Clinical trials: Intestinal Mucositis
Chemotherapy, Colorectal Cancer
Effect of Losartan on the Incidence and Severity of Chemotherapy-Induced Mucositis in Gastrointestinal Cancer Patients
Mucositis is a common and clinically significant side effect of both anticancer chemotherapy and radiation therapy that can affect any portion of the gastrointestinal tract.
- Conditions
- Chemotherapy, Colorectal Cancer, Intestinal Mucositis, Oral Mucositis
- Trial name
- NCT05871333
- Testing
- Losartan 50mg Tab
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Colorectal Cancer
Effect of Atorvastatin on 5-Fluorouracil Induced Mucositis
5-Fuorouracil (5-Fu) remains one of the most effective and most commonly used drugs to treat colorectal cancer. Mucositis is a major complication that occurs in approximately 80% of patients receiving 5-FU and results in…
- Trial name
- NCT04151355
- Testing
- Atorvastatin 20mg
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Intestinal Mucositis, Inflammation
Semaglutide in Auto-HSCT
The primary objective of this clinical trial is to ievaluate the effect of semaglutide (GLP-1 receptor agonist) in reducing intensity of gastrointestinal (GI) mucositis in patients undergoing high-dosage chemotherapy followed by…
- Conditions
- Intestinal Mucositis, Inflammation, Chemotherapeutic Toxicity
- Trial name
- PROTECT (NCT06449625)
- Testing
- Semaglutide Pen Injector [Ozempic]
- Volunteers
- 40 people
- Sponsor
- Klaus Gottlob Müller
Colon Cancer
A Study of Palifermin for the Reduction of Oral Mucositis in Subjects With Stage 2B or 3 Locally Advanced, Colon Cancer
The purpose of this study is to evaluate the efficacy, safety, and tolerability of palifermin (recombinant human keratinocyte growth factor, rHuKGF) in reducing the incidence of oral mucositis in subjects with stage 2B and 3…
- Trial name
- NCT00393822
- Testing
- palifermin
- Volunteers
- 100 people
- Sponsor
- Amgen
Pelvic Toxicity, Radiation Toxicity
Gut Microbiome in Gynecological Cancer Patients With Pelvic Toxicity: Controls Versus Ozone Treatment. (MicrOzoGineTox)
Patients treated for gynecological tumors with radiotherapy (RT) and/or chemotherapy (CT) frequently develop pelvic toxicity (TPIRQT), a condition that can become persistent, progressive, and refractory to standard treatments.
- Conditions
- Pelvic Toxicity, Radiation Toxicity, Chemotherapy Toxicity, Gynecological Tumors
- Trial name
- MicrOGineTox (NCT07259681)
- Where
- 2 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Bernardino Clavo, MD, PhD
Colo-rectal Cancer, Neuropathy;Peripheral
Protective Effect of Pentoxifylline Against Chemotherapy Induced Toxicities in Patients With Colorectal Cancer
This study aims to: Evaluate the possible protective effect of pentoxifylline against oxaliplatin induced peripheral neuropathy and chemotherapy induced mucositis in patients with stage II and stage III colorectal cancer.
- Conditions
- Colo-rectal Cancer, Neuropathy;Peripheral, Mucositis
- Trial name
- NCT05590117
- Testing
- Pentoxifylline, FOLFOX-6 regimen
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Tanta University
Inflammatory Bowel Diseases, Crohn Disease
Remote Monitoring of IBD
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBD) with a heterogeneous disease course.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT05886322
- Testing
- patient reported outcome measures, fecal calprotectin, colonoscopy
- Where
- 5 sites in Netherlands
- Volunteers
- 400 people
- Sponsor
- Maastricht University Medical Center
Cancer
The FOCCUS Study: "Focusing on Cancers Chemotherapys' Untreated Symptoms"
The aim of the study is to identify how often gastrointestinal problems interfere with quality of life as a result of treatment for cancer with chemotherapy.
- Trial name
- FOCCUS (NCT02121626)
- Where
- United Kingdom
- Volunteers
- 248 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Irritable Bowel Syndrome
A Randomized Controlled Pilot Trial of Mesalazine in Patients With Irritable Bowel Syndrome
Emerging evidence indicates the presence of low-grade mucosal inflammation and its pathogenetic role in IBS. The aim of this pilot study is to provide that mesalazine treatment of IBS patients reduces low grade colonic…
- Trial name
- NCT00774007
- Testing
- mesalazine
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- SOFAR S.p.A.
Intestinal Permeability, Gastrointestinal Irritation
The Effects of Probiotics on Intestinal Permeability in Gastrointestinal Cancer Patients in Chemotherapy
The aim of this study is to test the hypothesis that adjuvant administration of probiotics in cancer patients undergoing chemotherapy can reduce a chemo-induced increased intestinal permeability.
- Conditions
- Intestinal Permeability, Gastrointestinal Irritation, Mucositis
- Trial name
- NCT03704727
- Testing
- Probiotic
- Where
- Denmark
- Volunteers
- 5 people
- Sponsor
- University of Copenhagen
Colitis, Mucositis
Lipid Use, Nutrition, and Colitis in Patients With Hematological Malignancies
In patients with acute myelogenous leukemia (AML), a high proportion will suffer from inflammation of the large bowel (colitis) during their intensive treatment.
- Conditions
- Colitis, Mucositis, AML
- Trial name
- LUNCH1 (NCT00533078)
- Testing
- omegaven
- Where
- Switzerland
- Volunteers
- 14 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Mucositis
Phase 2a Study to Evaluate Suppression of 5-Fluorouracil -Induced Mucositis by TK112690
Patients expected to receive a 500 mg/m2 of Leucovorin by iv \& 500 mg/m2 of Fluorouracil (5FU) by iv bolus for their Colorectal Cancer.
- Trial name
- NCT05669521
- Testing
- TK-112690
- Where
- 5 sites in India
- Volunteers
- 24 people
- Sponsor
- Tosk, Inc.
Irritable Bowel Syndrome With Diarrhea
Effect of FODMAPs on Mucosal Inflammation in IBS Patients
OBJECTIVE: To gain mechanistic insights, we will compare effects of low fermentable oligosaccharides, disaccharides and monosaccharides and polyols (FODMAP) and high FODMAP diets on symptoms and colonic protease expression in…
- Trial name
- NCT03221790
- Testing
- Low FODMAP Diet followed by a High FODMAP Diet
- Volunteers
- 20 people
- Sponsor
- Queen's University
HIV Infections
Effect of an Anti-Inflammatory Drug on Gut Mucosa in HIV Infected Patients
The lining of the gastrointestinal tract contains specialized lymphoid tissue that is part of the immune system. Like other parts of the immune system, HIV attacks this lymphoid tissue.
- Trial name
- NCT00069498
- Testing
- 5-aminosalicylic acid
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Functional and Motility Related Gastrointestinal Disorders Such as Irritable Bowel Syndrome and Functional Dyspepsia
A Pharmacy-based Study to Learn More About How Well Iberogast Works, How it Affects the Body, How it is Used, and User Satisfaction in Patients With Functional and Motility-related (Stomach and Bowel Movement-related) Gastrointestinal Diseases, Including Irritable Bowel Syndrome
Researchers want to learn more about the day-to-day use of Iberogast in people who have functional and motility-related gastrointestinal (stomach and bowel) diseases.
- Trial name
- NCT04993989
- Testing
- Iberogast (STW5, BAY98-7411)
- Where
- Germany
- Volunteers
- 843 people
- Sponsor
- Bayer
Ulcerative Colitis
Safety/Efficacy Study of Bovine Intestinal Alkaline Phosphatase in Patients With Moderate to Severe Ulcerative Colitis
Ulcerative colitis is characterized by abnormal activation of, and damage to, the colon epithelium, which is considered to be a central pathogenic mechanism.
- Trial name
- NCT00727324
- Testing
- bovine intestinal alkaline phosphatase (BIAP)
- Where
- 11 sites in Czechia, Italy
- Volunteers
- 22 people
- Sponsor
- AM-Pharma
Crohn's Disease, Mucosal Inflammation
Assessment of Mucosal Activity to Improve the Prognosis of Patients With Crohn's Disease Treated With Immunosuppressants
This study will test that individualized treatment in patients with Crohn's Disease in remission or mild clinical activity under immunosuppressants may improve prognosis, rather than just treating flares.
- Trial name
- ADACAL (NCT01562951)
- Testing
- ADALIMUMAB
- Where
- 30 sites in Belgium, France and 1 more
- Volunteers
- 15 people
- Sponsor
- Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
Transplant; Intestine, Transplant; Complication, Rejection
The Endoscopic Assesment of Intestinal Grafts
The study validates prospectively a new endoscopic scoring system (Gothenburg Intestinal Transplant Endoscopy Score, GITES) designed to summarize and stratify the abnormal ileal endoscopic findings after intestinal…
- Conditions
- Transplant; Intestine, Transplant; Complication, Rejection, Transplant; Failure, Bowel, Enteritis
- Trial name
- INTEGRATE (NCT03444675)
- Where
- 4 sites in United States, Argentina and 2 more
- Volunteers
- 80 people
- Sponsor
- Sahlgrenska University Hospital
Inflammatory Bowel Diseases
Mitochondrial DAMPs as Mechanistic Biomarkers of Mucosal Inflammation in Crohn's Disease and Ulcerative Colitis
The MUSIC study is a multi-centre, longitudinal study set in the real world IBD clinical setting to investigate and develop a new biomarker approach that aims to inform both patients and clinicians of the current state of the…
- Trial name
- MUSIC (NCT04760964)
- Where
- 3 sites in United Kingdom
- Volunteers
- 250 people
- Sponsor
- University of Edinburgh
Intestinal Permeability, Challenge Test
Intestinal Barrier Function and Probiotics.
Rationale: Enterotoxigenic Escherichia coli (ETEC) bacteria adhere to the mucosa of the proximal intestines. There it produces an toxin which presents a local and relevant challenge to the intestines.
- Conditions
- Intestinal Permeability, Challenge Test, Intestinal Health, Inflammation
- Trial name
- NCT01241201
- Testing
- Priobiotic supplement VSL#3
- Where
- Netherlands
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- TNO