Clinical trials: Intestinal Metaplasia of Gastric Mucosa
Gastric Atrophy, Gastric Intestinal Metaplasia
A Study Collecting Health Information to Understand and Prevent Gastric Cancer
The purpose of this study is to create a registry of participants with precursor lesions for gastric cancer, including gastric atrophy, intestinal metaplasia, and dysplasia.
- Conditions
- Gastric Atrophy, Gastric Intestinal Metaplasia, Dysplasia, Gastric Adenocarcinoma
- Trial name
- NCT06370143
- Testing
- Questionnaire
- Where
- 7 sites in United States
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Gastric Cancer, Gastric Intestinal Metaplasia
Cytosponge for Gastric Intestinal Metaplasia
Gastric cancer has a very poor prognosis. The disease is often diagnosed at a late stage, when curative treatment options are limited or ineffective.
- Conditions
- Gastric Cancer, Gastric Intestinal Metaplasia, Gastric Atrophy
- Trial name
- CyGIM (NCT05657080)
- Testing
- Cytosponge-TFF3
- Where
- United Kingdom
- Volunteers
- 226 people
- Sponsor
- University of Cambridge
Helicobacter Pylori, the Operative Link on Gastric Intestinal Metaplasia
The Influence of Helicobacter Pylori Eradication on Gastric Pathology: a Long-term, Prospective Cohort Study
Helicobacter pylori (H. pylori) infection, affecting an estimated 50% of the global population, is a main cause of chronic gastritis, peptic ulcers and gastric cancer.
- Conditions
- Helicobacter Pylori, the Operative Link on Gastric Intestinal Metaplasia, Operative Link on Gastric Intestinal Assessment
- Trial name
- NCT02933229
- Testing
- biopsy, H. pylori eradication
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shandong University
Diagnostic Yield of Gastric Neoplasia
PCLE for the Diagnosis of Gastric Intestinal Metaplasia, Intraepithelial Neoplasia, and Carcinoma
Early detection of gastric intestinal metaplasia (GIM) intraepithelial neoplasia (IN), and gastric cancer are essential to improve patients' outcomes.
- Trial name
- PCLE (NCT02515721)
- Testing
- pCLE-TB, virtual chromoendoscopy-TB
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Shandong University
Gastric Intestinal Metaplasia, Confocal Laser Endomicroscopy
A Comparison of pCLE Based Targeted Biopsy and WLE Based Standard Biopsy in Staging the Operative Link on Gastric Intestinal Metaplasia (OLGIM): A Randomized，Cross-over Study
Gastric intestinal metaplasia (GIM) is an important premalignant lesion for gastric cancer. Precisely surveillance of patients with GIM may result in early detection and improved prognosis.
- Conditions
- Gastric Intestinal Metaplasia, Confocal Laser Endomicroscopy, Operative Link on Gastric Intestinal Metaplasia, Biopsy
- Trial name
- NCT02930616
- Testing
- Patients in Group 1 will receive pCLE at first and WLE 2 months later, patients in Group 2 will receive WLE at first and pCLE 2 months later.
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shandong University
Gastric Dysplasia, Gastric Intestinal Metaplasia
Validation of an Artificial Intelligence System Based on Raman Spectroscopy for Diagnosis of Gastric Premalignant Lesions and Early Gastric Cancer
Early detection and treatment of gastric premalignant lesion and early gastric cancer (EGC) have been proposed to improve outcomes of gastric cancer.
- Conditions
- Gastric Dysplasia, Gastric Intestinal Metaplasia, Gastric Cancer
- Trial name
- NCT04869618
- Testing
- Raman spectroscopy based device (SPECTRA IMDx)
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- Changi General Hospital
Esophageal Cancer, Gastric Cancer
Diagnostic Performance Indicators in Upper GI Endoscopy:PROSPERO Study
Cancers of the upper gastro-intestinal tract, including esophagus (gullet), stomach and small bowel, are amongst the deadliest malignancies.
- Conditions
- Esophageal Cancer, Gastric Cancer, Barrett Esophagus, Gastric Atrophy
- Trial name
- PROSPERO (NCT04843397)
- Volunteers
- 1,000 people
- Sponsor
- University of Cambridge
Gastric Intestinal Metaplasia, Artificial Intelligence
Automatic Evaluation of the Severity of Gastric Intestinal Metaplasia With Pathology Artificial Intelligence Diagnosis System
The OLGIM staging system is highly recommended for a comprehensive assessment of GIM severity to evaluate patients' gastric cancer risk.
- Conditions
- Gastric Intestinal Metaplasia, Artificial Intelligence, Pathology, Gastric Cancer
- Trial name
- NCT05447221
- Testing
- The diagnosis of Artificial Intelligence and pathologists
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shandong University
Intestinal Metaplasia of Gastric Mucosa, Confocal Laser Endomicroscopy
Artificial Intelligence Confocal Laser Endomicroscopy for Real-time Assessment of Gastric Cancer Risk.
Current national guidelines recommend the use of OLGIM score to evaluate the risk of gastric cancer in patients, and close gastroscopic monitoring should be performed after OLGIM grade III/IV.
