Clinical trials: Intestinal Microbiome
Beneficial Bacteria in Gut
Color Synbiotics Study
This study is initiated to investigate the effect of infant formula with added specific synbiotics mixture on proportion of beneficial bacteria.
- Trial name
- NCT01813175
- Testing
- Regular non-hydrolysed cow's milk I, Regular non-hydrolysed cow's milk II, Regular non-hydrolysed cow's milk - control
- Where
- 3 sites in Thailand
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Dysmenorrhea
The Impact of Oral Probiotics on Improving the Quality of Life in Patients With Dysmenorrhea.
Menstrual pain is mainly divided into primary dysmenorrhea and secondary dysmenorrhea, the former is caused by menstrual uterine muscle movement; the latter is caused by certain diseases, such as Endometriosis, Uterine fibroids…
- Trial name
- NCT07530081
- Testing
- High dose Probiotic, Low dose probiotic
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Glac Biotech Co., Ltd
Healthy
Batch Fermentation and Microbiome Analysis
The correlation between diet and microbiota as well as the effect of microbiota on human health is well established. Studies have shown that people following specific diets have different microbiome profile compared to those…
- Trial name
- NCT06097130
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Irritable Bowel Syndrome
Fructo-oligosaccharides and Irritable Bowel Syndrome
Fructo-oligosaccharides are known as prebiotic ingredients to modulate the composition of the intestinal microbiota and particularly to stimulate the growth of Bifidobacteria.
- Trial name
- NCT00806104
- Testing
- Fructo-oligosaccharides, Maltodextrins
- Where
- 2 sites in France, Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beghin-Meiji
Prebiotics, Metagenomic Next Generation Sequencing
Assessing Changes in the Gut Microbiome of Non-Gastrointestinal Disordered Subjects Before and After Oral Prebiotic Supplementation Using the SIMBA Capsule
This is a randomized, double-blind, placebo-controlled, parallel-group clinical study. The primary objective is to assess the changes in the small intestinal (SI) metagenomic profile of healthy participants without any known…
- Conditions
- Prebiotics, Metagenomic Next Generation Sequencing, Microbiome, Small Intestine
- Trial name
- NCT07788924
- Testing
- FiberSmart
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Anderson Advanced Ingredients
Gut Microbiota
Effects of Riboflavin on Faecalibacterium Prausnitzii and the Gut Microbiota
The purpose of this trial is to investigate comprehensively the effect of riboflavin supplementation on the abundance of F. prausnitzii and on other members of the gut microbiota in faeces of healthy volunteers.
- Trial name
- NCT02929459
- Testing
- Riboflavin Dose 1, Riboflavin Dose 2
- Where
- Netherlands
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Microbiome
Effect of a Probiotic or Postbiotic on Gut Microbiome During Antibiotic Treatment
This study assesses the effects of a probiotic or postbiotic on gut microbiome during antibiotic treatment.
- Trial name
- POTATO-2 (NCT07594860)
- Testing
- Probiotic, Postbiotic
- Where
- Greece
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Ulcerative Colitis
A Study to Investigate Efficacy and Safety of KBL697 in Patients With Mild to Moderate Active Ulcerative Colitis
The study is designed to investigate efficacy and safety of KBL697 in patients with mild to moderate active ulcerative colitis. KBL697 has been developed as a potential new treatment for ulcerative colitis.
- Trial name
- NCT04898348
- Testing
- KBL697
- Where
- Australia
- Sponsor
- KoBioLabs
Intestinal Bacteria Flora Disturbance
Allium Extracts on the Intestinal Microbiota in Healthy Resident Volunteers.
To evaluate the effect of daily consumption of a combination of garlic and onion extracts on the intestinal microbiota and the production of short chain fatty acids in elderly healthy volunteers living in a residence.
- Trial name
- NCT05016999
- Testing
- Garlic and onion concentrate
- Where
- Spain
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- DOMCA S.A.
Hematologic Diseases, Chemotherapy Effect
Safety and Tolerability Evaluation of MaaT033
Richness and diversity of gut microbiota are increasingly found to be associated with cancer outcomes. Moreover, an adequately responsive immune system seems to rely on the existence of a functioning gut ecosystem that includes…
- Trial name
- CIMON (NCT04150393)
- Testing
- MaaT033 capsule
- Where
- 4 sites in France
- Volunteers
- 21 people
- Sponsor
- MaaT Pharma
Healthy Volunteer
Calorie Restriction Intervention Induces Enterotype-associated BMI Loss in Nonobese Individuals
Calorie restriction (CR), which has the potential effect on weight loss and blood amino acids, has been demonstrated to associate with gut microbiota in humans, especially in obese individuals.
- Trial name
- CRDI (NCT04044118)
- Testing
- Low Calorie Diet
- Where
- China
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- BGI-Shenzhen
Healthy Volunteers
Gut Microbiome and Metabolic Health Study
The goal of this clinical trial is to assess whether TRPTI (oleoylethanolamide) can reduce plasma imidazole propionate levels and improve insulin sensitivity and metabolic health in healthy adults aged 18 years and above with BMI…
- Trial name
- IMPTRP (NCT07457723)
- Testing
- TRPTI 300mg
- Where
- Australia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- RDC Clinical Pty Ltd
Gut Microbiota Modulation
The Role of Probiotic LH76 in Human Gut Health
This study aims to evaluate the safety and efficacy of the probiotic LH76 as a dietary supplement in healthy adults. The research will assess its effects on gut microbiota composition, intestinal health, and immune function…
- Trial name
- NCT06875375
- Testing
- probiotic LH76
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Microbiota, Eczema
Infant Restore: Efficacy of Microbiome Analysis and Education
The goal of this clinical trial is to learn if a microbiome analysis, education, and recommendation program can improve gut health, reduce future health risks, and empower parents in their children's health in infants aged 0-3…
- Conditions
- Microbiota, Eczema, Microbiome, Gut Microbiome
- Trial name
- NCT06424691
- Testing
- Tailored Recommendations, Consult Call, Email Series
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Seeding Inc
Colorectal Adenoma, Colorectal Cancer (CRC)
Evaluation of Gixam's Performance in a FIT Negative Population
In the United States, colorectal cancer ranks second to lung cancer as a cause of cancer death and is the third most commonly occurring cancer in both men and women.
- Conditions
- Colorectal Adenoma, Colorectal Cancer (CRC), Colorectal Cancer (CRC) Screening
- Trial name
- NCT06612281
- Testing
- colorectal cancer (CRC) screening, colorectal cancer screening, Colonoscopy after bowel cleansing
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Jubaan Ltd.
Colonic Neoplasms
Metabiomics Colon Cancer Clinical Research Study
The specific aim of the study is to determine the false negative rate of the Metabiomics Colon Polyp and Colorectal Cancer Assay for Cancer.
- Trial name
- NCT02151123
- Where
- United States
- Sponsor
- Metabiomics Corp
Healthy
Influence of Food Matrix on Prebiotic Efficacy in Inulin Type Fructans
The aim of the study is to investigate whether the food matrix has an influence on the prebiotic efficacy (bifidobacteria growth) of chicory-derived Orafti® inulin in healthy adult volunteers.
- Trial name
- NCT05581615
- Testing
- Inulin
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Colorectal Cancer, Tumor
Microbiome in Colorectal Cancer Onset and Progression
This is an observational study with the goal to improve the robustness of the scientific evidence linking Fusobacterium nucleatum (Fn) and/or other microorganisms to colorectal cancer (CRC) onset and/or progression.
- Conditions
- Colorectal Cancer, Tumor, CRC, GI Cancer
- Trial name
- NCT05368688
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Viome
Bacterial Microflora Reduction
Comparative Study of Antimicrobial Effectiveness
Comparative Study of Antimicrobial Effectiveness Evaluation of 26 ml Project X, 5.1ml Project X and Prevantics® Maxi Swabstick following ASTM E1173 - Standard Test Method for Evaluation of Preoperative, Precatheterization, or…
- Trial name
- NCT03817580
- Testing
- Project X 26ml, Project X 5.1ml, Prevantics Maxi Swabstick
- Where
- Romania
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Professional Disposables International, Inc.
Healthy Adults
Probiotic LR08 Improves Gut and Metabolism
Evaluate the efficacy and safety of LR08 as a dietary supplement compared to a placebo in enhancing intestinal health and immune function in healthy adults.
- Trial name
- NCT06875362
- Testing
- Probiotic
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.