Clinical trials: Intestinal Flora
Changes in Gut Microbiota, Gut Metabolites, Respiratory Symptoms, and Well-being Index
A Probiotic for Health Outcomes in Short-Term Overseas Travel
With the improvement of living standards, travel has become a common form of leisure. However, travelers often face changes in living environments, dietary habits, and sleep schedules, all of which can impact the gut microbiota…
- Trial name
- NCT07705659
- Testing
- Bifidobacterium longum, Maltodextrin
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- DiproBio (Shanghai) Co., Ltd.
Pemphigoid, Benign Mucous Membrane, Gingivitis Hyperplastic
Peridontal and Intestinal Microbiota in Patients With Gingival Scarring Pemphigoid
Patients suffering from Mucous Membrane Pemphigoid with desquamative gingivitis (MMPg) generally present a more degraded periodontal condition compared with controls.
- Trial name
- MICROPC (NCT06291350)
- Testing
- Plaque sampling and stool collection, periodontal examination
- Where
- 3 sites in France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Colorectal Cancer (CRC), Endocrine Disruptors
Effects of Endocrine Disruptors on the Gut Microbiota and Assessment of Their Impact on Colorectal Cancer Development (PERMICA)
Colorectal cancer is the third most common cancer worldwide, yet it was the second leading cause of cancer-related deaths in 2020. The average French population faces a colorectal cancer risk partly linked to lifestyle factors.
- Conditions
- Colorectal Cancer (CRC), Endocrine Disruptors, Microbiota, Dysbiosis
- Trial name
- PERMICA (NCT06809660)
- Testing
- Collection of biological samples and clinical data
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Vaginal Microflora
Clinical Evaluation of Effects of an Investigational Tampon on Vaginal Microflora
Subjects will be using investigational or control tampons during their menstrual period but these tampons are not intended to prevent, treat or diagnose an infection or other disease condition.
- Trial name
- NCT00913523
- Testing
- Experimental - Tampon with GML
- Where
- 2 sites in United States
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Microbiota
Gut Microbiota and Nonpuerperal Mastitis
Nonpuerperal mastitis (NPM), mainly including Plasma cell mastitis (PCM) and Granulomatous mastitis (GM), which clinical presentation is an accessible and painful breast mass accompanied by skin redness and swelling, nipple…
- Trial name
- NCT05051215
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Metabolic Disease, Inflammation
Gut Microbiota-dependent Health Impacts of Haskap Berries
Polyphenol-rich Haskap berries (Haskap) have untapped therapeutic potential to improve human health, and agricultural producers in northern U.S. states are poised to increase production if consumer demand increases.
- Conditions
- Metabolic Disease, Inflammation, Microbial Colonization
- Trial name
- HIH (NCT06546020)
- Testing
- Haskap berry smoothie
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Montana State University
Cognitive Decline, Cognitive Dysfunction
Polyphenols and Cognitive Decline
Globally, populations are aging thereby increasing healthcare burden, overall cognitive impairment, and dementia including Alzheimers diseases (AD).
- Trial name
- MAEVE (NCT06507254)
- Testing
- Polyphenol Supplement
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Healthy Infants
Efficacy of Two HMOs in Chinese Infants
This is a randomized, controlled, double-blind, intervention trial of healthy male and female term infants to evaluate the efficacy of the 2 HMOs on beneficially modulating the gut microbiota, gut maturation, gut barrier…
- Trial name
- NCT06361719
- Testing
- Experimental Group (EG), Control Group (CG)
- Where
- China
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Alzheimer Disease, Gut Microbiota
A Longitudinal Study to Explore the Impact of Gut Microbiome on Brain Health in Alzheimer's Disease
Gut microbiota dysfunction is associated with Alzheimer's disease (AD). However, the potential modulatory mechanism remains unclear.
- Conditions
- Alzheimer Disease, Gut Microbiota, Metabonomics, Magnetic Resonance Imaging
- Trial name
- NCT06837272
- Testing
- Multi-omics features extraction
- Where
- China
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Jining Medical University
Cognition, Affect (Mental Function)
PRECOG Pilot Project
This pilot study aims to investigate the chronic effects of a prebiotic blend on cognitive, affective and gut microbiome outcomes in healthy adults aged 60-75 years.
- Conditions
- Cognition, Affect (Mental Function), Gut Microbiome
- Trial name
- NCT06911957
- Testing
- Prebiotic blend
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Reading
Gut Microbiota
Characterization of the Gastrointestinal Microbiota in Term Newborn Infants After 4 Weeks Supplementation of Probiotics
A mono center, open label, pilot study in term newborn infants. The study will investigate the effect of supplementation with probiotics on the presence of total Bifidobacterium in the infant feces.
- Trial name
- NCT04994834
- Testing
- Probiotics
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Chr Hansen
Obesity, Metabolic Diseases
Adaptation of Human Gut Microbiota to Energetic Restriction
Gut microbiota ecology is altered in obesity and could link obesity and its complications. Bariatric surgery enables a major and sustained weight loss therefore improving obesity related disease.
- Conditions
- Obesity, Metabolic Diseases, Nutrition Disorders, Body Weight
- Trial name
- microbaria (NCT01454232)
- Testing
- stools sampling, adipose tissue biopsy
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
NAFLD, Fecal Microbiota
Dietary Counseling Coupled With FMT in the Treatment of Obesity and NAFLD - the DIFTOB Study
There are several studies performed to reveal the linkage between diet, fecal microbiota, and obesity. Human fecal microbiota transplantations in this asset are still scarce.
- Conditions
- NAFLD, Fecal Microbiota, Gut Microbiota, Obesity
- Trial name
- DIFTOB (NCT05607745)
- Where
- 3 sites in Finland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Diarrhea
Study of the Interactions Between Dientamoba Fragilis and the Gut Microbiota
D.fragilis is an intestinal protozoon that feeds by phagocytosis of intestinal bacteria. The study aim to determine if the carriage of the intestinal parasite D.fragilis is associated to changes of gut microbiota in subjects…
- Trial name
- NCT02534272
- Testing
- Stool sampling and sequencing of gut microbiota.
- Where
- 4 sites in France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Apnea, Sleep
Effects of CPAP on Cognitive Function, Neurocognitive Architecture and Function in Patients With OSA: The SMOSAT Trial
Multiple clinical studies have indicated that obstructive sleep apnea (OSA), the most common chronic sleep disorder, may affect neurocognitive function, and that treatment for continuous positive airway pressure (CPAP) has some…
- Trial name
- NCT02886156
- Testing
- CPAP, BSC
- Where
- China
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Healthy
Almonds: Digestive Health and Immune Function of Adults and Children
The purpose of this study is to determine whether incorporating almonds into the diets of families with young children will induce beneficial changes in gastrointestinal function, the fecal microbiota profile, and immune and…
- Trial name
- NCT01973595
- Testing
- Almonds, Then no almonds, No Almonds, Then almonds
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Florida
Small Intestinal Bacterial Overgrowth (SIBO)
Botanical Blend on the Gut Microbiome and Gut-Skin-Axis in Small Intestinal Bacterial Overgrowth (SIBO)
The purpose of this study is to assess how an oral botanical blend alters the gut microbiome and the skin biophysical properties in people with SIBO.
- Trial name
- NCT04867512
- Testing
- Liquid Tincture, GI Detox, Olivirex
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Heart Failure
The Role of Gut Microbiota in Heart Failure and Pre-Heart Failure With Preserved Ejection Fraction
Gut microbiota play an important role in normal cardiovascular function and pathophysiology of cardiovascular diseases. Patients with heart failure (HF) have substantial hemodynamic changes which lead to intestinal hypoperfusion…
- Trial name
- NCT02728154
- Testing
- Blood Sample, Stool Sample
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Occasional Constipation, Gastrointestinal Health
A Clinical Trial to Investigate the Efficacy of Acacia Fiber on Gastrointestinal Health and Microbiota Composition in Healthy Adults With Occasional Constipation
The goal of this randomized blinded placebo-controlled clinical trial is to investigate the effect of low- and high-dose supplementation of Acacia fiber on gut health and microbiota composition in adults with occasional…
- Conditions
- Occasional Constipation, Gastrointestinal Health, Gut Microbiota Composition
- Trial name
- NCT07703254
- Testing
- Low-dose Acacia fiber, High-dose Acacia fiber
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Nexira
Menopause
The Role of the Gut Microbiota in Estrogen Metabolism and Dietary Flax as a Potential Modulator.
The purpose of this pilot study is to determine if suppressing estrogen in premenopausal women results in changes in gut microbiota and if dietary flaxseed modulates these changes.
- Trial name
- NCT03183102
- Testing
- Flaxseed
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Colorado State University