- Trial name
- NCT05459428
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shandong University
Gastric Intestinal Metaplasia
Confocal Laser Endomicroscopy With Cresyl Violet for in Vivo Diagnosis of Gastric Intestinal Metaplasia
Confocal laser endomicroscopy (CLE) is a novel endoscopic system which can provide approximately 1000-fold magnification of the gastrointestinal mucosa.
- Trial name
- NCT03672708
- Testing
- Cresyl violet
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Shandong University
Gastric Intestinal Metaplasia
The Efficacy of Severe Whitening and Delayed Fading in Acetic Acid-enhanced Endoscopy for Diagnosing Gastric Intestinal Metaplasia
Investigators found that the degree and the duration of aceto-whitening differed between gastric intestinal metaplasia(GIM) and the surrounding normal mucosa: the area of GIM showed a severe degree of aceto whiteness and the…
- Trial name
- NCT02806115
- Testing
- acetic acid-enhanced endoscopy, Acetic Acid, endoscope
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shandong University
Dyspepsia
The Role of Narrow-Band Imaging Endoscopy in Diagnosing Gastric Intestinal Metaplasia
The purpose of this study is to determine if endoscope with NBI(narrow banding imaging)can detect intestinal metaplasia( consider pre malignant condition) and use a targeting biopsy in case of suspected intestinal metaplasia
- Trial name
- NCT00673699
- Testing
- Gastric mucosal biopsy
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Hillel Yaffe Medical Center
Gastric Intestinal Metaplasia
Efficacy of an AI System in Training Endoscopists to Assess Gastric Intestinal Metaplasia Via the EGGIM Score
This prospective randomized controlled trial with a crossover design incorporated image-enhanced endoscopy (IEE) videos demonstrating complete standardized examinations of five standard gastric areas (antrum greater curvature…
- Trial name
- NCT07208864
- Testing
- AI-assisted EGGIM scoring, Conventional EGGIM scoring
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Qilu Hospital of Shandong University
Flow Determination
Real-time Observation of Microcirculatory Hemodynamics in Gastric Intestinal Metaplasia by Confocal Laser Endomicroscopy
The morphologic change of microvessels has the clinical value to distinguish cancerous from non-cancerous mucosa. The aim of this study was to observe gastric mucosa microcirculatory hemodynamic changes real-time using pCLE…
- Trial name
- NCT02595151
- Testing
- CLE
- Where
- China
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Shandong University
Gastric Intestinal Metaplasia
I-scan With Magnification for the Detection of Gastric Intestinal Metaplasia
The purpose of this study is to assess whether i-scan with magnification can reduce the biopsy number needed per patient for the detection of gastric intestinal metaplasia without the loss of corresponding diagnostic yield.
- Trial name
- NCT02516735
- Testing
- I-scan with magnification, Standard endoscopy
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Shandong University
Intestinal Metaplasia, Gastric Cancer
Gastric Cancer Precursor Lesions (GCPL) Study
Background: Gastric cancer is a leading cause of cancer deaths around the world. This disease is a serious problem in places like East Asia, Central and South America, and Eastern Europe.
- Trial name
- NCT03188406
- Where
- 9 sites in Chile
- Volunteers
- 1,300 people
- Sponsor
- National Cancer Institute (NCI)
Probe-based Confocal Laser Endomicroscopy, the Operative Link on Gastric Intestinal Metaplasia
The Efficacy of Probe-based Confocal Laser Endomicroscopy in Staging OLGIM
Gastric intestinal metaplasia (GIM) is an important premalignant lesion for gastric cancer. Precisely surveillance of patients with GIM may result in early detection and improved prognosis.
- Trial name
- NCT02932735
- Volunteers
- 30 people
- Sponsor
- Shandong University
Gastric Intestinal Metaplasia
Diagnosis of Gastric Intestinal Metaplasia With High Definition Endoscopy and Optic Enhancement
The purpose of this study is to assess whether high definition endoscopy with Optic Enhancement can reduce the biopsy number needed per patient for the detection of gastric intestinal metaplasia without the loss of corresponding…
- Trial name
- NCT02725034
- Testing
- Standard endoscopy, High definition endoscopy with Optic Enhancement
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shandong University
Gastric Intestinal Metaplasia
Metformin Efficacy and Safety for Gastric Intestinal Metaplasia
Gastric intestinal metaplasia significantly increases the risk of gastric cancer. Metformin, a biguanide, which is widely used for treating diabetes mellitus, has recently been suggested to have a suppressive effect on…
- Trial name
- NCT05288153
- Testing
- Metformin, Folate
- Where
- 2 sites in China
- Volunteers
- 140 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Gastric Intestinal Metaplasia
The Learning Curve of Probe-based Confocal Laser Endomicroscopy (pCLE) Images Interpretation in Gastric Intestinal Metaplasia (GIM)
The Learning Curve of Probe-based Confocal Laser Endomicroscopy (pCLE) images interpretation in Gastric Intestinal Metaplasia (GIM) Objective: The aim of this study is to evaluate the learning curve of pCLE images interpretation…
- Trial name
- NCT01491724
- Where
- Thailand
- Volunteers
- 5 people
- Sponsor
- King Chulalongkorn Memorial Hospital