Clinical trials: Intestinal Microbiome
Nutrition, Healthy
Effect of L. Plantarum Probiotic Supplementation on Broccoli Sulforaphane Bioavailability: Randomised Double-blind Placebo-controlled Crossover Study
Broccoli has the precursor of an active compound (sulforaphane) that has shown a wide range of health promoting benefits. Sulforaphane formation depends on the conversion of glucoraphanin (precursor) by myrosinase enzyme.
- Trial name
- PRO-BROC (NCT06561893)
- Testing
- Broccoli sprouts extract supplementation
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Colonization, Asymptomatic, Colonisation
Encapsulated Probiotics & Gut Microbiota
The aim of this study is to determine whether encapsulation of probiotic bacteria using natural plant protein can enhance bacterial colonisation.
- Trial name
- Probiotics (NCT07439978)
- Testing
- probiotic containing L.rhamnosus R0011 strain, 200 ml yogurt drink
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Healthy, Hyperuricemia, Gout
Acute Effects of a Urate-lowering Bacterial Therapeutic on Small Intestinal Transcriptomics and Glycomics in Healthy Subjects
This is a pilot study investigating how a novel probiotic supplement (BEO001), with and without a dietary fiber (beta-glucan), affects the lining of the small intestine in healthy people.
- Trial name
- Bugs4U-MoA (NCT07366749)
- Testing
- BEO001 Probiotic, BEO001 Probiotic + Beta-Glucan
- Where
- Sweden
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Infant Nutrition
A New Adaptive Feeding Plan for Newborns
The purpose of this clinical trial is to identify the infant formula(s) for which the investigators get the closest gut maturation index compared to the one they get with breastfed babies.
- Trial name
- NCT00984230
- Testing
- BSF, BSF + Lactoferrin + Probiotics, BSF + Lactoferrin + Probiotics + OS
- Where
- 6 sites in Austria, France and 1 more
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Athlete
To Explore the Effects of Different Training Periods and Dietary Pattern on the Gut Microbiota, Metabolites and Protein Expression Levels of Strength and Endurance Athletes and to Find Relevant Biological Indicators.
The gastrointestinal tract contains hundreds of millions of microorganisms, collectively called the intestinal flora, which plays an important role in the health of the host.
- Trial name
- NCT04710667
- Where
- Taiwan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
Con, Cons ti
Probiotic for Alleviating Functional Constipation in Adults
To investigate the clinical effects of probiotics in relieving chronic constipation in adults, and evaluate the improvement of symptoms in patients with constipation as well as their impacts on gastrointestinal function and gut…
- Conditions
- Con, Cons ti, Con s ti
- Trial name
- NCT07649564
- Testing
- Probiotic
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Anorexia Nervosa, Dysbiosis
Alteration of Symbiosis Intestinal Microbiota on Patients With Anorexia Nervosa
The purpose of this study will be to study the association between the level of psychic symptomatic of anorexia nervosa (AN) (intensity of food restriction, symptoms of anxiety and depression) and alteration of host environment…
- Conditions
- Anorexia Nervosa, Dysbiosis, Anxious Depression
- Trial name
- INT-METAVOSA (NCT05632497)
- Testing
- Stool and blood samples
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Microbiota, Nutrition, Healthy
Effect of the Sustainable Diet on Gut Microbiota and the Metabolome: a Randomised Crossover Study
Unhealthy diets are closely linked to non-communicable diseases and constitute higher risk of morbidity and mortality than unsafe sex, alcohol, tobacco and drugs use combined.
- Trial name
- SUSUGUT (NCT05231317)
- Testing
- Plant-based diet, Western diet
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Hemorrhagic Stroke, Acute
Predictive Value of Human Microbiome and Serological Markers for Clinical Outcome of Cerebral Hemorrhage
Objective: To explore the predictive value of characteristic disorder of intestinal flora for clinical prognosis in patients with intracerebral hemorrhage.
- Conditions
- Hemorrhagic Stroke, Acute, Outcomes, Metabolites
- Trial name
- NCT05551923
- Testing
- intestinal flora disturbance
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Diffuse Large B Cell Lymphoma
Characterization and Clinical Impact of the Gut Microbiota in Lymphoma
The study is a prospective observational single-center cohort study which compare the gut microbiome of newly diagnosed Diffuse Large B-cell Lymphoma patients with the gut microbiome of healthy controls.
- Trial name
- NCT06161896
- Testing
- Stool samples
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Lars Møller Pedersen
Healthy Subjects
Safety and Efficacy Study of Different DAV132 Dose Regimens in Healthy Volunteers
The purpose of this study is to evaluate whether different DAV132 dose regimens are safe and effective for capturing fecal residues of moxifloxacin in healthy volunteers.
- Trial name
- NCT02917200
- Testing
- Moxifloxacin, DAV132, Negative control
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Da Volterra
Colorectal Adenoma and Carcinoma
Investigation of the Role of the Microbiome in the Pathogenesis of Colorectal Adenoma and Carcinoma
The purpose of this study is the investigation of new host-microbiome interactions promoting adenoma formation and adenocarcinoma progression.
- Trial name
- NCT02947607
- Testing
- Colon biopsies
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 799 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Intestinal Bacteria Flora Disturbance
The Effect of Fruit/Vegetable Drinks on the Human Intestine
This is a 4 ½ week study with 20 healthy subjects (including a 2 week run-in ) . Subjects will be taking vegetable/fruit juice supplementation for 3 days.
- Trial name
- NCT02377063
- Testing
- Pressed Juice
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Gut Microbiota, Gastrointestinal Symptoms
Mother-Infant Cohort Study in Malaysia and China
This mother-infant cohort study aims to determine the geographic differences in the microbial profiles in breast milk from mothers living in Malaysia and China that are potentially important determinants of infant development.
- Conditions
- Gut Microbiota, Gastrointestinal Symptoms, Temperament, Eczema
- Trial name
- NCT04919265
- Testing
- No intervention - mother-infant cohort study
- Where
- Malaysia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Aging, Cognition Improvement
Westlake Aging Cohort (WeAC)
The Westlake Ageing Cohort (WeAC) is a longitudinal cohort study conducted in Hangzhou, Zhejiang Province, China. The investigators aim to enroll 2,800 participants aged 55 years and older for long-term follow-up.
- Conditions
- Aging, Cognition Improvement, Cognition Disorders, Cognition
- Trial name
- NCT07373444
- Where
- 2 sites in China
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Westlake University
Noninfectious Uveitis
The Microbiome in Uveitis and Pediatric Inflammatory Diseases
Chronic, noninfectious uveitis in children, associated with various systemic inflammatory diseases, carries a high risk of vision loss.
- Trial name
- MUMIP (NCT07885501)
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Depressive Symptoms
The MIND-GUT Digital Pilot Intervention Study
This 12-week pilot study aims to evaluate the feasibility and effectiveness of a dietary intervention targeting diet, obesity, mental health, and the gut microbiome in promoting weight loss and enhancing mental health among obese…
- Conditions
- Obesity, Depressive Symptoms, Anxiety, Stress
- Trial name
- MINDGUT (NCT06374407)
- Testing
- Dietary intervention based on the MIND diet
- Where
- Sweden
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Skövde
Focus on Healthy Infant Growth.
Infant Formula Supplemented With Probiotic Microorganisms and/or Prebiotic.
Evaluation the nutritional suitability of a based milk infant formula supplemented with friendly bacteria (probiotic microorganisms) and or nutritional fibers (prebiotic) to healthy, full term infants compare with an otherwise…
- Trial name
- NCT00836771
- Testing
- Infant Formula
- Where
- Israel
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Materna Laboratories
Obesity, Abdominal, Diabete Type 2
Production of Gut Microbiota-Derived Metabolites in Response to Different Fatty Acid Profiles
The proposed project mainly aims to investigate the microbial processes leading to dietary metabolites production, independently of long-term microbiota adaptation to the diet, by measuring the microbiota-derived metabolite…
- Trial name
- METAc (NCT05917132)
- Testing
- Nutritionnal intervention
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Laval University
Healthy
Cranberry Flavan-3-ols Consumption and Gut Microbiota in Healthy Adults
Consumption of (poly)phenols is recognized to have beneficial effects on health. However, heterogeneous results are obtained in clinical trials due to high inter-individual variability.
- Trial name
- NCT05931237
- Testing
- Cranberry extract capsules
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Laval University