Clinical trials: Intestinal Microbiota
Anxiety Depression
Probiotics Regulate Intestinal Health and Alleviate Anxiety
This study is a randomized, double-blind, placebo-controlled trial aimed primarily at investigating the effects of Weizmannia coagulans BC99 on alleviating anxiety and depression and the gut microbiota.
- Trial name
- NCT07353320
- Testing
- probiotics group
- Where
- China
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Vaginal Microflora
Clinical Evaluation of Effects of an Investigational Tampon on Vaginal Microflora
Subjects will be using investigational or control tampons during their menstrual period but these tampons are not intended to prevent, treat or diagnose an infection or other disease condition.
- Trial name
- NCT00913523
- Testing
- Experimental - Tampon with GML
- Where
- 2 sites in United States
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
HIV, Immune Cells (Mucosal and Systemic)
Quantification of Immune Cells in Women Using Contraception (CHIC II)
This study is being done to understand if using birth control causes changes in the immune cells within the reproductive tract (including the cervix and the lining of the uterus) of healthy women.
- Conditions
- HIV, Immune Cells (Mucosal and Systemic), Contraception
- Trial name
- CHIC-II (NCT01873170)
- Testing
- levonorgestrel exposure, DMPA exposure, etonogestrel exposure
- Where
- United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy Adult Participants, Vitamin D Insufficiency
Supplementation of Cholecalciferol and Related Active Metabolites Through Bioenhancing Layer's Eggs
The purpose of this research is to evaluate if 1) consumption of vitamin D3- or 25(OH)D3-biofortified eggs will increase vitamin D and 25(OH)D status in young adults who consume these bioenhanced eggs, 2) to determine if the gut…
- Trial name
- SCRAMBLE (NCT07859280)
- Testing
- Vitamin D3 bioenhanced eggs, 25(OH)D3 bioenhanced eggs
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cornell University
Type 2 Diabetes
Exercise, Gut Microbiota and Type 2 Diabetes
This randomized, parallel, controlled study, will investigate the effect of regular exercise on GM composition, inflammatory status, and insulin sensitivity, in the progression from normal glucose tolerance (NGT), to prediabetes…
- Trial name
- Ex-GM-T2D (NCT06562842)
- Testing
- Regular exercise, Control comparator
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Colorectal Cancer
The Role of Gut Microbiome and Chronic Inflammation in Young-onset Colorectal Cancer
This study aims to investigate the role of gut microbiome pattern and inflammation marker NF-ҡB in young-onset colorectal cancer
- Trial name
- NCT04011969
- Testing
- Score assessment, Blood sampling, Fecal sampling
- Where
- Indonesia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Nutritional and Metabolic Diseases, Endocrine System Diseases
Observational Study of Blood Glucose Levels and Gut Microbiota in Healthy Individuals
Categorization of glucose levels into 'healthy', 'pre-diabetic' or 'diabetic' is increasingly seen as artificial. Furthermore, most micro and macrovascular complications may be present already at the pre-diabetic stage.
- Conditions
- Nutritional and Metabolic Diseases, Endocrine System Diseases, Disorders of Environmental Origin
- Trial name
- NCT01892956
- Testing
- Nutritional intervention
- Where
- Israel
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Healthy Nutrition, Food Preferences
The Associations Between Gut Length, Gut Microbiota and Food Assimilation
The purpose of this observational study is to explore the relationships between gut length, the microbiota and food energy assimilation rates in humans.
- Conditions
- Healthy Nutrition, Food Preferences, Metabolic Syndrome, Protection Against
- Trial name
- NCT06377956
- Testing
- Observation without intervention
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Alzheimer's Disease, rTMS Stimulation
The Underlying Neural Mechanism of TMS in Improving the Imbalance of "Microbiota-brain-gut Axis" in Alzheimer 's Disease Population
What is this study about? This study focuses on Alzheimer's Disease (AD), a common neurodegenerative disease that affects memory, thinking, and daily life.
- Trial name
- NCT07346794
- Testing
- TMS
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
COPD, Microbial Colonization
Partially Hydrolyzed Guar Gum (PHGG) for Amelioration of Chronic Obstructive Pulmonary Disease (COPD)
Some components of the diet could promote the growth of certain bacterial strains present in the intestine, which are closely associated with benefits for host health.
- Conditions
- COPD, Microbial Colonization, Respiratory Tract Disease
- Trial name
- NCT05126654
- Testing
- Partially Hydrolyzed Guar Gum (PHGG)
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fu Jen Catholic University Hospital
Lactose Intolerance
Association Between Lactase Deficiency, and the Small Intestinal Microbiome in Adults.
The purpose of this study is to study the role of the enzyme (substance produced by the body that helps in a biochemical reaction like digestion in the body) responsible for digestion of lactose and the role of the gut bacteria…
- Trial name
- NCT03860051
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Indiana University
Focus of Study: 1- Effect of Tea Consumption on Gut Microbiota, Focus of Study: 2- Effect of Tea Consumption on Body-iron Status
Can the Reduction of Iron Availability Caused by Tea Consumption Change the Gut Microbiota Composition and Disrupt Host Body-iron Status
Iron is an essential micronutrient for nearly all living organisms, including microbes. The adult human body contains approximately 3-5 g of iron (45-55 mg/kg of body weight in adult women and men, respectively).
- Trial name
- NCT05019573
- Testing
- Black tea
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Reading
Colorectal Cancer, Diet Habit
Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer
A Mediterranean Diet (MedDiet), a largely plant-based dietary pattern, is relevant to CRC prevention and microbial production of anti-cancer metabolites in observational studies.
- Trial name
- Bridge CRC (NCT04753359)
- Testing
- Med, WL
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Crohn Disease
Mother-to-Infant Transfer of Bacteriome, Fungome, Virome, and Metabolome in Health and Crohn's Disease
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are caused by the loss of mucosal tolerance towards the commensal microbiota resulting in inflammatory responses.
- Trial name
- NCT05112497
- Testing
- No intervention procedure
- Where
- Hong Kong
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Fecal Microbiota Transplantation
Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease
Fecal microbiota transplantation (FMT), defined as infusion of feces from healthy donors to affected subjects, is a method to restore a balanced gut microbiota and has attracted great interest in recent years due to its efficacy…
- Trial name
- FMT-IBD (NCT04436874)
- Testing
- endoscopy
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Dysbiosis
The Effect of Glucomannan Powder on Improving Gut Microbiota.
The object of this study is evaluating the effects of the Glucommanan on the healthy human subjects who are. In this trial, at most 30 healthy subjects whose ages are 20~65 years old (15 for placebo and 15 for intervention)will…
- Trial name
- NCT07231003
- Testing
- Glucomannan
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
IBS (Irritable Bowel Syndrome)
High-Resolution Measurements of Diet-Microbiome Interactions
The goal of this clinical trial is to characterize regional intestinal fermentation physiology and determine how the response to fermentable dietary fiber differs between healthy individuals and individuals with irritable bowel…
- Trial name
- NCT07856823
- Testing
- Inulin, Low-fiber control breakfast shake, Atmo Gas-Sensing Capsule
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Stanford University
Inflammatory Bowel Diseases, Parkinson Disease
Gut Microbiota Dysbiosis and Translocation During IBD and Parkinson
Inflammatory bowel diseases (IBD) and Parkinson disease (PD) are complex and multifactorial pathologies. Gut microbiota seems to play an active role.
- Trial name
- Medibiote1 (NCT04159727)
- Testing
- stool and blood analysis
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hôpital Européen Marseille
Colonization, Asymptomatic, Colonization
Probiotic Delivered to the Small Intestine Changes Microbiota
This study will determine whether encapsulation of probiotic bacteria using natural plant protein can enhance bacterial colonisation.
- Trial name
- Probiotic (NCT07510282)
- Testing
- Probiotic containing L.rhamnosus R0011 strain, 200 ml yogurt drink
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Insulin Resistance
Impact of Starch Digestibility on Glycemic Variability and Control, Cardiometabolic and Inflammatory Profiles, Microbiota and Intestinal Health in Subjects With Insulin Resistance
To study the potential impact of a diet rich in both Slowly Digestible Starch (SDS) and Resistant Starch (RS), we propose a 2-month nutritional intervention study in which we will study the evolution of carbohydrate variability…
- Trial name
- GLYMICARE (NCT07408479)
- Testing
- Balanced diet high in Slowly Digestible Starch and Resistant Starch, Balanced diet low in Slowly Digestible Starch and Resistant Starch
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
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