Clinical trials: Intestinal Functional Disorder
Irritable Bowel Syndrome
Randomised Double-blind Active vs. Placebo Clinical Trial on the Effect of a Food Supplement on IBS in Children
The goal of this clinical trial is to test a food supplement in children of 3-17 years with IBS. The main questions it aims to answer are: Is the tested supplement able to improve and/or reduce IBS-related symptoms? After…
- Trial name
- NCT06123234
- Testing
- Verum
- Where
- Italy
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Irritable Bowel Syndrome
Fructose and Fructans in Irritabla Bowel Syndrome
The purpose of the study is to investigate if patients with Irritable Bowel Syndrome (IBS) who also report bloating are more likely to report clinically important gastrointestinal symptoms after consuming fructose or fructans…
- Trial name
- FABS (NCT01776853)
- Testing
- Glucose, Fructose, Fructans
- Where
- United Kingdom
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome
The Effect of Zespri Green Kiwifruit on Digestive and Gut Health Functions
The proposed study will primarily demonstrate the efficacy of kiwifruit as a food intervention for the relief of constipation and associated symptoms in functionally constipated adults, and those with IBS-C.
- Trial name
- NCT02888392
- Testing
- Kiwifruit, Psyllium
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zespri International Limited
Endothelial Dysfunction
The Association Between Food Timing and Composition on Gastrointestinal Injury, Stress Hormone and Gastrointestinal Complains.
The study aimed to check the influence of timing and composition of diet on markers of gut injury, endotoxemia and stress.
- Trial name
- NCT06403241
- Testing
- 2000 meter ergometer test
- Where
- Poland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Gastrointestinal Dysfunction, Metabolic Disturbance
Hemp Fiber Ingestion and Gut Permeability After Exercise
Two bioactive compounds, N-trans-caffeoyl tyramine (NCT) and N-trans-feruloyl tyramine (NFT), have been investigated for potential gut health benefits. The shells of hemp seeds are a rich source of NCT and NFT.
- Trial name
- NCT06204666
- Testing
- High Dose Hemp Fiber Bar, Low Dose Hemp Fiber Bar
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Memory Decline, Cognitive Decline
Anti-inflammatory Probiotics in Cognitive Functioning
The goal of this study is to explore the potential impact of an anti-inflammatory probiotic mixture of psychobiotics including Bifidobacterium longum Rosell®-175 and Lactobacillus helveticus Rosell®-52 on cognitive functions in…
- Conditions
- Memory Decline, Cognitive Decline, Cognitive Aging
- Trial name
- CoProM (NCT07165977)
- Where
- Poland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Social Sciences and Humanities, Warsaw
Colorectal Cancer, Inflammatory Bowel Disease
Changes of Muramyl Dipeptide in Intestinal and Extra-intestinal Diseases
Nucleotide-binding oligomerization domain 2 (Nod2) signaling is critical for human health.To figure out the clinical relevance of NOD2 ligands, the investigators plan to evaluate the change of NOD2 ligands in inflammatory bowel…
- Conditions
- Colorectal Cancer, Inflammatory Bowel Disease, Atherosclerotic Cardiovascular Disease, Type2 Diabetes Mellitus
- Trial name
- NCT04924686
- Testing
- Observational studies, no intervention
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Obesity, Growth
Essential Fatty Acids During Complementary Feeding
The objective of this intervention study is to examine the effect of n-3 LCPUFA on growth and body composition, intestinal health and microbiotic composition, immune function and risk markers for later diseases in 9-18 months old…
- Conditions
- Obesity, Growth, Metabolic Syndrome, Cardiovascular Disease
- Trial name
- EFiON (NCT00631046)
- Testing
- Fish Oil, Sunflower Oil
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Irritable Bowel Syndrome
Validation of Surrogate Measures in Irritable Bowel Syndrome (IBS)
Visceral and somatic hypersensitivity as evidence of central sensory sensitization occur in the majority of Irritable Bowel Syndrome (IBS) patients.
- Trial name
- NCT00693732
- Testing
- Escitalopram treatment, Quantitative sensory testing
- Where
- 2 sites in Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Traumatic Brain Injury, Fatigue
Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy
Patients with a history of mild traumatic brain injury (mTBI) or post acute sequelae of SARS-CoV-2 (PASC) and abnormal growth hormone secretion, as measured by glucagon stimulation test, will be treated with replacement growth…
- Conditions
- Traumatic Brain Injury, Fatigue, Cognitive Impairment, COVID-19
- Trial name
- NCT03554265
- Testing
- Somatropin
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Opioid-Induced Bowel Dysfunction, Constipation
The Influence of Tramadol on Opioid-induced Bowel Dysfunction
Tramadol is a weak opioid and widely used to treat moderate to severe pain. Stronger opioids are known to inhibit gastrointestinal motility and secretion, however the effects of tramadol on gastrointestinal function remains less…
- Trial name
- NCT06385561
- Testing
- Tramadol
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Asbjørn Mohr Drewes
Constipation, Gastrointestinal Dysfunction
Effect of Polydextrose on Fecal Bulk and Bowel Function in Mildly Constipated Subjects
Polydextrose (PDX) (8-30g/day) has been reported to increase faecal bulk and consistency, leading to easier stool passage in healthy subjects.
- Trial name
- NCT05309837
- Testing
- Polydextrose
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Tate & Lyle
Irritable Bowel Syndrome
Efficacy of a Probiotic Blend to Reduce Gastrointestinal Symptoms in Patients With Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a recurrent, functional disorder characterized by abdominal pain and discomfort, changes in bowel habits and gastrointestinal symptoms such as distension and sensation of abdominal inflammation…
- Trial name
- NCT05819281
- Testing
- Probiotic blend
- Where
- Brazil
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Environmental Enteric Dysfunction
Capsule Endomicroscopy for Visualization of the Small Intestine in EED Population in Pakistan
This pilot study will test the feasibility and tolerability of the tethered OCT capsule and Trans Nasal Endomicroscopy probe and accessory devices for imaging the small intestine in subjects with EED and a matched non-EED cohort.
- Trial name
- NCT04275167
- Testing
- Tethered Capsule Endomicroscope/Trans Nasal Endomicroscope
- Where
- Pakistan
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cognitive Dysfunction, Dietary Habits
Nutrition, gUT Microbiota, and BRain AgINg: the NutBrain Study
Epidemiological evidence suggests that healthy diet is associated with a slowdown of cognitive decline leading to dementia, but the underlying mechanisms are still partially unexplored.
- Trial name
- NutBrain (NCT04461951)
- Testing
- Lifestyles (exposure)
- Where
- Italy
- Volunteers
- 643 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Irritable Bowel Syndrome
Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome
The purpose of this study is to provide new information and to determine which kinds of brief, tolerable, experimental pain are affected by the drugs being studied in patients with irritable bowel syndrome, a disease that causes…
- Trial name
- NCT00100425
- Testing
- Viceral Perception Testing
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Irritable Bowel Syndrome
The Expression of the Ionotropic Glutamate Receptors in Colon of IBS
The study aims to determine the expression of the ionotropic glutamate receptors in colon of irritable bowel syndrome (IBS) patients and evaluate the relationship between the ionotropic glutamate receptors and IBS symptoms.
- Trial name
- NCT02512146
- Testing
- colonoscopy
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shandong University
Irritable Bowel Syndrome (IBS)
A Study To Investigate The Effect Of Solabegron (GW427353) On Gastrointestinal Transit In Healthy Volunteers
This study will test the hypothesis that GW427353, a beta-3 adrenergic agonist, retards the emptying of the colon and increases total colonic transit time.
- Trial name
- NCT00401479
- Testing
- Solabegron (GW427353)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Crohn Disease, Ulcerative Colitis
OptiCal Study -Optimizing Fecal Calprotectin Monitoring: a Clinical Study Comparing CalproLab Against PhiCal and Evaluating Its Association With the Gut Microbiome
Study Aims: To analyze stool specimens to test and validate the CalproLab assay against the predicate PhiCal in order to determine performance characteristics. And to correlate Calpro levels to the gut microbiome composition.
- Conditions
- Crohn Disease, Ulcerative Colitis, Irritable Bowel Syndrome, Celiac Disease
- Trial name
- OptiCal (NCT03051204)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Functional Abdominal Pain Syndrome
The Effects of Probiotics, Lactobacillus GG, in the Treatment of Abdominal Pain in Children With Functional Abdominal Pain Disorders
Recurrent or chronic abdominal pain is one of the common gastrointestinal problems in children. While most children do not have organic origins (so called functional abdominal pain disorders; FAPDs), the symptoms can nevertheless…
- Trial name
- NCT06310733
- Testing
- LGG
- Where
- Thailand
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University