Clinical trials: Intestinal Cholesterol Absorption
Ileostoma
Plant Stanol Ester Beverage and Ileostoma Patients
We aim to examine efficacy of a plant stanolester beverage to lower serum cholesterol and LDL-cholesterol levels, when given with or without a fatty acid preparation.
- Trial name
- STOMA (NCT00846937)
- Testing
- Plant stanolester and fatty acid
- Where
- Finland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Healthy Participants
GPR146 and Cholesterol Metabolism
Blood cholesterol balance is regulated by an interplay between the small intestine and the liver. Recently, a new protein (cholesin) was discovered, which is secreted by intestinal cells after dietary cholesterol intake.
- Trial name
- GPR146 (NCT07142317)
- Testing
- Cholesterol-poor, plant sterol-poor shake, Cholesterol-rich, plant sterol-poor shake, Cholesterol-rich, plant sterol-rich shake
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Intestinal Cholesterol Absorption
Algae and Cholesterol Absorption
The primary objective of this study is to investigate the effects of wakame and spirulina consumption on intestinal cholesterol absorption.
- Trial name
- NCT03380611
- Testing
- Wakame, Spirulina, Control
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Heart Diseases, Metabolism, Inborn Errors
Higher-Dose Ezetimibe to Treat Homozygous Sitosterolemia
This study will test the safety and effectiveness of 40 mg of ezetimibe (Zetia ) daily in lowering blood levels of cholesterol and of the plant sterols sitosterol and campesterol in patients with homozygous sitosterolemia, an…
- Trial name
- NCT00099996
- Testing
- SCH-58235, Ezetimibe
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Metabolic Syndrome X
Effects of Selective Inhibition of Cholesterol Absorption With Ezetimibe on Intestinal Cholesterol Homeostasis in Dyslipidemic Men With Insulin-resistance - a Pilot Study
Ezetimibe has been shown to inhibit cholesterol absorption and several lines of evidence from in vitro systems and animal models suggest that this effect is associated with an increase in low-density lipoprotein (LDL) receptor…
- Trial name
- EZEmRNA (NCT01849068)
- Testing
- Ezetimibe
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Laval University
Cholesterol
A Research Study to Evaluate MK0653 (Ezetimibe) and Simvastatin, Given Together and Alone, on Intestinal Absorption of Cholesterol (0653-050)(COMPLETED)
To determine the effect of ezetimibe and simvastatin given together, and ezetimibe and simvastatin given alone on intestinal cholesterol absorption.
- Trial name
- NCT00652301
- Testing
- ezetimibe, simvastatin
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Lipoidosis
SCH-58235 (Ezetimibe) to Treat Homozygous Sitosterolemia
This study will test the safety and effectiveness of SCH-58235 (Ezetimibe) in lowering sitosterol, plant sterol and cholesterol blood levels in patients with homozygous sitosterolemia when added to the patients' current treatment…
- Trial name
- NCT00045812
- Testing
- SCH-58235
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)