Clinical trials: Intestinal Transplant
Ulcerative Colitis
Fecal Microbiota Transplantation (FMT) in the Management of Active Ulcerative Colitis
Manipulation of the intestinal microbiota through FMT is a potential therapeutic target for IBD patients. Studies are now required to determine if repeated FMT can overcome the apparent immune response to FMT thereby maintaining…
- Trial name
- NCT02227342
- Testing
- Fecal Microbiota Transplant
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of Alberta
Rectal Cancer, Erectile Dysfunction
Stem Cell Therapy Combined With NeuroRegen Scaffold™ in Patients With Erectile Dysfunction After Rectal Cancer Surgery
Erectile dysfunction (ED) is one of the commonest complications in men after rectal cancer treatment. The purpose of this study is to assess the safety and efficacy of autologous bone marrow mononuclear cells (BMMCs) or…
- Trial name
- NCT02648386
- Testing
- Laparoscopic surgery, NeuroRegen scaffold transplantation, NeuroRegen scaffold/BMMCs transplantation
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Chinese Academy of Sciences
Colorectal Cancer, Liver Metastasis
Liver Transplantation and Colorectal Cancer
Colorectal liver metastases (CLM) are currently considered an absolute contraindication for liver transplantation (Lt) although Lt for other primary and secondary liver malignancies show excellent outcome in selected patients.
- Trial name
- NCT01479608
- Testing
- Liver transplantation and liver resection
- Where
- Norway
- Volunteers
- 25 people
- Sponsor
- Oslo University Hospital
Allografted With Myeloablative Conditioning
Complement and Graft-versus-host Disease
Allogeneic haematopoietic stem cell transplantation (HSCT) often remains the only curative treatment for haematological malignancies.
- Trial name
- NCT01520623
- Testing
- Serum concentration /Serum inflammatory
- Where
- 3 sites in France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multidrug Resistant Organisms, Faecal Microbiota Transplantation
The Effect of Faecal Microbiota Transplantation (FMT) on Eradication of Multidrug Resistant Organisms (MRO) in Intestinal Carriers
The aim of this study is to investigate the effect of faecal microbiota transplantation (FMT) on eradication of multidrug resistant organisms (MRO) in the intestine.
- Trial name
- FEMRO (NCT05742074)
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 83 people
- Sponsor
- Hvidovre University Hospital
Ulcerative Colitis
The Effect of Therapeutic Fecal Transplant on the Gut Microbiome in Children With Ulcerative Colitis
Ninety Six patients with mild to moderate ulcerative colitis will be randomized to double blind, placebo controlled study. The safety and efficacy of the intervention will be closely monitored.
- Trial name
- FMT_UC (NCT02291523)
- Testing
- Fecal Microbial Transplant
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Irritable Bowel Syndrome
Donor Selection for Faecal Microbiota Transplantation in Irritable Bowel Syndrome
Five hundred patients are randomized 1:1:1:1 into placebo (own feces), or receiving 90 g fecal transplant from donor A, donor B or donor C.
- Trial name
- NCT06171126
- Testing
- Faeces from donor A, Faeces from donor B, Faeces from donor C
- Where
- 3 sites in Norway
- Volunteers
- 500 people
- Sponsor
- Haukeland University Hospital
Diabetes, Insulin Resistance
Measurement of the Pancreas Function in Patients With More Than One Pancreas After Liver and Small Bowel Transplantation
Under chronic immunosuppressive and corticosteroid therapy, transplant patients have a tendency to develop in the long-term diabetes.
- Conditions
- Diabetes, Insulin Resistance, Liver/Small Bowel Transplant
- Trial name
- NCT01621516
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Stem Cell Transplantation in Treating Patients With Hematologic Cancer
RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy and radiation therapy used to kill tumor cells.
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT00004904
- Testing
- anti-thymocyte globulin, filgrastim, cladribine
- Where
- United States
- Sponsor
- Northwestern University
Inflammatory Diseases
Study of Efavaleukin Alfa in Healthy Chinese, Japanese, and Caucasian Participants
The primary objective of this study is to evaluate the pharmacokinetics (PK) of efavaleukin alfa after single subcutaneous (SC) administration in healthy Chinese, Japanese, and Caucasian participants.
- Trial name
- NCT04987333
- Testing
- Efavaleukin alfa
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Amgen
Crohn's Disease
Pilot Study of Stem Cell Transplantation for Children and Young Adults With Refractory Crohn's Disease.
