Clinical trials: Intestinal Transplant
Graft-versus-host Disease
Metabolome and Microbiome Impact on Acute GVHD in Recipients of Hematopoietic Transplant
Recent published data suggest that specific alterations in intestinal metabolome signature of hematopoietic stem cell transplant (allo-SCT) recipients might influence incidence and severity of acute graft versus host disease…
- Trial name
- AlloBolome (NCT05186857)
- Where
- 9 sites in Spain
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Liver Transplant; Complications
Placement of Biliary Drainage Stent to Prevent Biliary Intestinal Anastomosis After Liver Transplantation in Children
Liver transplantation is an effective method for treating end-stage liver disease and metabolic diseases in children. With the advancement of surgical techniques and the improvement of perioperative management, the survival rates…
- Trial name
- NCT06048445
- Testing
- intraoperative plancement of Biliary Drainage Stent
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Zhejiang University
Crohn's Disease
Autologous Stem Cell Transplant for Refractory Crohn's Disease
Crohn's disease is an 'auto-immune' disorder of the gut. In this condition the body's own immune system is fighting its gut and causing inflammation and other symptoms.
- Trial name
- NCT02676622
- Testing
- mobilization of stem cells to prepare for Leukapheresis, Leukapheresis- Collection of stem cells, Preparative regimen 4-6 weeks after Leukapheresis
- Sponsor
- Nationwide Children's Hospital
Colorectal Cancer, Liver Metastases
The Swedish Study of Liver Transplantation for Non-resectable Colorectal Cancer Metastases
To evaluate if the addition of liver transplantation primarily utilizing liver grafts from extended criteria donors not utilized for approved indications to conventional treatment of non-resectable/ non-abatable colorectal liver…
- Conditions
- Colorectal Cancer, Liver Metastases, Colorectal Liver Metastases
- Trial name
- SOULMATE (NCT04161092)
- Testing
- Liver transplantation Ltx, Best alternative care
- Where
- 2 sites in Sweden
- Volunteers
- 45 people
- Sponsor
- Vastra Gotaland Region
Acute Pancreatitis, Intestinal Bacteria Flora Disturbance
Fecal Microbiota Transplantation (FMT) for Severe Acute Pancreatitis(SAP)
Severe acute pancreatitis is an acute and rapid progress of the digestive system disease.Most patients with severe pancreatitis associated with intestinal mucosal barrier dysfunction.Intestinal microflora,an important part of the…
- Conditions
- Acute Pancreatitis, Intestinal Bacteria Flora Disturbance, Intestinal Dysfunction, Fecal Microbiota Transplantation
- Trial name
- NCT03015467
- Testing
- Fecal Microbiota Transplantation, normal saline
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Chengdu Medical College
Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma
MORAb-004 in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma
This phase I trial studies the side effects and best dose of MORAb-004 in treating young patients with recurrent or refractory solid tumors or lymphoma.
- Conditions
- Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Childhood Burkitt Lymphoma
- Trial name
- NCT01748721
- Testing
- anti-endosialin/TEM1 monoclonal antibody MORAb-004, pharmacological study, laboratory biomarker analysis
- Where
- 20 sites in United States
- Volunteers
- 27 people
- Sponsor
- Morphotek
Irritable Bowel Syndrome
Effects of Faecal Microbiota Transplantation in Patients With IBS
Irritable bowel syndrom (IBS) is a common chronic gastrointestinal disorder that affects 10-20% of the world population. The prevalence of IBS in Norway is between 8% and 25%.
- Trial name
- NCT03822299
- Testing
- healthy feces microbiota
- Where
- Norway
- Volunteers
- 164 people
- Sponsor
- Helse Fonna
Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome
Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic Malignancies
This study will determine the safety and applicability of experimental forms of umbilical cord blood (UCB) transplantation for patients with high risk hematologic malignancies who might benefit from a hematopoietic stem cell…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission
- Trial name
- NCT01652014
- Testing
- cyclophosphamide, fludarabine phosphate, mycophenolate mofetil
- Where
- United States
- Sponsor
- University of Medicine and Dentistry of New Jersey
Ulcerative Colitis
Fecal Microbiota Transplantation in Patients With Ulcerative Colitis
The purpose of this study is to find out whether a single fecal microbiota transplantation is an effective and safe treatment as an adjunct to standard therapy in patients with ulcerative colitis.
- Trial name
- NCT01961492
- Testing
- Fecal microbiota transplantation
- Where
- Finland
- Sponsor
- Turku University Hospital
HIV
Fecal Microbiota Transplantation in HIV
Even in individuals treated for HIV, chronic immune activation persists and is associated with increased cardiovascular disease, liver disease, and mortality.
- Trial name
- FMT-HIV (NCT02256592)
- Testing
- Fecal Microbiota
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of California, San Francisco
Small Intestinal Bacterial Overgrowth
Pilot Feasibility Study of Fecal Microbiota Transplant for the Treatment of Small Intestinal Bacterial Overgrowth
The objective of the study is to assess feasibility, and clinical efficacy of a novel Fecal Microbiota Transplantation protocol for the treatment of pediatric small intestinal bacterial overgrowth (SIBO).
