Clinical trials: Intestinal Dysfunction
Obesity, Liver Diseases
Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. While weight loss through lifestyle modification is the standard treatment, most patients regain weight limiting…
- Conditions
- Obesity, Liver Diseases, Liver Fibrosis, Liver Fat
- Trial name
- NCT06138821
- Testing
- ESG + lifestyle modification, Lifestyle modification
- Where
- 2 sites in United States
- Volunteers
- 132 people
- Sponsor
- Pichamol Jirapinyo, MD, MPH
Crohn's Disease, Peri-anal Fistulas
Investigation of Sexual Function in Crohn's Disease Patients With Perianal Fistulas
Objective: The aim of this study is to investigate whether Crohn's Disease patients with peri-anal fistulas will suffer from sexual dysfunction in an attempt to help us identify Crohn's Disease patients that would benefit from…
- Conditions
- Crohn's Disease, Peri-anal Fistulas, Sexual Dysfunction
- Trial name
- NCT01635543
- Where
- Canada
- Sponsor
- University of British Columbia
Colorectal Cancer, Inflammatory Bowel Diseases
Sublingual Microcirculation and Postoperative Ileus
The aim of this pilot study is to establish if a correlation between sub-lingual microcirculation measured by Orthogonal polarization spectral (OPS) imaging and symptoms of postoperative ileus exist in patients undergoing…
- Conditions
- Colorectal Cancer, Inflammatory Bowel Diseases, Gastrointestinal Dysfunction
- Trial name
- NCT01828047
- Testing
- orthogonal polarization spectral (OPS) imaging
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Gabriele Baldini, MD, MSc, Assistant Professor
Leaky Gut Syndrome
Effect of Colostrum on Gut Permeability and Endotoxin Level in Chronic Alcoholic Disease
Chronic alcohol ingestion is related with leaky gut syndrome. Colostrum is well-studied that it has a effect of decreasing the degree of leaky gut syndrome.
- Trial name
- NCT01088087
- Testing
- colostrum
- Where
- South Korea
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Moderate Acute Malnutrition, Stunting
Eggs for Gut Health
The goal of this clinical trial is to test egg powder supplementation in children with moderate acute malnutrition in Sierra Leone.
- Conditions
- Moderate Acute Malnutrition, Stunting, Environmental Enteric Dysfunction, Severe Acute Malnutrition
- Trial name
- NCT06002438
- Testing
- Whole egg powder, Corn powder, Supercereal Plus
- Where
- 10 sites in Sierra Leone
- Volunteers
- 461 people
- Sponsor
- Washington University School of Medicine
Crohn's Disease (CD)
A Pilot Study: Micro and NanoPlastics in Association With Crohn's Disease
Micro and nanoplastics (MNPs) are environmental contaminants found in food and water. Recent evidence suggests these particles may be linked to intestinal inflammation and changes in gut bacteria, which are key features of…
- Trial name
- NCT07630883
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- Mak Wing Yan
Impaired Glucose Regulation, Impaired Glucose Tolerance (Prediabetes)
Probiotic Impact on Cognitive Performance, and Metabolic Outcomes in Overweight Young Adults With Impaired Glucose Regulation
This 12-week, double-blind, placebo-controlled trial will examine whether daily supplementation with the Lab4P probiotic can improve cognitive performance and metabolic health in overweight adults aged 18 to 40 with impaired…
- Conditions
- Impaired Glucose Regulation, Impaired Glucose Tolerance (Prediabetes), Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Overweight (BMI > 25)
- Trial name
- ProCog (NCT07073781)
- Testing
- Lab4p Probiotic Consortium
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Leeds Beckett University
Opioid-Induced Bowel Dysfunction
Opioid-induced Bowel Dysfunction Pivotal Assessment of Lubiprostone
The primary purpose of this study is to evaluate the efficacy and safety of lubiprostone administration in patients with opioid-induced bowel dysfunction (OBD).
- Trial name
- OPAL (NCT00597428)
- Testing
- Lubiprostone
- Where
- 114 sites in United States, Canada
- Volunteers
- 437 people
- Sponsor
- Sucampo Pharma Americas, LLC
Rectal Tumor, Women
Study of the Prevalence of Sexual Dysfunction in Women After Rectal Cancer Surgery and Analysis of the Impact of a Sexologist Intervention
RectSexQoL is a study aiming at determining the prevalence of female sexual dysfunction after rectal cancer surgery. It has the goal as well to analyse the impact of an intervention given by a sexologist to such patients.
- Conditions
- Rectal Tumor, Women, Sexuality, Life Quality
- Trial name
- RectSexQol (NCT05933122)
- Testing
- sexologist consult, standart of care
- Where
- 6 sites in France
- Volunteers
- 144 people
- Sponsor
- University Hospital, Limoges
Urinary Incontinence, Fecal Incontinence
Safety and Performance of UCon for the Treatment of the Symptoms of Overactive Bladder (OAB) / Bowel Dysfunction (BD)
This clinical investigation is a single-arm, prospective, multicentre, early feasibility study, which is used to evaluate the device design of UCon with respect to initial clinical safety and device performance in a small number…
- Conditions
- Urinary Incontinence, Fecal Incontinence, Urge Incontinence, Nocturia
- Trial name
- NCT05368246
- Testing
- UCon
- Where
- 3 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- InnoCon Medical
Sepsis, Intestinal Dysfunction
Effect of Electroacupuncture on Sepsis-induced Intestinal Dysfunction
1. Title: Effect of electroacupuncture on sepsis-induced intestinal dysfunction 2. Research center: single center 3. The Design of the study: Randomized, double-blind, controlled study 4.
