Clinical trials: Intestinal Stricture
Intestinal Stricture
POISE I Pilot Study
POISE I study is a feasibility study for evaluating the safety and efficacy of DCB.
- Trial name
- POISE (NCT03886324)
- Testing
- GIE Medical Drug Coated Balloon
- Where
- Paraguay
- Volunteers
- 10 people
- Sponsor
- GIE Medical
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Strictures Due to Crohn's Disease
A Phase 2, Placebo-Controlled Study of Oral RXC008 for Crohn's Strictures
Crohn's disease (CD) is chronic inflammatory bowel disease where any part of the Gastrointestinal (GI) tract can become inflamed and develop fibrotic strictures.
- Trial name
- ROCKETEER (NCT07832435)
- Testing
- High Dose, Low Dose
- Volunteers
- 180 people
- Sponsor
- Redx Pharma Ltd
Crohn Disease, Stricture; Bowel
Prospective Randomized Comparative Study of the Treatment of Multisegmental Fibrostenosing Crohn's Disease.
Stenosis is one of the most frequent complications in patients with Crohn's disease (CD). In particular, CD patients with multi segmental intestinal strictures are often faced with short bowel syndrome after repeated or extensive…
- Trial name
- SUREST (NCT04865484)
- Testing
- Surgical resection, Endoscopic stricturotomy, Strictureplasty
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Gastric Foreign Body, Nos, Disorder of Abdomen (Disorder)
Transluminal Flexible Endoscopic Procedure in Foregut and Urologic Surgery
NOTES access is safe and feasible in the controlled human setting and comparable to standard-of-care surgical techniques. NOTES exploration of the abdomen provides adequate visualization comparable to laparoscopy.
- Conditions
- Gastric Foreign Body, Nos, Disorder of Abdomen (Disorder), Foreign Body in Esophagus, Prostatic Diseases
- Trial name
- NOTES (NCT00484783)
- Testing
- Natural Orifice Transluminal Endoscopic Surgery (NOTES), Natural Orifice Translumenal Endoscopic Surgery (NOTES)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University Hospitals Cleveland Medical Center
Anastomotic Leak, Anastomotic Haemorrhage
THREE-row Circular STAPLER in Low Anterior Resection for Rectal Cancer
This trial aims to assess safety and efficacy of three-row circular staplers compared to two-row surgical stapllers in short-term and long-term perspective in patients with rectal cancer undergoing low anterior resection with…
- Conditions
- Anastomotic Leak, Anastomotic Haemorrhage, Anastomotic Complication, Rectal Neoplasms
- Trial name
- THREESTAPLER (NCT03910699)
- Testing
- Three-row circular stapler, Two-row circular stapler
- Where
- Russia
- Volunteers
- 154 people
- Sponsor
- Russian Society of Colorectal Surgeons
Mesenteric Ischemia, Bowel; Ischemic
Copenhagen Mesenteric Stent Study - A Randomized Trial of Stent Versus Covered Stent Treatment for Chronic Mesenteric Ischemia
Chronic mesenteric ischemia (CMI) is often caused by narrowings in the arteries providing blood to the intestines. Endovascular stent placement is considered the preferred treatment for this condition.
- Conditions
- Mesenteric Ischemia, Bowel; Ischemic, Superior Mesenteric Atherosclerosis, Mesenteric Artery Stenosis
- Trial name
- COMESS (NCT05244629)
- Testing
- BMS vs. CS
- Where
- Denmark
- Volunteers
- 98 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Colonic Obstruction, Colonic Stricture
Treatment of Colonic Obstruction With Cook Evolution® Colonic Stent System
The objective of this registry is to compile clinical data on the use of the Evolution® Colonic Stent System for the palliative treatment of colonic obstruction or strictures caused by malignant neoplasms and to relieve acute…
- Conditions
- Colonic Obstruction, Colonic Stricture, Large Bowel Obstruction
- Trial name
- NCT01102283
- Testing
- Evolution(R) Colonic Stent
- Where
- 10 sites in Canada, Denmark and 5 more
- Volunteers
- 80 people
- Sponsor
- Cook Group Incorporated
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Crohn Disease
Safety and Efficacy of MBF-118 in Patients with Crohn Disease
This is a Phase IIa (proof of concept), single center clinical trial to evaluate the safety and efficacy of daily MBF-118 oral treatment during 28 days in Crohn's disease patients on top of standard of care.
- Trial name
- NCT05940558
- Testing
- MBF-118 oral capsules
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Medibiofarma S.L.
Crohn Disease
Open-label Single-arm Study to Assess the Efficacy of Mirikizumab in Patients With Inflammatory Strictures Due to CD
This is an open-label, single-arm, phase 4 study to assess the safety and efficacy of mirikizumab in approximately 60 participants with stricturing CD.
