Clinical trials: Intestinal Microbiome
Exercise, Overreaching
Impact of Training Load on the Gut miCrobiome And Its Relation to exeRcise Performance, mUscle Phenotype, and markerS of Overreaching in Healthy Men
The goal of this study is to learn how different amounts of supervised indoor cycling training change gut health (gut bacteria, the substances gut bacteria make, and the gut barrier integrity), and how these changes relate to…
- Conditions
- Exercise, Overreaching, Butyrate, Gut Microbiome
- Trial name
- ICARUS (NCT07481578)
- Testing
- Supplement, Moderate load exercise training, High load exercise training
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Stefan De Smet
Healthy Volunteers
Effect of Tebipenem on Normal Human Intestinal Microbiota
The overall purpose of this study is to support the development of an oral formulation of TBPM-PI-HBr by assessing the potential ecological effects of tebipenem on the normal intestinal microbiota as compared to the effects of…
- Trial name
- NCT04376554
- Testing
- TBPM-PI-HBr, amoxicillin-clavulanate
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Spero Therapeutics
Irritable Bowel Syndrome, Irritable Bowel Syndrome With Diarrhea (IBS-D)
Efficacy of Repeated Transcranial Magnetic Stimulation Combined With a Live Probiotic Tablet (Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus Cereus Tablets, Live) in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
To evaluate the overall efficacy of repeated Transcranial Magnetic Stimulation(rTMS) combined with a Live Probiotic tablet (Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus cereus Tablets, Live) in…
- Conditions
- Irritable Bowel Syndrome, Irritable Bowel Syndrome With Diarrhea (IBS-D), Repetitive Transcranial Magnetic Stimulation (rTMS), Probiotic
- Trial name
- NCT06960369
- Testing
- rTMS combined with Live Probiotic tablet
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Soochow University
Diet, Healthy, Systemic Inflammatory Response
Effect Dietary Fibre Supplementation on Gut Microbiota Composition
The study involves taking pectin fibre at increasing doses ranging from 5g, 10g and 15g for a total period of 6 weeks with the increase every 2 weeks.
- Trial name
- NCT06758570
- Testing
- Pectin dosages
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Elizabeth Simpson
Ulcerative Colitis
The Effect of Therapeutic Fecal Transplant on the Gut Microbiome in Children With Ulcerative Colitis
Ninety Six patients with mild to moderate ulcerative colitis will be randomized to double blind, placebo controlled study. The safety and efficacy of the intervention will be closely monitored.
- Trial name
- FMT_UC (NCT02291523)
- Testing
- Fecal Microbial Transplant
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Healthy
Pharmacokinetics and Bioavailability of Pomegranate Phenolics and Urolithins in Healthy Subjects.
Pomegranate phenolics (such as the ellagitannin punicalagin and ellagic acid) are metabolized by the human gut microbiota to yield a number of metabolites called urolithins (mainly Uro-A).
- Trial name
- POMEkinetics (NCT02056496)
- Testing
- Pomegranate extract
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Microbial Colonization, Small Intestinal Bacterial Overgrowth
High-fat Diet (HFD) and Small Intestinal Microbiome
The investigators aim to characterize the upper small intestinal microbiome in healthy conditions in dependency on feeding condition (starved vs.
- Trial name
- FATBOM (NCT07019142)
- Testing
- HFD
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diet, Healthy, Metabolic Disease
Interactions Between Diet, Microbiome and Abiotic Conditions in the Gut
The aim of this study is to explore the interplay between environmental (abiotic) factors in the gut and the gut microbiota composition, diversity and metabolism.
- Trial name
- PRIMA (NCT04804319)
- Testing
- 9-days habitual diet
- Where
- Denmark
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Gut Microbiome, Linear Growth
Effects of Complementary Feeding on Infant Growth and Gut Health
This study plans to learn more about how consuming different foods during the time of early complementary feeding (~5 to 12 months) affects growth and the development of bacteria living inside your baby's gut through school-age.
- Trial name
- MINT (NCT05012930)
- Testing
- Baby Foods - Meat, Baby Foods - Dairy, Baby Foods - Plant
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Gut Microbiome, Healthy Donors
Investigating the Impact of the Seaweed Derived Food Additive, Carrageenan, on the Human Gut Microbiome
The goal of this study is to investigate whether a seaweed derived food additive, carrageenan, has an impact on the human gut microbiome in vivo.
- Trial name
- NCT06738329
- Testing
- Carrageenan gummy sweet, Carrageenan and inulin gummy sweet
- Where
- United Kingdom
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Reading
Diarrhea-predominant Irritable Boewl Syndrome
Efficacy and Safety of Modified Gegen Qinlian Decoction for Diarrhea-predominant Irritable Boewl Syndrome
Diarrhea-predominant irritable boewl syndrome(IBS-D) seriously affect the quality of life in patients. Clinically, it is effective to apply therapeutic method of clearing heat and promoting diuresis to the common syndrome of…
- Trial name
- NCT04312477
- Testing
- Modified Gegen Qinlian Decoction
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Human Microbiome
The Effects of Terminalia Chebula Fruit Extract on the Gut Microbiome and Skin Biophysical Properties
The purpose of this study is to assess the use of oral Terminalia chebula fruit extract on the gut microbiome and skin biophysical properties. The fruit is commonly used for skin treatments in India.
- Trial name
- NCT04597502
- Testing
- Terminalia Chebula fruit extract, Topical Terminalia Chebula
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Bifidobacteria, Healthy Volunteers
Effects of Xylooligosarcharide on Composition of the Human Colonic Microflora
Human and animal studies demonstrate that xylooligosaccharides (XOS) are a highly efficacious prebiotic ingredient that delivers benefits at a minimum level of 1.4 g/day (d), which is much lower than levels required by…
- Trial name
- XOS (NCT01861964)
- Testing
- Xylooligosarcharide 1.4g, Xylooligosarcharide 2.8g
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Hypertension, Gut Dysbiosis
The Effects of a Commercially Available Synbiotic on the Gut Microbiome and Cardiometabolic Health
The purpose of this study is to see the effect of 30 days of synbiotic vs. probiotic supplementation (usingJuice+ nutrition products) on body weight, metabolism, cardiovascular health, and gut health.
- Conditions
- Hypertension, Gut Dysbiosis, Overweight , Obesity
- Trial name
- NCT07515443
- Testing
- Synbiotic
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Southern Utah University
Heart Diseases, Microbial Colonization
Dairy Fat and Fermentation Study
The purpose of the study is to compare the effect of consuming full-fat (regular) and fat-free (skim) milk, as well as full-fat and fat-free yogurt (a fermented dairy product), on microorganisms in your gut as well as the…
- Conditions
- Heart Diseases, Microbial Colonization, Inflammation
- Trial name
- NCT05840081
- Testing
- Milk or yogurt beverage
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Tufts University
Antimicrobial Agent, Cephalosporins
Effect of Ceftobiprole on Human Intestinal Microflora
The purpose of the study is to investigate the effect of ceftobiprole treatment on intestinal microflora in healthy volunteers.
- Conditions
- Antimicrobial Agent, Cephalosporins, Drug Resistance
- Trial name
- NCT00965042
- Testing
- Ceftobiprole
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Arterial Stiffness, Blood Pressure
Prebiotic Effects of California Grapes on Gut Health and Cardiometabolic Health in Overweight Men and Women
The goal of this clinical trial is to assess the impact of table grape consumption on gut microbiome, intestinal permeability, systemic inflammation, and vascular function in healthy overweight men and women aged 45-70 years.
- Conditions
- Arterial Stiffness, Blood Pressure, Dysbiosis, Inflammation
- Trial name
- CALGRAM (NCT06544954)
- Testing
- Freeze-dried grape powder
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Crohn, Ulcerative Colitis (UC)
Research and Follow-up of the Determinants of the Progression and Complications of Inflammatory Bowel Diseases Treated or Not With Immunosuppressants.
Inflammatory Bowel Diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic, disabling conditions affecting young adults, marked by flare-ups and remissions.
- Conditions
- Crohn, Ulcerative Colitis (UC), IBD (Inflammatory Bowel Disease)
- Trial name
- SUIVITHEQUE2 (NCT07172945)
- Testing
- Blood, fecal, saliva, intestinal content samples and biopsies
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Delirium of Mixed Origin, Microbial Colonization
The Gut Microbiota and Delirium in the ICU
To investigate whether the composition of the gut microbiota is different in patients that develop delirium during critical illness as compared to patients who do not.
- Trial name
- GuMDel-ICU (NCT03328377)
- Testing
- Metagenomic analysis of gut microbiota
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Gastrointestinal Function
Effect of MSPrebiotic on Gastrointestinal Function and Blood Glucose Levels
The objective of the study is to investigate the impact of daily consumption of MSPrebiotic at a dosage level of 30 g per day for 12 weeks on gastrointestinal microbiota in the elderly (> 70 years age) and another age group (30…
- Trial name
- NCT03910153
- Testing
- MSPrebiotic
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- MSP Starch Products Inc.