
- NCT05601791
- Testing
- Epidural Steroid Injection, Percutaneous Laser Disc Decompression
- Where
- Croatia
- Volunteers
- 116 people
- Sponsor
- Osijek University Hospital
Sciatica, Lumbar Disc Herniation
Electroacupuncture for Insomnia in Patients With Chronic Sciatica Due to Lumbar Disc Herniation: a Randomized Controlled Trial
The goal of this clinical trial is to learn if electroacupuncture can improve sleep in people with chronic sciatica caused by lumbar disc herniation. It will also assess the safety of this treatment.
- Conditions
- Sciatica, Lumbar Disc Herniation, Insomnia
- Trial name
- NCT07576348
- Testing
- Electroacupuncture
- Volunteers
- 114 people
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Lumbar Radiculopathy, Lumbar Herniated Disk
Does Intraoperative Application of Steroids Affect Early Outcomes in Patients Undergoing Endoscopic Lumbar Discectomy?
Prospective randomised trial assessing whether intraoperative application of steroids leads to better clinical outcomes in patients submitted to lumbar discectomy
- Trial name
- NCT07411326
- Testing
- Intervention Group, Control group (Normal Saline) (C)
- Where
- Portugal
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar De São João, E.P.E.
Cervical Foraminal Stenosis, Cervical Disc Herniation
Safety and Efficacy of Electromagnetic Navigation System Assisted Percutaneous Endoscopic Lumbar Decompression
There is a shallow learning curve with TELD (transforaminal endoscopic lumbar discectomy). The aim of this study is to assess the safety and efficacy of TELD assisted by electromagnetic navigation for treating lumbar disc…
- Trial name
- NCT05270486
- Testing
- Electromagnetic navigation system
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Régional de la Citadelle
Prolapsed Lumbar Disc, Prolapsed Cervical Disc
Patient Registry to Observe Outcomes Following Implantation of the VariLift Interbody Fusion Device
The registry has been designed as a prospective, observational program for patients undergoing lumbar or cervical fusion using VariLift device with the ultimate goal to aid in the development of strategic treatment pathways and…
- Conditions
- Prolapsed Lumbar Disc, Prolapsed Cervical Disc, Intervertebral Disc Degeneration, Spondylolisthesis, Grade 1
- Trial name
- NCT01944345
- Where
- 3 sites in United States
- Volunteers
- 69 people
- Sponsor
- Wenzel Spine
Cervical Disc Herniation, Intervertebral Disc Displacement
Gelified Radiopaque Ethanol (Absolute Gel) in Cervical Disc Herniation: an Observational Study in Routine Clinical Practice (GENESIS)
GENESIS is a single-centre, observational, non-interventional, no-profit, investigator-initiated study conducted at Ospedale di Vimercate, ASST Brianza (Italy).
- Conditions
- Cervical Disc Herniation, Intervertebral Disc Displacement, Neck Pain, Chronic Pain
- Trial name
- GENESIS (NCT07832929)
- Testing
- Absolute Gel (radiopaque gelified ethanol)
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Aurel Mengri
Radiculopathy of Lumbosacral Spine Due to Disc Disorder
Short-term Effectiveness of Gabapentin Versus Placebo in Acute Lumbosacral Radiculalgia by Herniation Disc (GRADE)
The study consists in evaluating the analgesic efficacy of Gabapentin versus Placebo in the short term (72h) acute lumbosacral radiculalgia due to disc herniation.
- Trial name
- GRADE (NCT04865042)
- Testing
- Gabapentin 300mg
- Where
- 5 sites in France
- Volunteers
- 144 people
- Sponsor
- Lille Catholic University
Cervical Disc Herniation
Pharmacopuncture Therapy for Cervical Disc Herniation: A Pilot Study
This is pilot study for a 3-arm parallel pragmatic randomized controlled trial that will compare pharmacopuncture therapy, acupunture therapy and physical therapy, medication(prn) for cervical disc herniation.