This is a study for people with Crohn's Disease (CD) that are not responsive to standard treatment. CD is a chronic disease with an auto-immune component that goes away and relapses over the years and causes lifelong impairment…
- Trial name
- NCT02225795
- Testing
- Hematopoietic stem cell transplantation
- Sponsor
- TriStar Health
Adults With Ulcerative Colitis
Evaluation the Safety and Efficacy of Lyophilized Fecal Microbiota Transplantation Administered Orally for Prevention of Relapse or Intestinal Inflammation in Adults With Ulcerative Colitis
The purpose of the study is to evaluate the efficacy and safety of lyophilized PRIM-DJ2727 capsules given orally in subjects with ulcerative colitis at remission stage.
- Trial name
- NCT04373473
- Testing
- PRIM-DJ2727
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- The University of Texas Health Science Center, Houston
Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma
Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant
This clinical trial studies personalized dose monitoring of busulfan and combination chemotherapy in treating patients with Hodgkin or non-Hodgkin lymphoma undergoing stem cell transplant.
- Conditions
- Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma
- Trial name
- NCT01959477
- Testing
- busulfan, etoposide, cyclophosphamide
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Case Comprehensive Cancer Center
Hypertension
Effect of Gut Microbiome Restoration on Primary Hypertension Via FMT
Mounting preclinical and clinical evidences have proved the causal role of gut microbiota on the pathogenesis of primary hypertension.
- Trial name
- FMT (NCT04406129)
- Testing
- FMT capsules
- Where
- 7 sites in China
- Volunteers
- 120 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Clostridium Difficile, Ulcerative Colitis
FMT in Patients With Recurrent CDI and Ulcerative Colitis: Single Infusion Versus Sequential Approach
Clostridioides difficile infection (CDI) is the most frequent cause of infectious diarrhea in hospitalized patients and is responsible for 20-30 % of antibiotic-associated diarrhea cases.
- Trial name
- NCT06071312
- Testing
- single FMT, sequential FMT
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Irritable Bowel Syndrome
Donor Versus Autologous Fecal Microbiota Transplantation for Irritable Bowel Syndrome
Many patients with irritable bowel syndrome (IBS) do not experience adequate symptom relief with current treatments. The pathophysiology of IBS is diverse, controversial and not completely understood.
- Trial name
- NCT04691544
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- Norway
- Volunteers
- 450 people
- Sponsor
- University Hospital of North Norway
Inflammatory Bowel Disease (IBD)
Gut Microbial Transplantation in Pediatric Inflammatory Bowel Diseases
Inflammatory bowel disease (IBD) is a chronic, debilitating, relapsing inflammatory disorder affecting the gastrointestinal tract which does not have a medical cure.
- Trial name
- GMT (NCT01560819)
- Testing
- Gut Microbial Transplantation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Corewell Health West
Human Papillomavirus Infection, Anal HPV Infection
Epidemiology of Anal Human Papillomavirus Carriage in Female Solid Organ Transplant Recipients With More Than 10 Years of Immunosuppression
Anal canal cancer is primarily associated with persistent infection by high-risk human papillomavirus (HR-HPV), particularly HPV-16.
- Conditions
- Human Papillomavirus Infection, Anal HPV Infection, Human Papillomavirus 16 Infection
- Trial name
- EPAHTOS (NCT07858201)
- Testing
- Anal Self-Sampling for High-Risk HPV Detection
- Volunteers
- 190 people
- Sponsor
- University Hospital, Montpellier
Crohn Disease
Crohn's Allogeneic Transplant Study
This phase II trial studies how well giving a donor bone marrow transplant (BMT) works in treating patients with refractory Crohn's Disease.
- Trial name
- CATS (NCT01570348)
- Testing
- Allogeneic Bone Marrow Transplantation, Cyclophosphamide, Fludarabine Phosphate
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Fred Hutchinson Cancer Center
Colorectal Cancer, Liver Metastases
Living Donor Liver Transplantation for Unresectable Colorectal Cancer Liver Metastases
Patients with unresectable liver metastases (LM) from colorectal cancer (CRC)have a poor prognosis. In patients with resectable disease, surgery offers a distinct survival benefit.
- Trial name
- NCT02864485
- Testing
- live donor liver transplantation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto