Clinical trials: Intestinal Absorption
Ileostomy; Functional Disturbance, Healthy
Carotenoid Absorption and Metabolism From Green-leafy Vegetable Matrices
Absorption and metabolism of carotenoids from two types of spinach preparations will be investigated in two study groups, short bowel/ileostomy and healthy, respectively.
- Trial name
- Popeye (NCT02450227)
- Testing
- Spinach - Whole leaf (10 mg lutein), Spinach - Minced (10 mg/lutein)
- Where
- 2 sites in Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy
Provitamin A Absorption and Conversion With Avocados
Vitamin A is necessary in the human diet. The form of vitamin A found in fruits and vegetables is not "active" and must be converted to the active form in the human body.
- Trial name
- NCT01432210
- Testing
- Post-prandial Feeding Study
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Healthy
Folate Absorption Across the Large Intestine
The objective of this study is to determine whether the intact human colon with an unaltered microflora distribution absorbs folate and to what extent it is absorbed into the systemic circulation using a dual/oral intravenous…
- Trial name
- NCT00941174
- Testing
- 13C5-Calcium-L-Leucovorin
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Digestibility
Effects of Time-restricted Eating on Nutrient Absorption in Healthy Adults
This 2-period, crossover, controlled-feeding trial will investigate the effects of early time-restricted eating (8am-2pm), compared to a control eating timeframe (8am-8pm), on energy and macronutrient digestibility, the thermic…
- Trial name
- NCT04877262
- Testing
- weight maintenance diet (WMD)
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Florida State University
Healthy Participants
GPR146 and Cholesterol Metabolism
Blood cholesterol balance is regulated by an interplay between the small intestine and the liver. Recently, a new protein (cholesin) was discovered, which is secreted by intestinal cells after dietary cholesterol intake.
- Trial name
- GPR146 (NCT07142317)
- Testing
- Cholesterol-poor, plant sterol-poor shake, Cholesterol-rich, plant sterol-poor shake, Cholesterol-rich, plant sterol-rich shake
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
Imaging the Effect of Experimental Stress on Small and Large Bowel Water During Fructose Absorption
The investigators have been developing new, non-invasive magnetic resonance imaging (MRI) techniques to image the small bowel. Building on those studies the investigators want to study, in healthy volunteers, the effects of…
- Trial name
- NCT01763281
- Testing
- CRH
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Intestinal Permeability
Intestinal Permeability
Rationale: Intestinal permeability of subjects can vary depending on their health status. It is therefore important to be able to measure and quantify intestinal permeability in a standardized way.
- Trial name
- NCT01049386
- Testing
- No intervention, Sugar absorption test
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- TNO
Healthy Young Adults, Physiology
Does Paracetamol Influence the Release of Gut Hormones, Glucose Absorption and Glycemia?
The study aim is to determine whether acute inhibition of endogenous prostaglandin synthesis by paracetamol affects the release of gut hormones, glucose absorption and glycemia in healthy young individuals
- Trial name
- NCT07821515
- Testing
- Paracetamol
- Where
- 2 sites in Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
the Local Renin-angiotensin System (RAS) in Small Intestinal Mucosa in Man
Effects of Probiotic VSL#3 on Expression of Small Intestinal Renin-angiotensin System
Probiotics have become very popular and are by WHO defined as "Live microorganisms which when administered in adequate amounts confer a health benefit on the host".
- Trial name
- NCT01635192
- Testing
- VSL#3
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Nebulizers and Vaporizers
Explorative Clinical Investigation to Investigate the Ability of PreciseInhale to Direct Regional Lung Targeting and Reduce the Degree of Throat Deposition and Subsequent Gastrointestinal Absorption in Healthy Volunteers After Inhalation of Test Drug Substances Via the PreciseInhale System
This is a single site, open label, 4-inhalation sessions, explorative clinical investigation to investigate the ability of PreciseInhale to direct regional lung targeting and reduce the degree of throat deposition and subsequent…
- Trial name
- NCT04946630
- Testing
- PreciseInhale, Seretide Evohaler forte
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Inhalation Sciences Sweden AB
Obesity, Morbid, Bariatric Surgery
Physiological Effects of Gastric Sleeve Operation
After gastric sleeve patients undergo a substantial weight loss, but the physiological mechanisms behind the weight loss is not fully elucidated.
