Clinical trials: Intestinal Microbiota
Gut Microbiota Dysbiosis and Nutrition
Inulin and the Gut Microbiota in Healthy Adults
In this study the effects of a fibre dietary supplement on the gut microbiome in healthy adults will be investigated. For this purpose, a 14-day dietary supplementation with inulin or placebo (maltodextrin) will be carried out in…
- Trial name
- INLITE (NCT05399316)
- Testing
- Inulin, Maltodextrin
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Experimental and Clinical Research Center
Healthy
Impact of Soluble Arabinoxylan and Rice Bran Fiber on the Gut Microbiome in Healthy Adults
The importance of the gut microbiota for general health has been recently elucidated, but little is known about the impact of different types of nutrients on the gut microbiota.
- Trial name
- NCT06873204
- Testing
- Soluble Arabinoxylan, Rice Bran
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Purdue University
Healthy
Effect of Fructose on Colonic Microflora
Fructose is the principal carbohydrate in fruits and is added to many food products. This 6 carbon sugar is associated with a number of ill effects, like promotion of high triglycerides,precipitation of gout in men,possible…
- Trial name
- MEF (NCT00775567)
- Testing
- Fructose powder
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Restless Legs Syndrome
Gut Microbiota and Bacterial Translocation in Restless Legs Syndrome
Restless Legs Syndrome (RLS) is a common neurological sensorimotor disorder defined by an urge to move the legs when at rest that increase in the evening and at night.
- Trial name
- RLS-BIOT (NCT05985421)
- Testing
- Fecal collection, Blood sampling, Polysomnography
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Infant Development, Gut Microbiome
Characterisation of the Gut Microbiota in Term Infants After Maternal Supplementation of Probiotics
A monocenter, open label pilot study in pregnant women and their offspring with at least four weeks prenatal and four weeks postnatal maternal intervention with a study product consisting of four different food constituents.
- Trial name
- NCT04987593
- Testing
- Probiotics
- Where
- Denmark
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Chr Hansen
Gut Microbiome, Body Composition
Mediterranean Diet Uptake and Nutrition on Child Health, Inflammation, and Early-life Symbiosis (MUNCHIES) Study
Toddlerhood (ages 2-3) is a critical window when the gut microbiome is still developing and eating habits are being established. Yet, many Canadian toddlers eat diets high in sugar and salt, which may affect long-term health.
- Conditions
- Gut Microbiome, Body Composition, Adherence, Metabolites
- Trial name
- MUNCHIES (NCT07309536)
- Testing
- Mediterranean Diet Nutrition Program, Standard Diet Education Program
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of New Brunswick
Narcolepsy Type 1, Bacterial Translocation
Bacterial Translocation and Gut Microbiota in Type 1 Narcolepsy Patients Versus a Control Population
Narcolepsy type 1 (NT1) is a rare disease characterized by severe drowsiness, cataplexy, hypnagogic hallucinations, sleep paralysis, poor night sleep, and often obesity.
- Trial name
- NARCOBIOTE (NCT06292598)
- Testing
- Blood sample, Stool sample, CSF sample
- Where
- 2 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Changes in Gut Microbiota Composition After Lactulose Exposure
Elucidating the Influence of Lactulose Intake on the Gut Microbiota Composition
This study will test the influence of lactulose of the human gut microbiota. Healthy volunteers will ingest 50g of lactulose and donate stool samples 1 day before as well as 1-2 days and 14 days after the test.
- Trial name
- Lactulose (NCT02397512)
- Testing
- application of lactulose, application of sucrose
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Diet Modification, HDL
Effects of Short-term Diet on HDL Composition and Function
The primary objective of this study is to generate preliminary data on the effects of a short-term diet of either fast food or Mediterranean type diet on HDL and microbiota composition and function in healthy subjects, which…
- Conditions
- Diet Modification, HDL, Inflammation
- Trial name
- NCT03205254
- Testing
- Mediterranean Diet, Fast food diet
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Hyperphosphatemia
Velphoro and Impact on the Oral Cavity and Gut Microbiome
This pilot study will be carried out to determine if the regular intake of iron-based Velphoro® by hyperphosphatemia patients influences the microbiome in the oral cavity and/or the gut.
- Trial name
- MicrobiomEisen (NCT03409757)
- Testing
- Velphoro, saliva collection, Supragingival biofilm collection
- Where
- Germany
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Hypertensive Disorder Complicating Pregnancy
Multivariate Analysis and Prediction of Hypertensive Disorder Complicating Pregnancy and Its Related Mechanism
Hypertensive disorder complicating pregnancy (HDP) is a unique disease during pregnancy, accounting for about 5.2% ~ 8.2% of pregnant women in the world, which seriously threatens the health and life safety of mothers and…
- Trial name
- NCT06995456
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Diet Modification
Effect of Phytin on Human Gut Microbiome (EPoM)
Within many plants, such as seeds, nuts and cereals, there is a compound called phytic acid. Phytic acid has many beneficial properties, including producing molecules which slows down the damage that can be caused to other…
- Trial name
- EPoM (NCT03917693)
- Testing
- Phytin, rice extract
- Where
- 2 sites in United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Glucose Tolerance
Dietary Fibre and Metabolic Benefits
The aim of the project is to study the connection between bacterial fermentation in the colon of prebiotic substrates and effects on systemic metabolism and appetite i healthy humans
- Trial name
- NCT03423381
- Testing
- Cereal product 1, Cereal product 2, Cereal product 3
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Lund University
Health Behavior
Short and Long Term Effect of Early Infant Feeding and Nutritional Status on the Children's Health
This study evaluates the early infant feeding in the infant intestinal microecology and the long term health. 300 healthy term newborns were involved into the study on its first stage.
- Trial name
- NCT02658500
- Testing
- Infant Formula, breast milk
- Where
- 4 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Beijing Sanyuan Foods Co Ltd
Irritable Bowel Syndrome, Colitis, Ulcerative
Advanced Metagenomic Analysis of Human Colonic Microbiota in Patients With Chronic GI Disorders
This clinical trial hypothesize that Gut Microbiota (bacteria, viruses, fungi)play a major role in the occurrence and progression of many chronic gastrointestinal diseases like Irritable Bowel Syndrome, Inflammatory Bowel…
- Conditions
- Irritable Bowel Syndrome, Colitis, Ulcerative, Crohn Disease, Colonic Neoplasms
- Trial name
- NCT01099111
- Where
- Saudi Arabia
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- King Fahad Medical City
Postprandial Blood Glucose, Gut Microbiota
Effect of Fat Quality on Glycemic Regulation and Gut Microbiota After a Short-time Intervention in Healthy Individuals
The overall aim is to investigate effects of saturated versus polyunsaturated fat on glycemic regulation and satiety in a postprandial study with healthy individuals.
- Conditions
- Postprandial Blood Glucose, Gut Microbiota, Satiety
- Trial name
- NCT03658681
- Testing
- Saturated fat 14.9 E%, Polyunsaturated fat 13.6 E%
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University
Gut Microbiome, Immune Responses
Effects of Probiotic Supplementation on Gut Health, Immune Response, and Well-Being
This randomized, double-blind, placebo-controlled exploratory study will evaluate the effects of daily probiotic supplementation on gut barrier function, immune-related markers, and well-being in healthy adults with mild to…
- Conditions
- Gut Microbiome, Immune Responses, Well-being
- Trial name
- NCT07779265
- Testing
- Probiotic capsules
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Orthomol Pharmazeutische Vertiebs GmbH
Infant Allergy, Infant Gut Health
Study on the Impact of Different Feeding Methods on Allergy Prevention and Digestive Absorption in Infants and Young Children
Based on a real-world research paradigm, this study aims to evaluate the performance of infants fed via different methods-specifically goat milk formula, control formula, and breastfeeding-regarding allergy prevention and protein…
- Conditions
- Infant Allergy, Infant Gut Health, Infant Respiratory Diseases, Infant Feeding Scale
- Trial name
- NCT07886437
- Testing
- Observation, biological sample collection: stool
- Where
- China
- Volunteers
- 696 people, healthy volunteers welcome
- Sponsor
- Tsinghua University
Healthy
Effect of Daily Consumption of a Novel Biscuit Enriched With Edible Mushrooms, on Intestinal Health-related Parameters
The purpose of the study is to assess the effect of dietary intervention that includes the daily consumption of a novel biscuit (enriched with the selected mushrooms rich in β-glucans) on gut health related parameters of healthy…
- Trial name
- FUNglucan (NCT04759625)
- Testing
- Novel biscuit enriched with mushroom powder containing 3g of β-glucans
- Where
- Greece
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Anorexia Nervosa, Dysbiosis
Alteration of Symbiosis Intestinal Microbiota on Patients With Anorexia Nervosa
The purpose of this study will be to study the association between the level of psychic symptomatic of anorexia nervosa (AN) (intensity of food restriction, symptoms of anxiety and depression) and alteration of host environment…
- Conditions
- Anorexia Nervosa, Dysbiosis, Anxious Depression
- Trial name
- INT-METAVOSA (NCT05632497)
- Testing
- Stool and blood samples
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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