- Trial name
- NCT04646629
- Testing
- electroacupuncture treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jianbo Yu
Ileostomy - Stoma, Rectal Cancer
Alterations of Gut Microbiome, Function, and Its Intervention After Defunctioning Ileostomy
This study focused on the alterations of gut microbiome and function during defunctioning ileostomy, and observed the effects of probiotic intervention on intestinal microbiome and function.
- Conditions
- Ileostomy - Stoma, Rectal Cancer, Microbial Disease, Intestinal Functional Disorder
- Trial name
- NCT05759741
- Testing
- MIYAIRI 588
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Huashan Hospital
Fecal Impaction, Lower Urinary Tract Disorder
Development of Fecal Scoring for the Management of Fecal Impaction With Regards to Lower Urinary Tract Dysfunction
The role of bowel bladder disorder, or BBD, has been highlighted as a major player in vesicoureteral reflux and urinary tract infection (UTI).
- Conditions
- Fecal Impaction, Lower Urinary Tract Disorder, Bladder Dysfunction, Bowel Dysfunction
- Trial name
- NCT04579731
- Testing
- Lactitol Monohydrate
- Where
- South Korea
- Volunteers
- 187 people
- Sponsor
- Seoul National University Hospital
Esophagus Cancer, Stomach Cancer
Effects of S-1 and Capecitabine on Coronary Artery Blood Flow
Fluoropyrimidine chemotherapy agents , such as 5-fluorouracil and capecitabine, are occasionally associated with cardiac toxicity.
- Conditions
- Esophagus Cancer, Stomach Cancer, Small Bowel Cancer, Colon Cancer
- Trial name
- FluoHeart (NCT02216149)
- Testing
- S-1, Capecitabine, Oxaliplatin
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Heikki Joensuu
Chronic Granulomatous Disease
Neutrophil Oxidative Burst in Early and Late Onset Pediatric Inflammatory Bowel Disease
ABSTRACT Introduction Residual or absent oxidase function in peripheral neutrophils may point to an inborn defect of neutrophil function - chronic granulomatous disease (CGD) - whereas low to normal oxidative burst capacity has…
- Trial name
- NCT06162936
- Testing
- Phagoburst, Lymphocytes subsets, Genetic testing
- Where
- Romania
- Volunteers
- 150 people
- Sponsor
- National Institute for Mother and Child Health Alessandrescu Rusescu
Pelvic Organ Prolapse
Exair® Versus Native Tissue Repair for Prolapse
The purpose of this study is to compare safety and effectiveness of the Exair Prolapse Repair System for treatment of pelvic organ prolapse to traditional native tissue repair through 36 months of follow-up.
- Trial name
- NCT02162628
- Testing
- Exair Prolapse Repair System, Total Native Tissue Repair
- Where
- 14 sites in United States, Canada
- Volunteers
- 79 people
- Sponsor
- Coloplast A/S
Aging, Vascular Stiffness
Acetate and Age-associated Arterial Dysfunction
Cardiovascular diseases are the leading cause of morbidity and mortality and contribute most to healthcare costs in the U.S. Age is the strongest cardiovascular disease risk factor, with >90% of all deaths from cardiovascular…
- Conditions
- Aging, Vascular Stiffness, Vascular Dilation
- Trial name
- NCT05424263
- Testing
- Calcium Acetate Oral Solution, Calcium Carbonate Oral Suspension
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Low Anterior Resection Syndrome
Bowel Dysfunction After Rectal Cancer Treatment
Bowel dysfunction after rectal cancer treatment may significantly affect the quality of life. Our study aimed to estimate the incidence and characterize the Low Anterior Resection Syndrome(LARS).
- Trial name
- NCT05020132
- Where
- Spain
- Volunteers
- 113 people
- Sponsor
- Consorci Sanitari de Terrassa
Endothenial Dysfunction, Iron Status
Inflamation, Gut Leakage, Iron Status After 6000m Ergometer Test in Elite Rowers.
The influence of a 6000m ergometer test on the markers of gut injury, endotoxemia, iron status, stress and inflammation in elite rowers.
- Conditions
- Endothenial Dysfunction, Iron Status, Oxidative Stress
- Trial name
- 6000m (NCT06890741)
- Testing
- exercise test
- Where
- Poland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Rectal Cancer
Intraoperative Monitoring of the Pelvic Autonomic Nerves
One of the major problems of rectal cancer surgery is pelvic autonomic nerve damage, which is the main cause of urogenital dysfunction influencing postoperative quality of life.
- Trial name
- NEUROS (NCT01585727)
- Testing
- TME, Neuromonitoring
- Where
- Germany
- Volunteers
- 188 people
- Sponsor
- Johannes Gutenberg University Mainz