Clinical trials: Intestinal Anastomosis
Rectal Neoplasm
Loop Ileostomy Closure:Stapled or Hand-sewn Anastomoses? Suture or Mesh Closure of the Stoma Site?
There are severel problems associated with the closing of a temporary loop-ileostomy after surgery for rectal cancer. The purpose of this study is to answer two questions: 1.
- Trial name
- LISTO (NCT02669992)
- Testing
- Stapled or Hand-sewn anastomosis, Mesh or suture stoma site closure
- Where
- 11 sites in Sweden
- Volunteers
- 400 people
- Sponsor
- Karolinska University Hospital
Rectal Cancer
Side-to-end Anastomosis Versus Colon J Pouch for Reconstruction After Low Anterior Resection for Rectal Cancer (SAVE)
Primary hypothesis: Side-to-end anastomosis is non-inferior to colon J pouch for reconstruction after low anterior resection for rectal cancer in fecal incontinence (Wexner score).
- Trial name
- SAVE (NCT01006577)
- Testing
- side-to-end anastomosis, colon j pouch
- Where
- Germany
- Volunteers
- 306 people
- Sponsor
- Charite University, Berlin, Germany
Postoperative Pancreatic Fistula, Delayed Gastric Emptying
Pancreaticoduodenectomy With or Without Braun Enteroenterostomy: Comparison of Postoperative Pancreatic Fistula and Delayed Gastric Emptying
The investigators plan to perform a prospective randomized, head-to-head trial to test the hypothesis that the addition of Braun enteroenterostomy to standard pancreaticoduodenectomy (PD) reconstruction can decrease the rates of…
- Trial name
- NCT01481753
- Testing
- pancreaticoduodenectomy without Braun enteroenterostomy, Braun enteroenterostomy
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- Johns Hopkins University
Colorectal Cancer, Perioperative/Postoperative Complications
J-Pouch Coloanal Anastomosis Compared With Side-to-End Coloanal Anastomosis After Radiation Therapy and Surgery to Remove the Rectum in Treating Patients With Rectal Adenocarcinoma
RATIONALE: A coloanal anastomosis may be effective in restoring bowel function after radiation therapy and surgery to remove the rectum.
- Trial name
- NCT00070005
- Testing
- conventional surgery, management of therapy complications
- Where
- 9 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diverticular Disease of Colon, Colostomy Complication
Comparing Hartmann's Procedure and Primary Resection With Anastomosis in Hinchey III-IV Diverticulitis: Focus on Ostomy Closure and Long-Term Outcomes
Brief Summary This multicenter study compares the effectiveness of primary anastomosis with diverting loop ileostomy to Hartmann's procedure for managing perforated sigmoid diverticulitis in stable patients.
- Conditions
- Diverticular Disease of Colon, Colostomy Complication, Colostomy - Stoma
- Trial name
- ARES (NCT06794905)
- Volunteers
- 578 people
- Sponsor
- Azienda Sanitaria Locale Napoli 2 Nord
Colorectal Cancer, Colorectal Surgery
Pre-emptive Endoscopic Vacuum Therapy Reduces the Incidence of Anastomotic Leakage After Colorectal Cancer Surgery
Evaluate the safety and efficacy of postoperative Pre-emptive EVT (PEVT) in reducing the incidence of anastomotic leaks within 30 days after surgery in patients with colorectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Surgery, Complications, Anastomotic Leakage
- Trial name
- NCT07208786
- Testing
- PEVT
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Nanchong Central Hospital
Rectal Cancer, Colorectal Cancer
Endoscopic Visualisation of Anastomosis in Colorectal Cancer Surgery
A randomised feasibility study into the use of endoscopic visualisation of rectal anastomosis vs. current practice and the effect on anastomotic leak rates in patients undergoing rectal surgery for bowel cancer in a tertiary…
- Conditions
- Rectal Cancer, Colorectal Cancer, Anastomotic Leak, Intraoperative Endoscopy
- Trial name
- EVACCS (NCT04738240)
- Testing
- Intra-operative endoscopy
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Plymouth
Colorectal Cancer, Postoperative Complications
The Impact of Transanal Decompression Tube Placement After Colorectal Anastomosis: A Randomized Trial
There is currently no standardization in the use of the transanal decompressive tube during the postoperative after a colorectal surgery. The available evidence is based on studies with methodological differences.
- Conditions
- Colorectal Cancer, Postoperative Complications, Anastomotic Leak, Anastomotic Complication
- Trial name
- SONDES (NCT04890015)
- Testing
- Intraoperative transanal decompression tube placement
- Where
- Spain
- Volunteers
- 202 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Pancreatic Neoplasms, Pancreatitis, Chronic
Magnetic Compressive Technique for Pancreatic Intestinal Anastomosis
In recent five years, the investigators have successfully developed different types of magnets and utilized in biliojejunostomy, concomitant biliojejunostomy and pancreaticojejunostomy during Whipple.
- Trial name
- MCTPIA (NCT03780946)
- Testing
- Magnetic anastomosis for pancreaticojejunostomy, Traditional hand-sewn anastomosis
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Rectal Cancer, Anastomotic Leak
Does the Management of Anastomotic Leakage After Low Rectal Resection Affect Survival
The aim of this retrospective cohort-study is to assess the effects of AL and its severity divided according the ISREC-classification on the long-term oncological outcome.
- Trial name
- ISRECLeak (NCT06059924)
- Testing
- Anastomotic leakage
- Where
- Switzerland
- Volunteers
- 941 people
- Sponsor
- Cantonal Hospital of St. Gallen
Ulcerative Colitis, Inflammatory Bowel Diseases
Colectomy Reconstruction for Ulcerative Colitis, Ileorectal Anastomosis vs Ileal Pouch-Anal Anastomosis in Ulcerative Colitis.