- Trial name
- NCT03046186
- Testing
- Mixed meal test with double tracer technique
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Anemia, Iron-Deficiency
Tea Consumption and Iron Bioavailability in Women Using a Stable Isotope
The purpose of this study is to investigate the inhibition effect of tea consumption on non haem iron absorption with the use of an iron tracer.
- Trial name
- NCT02365103
- Testing
- Test meal I (given with water), Test meal II (simultaneously with tea), Test meal III (1 hour after test meal)
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Chester
Healthy
Pharmacoscintigraphic Investigation Into the Absorption of Nevirapine When Released Into Different Parts of the Gastro-intestinal Tract in Healthy Males
Study to determine the absorption of Nevirapine from different regions of the Gastro Intestinal tract.
- Trial name
- NCT02191189
- Testing
- Nevirapine suspension, into Enterion™ capsule, Nevirapine suspension
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Osteoporosis, Osteopenia
The Effect of Chymosin on the Intestinal Absorption of Calcium
An adequate calcium intake is important for bone turnover and the risk of developing osteoporosis. Yet many studies have documented that supplementation with calcium tablets are often associated with a poor compliance, therefore…
- Trial name
- Chymosin (NCT01370941)
- Testing
- Drug A Chymosin
- Where
- Denmark
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Gut -Microbiota, Inflamation
Impact of a Cricket and Black Soldier Fly Larvae-Fortified Cracker on the Gut Microbiome and Iron Status in Malagasy Schoolchildren
The purpose of this study is to determine the health impacts of consistent consumption of insect-fortified crackers among school-aged children in Madagascar.
- Conditions
- Gut -Microbiota, Inflamation, Iron Absorption
- Trial name
- NCT07439185
- Testing
- Cricket and Black Soldier Fly Larvae-fortified Cracker, Rice and Corn Cracker
- Where
- Madagascar
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Cornell University
Pharmacokinetics of Flavonoids in Humans
An Acute Human Intervention With Flavonoid to Investigate Absorption, Metabolism and Excretion
The era of general dietary recommendations for the whole population may be coming to an end, as it is becoming apparent that we are all unique and do not respond in the same way to the same foods.
- Trial name
- COB (NCT01922869)
- Testing
- Flavonoids
- Where
- United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Taste Receptors, Nutrient Sensing
The Effect of Artificial Sweeteners on Blood Glucose Response
The purpose of this study is to determine whether the presece of the artificial sweeteners aspartame, saccharin and asceulfame-k affect the blood glucose responses to an orally incested glucose solution.
- Conditions
- Taste Receptors, Nutrient Sensing, Intestinal Absorption, Blood Glucose
- Trial name
- NCT01246492
- Testing
- Artificial Sweeteners
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northumbria University
Intestinal Disorders, Bowel Diseases, Inflammatory
TD-1473 Absorption, Distribution, Metabolism and Excretion (ADME) Study in Healthy Male Subjects
This is an open-label, 2-cohort study to evaluate the absolute bioavailability, absorption, distribution, metabolism and excretion of TD-1473 in healthy male subjects.
- Trial name
- NCT03408470
- Testing
- TD-1473 oral capsule, [14C]-TD-1473 IV bolus, [14C]-TD-1473 Oral Capsule
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Celiac Disease, Gluten Sensitivity
Bovine Colostrum to Prevent Absorption of Gluten
To investigate the use of hyperimmune bovine colostrum to reduce gluten absorption. A double-blind, cross-over study will be performed in which persons who are following a strict gluten-free diet will be challenged with oral…
- Conditions
- Celiac Disease, Gluten Sensitivity, Non-celiac Gluten Sensitivity
- Trial name
- NCT05555446
- Testing
- Bovine colostrum
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Milky Way Life Sciences LLC
Metabolic Disorder; Carbohydrate, Absorption, Intestine
Determination of the Postprandial Responses to Two Cereal Foods Differing by Their SDS Content Consumed Alone.
This study aimed at determining the 4-hours postprandial blood glucose and insulin responses to the ingestion of cereal product differing by their SDS content.
- Trial name
- NCT02538653
- Testing
- Sandwich biscuit high in SDS, Co-extruded cereal low in SDS
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.