Clinical trials: Intestinal Microbiota
Cardiovascular Risk Factor
The Salty Gut: Effects of High Dietary Salt Intake on the Gut Microbiota
Gut microbiota has a role in cardiovascular disease and recent findings in rodents show dietary salt can negatively alter gut microbiota composition. High salt intake is a risk factor for cardiovascular disease.
- Trial name
- NCT04229680
- Testing
- High Salt, Recommended Salt
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Sleepiness, Fatigue
Integral Physiological Adaptations to Carbohydrate Periodization
The purpose of this study is to examine the effect of long-term carbohydrate periodization protocols on sleep architecture, sleep quality, daytime sleepiness, physical performance, body composition, gut microbiome, and miRNA in…
- Conditions
- Sleepiness, Fatigue, Feeding Patterns, Daytime Sleepiness, Excessive
- Trial name
- IPACP (NCT05464342)
- Testing
- Evening LGI Carbohydrate Consumption Group, Evening HGI Carbohydrate Consumption, Evening NO-CHO Carbohydrate Consumption
- Where
- 2 sites in Cyprus, Greece
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Undernourished, Anorexia Nervosa
Intestinal Metagenome of Undernourished in Patients
The objective of this trial is to evaluate gut microbiota changes in undernourished patients with anorexia nervosa under enteral nutrition.
- Trial name
- INT-METAVOSA (NCT02920073)
- Where
- France
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
IBS - Irritable Bowel Syndrome, Post Infection Syndrome
Gut Microbiome in Patients With Post-infectious Irritable Bowel Syndrome
Observational, multicenter, prospective study aimed at characterizing the gut microbiome in patients with post-infectious irritable bowel syndrome (PI-IBS) using whole genome sequencing (WGS).
- Trial name
- MicroRestore (NCT07517029)
- Where
- Italy
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Severe Malnutrition, Malnutrition
Characterizing the Gut Microbiota Alteration Associated With Severe Acute Malnutrition
The investigators performed two case-control studies in Niger and Senegal analysing fecal microbiota to characterize the specificity of the gut microbiota alteration associated with severe acute malnutrition (SAM).
- Conditions
- Severe Malnutrition, Malnutrition, Infant Nutrition Disorders, Child Nutrition Disorders
- Trial name
- NCT02413905
- Testing
- Stool samples
- Where
- 2 sites in Niger, Senegal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut Hospitalo-Universitaire Méditerranée Infection
Alzheimer Disease, Gut Biome
Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers
Spousal caregivers of Alzheimer's Dementia (AD) patients have an elevated risk of developing AD in the future. Past studies have shown the presence of serum indicators correlated with gut biome dysfunction in AD patients.
- Trial name
- NCT05601856
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Obesity and Obesity-related Medical Conditions
Egg Intake, Metabolic Outcomes and Choline Levels
The purpose of this research is to determine the effect of additional daily egg intake on metabolic phenotypes and metabolism in the context of obesity.
- Trial name
- NCT06687122
- Testing
- 3 whole eggs
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Influenza
The Interaction Between Mucosal Microbiota Colonization and the Immune Response to an Intranasal Influenza Live Attenuated Vaccine
This is a single-center, randomized, open-label trial designed to explore the interaction between mucosal microbiota colonization in the nasal cavity and gut and the immune response to an intranasal live attenuated influenza…
- Trial name
- NCT06609811
- Testing
- Intranasal Influenza Live Attenuated Vaccine
- Where
- China
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Colorectal Cancer Screening, Colorectal Cancer (CRC)
Improving Colorectal Cancer Early Screening in Portugal: Identification of Gut Microbiome Biomarkers in Stool (GUTBIOME-PT)
Colorectal cancer (CRC) is a major public health problem, responsible for 2 million new cases and almost 1 million deaths annually worldwide.
- Conditions
- Colorectal Cancer Screening, Colorectal Cancer (CRC), Microbiome
- Trial name
- GUTBIOME-PT (NCT06741293)
- Testing
- No intervention: observational study
- Where
- Portugal
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Gulbenkian Institute for Molecular Medicine
Acute Ischaemic Stroke, Depression
Screening of New Markers of Gut Microbiota in Stroke and Depression: a Cross-sectional Study
Objectives of Study： Through the cross-sectional study of stroke and depression, key biomarkers are targeted by screening disease-associated intestinal bacteria, metabolites and immune factors through multi-omics techniques.
- Trial name
- NCT06379464
- Where
- China
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Functional Dyspepsia
Mechanisms of Electroacupuncture for Functional Dyspepsia Based on "Enterotypes" and Metabolomics
The goal of this clinical trial is to explore the clinical efficacy and possible mechanisms of electroacupuncture treatment for functional dyspepsia (FD).
- Trial name
- NCT05920395
- Testing
- Electro-acupuncture
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Wuhan Central Hospital
Allergic Rhinitis
The Dysbiosis of the Intestinal Microbiota in Individuals With Allergic Rhinitis (MICRORIN)
Allergic rhinitis (AR) is triggered by environmental allergens such as pollen and mites, and is associated with several symptoms such as itching and nasal congestion, sneezing or tearing and redness of the eyes.
- Trial name
- MICRORIN (NCT03946553)
- Where
- Spain
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Healthy
The Exploration of the Regulatory Effect of Zinc on Intestinal Flora in Healthy Adults
In this A Single-center, Prospective, Self-controlled trial, subjects should avoid a high-Zinc diet for 2 weeks and then take Zinc supplements for 2 weeks.
- Trial name
- NCT05597137
- Testing
- Zinc Gluconate
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- The Seventh Affiliated Hospital, Southern Medical University
Diet, Healthy, Breath Analysis
Why Calories Are Not the Same - a Gut Explanation?
The aim of this study is to understand how the gut microbiome influences how much dietary energy humans excrete via feces. This study is based on the hypothesis that levels of methane in exhaled breath represent two different gut…
- Trial name
- GutEnergy (NCT06932666)
- Testing
- Diet A group, Diet B group
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Gut Microbiota Diversity and Composition, Athletic Performance
Kefir, Gut Microbiota, and Athletic Performance in Soccer Players
This research work is a clinical trial that will assess the impact of kefir consumption on the gut microbiota profile and athletic performance of female soccer players of age 18-29 years.
- Conditions
- Gut Microbiota Diversity and Composition, Athletic Performance, Functional Food Intervention (Kefir), Body Composition
- Trial name
- KEFIR-SPORT (NCT06753422)
- Testing
- Kefir
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Metabolic Syndrome, Insulin Resistance
An Antiinflammatory Diet as Modulator of Cardiometabolic Risk and Body Weight in Healthy Subjects
Main scientific question: A previous intervention with an anti-inflammatory multifunctional dietary portfolio (MFD) showed remarkable reductions in cardiometabolic (CM) risk markers compared with a well-designed control diet.
- Conditions
- Metabolic Syndrome, Insulin Resistance, Overweight
- Trial name
- NCT02148653
- Testing
- Multifunctional diet (MFD), Control diet
- Where
- Sweden
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Lund University
Maternal Exposure, Health Behavior
Brain Probiotic and LC-PUFA Intervention for Optimum Early Life
Probiotics is suggested to play several roles in promoting health, including alleviating disease symptoms, protection against atopic disease, and modulating the immune system by improving the beneficial gut microbiota…
- Conditions
- Maternal Exposure, Health Behavior, Infant Development, Child Development
- Trial name
- BRAVE (NCT03851120)
- Testing
- Probiotics and LC-PUFA (480 mg DHA), Psychosocial stimulation and healthy eating education
- Where
- Indonesia
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Probiotics
Use of a Selected Mixture of Probiotic Strains for Degrading Gluten During Digestion
Gluten intake spreads worldwide, being the major food protein consumed in the Western diets (up to 20 g gluten/d). But gluten has unique and unusual features.
- Trial name
- NCT05798689
- Testing
- Probiotic administration and gluten
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Free University of Bozen-Bolzano
Healthy Volunteers
Influence of Beer on Gut Microbiota and Biochemical Outcomes: Alcohol Impact.
Our aim is to assess the effects of moderate consumption of beer and non-alcoholic beer on gut microbiota and biochemical biomarkers in healthy adults.
- Trial name
- NCT03513432
- Testing
- Beer with 5.20 % alcohol, Non-alcoholic beer with 0.45 % alcohol, Non-alcoholic beer with 0.00 % alcohol
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Overweight , Obesity, Glucose Metabolism
SucroMet Nutritional Intervention Trial
SucroMet is designed to evaluate how adding two commonly used sweeteners-sucrose (table sugar) and sucralose (a low-calorie sweetener)-at low and high doses may influence glucose regulation, including insulin resistance and…
- Trial name
- NCT07656298
- Testing
- Sucrose- Low dose, Sucrose - High Dose, Sucralose - Low Dose
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
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