Background There are no prospective trials comparing the two main reconstructive options after colectomy for Ulcerative colitis, ileal pouch anal anastomosis and ileorectal anastomosis.
- Conditions
- Ulcerative Colitis, Inflammatory Bowel Diseases, Ileostomy - Stoma
- Trial name
- CRUISE (NCT05628701)
- Testing
- Ileorectal anastomosis (IRA), Ileal pouch anal anastomosis (IPAA), ileostomy
- Where
- 4 sites in Sweden, United Kingdom
- Volunteers
- 100 people
- Sponsor
- Linkoeping University
Rectal Cancer, Ulcerative Colitis
Bioabsorbable Staple Line Reinforcement in Colorectal,Coloanal and Ileoanal Anastomoses
The primary purpose of this prospective, randomized multicenter center study is to evaluate and compare the outcomes of colorectal, coloanal and ileoanal anastomoses reinforced with a bioabsorbable staple line reinforcement…
- Conditions
- Rectal Cancer, Ulcerative Colitis, Familial Adenomatous Polyposis, Diverticulitis
- Trial name
- NCT00663819
- Testing
- GORE SEAMGUARD® Bioabsorbable Staple Line Reinforcement, Staple line without reinforcement
- Where
- 16 sites in United States
- Volunteers
- 258 people
- Sponsor
- W.L.Gore & Associates
Bowel Obstruction, Bowel Ischemia
Perfusion Rate Assessment by Near-infrared Fluorescence in Gastrointestinal Anastomoses
In this prospective, non-randomized cohort study, real-time intraoperative visualization using near-infrared-fluorescence by indocyanine green injection (ICG-NIRF) is performed at two to three time points during procedures of…
- Conditions
- Bowel Obstruction, Bowel Ischemia, Diverticulitis, Abnormality of the Gastrointestinal Tract
- Trial name
- NCT04709445
- Testing
- ICG-NIRF Imaging plus ingress and egress analysis
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Liver Transplant; Complications
Placement of Biliary Drainage Stent to Prevent Biliary Intestinal Anastomosis After Liver Transplantation in Children
Liver transplantation is an effective method for treating end-stage liver disease and metabolic diseases in children. With the advancement of surgical techniques and the improvement of perioperative management, the survival rates…
- Trial name
- NCT06048445
- Testing
- intraoperative plancement of Biliary Drainage Stent
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Zhejiang University
Rectum Cancer, Anastomotic Leak
Betacyanin for Early Diagnosis and Recovery of Anastomotic Leakage After Rectal Cancer Surgery: A Single-Center, Prospective, Controlled Trial
This single-center, prospective, controlled trial compares betacyanin versus conventional methods for early diagnosis and healing assessment of anastomotic leakage after rectal cancer surgery.
- Trial name
- NCT07726966
- Testing
- Betacyanin, Pelvic Drainage Fluid Betacyanin Assay
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Southwest Hospital, China
Necrotizing Enterocolitis
Primary Anastomosis Versus Enterostomy in the Surgical Treatment of Necrotising Enterocolitis
Necrotizing enterocolitis (NEC) is a devastating disease that affects the intestine of premature infants and is the most common surgical emergency in newborns.
- Trial name
- NCT04912453
- Testing
- Primary anastomosis, Enterostomy
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The University of Hong Kong
Low Rectal Cancer, Rectal Neoplasms
Reinforced Versus Conventional Anastomosis in Laparoscopic Low Rectal Cancer Resection: A Comparative Study
Study Description This prospective, controlled clinical study aims to compare the clinical outcomes of reinforced anastomosis using 8-10 interrupted sutures versus the conventional Dixon procedure in patients undergoing…
- Conditions
- Low Rectal Cancer, Rectal Neoplasms, Colorectal Cancer
- Trial name
- NCT07346534
- Testing
- Reinforced Anastomotic Suturing (8-10 Interrupted Sutures), Conventional Laparoscopic Dixon Procedure
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai 10th People's Hospital
Colo-rectal Surgery, Anastomotic Leak Large Intestine
Comparison of Rates of Anastomotic Leak in Patients Undergoing Colo-rectal Surgery When Bowel Perfusion and Resection Margin is Deterimined by Intra-operative Infra-red Thermography or by Conventional Method
Pilot RCT with 20 patients in both test and control group. In the control group resection \& anastomosis was done using the conventional method.
- Conditions
- Colo-rectal Surgery, Anastomotic Leak Large Intestine, Anastomotic Leak Rectum
- Trial name
- NCT06180564
- Testing
- Intra-operative Infra-red thermography
- Where
- India
- Volunteers
- 43 people
- Sponsor
- Sir Ganga Ram Hospital
Colonic Neoplasms, Rectal Neoplasms
NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery
After resection of diseased segments of the large intestine, the continuity of the intestine has to be restored. This can be done by suturing or with so called stapling devices.
- Conditions
- Colonic Neoplasms, Rectal Neoplasms, Diverticulitis, Inflammatory Bowel Diseases
- Trial name
- NCT01056913
- Testing
- Compression Anastomosis Device, follow-up colonoscopy
- Volunteers
- 62 people
- Sponsor
- St John of God Hospital, Vienna
Anastomotic Leak
Anastomotic Leakage After Anterior Resection for Rectal Cancer - Predictive Biomarkers and Rectal Blood Flow
The purpose of this study is to determine whether reduced rectal blood flow is associated with the extent of surgery when performing an operation to remove rectal cancer.
- Trial name
- NCT02401100
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Umeå University