- Trial name
- NCT05967871
- Testing
- Fecal Microbiota Transplant
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- McMaster Children's Hospital
Stem Cell Transplant Complications, Graft Versus Host Disease, Acute
Fecal Microbiota Transplantation for Steroid Resistant and Steroid Dependent Gut Acute Graft Versus Host Disease
The investigators hypothesize that perturbations in the intestinal microbiota following allogeneic hematopoietic stem cell transplantation (HSCT) are essential for the development and propagation of acute graft-versus-host…
- Conditions
- Stem Cell Transplant Complications, Graft Versus Host Disease, Acute, Fecal Microbiota Transplantation
- Trial name
- NCT03214289
- Testing
- Fecal Microbiota Transplantation
- Where
- Israel
- Volunteers
- 4 people
- Sponsor
- Sheba Medical Center
Acute Graft Versus Host Disease, Intestinal Graft Versus Host Disease
Methylprednisolone Sodium Succinate in Treating Patients With Acute Graft-versus-Host Disease of the Gastrointestinal Tract
This phase II trial studies how well methylprednisolone sodium succinate works in treating patients with graft-versus-host disease (GVHD) of the gastrointestinal tract that has begun within 100 days of transplant (acute GVHD).
- Trial name
- NCT02425813
- Testing
- Budesonide, Methylprednisolone Sodium Succinate
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Hematologic Malignancy
Study To Evaluate The Safety And Efficacy of PBCLN-010 In Combination With PBCLN-014 in Participants Receiving Allogeneic Hematopoietic Cell Transplantation
This is a Phase 2a, open-label, multicenter study to evaluate the safety and efficacy of HMO (PBCLN-010) and B. infantis (PBCLN-014) on the gut microbiome and GI domination by pathobionts in participants receiving allo-HCT.
- Trial name
- NCT06102213
- Testing
- B. infantis (PBCLN-014) and Human Milk Oligosaccharides (HMO) (PBCLN-010)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Prolacta Bioscience
Clostridium Difficile Infection, Ulcerative Colitis
Fecal Microbial Transplantation for C. Difficile and/or Ulcerative Colitis or Indeterminate Colitis
Fecal Microbiota Transplantation will be offered to eligible C. difficile patients (does not require Investigational New Drug designation) and to eligible ulcerative colitis or indeterminate colitis patients as Investigational…
- Conditions
- Clostridium Difficile Infection, Ulcerative Colitis, Indeterminate Colitis
- Trial name
- FMT (NCT03268213)
- Testing
- Fecal Microbial Transplantation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stony Brook University
Efficiency, Methodology
Fecal Microbiota Transplantation on Type 2 Diabetes Mellitus
The gut microbiota is considered to constitute a "microbial organ" which has pivotal roles in the body's metabolism. Evidence from animal and human studies strongly support the link between intestinal bacteria and type 2 diabetes…
- Trial name
- NCT01790711
- Testing
- FMT through mid-gut
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma
RATIONALE: Giving high doses of chemotherapy drugs, such as busulfan and cyclophosphamide, before a donor bone marrow transplant helps stop the growth of cancer cells.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Monoblastic Leukemia (M5a)
- Trial name
- NCT01177371
- Testing
- busulfan, cyclophosphamide, allogeneic bone marrow transplantation
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Case Comprehensive Cancer Center
Fecal Microbiota Transplantation, Crohn Disease
Microbial Restoration in Inflammatory Bowel Diseases
This is a prospective, two-centre, double-blind, parallel-arm, randomised, placebo-controlled trial evaluating the impact of FMT on patients with active Crohn's disease.
- Conditions
- Fecal Microbiota Transplantation, Crohn Disease, Inflammatory Bowel Diseases, Microbiome
- Trial name
- MIRO II (NCT04970446)
- Testing
- Antibiotics, Dietician designed diet, FMT
- Where
- Australia
- Volunteers
- 120 people
- Sponsor
- St Vincent's Hospital Melbourne
NAFLD, Fecal Microbiota
Dietary Counseling Coupled With FMT in the Treatment of Obesity and NAFLD - the DIFTOB Study
There are several studies performed to reveal the linkage between diet, fecal microbiota, and obesity. Human fecal microbiota transplantations in this asset are still scarce.
- Conditions
- NAFLD, Fecal Microbiota, Gut Microbiota, Obesity
- Trial name
- DIFTOB (NCT05607745)
- Where
- 3 sites in Finland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Non-Alcoholic Fatty Liver Disease, Fecal Microbiota Transplantation
Impact of FMT on the Phenome in Patients With NAFLD and Fibrosis
The goal of this pilot experimental medicine interventional study is to explore the degree of transferability of the gut microbiome and associated metabolomic changes in patients with non-alcoholic fatty liver disease (NAFLD) and…
- Trial name
- NCT06024681
- Testing
- Faecal microbiota transplant
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Imperial College London