- Trial name
- NCT05240586
- Testing
- pharmacopuncture therapy, acupuncture therapy, physical therapy, medication(prn)
- Where
- 7 sites in South Korea
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Jaseng Medical Foundation
Lumbar Disc Herniation
Effects of Exercise in Lumbal Disc Herniation
Lumbar disc herniation, which causes 5% of all low back pain, is the rupture of the annulus fibrosis in the intervertebral disc in the lumbar region and the protrusion of the nucleus pulposus at various degrees, and as a result…
- Trial name
- NCT05927051
- Testing
- Stabilization exercises, McKenzie exercises, Home exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Firat University
Radiculopathy
The Effectiveness of Selective Nerve Root Injections in Preventing the Need for Surgery
The median Orthopaedic surgery wait time in Canada is 36.7 weeks (Esmail 2008), thus there is a need to find alternative treatments for pathologies such as lumbar disc herniations (LDH).
- Trial name
- NCT01073995
- Testing
- Kenalog and Sensorcaine
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- Horizon Health Network
Inflammation, Neutrophil
SIII and Spontaneous Regression in Lumbar Disc Herniation
This study aimed to investigate the role of the Systemic Immune-Inflammatory Index (SIII) in patients with lumbar disc herniation (LDH) and to evaluate its potential clinical relevance in relation to treatment modality.
- Conditions
- Inflammation, Neutrophil, Lymphocyte, Neurosurgery
- Trial name
- SIII-LDH (NCT07367503)
- Testing
- Lumbar disc herniation treatment, Lumbar disc herniation surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Cervical Radiculopathy, Proprioception
Assessment of Upper Extremity Proprioception in Patients With Cervical Radiculopathy
There is no study in the current literature that systematically investigates the extent of upper-extremity proprioceptive impairment in patients with radicular neuropathic symptoms secondary to cervical disc herniation, nor its…
- Conditions
- Cervical Radiculopathy, Proprioception, Cervical Disc Herniation, Proprioception Reaching Test
- Trial name
- NCT07319156
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Marmara University
Cervical Disc Herniation, Cervical Radicular Pain
Does the Presence of Cervical Facet Tropism Affect the Response to Interlaminar Epidural Steroid Injections?
Facet joints are synovial joints located on the dorsolateral side of the vertebral column. Normally, both facet joints are symmetrical.
- Conditions
- Cervical Disc Herniation, Cervical Radicular Pain, Facet Tropism
- Trial name
- NCT05638074
- Testing
- Interlaminar Epidural Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Janbubi Jandaulyet
Herniated Disc, Intervertebral Disc Displacement
Efficacy of Gabapentin or Amitriptyline to Reduce Postoperative Pain After Lumbar Laminectomy and Diskectomy
The hypothesis of this study is that Gabapentin or Amitriptyline has no role in preemptive analgesia to reduce postoperative pain after lumbar diskectomies.
- Trial name
- NCT01014520
- Testing
- Gabapentin , Amitriptyline
- Where
- Iran
- Volunteers
- 120 people
- Sponsor
- Tabriz University
Lumbar Disc Herniation
RCT - Epidural Anesthetic Cocktail Following Endoscopic Lumbar Discectomy
The study aims to study the effect of intraoperative epidural application of anesthetic cocktail following endoscopic lumbar discectomy in improving postoperative pain, length of hospital stay, time at first dose analgesia…
- Trial name
- NCT05738759
- Testing
- Epidural Anesthetic Cocktail
- Where
- Thailand
- Volunteers
- 54 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Cervical Disc Herniation, Cervical Foraminal Stenosis
Endoscopic Posterior Cervical Foraminotomy Versus Anterior Cervical Discectomy and Fusion for Cervical Radiculopathy
Cervical radiculopathy caused by cervical disc herniation or foraminal stenosis is a common condition that may result in upper limb pain, sensory disturbances, and motor deficits.
- Conditions
- Cervical Disc Herniation, Cervical Foraminal Stenosis, Cervical Radiculopathy
- Trial name
- ENDOFOR (NCT07894159)
- Testing
- Uniportal Endoscopic Posterior Cervical Foraminotomy, Anterior Cervical Discectomy and Fusion
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Central Hospital, Nancy, France
Lumbar Disc Herniation
Full-Endoscopic vs Open Discectomy for the Treatment of Symptomatic Lumbar Herniated Disc
The purpose of this study is to compare the clinical and radiographic outcomes of full endoscopic lumbar discectomy versus open lumbar decompression for the treatment of lumbar herniated discs in which the patient's leg pain is…
- Trial name
- NCT02441959
- Testing
- Lumbar discectomy Open, Lumbar discectomy Endoscopic
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Yale University