Clinical trials: Intestinal Microbiota
Obesity, Inflammation
Walnut Consumption and Gut Microbiota
Obesity is a growing health issue that effects the majority of adults in the United States. Prevalence of other metabolic diseases are increased in obese adults, including systemic inflammation.
- Trial name
- NCT05441748
- Testing
- Walnuts, Walnut Oil, Control
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Changes in Gut Microbiota with Prebiotic Supplementation, Quality of Life
Effect of a Nutritional Supplement on Gut Microbiota in Adults
According to International Scientific Association for Probiotics and Prebiotics (ISAPP), a prebiotic is defined as a substrate that is selectively utilized by host microorganisms conferring a health benefit (Gibson et al, 2017).
- Trial name
- NCT06611215
- Testing
- Treatment
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Pharmavite LLC
Helminth Infection
Intestinal Microbiome Post-Azythromycin/Albendazole Treatment
Molecular testing of the gut microbiome and enteric pathogens is rapidly moving beyond targeted PCR testing to next generation sequencing techniques.
- Trial name
- NCT03032042
- Testing
- Azithromycin, Albendazole, Delayed treatment
- Where
- Ethiopia
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Intestinal and Lmmune Function Lmproved
Investigating the Efficacy of Probiotics in Enhancing Gastrointestinal and Immunological Health
Evaluate the effectiveness and safety of Ligilactobacillus salivarius LS97 as a food supplement compared to a placebo in improving intestinal and immune functions in healthy adults.
- Trial name
- NCT06886724
- Testing
- Probiotic
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Autoimmune Hepatitis, Primary Sclerosing Cholangitis
Liver-gut Axis Study Through Identification of Liver Disease-specific Microbiome
In this study, we aim to identify gut microbiomes specific to patients with chronic refractory liver disease and to conduct a gut-liver axis study on the pathogenesis and disease progression.
- Conditions
- Autoimmune Hepatitis, Primary Sclerosing Cholangitis, Non-Alcoholic Fatty Liver Disease, Liver Abscess
- Trial name
- LGAS (NCT06519162)
- Where
- South Korea
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chungnam National University Hospital
Healthy Infants
Study on the Effects of Probiotic on Infant Gut Microbiota and Immune Regulation
This is a probiotic intervention study in healthy infants aged 0 - 6 months. The primary objective is to evaluate the effects of Lacticaseibacillus paracasei LPB27 (also known as Lacticaseibacillus paracasei 207-27)…
- Trial name
- NCT07896083
- Testing
- Probiotic, Maltodextrin
- Where
- China
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- BYHEALTH Co., LTD
Photoaging
Effects of Dietary Soy Protein on Facial Wrinkles in Postmenopausal Women
Soy and soy-derived products are the primary dietary sources of isoflavones, particularly daidzein and genistein, for humans. Isoflavones are noted to have several effects on the skin including proliferation of keratinocytes…
- Trial name
- NCT04871750
- Testing
- Soy protein, Casein protein
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Androgen Levels
Effects of Probiotic Supplementation on Androgen Levels
The goal of this clinical trial is to evaluate the feasibility, safety, and preliminary effects of a probiotic supplement, Bacillus coagulans strain BRCAS-C3, on androgen levels in adult men and women.
- Trial name
- NCT07911813
- Testing
- Bacillus coagulans BRCAS-C3
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cardiometabolic Syndrome
Spices for Cultivating a Healthy Gut Microbiome and Cardiometabolic Profile
Among food products receiving attention for prebiotic functionality, spices represent a flavorful vehicle for cultivating a healthy gut microbiota.
- Trial name
- NCT06313580
- Testing
- Yogurt with added Spices, Yogurt without added Spices
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Influenza
Association Between Gut Microbiome and Dietary Determinants and Vaccine Response
This study evaluates the association between gut microbiome and dietary determinants and vaccine response. This study aims to learn if diet and the microbes (such as bacteria and viruses) found in your gut affect the body's…
- Trial name
- NCT05239403
- Testing
- Biospecimen Collection, Questionnaire Administration
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
HELICOBACTER PYLORI INFECTIONS, Metabolic Syndrome
Eradication of Helicobacter Pylori Improves Metabolic Syndrome Through Modulation of Gut Microbiota.
The Role of Gut Microbiota in the Mechanism of Helicobacter pylori Eradication-Induced Amelioration of Metabolic Syndrome-Related Parameters Study Sponsor: Nanjing First Hospital Principal Investigator: Dr.
- Trial name
- NCT07306988
- Testing
- Vonoprazan-Amoxicillin Dual Therapy, Vonoprazan-Amoxicillin with Bifidobacterium tetravaccae, Vonoprazan-Amoxicillin with Berberine
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Assessment of Gut Microbiota-Derived Amino Acid Metabolite Production in Patients With MASLD
Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a spectrum of liver disorders ranging from simple steatosis-a relatively benign and non-progressive condition-to metabolic dysfunction-associated…
- Trial name
- MASLD-GUT (NCT07313007)
- Testing
- stool sampling, dietary assessment, and collection of blood and urine samples
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Aspirin, Microbiota
Influence of Aspirin on Human Gut Microbiota Composition and Metabolome
Colorectal cancer (CRC) is the third most common cancer type in males and the second in females, accounting for about 693,900 deaths worldwide per year.
- Trial name
- NCT03450317
- Testing
- Aspirin 80mg
- Where
- Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Elderly, Probiotics
Effect of Multi-species Probiotic HOWARU® Restore, on Gut Microbiota of Elderly
The study is randomized, double-blinded and placebo-controlled with a duration of 24 weeks. Following randomization, healthy elderly are randomized into two groups receiving probiotics or placebo.
- Conditions
- Elderly, Probiotics, Clostridium Difficile, Gut Microbiota
- Trial name
- NCT02207140
- Testing
- HOWARU Restore
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gabriella C. van Zanten
End-stage Renal Disease
Modulation of Gut Microbiota in End-stage Renal Disease
In end-stage renal disease (ESRD) cardiovascular and infectious complications are common. The gut microbiome might play an important pathophysiological role.
- Trial name
- MGM-dialysis (NCT02568891)
- Testing
- Probiotic
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Graz
Temperament, Sleep
GUTLINK4KIDS Intervention
This study aims to investigate the chronic effects of prebiotic consumption on cognitive, behavioural and gut microbiome outcomes in children aged 3-5 years.
- Conditions
- Temperament, Sleep, Cognition, Emotion Regulation
- Trial name
- GUTLINK4KIDS (NCT07401212)
- Testing
- Prebiotic powder
- Where
- United Kingdom
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Reading
Obesity
Involvement of the Gut Microbiota-brain Cross-talk in the Loss of Eating Control
Overweight and obesity are increasingly prevalent worldwide. These bodyweight disorders are closely related to deficiencies in the control of food intake.
- Trial name
- GMBTalk-Food (NCT05646901)
- Where
- Spain
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Fasting
Fasting Effects on Metabolism and Immunity Study in Human
This study aims to investigate the effects of 1-week fasting but not prohibiting water drink on human immune function, metabolic indicators, and brain function in human, and to explore the underlying mechanisms of these changes…
- Trial name
- NCT06779201
- Testing
- Fasting
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Infant Formula, Breast Milk
Effects of Breast Milk Simulated Infant Formula
Objective：The aim of this trial is to assess effects of Kieember and Yashili infant formula on body growth, behavior development, intestinal comfort, infectious diseases, allergic diseases, the absorption of nutrients and gut…
- Trial name
- NCT05295030
- Testing
- Breast milk, Kieember Infant formula, Ruibuen®, Yashili Infant formula, Ruibuen®
- Where
- China
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Infant Growth, Infant Body Fat
Effect of Protein From Complementary Foods on Infant Growth, Body Composition and Gut Health
Current research shows that dairy protein accelerates infant weight gain, which is a risk factor for later on obesity and metabolic syndrome. However, dietary protein from other sources haven't been studied yet.
- Conditions
- Infant Growth, Infant Body Fat, Infant Gut Microbiome
- Trial name
- NCT02142647
- Testing
- a high-protein complementary diet with meat, a high-protein complementary diet with dairy
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
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