Clinical trials: Intestinal Permeability
Ulcerative Colitis, Healthy
GI Permeability Change in Response to Aquamin®
This trial is being completed to learn about how Aquamin® affects gastrointestinal permeability, or the control of material passing from inside the gastrointestinal tract through the gut wall into the rest of the body, in people…
- Conditions
- Ulcerative Colitis, Healthy, Irritable Bowel Syndrome With Diarrhea
- Trial name
- NCT04855799
- Testing
- Aquamin
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- James Varani
Healthy Volunteers
The Effects of the Synbiotic Ecologic 825/scFOS on Intestinal Barrier Function and Immune Modulation
In the present pilot study, the investigators will study the effects of a novel synbiotic, which is a mix of probiotics (Ecologic 825) in the presence of a prebiotic (short chain fructo-oligosaccharide (scFOS)), on mucosal…
- Trial name
- CRIB (NCT02018900)
- Testing
- Ecologic 825/scFOS
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity, Overweight
Long-term Effects of Arabinoxylans on Intestinal Barrier Function
The higher prevalence of overweight and obesity among the population contributes to increased incidences of chronic metabolic diseases.
- Trial name
- NCT01877044
- Testing
- NAXUS
- Where
- Netherlands
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Intestinal Permeability, Leaky Gut Syndrome
Dietary Supplements for Reduction of Intestinal Permeability Levels
A randomised and controlled trial, in which the effect of a dietary supplement is evaluated for reduction of intestinal permeability levels of subjects with high levels of zonulin in feces
- Conditions
- Intestinal Permeability, Leaky Gut Syndrome, Zonulin
- Trial name
- permeability (NCT06760377)
- Testing
- Dietary supplement Group
- Where
- Spain
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Obesity, Overweight and Obesity
Assess the Effect of a Whole Fruit Powder on Gut Microbiome Function on Overweight & Obese Adults
The goal of this clinical trial is to evaluate the effect of freeze-dried blueberry powder on the gut microbiome in overweight and obese adults.
- Trial name
- NCT06256653
- Testing
- Freeze-dried blueberries
- Where
- Ireland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College Cork
Endothelial Dysfunction
Effects of Krill Oil on Intestinal Integrity Markers in Elite Rowers.
The study aims to check the influence of krill oil on markers of intestinal injury and intoxication. Research group: the research will be conducted in a homogeneous group of professional rowers (N=30), all competitors qualified…
- Trial name
- NCT06271434
- Testing
- THYROX (Atlantic krill oil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Malnutrition Pregnancy, Malnutrition in Children
Early Life Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories
Malnutrition in women of reproductive age remains a public health concern in Sub-Saharan Africa (SSA). Malnutrition during pregnancy affects foetal growth with a tendency of the exposed infants to also develop it.
- Conditions
- Malnutrition Pregnancy, Malnutrition in Children, Malnutrition (Calorie), Environmental Enteric Dysfunction
- Trial name
- UZBCS-2 (NCT07195006)
- Testing
- Malnutrition in pregnancy as exposure, Poor WASH living conditions as exposure
- Where
- Zimbabwe
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Irritable Bowel Syndrome
The Effect of Serotonergic Modulation on Intestinal Permeability and Visceral Hypersensitivity in Healthy Individuals and Irritable Bowel Syndrome (IBS) Patients
Serotonin, 5-hydroxytryptamin (5-HT), plays an important role in regulating the gastrointestinal functions. In this study we will modulate the serotonin system with acute tryptophan depletion (ATD) and administration of…
- Trial name
- NCT00731003
- Testing
- Oxitriptan, Acute tryptophan depletion, Amino acid drink with tryptophan
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Irritable Bowel Syndrome
Sucrose Breath Test to Determine Intestinal Permeability in IBS
Irritable Bowel Syndrome (IBS) is a growing clinical diagnosis affecting 10-20% of the US population. While current diagnostic criteria aids in correctly diagnosing IBS, the cause of the disease still remains unclear.
- Trial name
- NCT01674088
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Metabolic Solutions Inc.
Leaky Gut Syndrome
Effect of Colostrum on Gut Permeability and Endotoxin Level in Chronic Alcoholic Disease
Chronic alcohol ingestion is related with leaky gut syndrome. Colostrum is well-studied that it has a effect of decreasing the degree of leaky gut syndrome.
