Clinical trials: Intestinal Motility
Gastroesophageal Reflux Disease
Factors Influencing the Human Gut Microbiome Profile in Multi-ethnic Groups of the Singapore Community (FAMES)
The objectives of this study are to examine the effects of ethnicity, gender, and proton pump inhibitor (PPI, omeprazole), on the human gut microbiome.
- Trial name
- FAMES (NCT02893709)
- Testing
- Omeprazole
- Where
- Singapore
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Changi General Hospital
Healthy
Magnetic Resonance Imaging of Motility in Crohn's 1
Crohn's disease (CD) is becoming more common. One of the main features of this disease is weight loss and malnutrition with symptoms such as tummy aches and bloating.
- Trial name
- MIC1 (NCT02717117)
- Testing
- Soup meal
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Gastrointestinal Motility Disorder
Intestinal Dysmotility in Patients With Functional Digestive Symptoms
Automatic and non-invasive diagnostic methods based on the analysis of internal (intraluminal) and external (abdominal) images have been recently developed to measure intestinal motility.
- Trial name
- NCT04764019
- Testing
- High resolution intestinal manometry
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Gastroesophageal Reflux Disease
The Effect of PPI in Preventing Gastroesophageal Reflux Disease of Seafarers
In view of the high incidence of GERD among seafarers and its continuing impact on the life quality of seafarers, it is necessary to use preventive treatment.
- Trial name
- NCT04696783
- Testing
- Esomeprazole Magnesium Enteric-coated Tablets, Lifestyle adjustment
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Gastroesophageal Reflux Disease
Mass Balance Study of [14C]X842 in Healthy Adult Male Subjects
This study is a single-site, single-dose, non-randomized, open-label study to assess the absorption, metabolism, and excretion profile of [14C]X842 in healthy adult male subjects.
- Trial name
- NCT07107672
- Testing
- [14C]X842
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Jiangsu Sinorda Biomedicine Co., Ltd
Gastroesophageal; Reflux With Esophagitis, Gastroesophageal Reflux
Study of Dietary Patterns and Food Diversity in Russian GERD Patients
The aim of the study is to assess food diversity and dietary patterns in Russian GERD patients
- Conditions
- Gastroesophageal; Reflux With Esophagitis, Gastroesophageal Reflux, GERD, Heartburn
- Trial name
- NCT04252144
- Testing
- Dietary assessment
- Where
- Russia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Russian Academy of Medical Sciences
Esophagitis, Inflammation
Comparison of Acid Reflux at Two Levels in the Esophagus Using the BRAVO Capsule
The purpose of this research is to study the level of acid exposure above the gastroesophageal junction and the distal esophagus in patients with reflux symptoms using a capsule type acid measurement system.
- Conditions
- Esophagitis, Inflammation, Gastritis, Abdominal Pain
- Trial name
- NCT00579410
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Small Bowel Disease, Motility Disorder
Study of Oro-cecal Transit Time in Healthy Subjects Using Scintigraphy and Lactulose Hydrogen Breath Test.
Radionuclide scintigraphy is the gold standard technique to interpret OCTT but there is no normative data available for its interpretation in Indian population.
- Conditions
- Small Bowel Disease, Motility Disorder, Irritable Bowel Syndrome
- Trial name
- NCT05004207
- Testing
- 99mTc Scintigraphy
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Gastrointestinal Motility, Postoperative Pain
Effects of Mobilization and Caffeine After Cesarean
This study Maims to assess bowel motility, pain and psychological well-being in women in the post-cesarean period by mobilizing them early and encouraging them to consume coffee.
- Conditions
- Gastrointestinal Motility, Postoperative Pain, Psychological Well-Being
- Trial name
- NCT07369726
- Testing
- caffeine consumption, Decaffeinated coffee
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KTO Karatay University
Dysbiosis, Cardiometabolic Health Indicators
Pulse Education and Children
This parallel-arm, randomized controlled trial will evaluate the effectiveness of a 6-week pulse-focused nutrition intervention in school-aged children (6-13 years).
