Clinical trials: Intestinal Permeability
Colitis, Ulcerative
A First Time in Human Study to Evaluate the Safety and Tolerability of GSK4381406 in Healthy Participants
This is a 3-part First Time in Human (FTIH) study to evaluate the safety, tolerability, and pharmacokinetics (PK) profile of GSK4381406 following administration of single ascending doses (Part 1), repeat ascending doses (Part 2)…
- Trial name
- NCT05999708
- Testing
- GSK4381406, Indomethacin
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Disbiosis, Abdominal Pain
Evaluation of the Beneficial Effects of a Probiotic Product in Healthy Adult Subjects.
A randomized, double-blind, placebo-controlled, cross-over trial performed at one centre in Italy to explore the ability of a multistrain probiotic mixture, to modulate markers of inflammation and intestinal barrier function and…
- Conditions
- Disbiosis, Abdominal Pain, Constipation, Diarrhea
- Trial name
- NCT03234452
- Testing
- Lactoflorene plus
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Montefarmaco OTC SpA
Irritable Bowel Syndrome, Visceral Hypersensitivity
Gut Permeability, Sensitivity and Symptomatology
To better understand the relationship between gut barrier function and the symptomatology and pathophysiology of irritable bowel syndrome (IBS).
- Trial name
- GPSS (NCT02358564)
- Testing
- Gastrointestinal Permeability Test, Upper Endoscopy, Rectal Barostat and Infusion of Fats
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy Adult Participants
Multilevel Exercise Response in Rowers
This observational study aims to evaluate multilevel physiological, molecular, metabolic, intestinal, immunological, and psychophysiological responses to rowing-specific exercise in elite rowers.
- Trial name
- NCT07613619
- Testing
- 2000-m rowing ergometer test, 6000-m rowing ergometer test
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Endothelial Dysfunction
Effect of 2000-meter Rowing Test on Parameters of Intestinal Integrity in Elite Rowers During Competitive Phase
The study aimed to check the 2000m ergometer test on markers of gut permeability in the competitive phase of rowers. 18 members of the Polish rowing team took part in the study.
- Trial name
- Rowers (NCT06372262)
- Testing
- ergometer test
- Where
- Poland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Preleukemia, Myelodysplastic Neoplasm
Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS
This is a single-arm pilot study of the feasibility and safety of metformin in patients with clonal cytopenia of undetermined significance (CCUS) or lower-risk myelodysplastic neoplasms (LR-MDS).
- Conditions
- Preleukemia, Myelodysplastic Neoplasm, Cytopenia, Preleukemic Anemia
- Trial name
- NCT04741945
- Testing
- Metformin
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kirsten Grønbæk
Healthy Volunteers
The Effects of the Synbiotic Ecologic 825/scFOS on Intestinal Barrier Function and Immune Modulation
In the present pilot study, the investigators will study the effects of a novel synbiotic, which is a mix of probiotics (Ecologic 825) in the presence of a prebiotic (short chain fructo-oligosaccharide (scFOS)), on mucosal…
- Trial name
- CRIB (NCT02018900)
- Testing
- Ecologic 825/scFOS
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Low-grade Inflammation, Increased Intestinal Permeability
Probiotics Against Low Grade Inflammation and Increased Intestinal Permeability in the Elderly
The purpose of this study is to evaluate the ability of a blend of berries and probiotics in reducing low-grade inflammation and intestinal permeability in the elderly. The intervention period is one month.
- Trial name
- NCT02342496
- Testing
- Active, only probiotics, Active, blend of berries and probiotics
- Where
- Sweden
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Probi AB
Obesity & Overweight
Changes in Intestinal Permeability and Systemic Inflammation Following Fast Food Overfeeding.
The purpose of this study is to investigate whether lifestyle factors can alter gut barrier integrity and whether disruptions of the gut barrier can trigger systemic and tissue-specific inflammation.
- Trial name
- ChIPS (NCT07893743)
- Testing
- Fast-food overfeeding
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Irritable Bowel Syndrome
The Effect of Serotonergic Modulation on Intestinal Permeability and Visceral Hypersensitivity in Healthy Individuals and Irritable Bowel Syndrome (IBS) Patients
Serotonin, 5-hydroxytryptamin (5-HT), plays an important role in regulating the gastrointestinal functions. In this study we will modulate the serotonin system with acute tryptophan depletion (ATD) and administration of…
- Trial name
- NCT00731003
- Testing
- Oxitriptan, Acute tryptophan depletion, Amino acid drink with tryptophan
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Microscopic Colitis
Ussing Experiments to Evaluate the Role of Medication-induced Microscopic Colitis
Medication use, especially NSAIDs and PPIs, prior to diagnosis is considered a risk factor for MC development. However, the exact pathophysiological mechanism is unclear.
- Trial name
- NCT02303132
- Testing
- Ussing experiment
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Insulin Resistance, Ethanol
The Effects of Ethanol on Intestinal Permeability and Gut Hormones
The aime of this study is to envsitigate if ethanol has an incretin effect. This is done by administration of ethanol orally vs. an isoethanolaemic i.v. infusion of ethanol.
- Conditions
- Insulin Resistance, Ethanol, Incretin Effect
- Trial name
- NCT03348371
- Testing
- Ethanol
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Intestinal Permeability, Inflammation
Induction of Gut Permeability by an Oral Vaccine
This study evaluates the effect of an oral typhoid vaccine on disruption of the intestinal barrier and response of the immune system.
- Conditions
- Intestinal Permeability, Inflammation, Vaccine, Typhoid Fever
- Trial name
- NCT04083950
- Testing
- Vivotif Typhoid Oral Vaccine, Aspirin (Positive Control)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Healthy
Effect of Zinc Carnosine on Intestinal Permeability in Healthy Volunteers
Zinc carnosine is a food supplement which is available in the health food shops. The investigators wish to see if it can reduce intestinal swelling in people who take non-steroidal anti-inflammatory (anti-swelling) drugs (NSAIDs…
- Trial name
- NCT00149149
- Testing
- Zinc Carnosine coadministered with Indomethacin
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Anorexia Nervosa
Study of Intestinal Permeability in Patients With Anorexia Nervosa
In healthy humans, the intestinal mucosa acts as an absorption organ and a defensive barrier preventing the passage of toxic substances from the intestinal lumen to the blood stream.
- Trial name
- PIANO (NCT02170467)
- Testing
- assessment of the intestinal permeability
- Where
- 2 sites in France
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Crohn Disease
Oral Administration of MB-102 Versus Dual Sugar Testing for Gut Permeability
The objectives of the study are to evaluate the safety and tolerability of oral administration of MB-102, and to evaluate the use of MB-102 as a means of measuring gut permeability in normal participants (n=10) and in those with…
- Trial name
- NCT03962998
- Testing
- Lactulose/Rhamnose solution, MB-102
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- MediBeacon
Celiac Disease, Irritable Bowel Syndrome
Gut Peptides and Intestinal Permeability in Celiac Disease and Irritable Bowel Syndrome
It is well known that the intestinal barrier is altered in celiac disease (CD), an autoimmune disease that develops in genetically predisposed subjects exposed to ingestion of wheat gliadin and of related prolamines of barley and…
- Trial name
- PPCD (NCT01574209)
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Focus: Simplified Method to Assess Intestinal Permeability
Biomarkers for Intestinal Permeability
This study aims to find easy-to-measure biomarkers of intestinal permeability as surrogate markers for effortful "gold standard" methods.
- Trial name
- NCT04667208
- Where
- Germany
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Obesity, Endotoxemia
Dietary Green Tea Confection For Resolving Gut Permeability-Induced Metabolic Endotoxemia In Obese Adults
This study is focused on assessing gastrointestinal-level improvements by which green tea limits metabolic endotoxemia. It is completed in two phases.
- Conditions
- Obesity, Endotoxemia, Inflammation
- Trial name
- NCT03413735
- Testing
- Green Tea Extract
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Healthy
A Study of Perturbation of Human Small Intestinal Colonic Permeability
The purpose of this study is to evaluate the effect of castor oil versus placebo on intestinal permeability in healthy individuals.
- Trial name
- NCT06033222
- Testing
- Ricinoleic Acid 750 mg, Ricinoleic Acid 1500 mg, Ricinoleic Acid 3000 mg
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic