Clinical trials: Intestinal Microbiota
Obesity (Disorder)
Effects of Gallotannins on the Gut Microbiome and How it Affects Inflammatory Markers Among Obese Individuals.
The goal of this clinical trial is to understand how gallotannin-rich (GT-rich) mangoes can reduce the inflammatory markers in obese individuals in vitro.
- Trial name
- NCT07505212
- Testing
- Gallotannin-rich mango, Lactiplantibacillus pentosus (probiotic), No Treatment Added
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Prairie View A&M University
Sebum Production, Stool Microbiome
Pilot Study of Triphala and Rubia Cordifolia on Gut Microbiome and Skin
Few studies have assessed the effects of Triphala and Rubia Cordifolia from a skin biophysical perspective. Here, we aim to understand how these herbs can modulate the skin's barrier properties and the gut microbiome.
- Conditions
- Sebum Production, Stool Microbiome, Transepidermal Water Loss, Facial Brrightness
- Trial name
- NCT03477825
- Testing
- Rubia Cordifolia, Triphala
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Healthy Nutrition
Effect of the Intake of Corbella Extra Virgin Olive Oil on the Microbiota-gut-brain Axis in Healthy Adults (HEVOOC)
The consumption of the improved extra virgin olive oil (EVOO) of the Corbella variety could have a beneficial effect on the microbiota-intestine-brain axis (MGBA).
- Trial name
- HEVOOC (NCT05898113)
- Testing
- EXTRA VIRGIN OLIVE OIL, OLIVE OIL LOW POLYPHENOL
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Healthy Adult Participants, Vitamin D Insufficiency
Supplementation of Cholecalciferol and Related Active Metabolites Through Bioenhancing Layer's Eggs
The purpose of this research is to evaluate if 1) consumption of vitamin D3- or 25(OH)D3-biofortified eggs will increase vitamin D and 25(OH)D status in young adults who consume these bioenhanced eggs, 2) to determine if the gut…
- Trial name
- SCRAMBLE (NCT07859280)
- Testing
- Vitamin D3 bioenhanced eggs, 25(OH)D3 bioenhanced eggs
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cornell University
Obesity, Dietary Intervention
Effects of Boron and Mediterranean Diets on Gut Microbiota and Metabolic Health
This study investigated the effects of a boron-rich diet compared with a Mediterranean-style diet (Smart Alternative Food Formulation; SAFF) on obesity-related outcomes in adults.
- Conditions
- Obesity, Dietary Intervention, Gut Microbiota, Cardiometabolic Risk Factors
- Trial name
- BOR-SAFF (NCT07156097)
- Testing
- Mediterranean-style Diet (SAFF), Boron-rich Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dicle University
Pulmonary Disease, Chronic Obstructive, Microbiota
The Gut-lung Axis in Chronic Obstructive Pulmonary Disease
Patients with chronic obstructive pulmonary disease (COPD) are 2-3 times more likely to occur together with chronic gastrointestinal tract (GIT) diseases, such as inflammatory bowel disease (IBD) or irritable bowel syndrome…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Microbiota, Immunity, Mucosal, Metabolism
- Trial name
- NCT03236480
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Healthy Volunteers
Influence of GanedenBC30 (Bacillus Coagulans GBI-30, 6086) on the Gut Microbiome in Healthy Adults
The purpose of this study is to investigate the effect of a GanedenBC30, a probiotic bacteria (Bacillus coagulans strain GBI-30, 6086), on the gut microbiome in healthy adults.
- Trial name
- NCT02872688
- Testing
- GanedenBC30
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nutrasource Pharmaceutical and Nutraceutical Services, Inc.
Debility
the Effect of Probiotics on Aging Population
This study intends to recruit aging population (over 65 years old). The investigators use 16 SrDNA sequencing technology, genome sequencing technology, metabonomics, random forest forecast model, analysing and selecting specific…
- Trial name
- TEOPOGP (NCT04911556)
- Testing
- Bifidobacterium longum
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Wuxi People's Hospital
Gastroesophageal Reflux Disease With Esophagitis
Evaluate the Intestinal Microbiome in Patients With Erosive Gastroesophageal Reflux Disease and in Asymptomatic Healthy Controls
. In this study, we investigated intestinal microbiomes, in individuals with Gastroesophageal Reflux Disease and healthy individuals, using metagenomic techniques.
- Trial name
- NCT04248296
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Hypertension, Type 2 Diabetes
Military Health and Nutrition Examination Study
The Military Health and Nutrition Examination Study (MHANES) is a Department of Defense funded study conducted by Pennington Biomedical Research Center and the US Army Research Institute of Environmental Medicine.
- Conditions
- Hypertension, Type 2 Diabetes, Dyslipidemias, Cardiovascular Diseases
- Trial name
- MHANES (NCT06380322)
- Where
- 6 sites in United States
- Volunteers
- 648 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Healthy
Effects of Seaweeds Combined With Probiotics on Intestinal Function of Healthy Subjects
The aims of this study are to investigate the effect of seaweeds which is one of the main ingredients of Korean traditional food 'Kimchi' and probiotics on intestinal function of healthy subjects.
- Trial name
- NCT01651741
- Testing
- Seaweed and Duolac7S, Seaweed and Duolac7S-P
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Korea Institute of Planning & Evalution for Technology of Food, Agriculture, Forestry & Fisherie
Dehydration, Cognitive Change
The Effects of Hydration on Gut Health and Thinking
The central hypothesis is that improving hydration through increased water consumption will change the relative abundance of mucolytic bacteria found in the stool.
- Conditions
- Dehydration, Cognitive Change, Gastrointestinal Microbiota
- Trial name
- WatUP (NCT05315531)
- Testing
- Water Intake
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Parkinson's Disease (PD)
Untreated Parkinson's Disease Work-up Assessing Resident Microbiota and Duodenal Barrier Function
The UPWARD study is a prospective hypothesis-generating study in individuals with untreated Parkinson's disease (PD) and age-matched healthy controls (HCs).
- Trial name
- UPWARD (NCT07418658)
- Testing
- Invasive sampling procedures, Non-invasive sampling procedures
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy Mothers, Healthy Infants
Maternal High Fibre Fermented Diet Effect on Breastfed Infant Gut Microbiome
Breastfeeding is recommended for babies from birth to six months old because breast milk provides all the nutrients babies need for growth and development.
- Trial name
- MumBabyGut (NCT06977113)
- Testing
- High Fibre Fermented Food Diet, Control Habitual Diet
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Microbiota, Eczema
Intestinal Microbiota Composition After Antibiotic Treatment in Early Life
In this prospective observational cohort study the potential clinical consequences of antibiotic use in early life and perturbations in the gastrointestinal microbiota composition due to that antibiotic use are studied.
- Conditions
- Microbiota, Eczema, Atopy
- Trial name
- INCA (NCT02536560)
- Where
- 4 sites in Netherlands
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Agentschap NL
Multiple Sclerosis
Retrospective Study on the Role of SCFA Modulation in Multiple Sclerosis
Recent studies show that gut microbiota strongly influences multiple sclerosis. These data suggest that the microbiota could have a direct effect on MS pathogenesis, although the mechanisms through which it modulates central…
- Trial name
- NCT06746896
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Prof. Massimo Filippi
Personalized Nutrition
ZOE METHOD Study: Comparing Personalized vs. Generalized Nutrition Guidelines
The ZOE Method Study will test the efficacy of personalized nutritional advice, delivered on an individual level through a digital device app; integrating dietary, lifestyle, physiological and metagenomic data, in improving…
- Trial name
- NCT05273268
- Testing
- Personalized nutrition, Generalized nutrition
- Where
- United States
- Volunteers
- 347 people, healthy volunteers welcome
- Sponsor
- Zoe Global Limited
Healthy
Xanthohumol Metabolism and Signature
A pilot study to assess the safety and tolerability of oral xanthohumol in humans, to identify a biological signature of xanthohumol exposure, and to characterize the role of xanthohumol metabolism by intestinal microorganisms in…
- Trial name
- XMaS (NCT03735420)
- Testing
- Xanthohumol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
Healthy
The Impact of Diet on the Gut-Microbiota-Brain Axis
This study aims to investigate the effects of an 8-week dietary intervention on cognitive function, stress, and the gut microbiota in healthy adults with low fibre intake.
- Trial name
- NMB (NCT05931562)
- Testing
- Fermented Foods, High Fibre, Combined Diet
- Where
- Ireland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University College Cork
Healthy
Trimethylamine-N-oxide Production and Metabolism
The purpose of this study was to understand the production of trimethylamine-N-oxide (TMAO) and its metabolites from dietary precursors found in fish, eggs and beef.
- Trial name
- NCT02558673
- Testing
- TMAO dietary precursors, Control (or active comparator)
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cornell University
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