- Trial name
- NCT01088087
- Testing
- colostrum
- Where
- South Korea
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Obesity, Circadian Dysregulation
Impact of Blueberry Consumption on Gastrointestinal Health
This study will evaluate the impact of blueberry consumption on markers of gastrointestinal health including gut microbiota, intestinal permeability, and gut-derived inflammation in those vulnerable to a unhealthy gut milieu.
- Trial name
- NCT03934177
- Testing
- Blueberry powder
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Crohn's Disease, Short Bowel Syndrome
Citrulline: A Plasmatic Marker to Assess and Monitor Small Bowel Crohn's Disease Patients
Citrulline is an amino acid produced in the intestine and in the liver, but the liver does not contribute significantly to circulating citrulline concentrations.
- Conditions
- Crohn's Disease, Short Bowel Syndrome, Malabsorption Syndromes, Celiac Disease
- Trial name
- NCT00138879
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- St Mark's Hospital Foundation
Healthy
The Effect of Capsaicin and Cinnamaldehyde on Intestinal Permeability
An altered permeability has been proposed to play an important role in the pathogenesis of several gastrointestinal disorders, such as irritable bowel syndrome and inflammatory bowel disease.
- Trial name
- NCT01667523
- Testing
- Capsaicin, Cinnamaldehyde
- Where
- Netherlands
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Intestinal Permeability
Intestinal Permeability
Rationale: Intestinal permeability of subjects can vary depending on their health status. It is therefore important to be able to measure and quantify intestinal permeability in a standardized way.
- Trial name
- NCT01049386
- Testing
- No intervention, Sugar absorption test
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- TNO
Healthy
Investigating Effects in Intestinal Permeability of Rich in Beta-glucans Pleurotus Eryngii Mushrooms Fermentation Supernatants: an Ex-vivo Study
The aim of the present study was to investigate the ability of Pleurotus eryngii mushrooms fermentation products (FS) to counteract induced intestinal hyperpermeability in human colonic tissues in an ex vivo system.
- Trial name
- FUNglucan (NCT05446610)
- Testing
- Fermented product of Pleurotus eryngii mushroom
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Microscopic Colitis
Ussing Experiments to Evaluate the Role of Medication-induced Microscopic Colitis
Medication use, especially NSAIDs and PPIs, prior to diagnosis is considered a risk factor for MC development. However, the exact pathophysiological mechanism is unclear.
- Trial name
- NCT02303132
- Testing
- Ussing experiment
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Colitis, Ulcerative
A First Time in Human Study to Evaluate the Safety and Tolerability of GSK4381406 in Healthy Participants
This is a 3-part First Time in Human (FTIH) study to evaluate the safety, tolerability, and pharmacokinetics (PK) profile of GSK4381406 following administration of single ascending doses (Part 1), repeat ascending doses (Part 2)…
- Trial name
- NCT05999708
- Testing
- GSK4381406, Indomethacin
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Inflammatory Bowel Diseases, Parkinson Disease
Gut Microbiota Dysbiosis and Translocation During IBD and Parkinson
Inflammatory bowel diseases (IBD) and Parkinson disease (PD) are complex and multifactorial pathologies. Gut microbiota seems to play an active role.
- Trial name
- Medibiote1 (NCT04159727)
- Testing
- stool and blood analysis
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hôpital Européen Marseille
Healthy
A Study of Perturbation of Human Small Intestinal Colonic Permeability
The purpose of this study is to evaluate the effect of castor oil versus placebo on intestinal permeability in healthy individuals.
- Trial name
- NCT06033222
- Testing
- Ricinoleic Acid 750 mg, Ricinoleic Acid 1500 mg, Ricinoleic Acid 3000 mg
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cardiometabolic Health Indicators, Vascular Function in Healthy Volunteers
Mango Intake and Gut and Cardiometabolic Health in Hispanic/Latino Adolescents
Mangos contain a number of nutrients that may improve gut and metabolic health. The purpose of this research is to see how eating mangos every day for 4 weeks instead of snacks high in calories and low in nutrients such as…
- Conditions
- Cardiometabolic Health Indicators, Vascular Function in Healthy Volunteers, Inflammation
- Trial name
- NCT07125001
- Testing
- Ataulfo mango
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, Davis