Clinical trials: Intestinal Metaplasia of Gastric Mucosa
Gastric Cancer, Gastric Intestinal Metaplasia
Chemoprevention of Gastric Carcinogenesis
A clinical study of the efficacy of oral alpha-difluoromethylornithine (eflornithine or DFMO) in male and female subjects ages 30-60 with gastric premalignant lesions in two high risk regions of Latin America.
- Trial name
- NCT02794428
- Testing
- Eflornithine
- Where
- 2 sites in Honduras, Puerto Rico
- Volunteers
- 91 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Gastric Cancer, Gastric (Stomach) Cancer
Gastric Cancer Endoscopic Screening in an Intermediate-risk Country - ROGCAS, a Dual-centre Pilot Program
Endoscopic screening of gastric cancer combined with screening colonoscopy
- Conditions
- Gastric Cancer, Gastric (Stomach) Cancer, Atrophic Gastritis, Intestinal Metaplasia of Gastric Mucosa
- Trial name
- ROGCAS (NCT06316882)
- Testing
- Screening endoscopy
- Where
- Portugal
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- Unidade Local De Saúde Do Norte Alentejano
Mucosal Microbiome, Gastric Intestinal Metaplasia
Mucosal Microbiome in Human Gastric Intestinal Metaplasia and Duodenal Tissue.
To investigate the mucosal microbiome in human gastric intestinal etaplasia and duodenal tissue.
- Conditions
- Mucosal Microbiome, Gastric Intestinal Metaplasia, Duodenum
- Trial name
- NCT02428426
- Testing
- endomicroscopy, targeted biopsy and 16s rRNA gene sequencing
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shandong University
Intestinal Metaplasia of Gastric Mucosa, Confocal Laser Endomicroscopy
Artificial Intelligence Confocal Laser Endomicroscopy for Real-time Assessment of Gastric Cancer Risk.
Current national guidelines recommend the use of OLGIM score to evaluate the risk of gastric cancer in patients, and close gastroscopic monitoring should be performed after OLGIM grade III/IV.
- Trial name
- NCT05459428
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shandong University
Intestinal Metaplasia of Gastric Mucosa, Gastric Dysplasia
Novel Approach to Surveillance of Gastric Lesions
This will be a pilot study investigating the feasibility of using pressurized irrigation of the stomach mucosa to obtain gastric aspirate cell samples for analysis and identification of premalignant lesions of the stomach.
- Conditions
- Intestinal Metaplasia of Gastric Mucosa, Gastric Dysplasia, Gastric Cancer, Atrophic Gastritis
- Trial name
- NCT04251403
- Testing
- Mucosal Irrigation
- Volunteers
- 10 people
- Sponsor
- New York Presbyterian Hospital
Autoimmune Diseases, Helicobacter Pylori Gastritis
Pyloric or Pseudopyloric Metaplasia of the Corpus Mucosa in Autoimmune Gastritis
The study is aimed to investigate the different rates of pyloric/ pseudopyloric metaplasia or spasmolytic polypeptide-expressing metaplasia (SPEM) of corpus between autoimmune gastritis and H. pylori-infected non-ulcer dyspepsia.
- Conditions
- Autoimmune Diseases, Helicobacter Pylori Gastritis, Anemia, Pernicious, Metaplasia
- Trial name
- PM_in_AIG (NCT05238181)
- Testing
- Assess pyloric or pseudopyloric metaplasia of corpus by H&E stains, Assess pyloric or pseudopyloric metaplasia of corpus by TFF2 immunohistochemistry stains, The assessment of corpus-predominant gastritis index (CGI), Operative Link for Gastritis Assessment (OLGA), and Operative Link on Gastric Intestinal Metaplasia assessment (OLGIM)
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Cheng-Kung University Hospital
Flow Determination
Real-time Observation of Microcirculatory Hemodynamics in Gastric Intestinal Metaplasia by Confocal Laser Endomicroscopy
The morphologic change of microvessels has the clinical value to distinguish cancerous from non-cancerous mucosa. The aim of this study was to observe gastric mucosa microcirculatory hemodynamic changes real-time using pCLE…
- Trial name
- NCT02595151
- Testing
- CLE
- Where
- China
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Shandong University
Intestinal Metaplasia of Gastric Mucosa
Intestinal Metaplasia Cohort for Gastric Cancer Prediction
In this study, we aim to establish a prospective cohort of patients with endoscopically and histologically confirmed intestinal metaplasia, collect gastric mucosal tissue samples from this cohort, and follow the development of…
- Trial name
- NCT06075199
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Seoul National University Hospital
Gastric Intestinal Metaplasia, Gastric Intraepithelial Neoplasia
Confocal Laser Endomicroscopy for the Diagnosis of Gastric Intestinal Metaplasia, Intraepithelial Neoplasia, and Carcinoma
i. To determine whether Confocal Laser Endomicroscopy (CLE) with optical biopsy and targeted mucosal biopsy improves the diagnostic yield of gastric IM/IN/CA in high risk populations compared to WLE with standard biopsy protocol.
- Conditions
- Gastric Intestinal Metaplasia, Gastric Intraepithelial Neoplasia, Gastric Carcinoma
- Trial name
- NCT01642797
- Testing
- Confocal laser endomicroscopy (Pentax, EG3870K), Standard White-light endoscopy (Pentax, 90i)
- Where
- 4 sites in Australia, China and 1 more
- Volunteers
- 242 people
- Sponsor
- Shandong University
Intestinal Metaplasia
Confocal Laser Endomicroscopy for the Detection of Gastric Intestinal Metaplasia: a Randomized Controlled Trial
The purpose of this study is to assess whether confocal laser endomicroscopy can reduce the biopsy number needed per patient for the detection of gastric intestinal metaplasia without the loss of corresponding diagnostic yield.
- Trial name
- NCT01024621
- Testing
- Endomicroscope, Standard endoscopy
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Shandong University
Gastric Intestinal Metaplasia
I-scan With Magnification for the Detection of Gastric Intestinal Metaplasia
The purpose of this study is to assess whether i-scan with magnification can reduce the biopsy number needed per patient for the detection of gastric intestinal metaplasia without the loss of corresponding diagnostic yield.
- Trial name
- NCT02516735
- Testing
- I-scan with magnification, Standard endoscopy
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Shandong University
Chronic Atrophic Gastritis, Gastric Carcinoma
Curcumin in Preventing Gastric Cancer in Patients With Chronic Atrophic Gastritis or Gastric Intestinal Metaplasia
This randomized phase IIb trial studies how well curcumin works in preventing gastric cancer in patients with chronic atrophic gastritis and/or gastric intestinal metaplasia.
- Trial name
- NCT02782949
- Testing
- Curcumin, Laboratory Biomarker Analysis, Quality-of-Life Assessment
- Where
- 2 sites in Honduras, Puerto Rico
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
Dyspepsia
The Role of Narrow-Band Imaging Endoscopy in Diagnosing Gastric Intestinal Metaplasia
The purpose of this study is to determine if endoscope with NBI(narrow banding imaging)can detect intestinal metaplasia( consider pre malignant condition) and use a targeting biopsy in case of suspected intestinal metaplasia
- Trial name
- NCT00673699
- Testing
- Gastric mucosal biopsy
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Hillel Yaffe Medical Center
Gastric Cancer, Intestinal Metaplasia of Gastric Mucosa
The GAstric Precancerous Conditions Study
Gastric cancer afflicts 27,000 Americans annually and carries a dismal prognosis. One reason for poor outcomes is late diagnosis, as the majority of gastric cancers in the United States are diagnosed at a relatively advanced…
- Conditions
- Gastric Cancer, Intestinal Metaplasia of Gastric Mucosa, Helicobacter Pylori Infection, Atrophic Gastritis
- Trial name
- GAPS (NCT04191551)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Stanford University
Gastric Atrophy, Gastric Intestinal Metaplasia
A Study Collecting Health Information to Understand and Prevent Gastric Cancer
The purpose of this study is to create a registry of participants with precursor lesions for gastric cancer, including gastric atrophy, intestinal metaplasia, and dysplasia.
- Conditions
- Gastric Atrophy, Gastric Intestinal Metaplasia, Dysplasia, Gastric Adenocarcinoma
- Trial name
- NCT06370143
- Testing
- Questionnaire
- Where
- 7 sites in United States
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Gastric Cancer (GC), Premalignant Lesion
AI-Based Risk Prediction Model for Upper Digestive Tract Cancer
Upper digestive tract cancers are often preceded by pre-malignant lesions, but there is limited evidence regarding optimal risk prediction models and screening strategies for disease progression and cancer development.
- Conditions
- Gastric Cancer (GC), Premalignant Lesion, Gastric Intestinal Metaplasia, Atrophic Gastritis
- Trial name
- NCT07605312
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Intestinal Metaplasia of Gastric Mucosa, Artificial Intelligence
Artificial Intelligence in Assessing Gastric Intestinal Metaplasia Via the EGGIM Score
The endoscopic grading system (EGGIM) has been widely used to assess the extent of gastric intestinal metaplasia during endoscopy.
- Conditions
- Intestinal Metaplasia of Gastric Mucosa, Artificial Intelligence, Endoscopy
- Trial name
- NCT07257796
- Testing
- The diagnostic performance of AI system and endoscopists
- Where
- 3 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Qilu Hospital of Shandong University
Stomach Neoplasms, Metaplasia
Acetic Acid Chromoendoscopy to Judge Gastric Intestinal Metaplasia
The presence and the extent of gastric intestinal metaplasia(IM) is a good indicator of high risk group of gastric cancer. Many methods was developed to survey it, including multiple gastric biopsy or methylene blue…
- Trial name
- IM (NCT01499576)
- Testing
- Acetic acid chromoendoscopy
- Where
- South Korea
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Konyang University Hospital
Probe-based Confocal Laser Endomicroscopy, the Operative Link on Gastric Intestinal Metaplasia
The Efficacy of Probe-based Confocal Laser Endomicroscopy in Staging OLGIM
Gastric intestinal metaplasia (GIM) is an important premalignant lesion for gastric cancer. Precisely surveillance of patients with GIM may result in early detection and improved prognosis.
- Trial name
- NCT02932735
- Volunteers
- 30 people
- Sponsor
- Shandong University
Stomach Cancer
Prognosis and Risk Factors of Gastric Cancer in Patients With Intestinal Metaplasia
This prospective cohort study aims to assess the incidence of gastric cancer in patients with intestinal metaplasia in body of stomach or angular incisure.
- Trial name
- GASTRIMED (NCT02325323)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris