Clinical trials: Intestinal Neoplasm
Breast Cancer, Colorectal Cancer
Detection of Cancer in Breath Samples by Trained Detection Dogs
The goal of this study is to show that trained detection dogs can identify breast, lung, prostate or colorectal cancer by sniffing masks containing breath samples.
- Conditions
- Breast Cancer, Colorectal Cancer, PROSTATE CANCER, Lung Cancer
- Trial name
- NCT06255041
- Where
- 2 sites in Israel
- Volunteers
- 1,386 people, healthy volunteers welcome
- Sponsor
- SpotitEarly
Anus Neoplasms
The Feasibility of Self or Partner-assisted Digital Anal Exam Screening
There is no standard screening protocol for anal cancer even as disease incidence increases. This single-visit study will clarify if single persons can do a self-digital anal exam, or perhaps the exam requires a partner, or if…
- Trial name
- NCT02384005
- Testing
- Self-anal exam arm
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Human Papilloma Virus, Cervical Cancer
Integrating a Health Information Technology System for Primary and Secondary Cervical Cancer Prevention
The project aims to increase HPV vaccination and cervical cancer screening through a web-based mobile health education program called, Wheel of Wellness (WoW) and a brief negotiated interview (BNI).
- Conditions
- Human Papilloma Virus, Cervical Cancer, Human Papillomavirus Infection, Oropharyngeal Cancer
- Trial name
- NCT03346915
- Testing
- WoW and BNI
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Adrenal Cortical Cancer, Brain Cancer
Spectroscopy With Surface Coils and Decoupling
The purpose of this study is to obtain chemical information from part of your body without a biopsy. This is done using a technique called magnetic resonance spectroscopy (MRS) which is similar to magnetic resonance imaging (MRI)…
- Conditions
- Adrenal Cortical Cancer, Brain Cancer, Breast Cancer, CNS Cancer
- Trial name
- NCT00581815
- Testing
- Proton-decoupled 31P MRS at 1.5T, 1H Spectroscopy at 1.5T and 3T
- Where
- United States
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
RAS Mutation, Ras (Kras or Nras) Gene Mutation
Leflunomide or Combination of MEK Inhibitor and Hydroxychloroquine for Refractory Patients With RAS Mutations
There is a huge variety of nucleotide substitutions that activate RAS. The search for new "universal" drugs for the RAS pathway that either interfere with RAS upregulation upstream in the signaling pathway or offset the…
- Conditions
- RAS Mutation, Ras (Kras or Nras) Gene Mutation, Colorectal Cancer Recurrent, Pancreas Cancer
- Trial name
- NТО-RAS (NCT06229340)
- Testing
- Leflunomide, The combination of MEK inhibitor + hydroxychloroquine( plaquenil) ± bevacizumab
- Where
- Russia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Colorectal Cancer, Colorectal Cancer Stage I
Web-based Learning Module on Optical Diagnosis of Early Colorectal Cancer
International guidelines recommend deciding the treatment of colorectal lesions based on the estimated histology by endoscopic optical diagnosis.
- Trial name
- LODIP (NCT05663788)
- Testing
- E-learning module
- Where
- 12 sites in United States, Japan and 2 more
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Lymphoma
Diphenoxylate / Atropine to Decrease FDG Activity During F-18 FDG PET
2-[18F]-fluoro-2-deoxyD-glucose positron emission tomography (FDG PET) has proven to be a valuable clinical tool for the staging and surveillance of lymphoma.1-6 Occasionally, lymph nodes in the mesentery and retroperitoneum can…
- Trial name
- NCT00583323
- Testing
- Lomotil, Normal saline
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Colorectal Cancer Screening, Colorectal Cancer (CRC)
Improving Colorectal Cancer Early Screening in Portugal: Identification of Gut Microbiome Biomarkers in Stool (GUTBIOME-PT)
Colorectal cancer (CRC) is a major public health problem, responsible for 2 million new cases and almost 1 million deaths annually worldwide.
- Conditions
- Colorectal Cancer Screening, Colorectal Cancer (CRC), Microbiome
- Trial name
- GUTBIOME-PT (NCT06741293)
- Testing
- No intervention: observational study
- Where
- Portugal
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Gulbenkian Institute for Molecular Medicine
Colorectal Neoplasms, Colonic Polyp
Adenoma Detection Rate Using Endocuff Vision in China
The primary aim of this study is to explore the usefulness of Endocuff Vision in colonoscopy on adenoma detection rate (ADR). Other aims include to explore the data below when Endocuff Vision is used.
- Conditions
- Colorectal Neoplasms, Colonic Polyp, Adenoma
- Trial name
- SinoEVADR (NCT03839277)
- Testing
- Endocuff Vision
- Where
- 5 sites in China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Colorectal Cancer
Blood Collection Sub-Study of Exact Sciences Protocol 2019-01: "Clinical Validation of an Optimized Multi-Target Stool DNA (Mt-sDNA 2.0) Test, For Colorectal Cancer Screening BLUE-C"
The primary objective of this sub-study, 2019-01B, is to collect blood specimens for research use in the development and validation of a blood-based test for colorectal cancer (CRC).
- Trial name
- NCT04144751
- Testing
- Blood Sample Collection
- Where
- 194 sites in United States
- Volunteers
- 23,494 people, healthy volunteers welcome
- Sponsor
- Exact Sciences Corporation
Colon Cancer
TVB 2640 for Resectable Colon Cancer Other Resectable Cancers; a Window Trial.
Primary Objective To evaluate the pharmacodynamic effects on metabolic endpoints (malonyl carnitine and tripalmitin levels) following short-term treatment with TVB-2640 in patients with resectable cancers Secondary Objectives To…
- Trial name
- NCT02980029
- Testing
- TVB-2640
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Mark Evers
Cancer of the Breast, Cancer of Stomach
Vocorder Device Validation in Clinical Settings - Continuous Monitoring of Individuals (Vocorder Clinical Validation-VCV)
This is performed under Vocorder project that is Co-Funded by the European Union. (Grant Agreement 101115442 VOCORDER HORIZON EIC-2022-PATHFINDERCHALLENGE-01).
- Conditions
- Cancer of the Breast, Cancer of Stomach, Colon Cancer, Lung Cancers
- Trial name
- VCV (NCT06711939)
- Where
- Greece
- Volunteers
- 515 people, healthy volunteers welcome
- Sponsor
- Mitera Hospital
Inflammatory Bowel Disease, Crohn Disease
Pneumococcal Vaccination in Patients With Inflammatory Bowel Disease
Patients with inflammatory bowel disease (IBD) will be assessed for immunologic response to pneumococcal vaccination. Patients with IBD meet criteria as outlined by the Centers for Disease Control (CDC) for pneumococcal…
- Conditions
- Inflammatory Bowel Disease, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT00829595
- Testing
- 23-valent polysaccharide pneumococcal vaccine (Pneumovax TM)
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Colorectal Cancer (Diagnosis)
ColoSense Post-Approval Study
The post-approval study (PAS) described here will supplement existing data generated in the CRC-PREVENT clinical trial. The primary outcomes of this supplemental study will include: clinical sensitivity, clinical specificity…
- Trial name
- NCT07069556
- Testing
- ColoSense
- Where
- United States
- Volunteers
- 12,500 people, healthy volunteers welcome
- Sponsor
- Geneoscopy, Inc.
Colorectal Cancer
Decision Aid to Technologically Enhance Shared Decision Making
Physicians face a challenge in promoting colorectal cancer screening (CRCS) in the face of multiple competing demands. A decision aid (DA) that clarifies patient preferences and improves decision quality could aid shared decision…
- Trial name
- DATES (NCT01514786)
- Testing
- Colorectal Web
- Where
- 14 sites in United States
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Colorectal Cancer
The Purpose of This Study is to Determine the Frequency of Colorectal Cancer in Male and Female Endurance Athletes Between the Ages of 35 and 50
The purpose of this study is to determine the frequency of colorectal cancer in male and female endurance athletes between the ages of 35 and 50.
- Trial name
- NCT05419531
- Testing
- prospective observational study - screening and follow up colonoscopy
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Inova Health Care Services
Colorectal Cancer
Development and Validation of Metabolic Biomarkers for Early Diagnosis, Prognosis, and Recurrence of Colorectal Cancer：MetBio-CRC
This prospective clinical observational study aims to construct a metabolite database specifically for colorectal cancer patients using metabolomics technology.
- Trial name
- NCT07068529
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Irritable Bowel Syndrome
A Phase 1, Randomized, Placebo-Controlled, Ascending Cohort, Dose Escalation Study in Normal Healthy Volunteers
GSK3179106 is a potent and relatively selective inhibitor of RET kinase which has been designed to be a safe and effective therapy for irritable bowel syndrome (IBS) patients .
- Trial name
- NCT02727283
- Testing
- GSK3179106
- Where
- Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Anal Cancer
ASSESSING THE GAY MALE EXPERIENCE WITH ANAL CANCER PREVENTION STRATEGIES
The purpose of this study is to describe current knowledge and opinions about anal cancer screening among men who have sex with men (MSM), as well as their experience receiving guideline-compliant care aimed at anal cancer risk…
- Trial name
- NCT05628194
- Testing
- Observational/Survery
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Colorectal Cancer
Efficacy of Perioperative Duloxetine as a Part of Multimodal Analgesia in Laparoscopic Colorectal Cancer Surgery
Our aim will be to evaluate the efficacy of perioperative Duloxetine in decreasing acute postoperative pain after laparoscopic colorectal cancer surgery and its role in reducing postoperative morphine requirements
- Trial name
- NCT04294953
- Testing
- Duloxetine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
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