Clinical trials: Intestinal Anastomosis
Rectal Cancer, Surgery
Transanal Transection and Single-stapled Anastomosis (TTSS) in Rectal Cancer Patients
The Transanal Transection and Single-Stapled anastomosis (TTSS) technique may be a valid alternative to traditional double-stapled anastomosis for low rectal cancer surgery.
- Trial name
- TTSS-REC (NCT06314646)
- Testing
- Transanal Transection and Single-Stapled anastomosis (TTSS), Double-stapled Total Mesorectal Excision (TME)
- Where
- Italy
- Volunteers
- 472 people
- Sponsor
- Istituto Clinico Humanitas
Ulcerative Colitis, Familial Adenomatous Polyposis
Is Diverting Ileostomy Necessary in Stapled Ileoanal Pouch?
Total proctocolectomy with ileal pouch anal anastomosis is the first choice surgical operation for management of ulcerative colitis and familial adenomatous polyposis.
- Trial name
- NCT01173250
- Testing
- adding diverting ileostomy, omitting diverting ileostomy
- Sponsor
- Mansoura University
Colorectal Neoplasms
A Novel Adaptive Anastomotic Technique for Left-sided Colonic and Rectal Resection
The C-REX device is design to help colorectal anastomoses construction and reduce the risk of anastomotic leak. This study aims to collect preliminary evidence on the effectiveness of C-REX a real-word setting.
- Trial name
- NOVA (NCT06481605)
- Testing
- C-REX
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Clinico Humanitas
Anastomotic Leak
Evaluation of Colonic Perfusion by Indocyanine Green Angiography During Colorectal Surgery
Despite advancements in technology and improved surgical techniques, the occurrence of anastomotic leakage (AL) after colorectal surgery remains between 4% and 30%.
- Trial name
- NCT06793280
- Testing
- intraoperative ICG angiography, No intraoperative ICG angiography
- Where
- Italy
- Volunteers
- 562 people
- Sponsor
- University of Roma La Sapienza
Quality of Life, Fecal Incontinence
J-Pouch vs Side-to-End Anastomosis After Hand-Assisted Laparoscopic Low Anterior Resection for Rectal Cancer
Current study aims to analyze the outcomes of j-pouch and side-to-end anastomosis in rectal cancer patients treated with laparoscopic hand-assisted low anterior resection
- Conditions
- Quality of Life, Fecal Incontinence, Postoperative Complications
- Trial name
- NCT02627729
- Testing
- Linear cutter-Circular stapler, Circular stapler
- Volunteers
- 74 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Rectal Neoplasms, Low Anterior Resection
Use of One Kind of Controllable Tube Ileostomy in the Low Rectal Cancer
Most surgeons suggest the use of fecal diverting to address the high morbidity and mortality associated with anastomotic leakage (AL) in patients with high risk factors on AL who are undergoing low anterior resections(LAR).
- Trial name
- CTI (NCT02012023)
- Testing
- Low anterior resection, tube ileostomy, loop ileostomy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Anastomotic Leak Rectum
Routine Endoscopic Evaluation of Colorectal Anastomoses for Early Detection of Anastomotic Leakage
The objective of this international prospective observational study is to evaluate the implementation of a point-of-care digital rectoscope (LumenEye) into routine care to detect colorectal anastomotic leakage in the early…
- Trial name
- REAL (NCT06493565)
- Testing
- Routine endoscopic anastomosis inspection
- Where
- 5 sites in France, Italy and 3 more
- Volunteers
- 150 people
- Sponsor
- Amsterdam UMC, location VUmc
Rectum Cancer, Stoma Colostomy
Effects of Modified Precision Functional Sphincter-Preserving Surgery (PPS) on Ultralow Rectal Cancer
RATIONALE: Colorectal cancer is one of the most common cancers. However, approaches to minimize surgical trauma, preserve anal function, avoid abdominal stoma, and improve quality of life for patients with ultralow rectal cancers…
- Conditions
- Rectum Cancer, Stoma Colostomy, Faecal Incontinence, Leakage, Anastomotic
- Trial name
- NCT05245565
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai 10th People's Hospital
Ileal Pouch
Study of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an IPAA (PROF)
The aim of this study is to assess the safety and preliminary efficacy of treatment with EXE-346, a live biotherapeutic, which may reduce bowel movement frequency in patients with an ileal pouch-anal anastomosis (IPAA) and lead…
- Trial name
- PROF (NCT05938465)
- Testing
- EXE-346
- Where
- 8 sites in United States
- Volunteers
- 50 people
- Sponsor
- Exegi Pharma, LLC
Rectal Neoplasms
A Prospective Clinical Study for Transanal Double Purse-string Rectal Anastomosis Preformed With KOL Stapler
The most challenge for the surgery of low rectal carcinoma was whether to perform low anterior resection (LAR) and preserve anal function improving the quality of life for patients, for which anastomotic leak is a great obstacle…
- Trial name
- NCT02565667
- Testing
- KOL, traditional staple
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Colon Cancer, Anastomosis
Intracorporeal or Extracorporeal Anastomosis After Laparoscopic Right Colectomy.
During the last few years, the laparoscopic right colectomy with intracorporeal ileocolic anastomosis (IIA) has been proposed as an alternative to laparoscopic right colectomy with extracorporeal ileocolic anastomosis (EIA) for…
- Trial name
- NCT03045107
- Testing
- Laparoscopic right colectomy with intracorporeal ileocolic anastomosis (IIA), Laparoscopic right colectomy with extracorporeal ileocolic anastomosis (EIA)
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- University of Turin, Italy
Ulcerative Colitis
Outcomes of Transanal Tran-section and Single-stapled (TTSS) Ileal Pouch-Anal Anastomosis
This study aims to compare the functional and surgical outcomes of Ulcerative Colitis (UC) patients undergoing Transanal Transection and Singl-Stapled (TTSS) versus Double-stapled Ileal Pouch-Anal Anastomosis (IPAA)
- Trial name
- TTSS-Pouch (NCT06331637)
- Testing
- Transanal Transection and Single-Stapled anastomosis (TTSS), Double-stapled anastomosis
- Where
- Italy
- Volunteers
- 174 people
- Sponsor
- Istituto Clinico Humanitas
Intestinal Anastomotic Leak
Risk Factors for Anatomic Leakage in Advanced Ovarian Cancer Surgery
Cytoreductive surgery is currently the main treatment for advanced epithelial ovarian cancer (AEOC), and the complete disease removal (RT=0) or the achievement of an optimal residual disease (RT < 1 cm) remain the factors with…
- Trial name
- NCT04604964
- Testing
- Evaluation of anastomotic leakage occurrence
- Where
- Italy
- Volunteers
- 515 people
- Sponsor
- Catholic University of the Sacred Heart
Small Bowel Anastomosis
Post Market Study of the Flexagon Only System and Flexagon Plus OTOLoc for Creation of Side-to-Side Duodeno-Ileal Diversion & Flexagon Plus OTOLoc Self Forming Magnet (SFM) System for Creation of Side-to-Side Jejunum-Jejunum and Ileal-Ileal Anastomoses
The objective of this study is to confirm the safety and effectiveness of the Flexagon \& Flexagon Plus OTOLoc systems when used to create respective side-to-side anastomosis in participants undergoing laparoscopic / endoscopic…
- Trial name
- NCT07695558
- Testing
- Small Bowel Anastomosis
- Volunteers
- 70 people
- Sponsor
- GI Windows, Inc.
Stoma Ileostomy, Stoma Colostomy
Conventional Hand Sewn End-To-End Anastomosis Versus Side-To-Side Anastomosis for Stoma Reversal: A Prospective Study
The goal of this clinical trial is to compare approaches to enterostomy reversal by hand-sewn end-to-end anastomosis versus side-to-side anastomosis (sub-divided into hand-sewn side-to-side anastomosis and stapled side-to-side…
- Conditions
- Stoma Ileostomy, Stoma Colostomy, Anastomosis, Ileus
- Trial name
- NCT05753709
- Testing
- Hand sewn end-to-end anastomosis, Hand sewn side-to-side anastomosis, Stapled side-to-side anastomosis
- Where
- India
- Volunteers
- 38 people
- Sponsor
- Sawai Mansingh Medical College
Intestinal Atresia, Anastomotic Complication
Stapled Anastomosis Versus Hand-sewn for Neonate With Intestinal Atresia
Neonatal intestinal atresia is the most difficult disease to apply stapled anastomosis. However, there are no high-quality clinical trial to verify its effectiveness.
- Trial name
- SAVSHA (NCT03754907)
- Testing
- Endocutter stapler, suture material
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zunyi Medical College
Anastomotic Leak Rectum, Rectal Cancer
Treatment of Anastomotic Leakage After Rectal Cancer Resection
The TENTACLE: Rectum study is a multinational retrospective cohort study that includes patients with anastomotic leakage after rectal cancer resection.
- Trial name
- TENTACLE:R (NCT04127734)
- Testing
- The efficacy of various interventions for anastomotic leakage after rectal cancer resection are investigated
- Volunteers
- 1,246 people
- Sponsor
- Radboud University Medical Center
Stoma Reversal Procedure
Clinical Evaluation of Cohera Sylys Surgical Sealant as an Adjunct to Standard Bowel Anastomosis Closure
A first in human study evaluating the safety of Sylys Surgical Sealant in protecting the anastomotic junction created during a stoma reversal procedure.
- Trial name
- NCT02196519
- Testing
- Sylys Surgical Sealant
- Volunteers
- 16 people
- Sponsor
- Cohera Medical, Inc.
Ulcerative Colitis, Inflammatory Bowel Diseases
Comparison of Functional Outcomes Between Transanal and Laparoscopic vs Open Ileal Pouch-Anal Anastomosis
Background: Ulcerative colitis (UC) and inflammatory bowel unclassified (IBDu) are inflammatory bowel diseases (IBD) involving the colon and rectum.
- Conditions
- Ulcerative Colitis, Inflammatory Bowel Diseases, Ileal Pouch
- Trial name
- FUNCTIon (NCT04722757)
- Testing
- ta-IPAA, tabd-IPAA
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Mount Sinai Hospital, Canada
Colorectal Cancer
Visbiome Effect on Colorectal Anastomosis and Local Recurrence
Determine whether the administration of Visbiome after colorectal surgery has any effect on anastomotic leak and local recurrence
- Trial name
- NCT03524638
- Testing
- Visbiome, Colorectal Surgery
- Sponsor
- University of Louisville