Clinical trials: Intestinal Microbiota
COVID-19 Vaccination, Gut Microbiota
Gut Microbiota Profile and Its Impact on Immunity Status in COVID-19 Vaccinated Cohorts
This study aims to examine the association between gut microbiota composition and the magnitude and duration of immune response in subjects who have received different COVID-19 vaccines in Hong Kong and to identify the…
- Trial name
- NCT04980560
- Where
- Hong Kong
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Non Communicable Diseases
The Impact of Dietary Intervention on Oxidative/antioxidant Markers and Gut Microbiota in Athletes
During intense physical exercise, there is an overproduction of reactive oxygen species, which leads to oxidative stress and reduced training and sports performance, as well as the development of chronic diseases.
- Trial name
- SportDiet (NCT06855979)
- Testing
- Food with high antioxidant potential
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Fecal Microbiota Transplantation
Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease
Fecal microbiota transplantation (FMT), defined as infusion of feces from healthy donors to affected subjects, is a method to restore a balanced gut microbiota and has attracted great interest in recent years due to its efficacy…
- Trial name
- FMT-IBD (NCT04436874)
- Testing
- endoscopy
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Infant Development
Early Iron Exposure on the Gut Microbiota in Young Infants
This study will look at the amount of iron in infant formula and how that affects a child's gut development. The children of mothers who plan to formula feed their children will be randomized to receive either high iron or low…
- Trial name
- IF (NCT03828708)
- Testing
- Iron in infant formula
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypercholesterolemia
Plant Stanols and Gene Expression Profile
Plant sterols and stanols are dietary components that are naturally present in plants. Their biological function in plants is comparable with these of cholesterol in animals.
- Trial name
- NCT01574417
- Testing
- control margarine, plant stanol-enriched margarine
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy, Sepsis
The Role of the Microbiota in the Systemic Immune Response
The objective of this study is to investigate the role of the gut microbiota in the systemic priming of immune effector cells. Twelve healthy male volunteers, 18-35 years of age, will be treated with broad spectrum antibiotics…
- Trial name
- MISSION-1 (NCT02340182)
- Testing
- Vancomycin, Ciprofloxacin, Metronidazole
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- W.J. Wiersinga, MD, PhD
Helicobacter Infections
Levofloxacin Versus Clarithromycin Triple Therapy in First-Line Treatment for Helicobacter Pylori Eradication
Clarithromycin-based triple therapy containing a proton-pump inhibitor (PPI) twice daily, amoxicillin 1g twice daily, and clarithromycin 500 mg twice daily for 7 days is one of the standard firs-line therapy for Helicobacter…
- Trial name
- NCT00816140
- Testing
- Cravit based triple therapy, Klaricid based triple therapy
- Where
- Taiwan
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
HIV
Diet / Gut Microbiome Interaction and Influence on Inflammatory Disease in HIV Patients
The primary objective is to assess the effect of short-term diet modification on the microbiome composition, and inflammatory/metabolic disease markers in Antiretroviral therapy (ART)-treated HIV-infected participants and Human…
- Trial name
- NCT02610374
- Testing
- Agrarian Diet, Western-type Diet
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Metabolic Disease, Inflammation
Gut Microbiota-dependent Health Impacts of Haskap Berries
Polyphenol-rich Haskap berries (Haskap) have untapped therapeutic potential to improve human health, and agricultural producers in northern U.S. states are poised to increase production if consumer demand increases.
- Conditions
- Metabolic Disease, Inflammation, Microbial Colonization
- Trial name
- HIH (NCT06546020)
- Testing
- Haskap berry smoothie
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Montana State University
Gastrointestinal Tolerance
A Double Blind Study on the Gastrointestinal Effects of Arabinoxylan (Leaf Fiber Extract).
The objective of this study is to investigate the effect on Arabinoxylan on gastrointestinal (GI) tolerance, bowel habits, and microbiota in adults.
- Trial name
- NCT04100460
- Testing
- 7.25 grams of Arabinoxylan leaf fiber extract, 14.5 grams of Arabinoxylan leaf fiber extract, Control - No Arabinoxylan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Comet Bio Inc.
Gut Microbiome, Gastrointestinal Microbiome
A Study to Explore the Role of Gut Flora in COVID-19 Infection
This study seeks to determine whether the virus which causes COVID-19, SARS-CoV-2, is shed in the stools of patients who are infected.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, COVID, COVID-19
- Trial name
- NCT04359836
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Evidence of Adaptation to Dietary Exposure to Fructans
Pilot Study of the Effect of Fructans on Fermentation in the Colon & Transit
Some carbohydrates (complex sugars) which are found in grains, fruit and vegetables, cannot be digested by humans. When eaten they pass through the small bowel to the large bowel, or colon.
- Trial name
- PERFECT (NCT01963364)
- Testing
- Inulin challenge, oligofructose supplement
- Where
- 2 sites in United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Allergic Rhinitis (AR)
Lacticaseibacillus Rhamnosus LRa05 for Alleviating Allergic Rhinitis
This clinical trial aims to evaluate the efficacy and safety of Lactobacillus rhamnosus LRa05 in alleviating allergic rhinitis symptoms and its effects on gut microbiota in 70 adults aged 18-60 years.
- Trial name
- NCT06699537
- Testing
- probiotic product, Maltodextrin
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Gut Microbiota, Glioblastoma Multiforme, Microglia, Tumor Related Macrophagocyte, Prognosis
Gut Microbiota and Glioblastoma Multiforme Prognosis
Glioma is the most common primary cancer of the central nervous system, and around 50% of patients present with the most aggressive form of the disease, glioblastoma.
- Trial name
- NCT03631823
- Testing
- Chemotherapy with temozolomide or no chemotherapy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Prebiotics, Metagenomic Next Generation Sequencing
Assessing Changes in the Gut Microbiome of Non-Gastrointestinal Disordered Subjects Before and After Oral Prebiotic Supplementation Using the SIMBA Capsule
This is a randomized, double-blind, placebo-controlled, parallel-group clinical study. The primary objective is to assess the changes in the small intestinal (SI) metagenomic profile of healthy participants without any known…
- Conditions
- Prebiotics, Metagenomic Next Generation Sequencing, Microbiome, Small Intestine
- Trial name
- NCT07788924
- Testing
- FiberSmart
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Anderson Advanced Ingredients
Gut Microbiome, Neurocognitive Correlates of Eating Habits
Tiny Tummies - A Milk Study
This is a 12-month, 2-arm randomized controlled trial (n=150) examining whether toddlers randomized at 12 months of age to 1.5 cup-equivalents/day of cow's milk-based dairy versus oat milk-based dairy, and followed to 24 months…
- Conditions
- Gut Microbiome, Neurocognitive Correlates of Eating Habits, Infants and Young Children, Sleep
- Trial name
- NCT07839156
- Testing
- Daily cow's milk products, Daily Oat Milk Exposure
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Irritable Bowel Syndrome
Mediterranean Diet and the Gut Microbiome
This study will evaluate the impact of a Mediterranean-style diet on microbiome diversity compared to a typical American diet. The study will observe the microbiome composition comparisons in healthy volunteers as well as in…
- Trial name
- NCT03269032
- Testing
- American Diet, Mediterranean-style Diet
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Liver Disease; Alcohol-Related, Gut Microbiota
Alterations of Gut Microbiota and Metabolites in ALD Patients
Alcohol-associated liver disease is one of the most prevalent liver diseases worldwide, and the leading cause of liver transplantation in the U.S.
- Trial name
- NCT05448144
- Testing
- Collect stool and blood samples from patients
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Polycystic Ovary Syndrome
The Role of Dysbiosis of Gut Microbiota in the Pathogenesis of PCOS.
Polycystic ovary syndrome (PCOS) has a significant impact on women's health, but its pathogenesis is not yet clear. Dysbiosis of gut microbiota may play a role in the pathological change of PCOS.
- Trial name
- NCT03843736
- Testing
- Lifestyle intervention, Probiotic Agent, Oral contraceptive
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Post Prandial Blood Glucose, Gut Microbiota
Intake of Beta-glucan and Postprandial Regulation of Blood Glucose Metabolism in Healthy Subjects
The overall aim is to investigate the intake of beta-glucan in relation to glucose metabolism and satiety in a postprandial study with healthy subjects.
- Conditions
- Post Prandial Blood Glucose, Gut Microbiota, Satiety
- Trial name
- NCT03293693
- Testing
- 0.5 g beta-glucan, 3.5 g beta-glucan, 8 g beta-glucan
- Where
- Norway
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University
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