- Trial name
- MIRIAD (NCT06997965)
- Testing
- Mirikizumab
- Where
- 8 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Alimentiv Inc.
Crohn Disease, Inflammatory Bowel Diseases
Stricture Definition and Treatment (STRIDENT) Drug Therapy Study
Two thirds of patients with Crohn's disease require intestinal surgery at some time in their life. Intestinal strictures, that is narrowing of the bowel due to inflammation and scarring, are the most common reason for surgery.
- Conditions
- Crohn Disease, Inflammatory Bowel Diseases, Stricture; Bowel
- Trial name
- STRIDENT (NCT03220841)
- Testing
- Adalimumab Injection, Thiopurine, Endoscopic balloon dilatation
- Where
- Australia
- Volunteers
- 78 people
- Sponsor
- St Vincent's Hospital Melbourne
Crohn Disease
Pre-stenotic Inflammation Following Endoscopic Balloon Dilatation in Crohn's Disease: A Prospective Study
As a consequence of chronic relapsing inflammation in Crohn's disease (CD), progressive bowel damage and scarring occurs in affected regions of intestine.
- Trial name
- NCT04803916
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Shaare Zedek Medical Center
Atherosclerotic Cardiovascular Disease, Coronary Artery Disease
Coated or Chewable Aspirin and a Hybrid Strategy to Mitigate Adverse Effects of Air Pollution in Stable Atherosclerotic Disease
Although both enteric-coated and plain formulations of aspirin are being used commonly, there are no high-quality comparisons between these formulations with respect to clinical efficacy outcomes in patients with atherosclerotic…
- Conditions
- Atherosclerotic Cardiovascular Disease, Coronary Artery Disease, Ischemic Heart Disease, Ischemic Stroke
- Trial name
- COATED-AIR (NCT06541691)
- Testing
- Enteric-coated aspirin, Plain aspirin, Hybrid strategy
- Where
- Iran
- Volunteers
- 3,000 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
Inflammatory Bowel Disease
Tracking the Natural Course of Silent Small Bowel Narrowing in Adults With Crohn's Disease
Crohn's disease is a long-term condition that causes inflammation in the digestive tract. Over time, some people develop narrowings in the small intestine, called "strictures." These strictures can block food and cause symptoms…
- Trial name
- SILENCE (NCT07167745)
- Where
- Serbia
- Volunteers
- 150 people
- Sponsor
- University Medical Center Zvezdara
Colorectal Cancer, Coffee
COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER
This is research study is assessing the effects of 6-g daily use of freeze-dried instant coffee on liver fat and fibrosis and the gut microbiome and metabolome in patients who have completed routine treatment (including surgery…
- Conditions
- Colorectal Cancer, Coffee, Gastrointestinal Microbiome, Stenosis
- Trial name
- COMMENCER (NCT05692024)
- Testing
- Nestlé NESCAFÉ® TASTER'S CHOICE® House Blend capsule.
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Crohn Disease
Endoscopic Balloon Dilation Versus Endoscopic Stricturotomy for Short Crohn's Strictures
Crohn's disease (CD) related strictures can be treated endoscopically by endoscopic balloon dilation (EBD) or endoscopic stricturotomy (EST). EBD is is the established endoscopic treatment for short strictures in Crohn's disease.
- Trial name
- BEST-CD (NCT05521867)
- Testing
- Endoscopic balloon dilation, Endoscopic stricturotomy with or without stricturoplasty
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Asian Institute of Gastroenterology, India
Crohn's Disease
Adalimumab Intralesional in Intestinal Strictures of Crohn's Disease Patients
We study if the administration of intralesional Adalimumab (directly injected in the stricture) associated to endoscopic dilatation has a higher success rate at week 8 compared with placebo in patients with Crohn's disease who…
- Trial name
- NCT01986127
- Testing
- Adalimumab
- Where
- 13 sites in Spain
- Volunteers
- 26 people
- Sponsor
- Sara Varea
Crohn Disease
Prospective Multicenter Randomized Comparative Study of the Treatment of de Novo Stenosis in Chron's Disease.
Stenosis is one of the most frequent complications in patients with Crohn's disease (CD), causing greater morbidity and increasing the probability of repeated surgery and short bowel syndrome (1-3).
- Trial name
- ENDOCIR (NCT04330846)
- Testing
- Surgical resection
- Where
- 16 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
Urethral Stricture, Male
Small Intestinal Submucosa Graft for Repair of Anterior Urethral Strictures
The field of research for this study is tissue engineering and the utilization of a small intestinal submucosa graft as a substitute biomaterial for conventional buccal mucosa in substitution urethroplasty of anterior urethral…
- Trial name
- NCT06192654
- Testing
- Small intestinal submucosa (SIS) graft urethroplasty, Autologous oral bucal mucosa graft urethroplasty
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xiaoyong Zeng