- Conditions
- Dysbiosis, Cardiometabolic Health Indicators, Education on Feeding and Health Status, Gut Motility
- Trial name
- NCT07648446
- Testing
- Education Only, Education + Pulse Provision, Cooking Class
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
Motility Disorder of Intestine, Ondansetron
Mode of Action of Ondansetron, a 5-HT Receptor 3 Antagonist, in Lactulose Induced Diarrhoea
This is a double-blind, two period, two treatment crossover trial of ondansetron verses placebo studying the effects of ondansetron in the small and large bowel, specifically its effects on the amount of water in the gut…
- Conditions
- Motility Disorder of Intestine, Ondansetron, Small Bowel Water
- Trial name
- MOLID (NCT03833999)
- Testing
- Ondansetron 8mg, abdominal MRI, Lactulose
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Effect of Gum Chewing on Regaining Bowel Motility After Cesarean Section
the Role of Gum Chewing in Regaining Bowel Motility in Patients Undergoing Cesarean Section
Aim:to evaluate the efficacy of postoperative gum chewing on the recovery of bowel motility after cesarean section.
- Trial name
- RCT (NCT03547284)
- Testing
- sugarless gum
- Where
- 2 sites in Egypt
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gastroesophageal Reflux Disease, Reflux Esophagitis
The Efficacy of i-Scan for Detecting Reflux Esophagitis
Endoscopy is a widely used modality for the diagnosis and classification of Gastroesophageal reflux disease (GERD), and the extent of esophageal mucosal breaks on endoscopy can be assessed.
- Trial name
- NCT01381991
- Testing
- i-scan
- Where
- South Korea
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Konkuk University Hospital
Visceral Obesity, Reflux Esophagitis
Adipokines and the Risk of Reflux Esophagitis
We aimed to risk faoctors for GERD and association between visceral obesity, plasma adipoline(leptin, adiponectin, IL-6, TNF-α)and development of reflux esophagitis in healthy Koreans.
- Trial name
- NCT01560598
- Where
- South Korea
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Gastrointestinal Motility and Defecation Conditions
Efficacy of Coffee Versus Peppermint Oil Intake in Promoting GIT Motility After Cesarean Section
It is a comparison between coffee effect versus peppermint oil in promoting GIT motility after cesarean section
- Trial name
- NCT04110600
- Testing
- Coffee effect on early gastric motility, Efficacy pepper mint oil on motility
- Where
- Egypt
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Gastroesophageal Reflux Disease With Esophagitis
Evaluate the Intestinal Microbiome in Patients With Erosive Gastroesophageal Reflux Disease and in Asymptomatic Healthy Controls
. In this study, we investigated intestinal microbiomes, in individuals with Gastroesophageal Reflux Disease and healthy individuals, using metagenomic techniques.
- Trial name
- NCT04248296
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Healthy
The Effect of Capsaicin and Cinnamaldehyde on Intestinal Permeability
An altered permeability has been proposed to play an important role in the pathogenesis of several gastrointestinal disorders, such as irritable bowel syndrome and inflammatory bowel disease.
- Trial name
- NCT01667523
- Testing
- Capsaicin, Cinnamaldehyde
- Where
- Netherlands
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Dysbiosis, Gastroesophageal Reflux Disease (GERD)
Effect of Bioflor on Gut Microbiota in Proton-Pump Inhibitor Users
Proton-pump inhibitors (PPIs) are widely used to treat acid-related stomach problems, such as heartburn and acid reflux. Long-term use of PPIs has been linked to changes in the gut bacteria and fungi (called the gut microbiota)…
- Trial name
- NCT07852676
- Testing
- Saccharomyces Boulardii 250 MG, Proton Pump Inhibitors (PPI)
- Where
- 3 sites in South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Gastrointestinal Motility, Healthy
Effects of Electroacupuncture at NP82 and SP15 on Bowel Motility in Healthy Subjects
This study aims to investigate how a specific combination of electroacupuncture points, Tongbian (NP82) and Daheng (SP15), affects bowel movements in healthy volunteers.
- Trial name
- EABM-HV (NCT07496697)
- Testing
- Electroacupuncture at NP82 (Tongbian) and SP15 (Daheng)
- Where
- Vietnam
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Gum Chewing, Bowel Function
Gum Chewing And Bowel Motility in Patients Undergoing Cesarean Section. Kasr el Ainy Experience
The aim of the present study was to evaluate the effect of chewing gum on the recovery of bowel function after cesarean section in women.
- Trial name
- RCT (NCT02533830)
- Testing
- sugarless gum, traditional management
- Where
- 2 sites in Egypt
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital