Clinical trials: Intestinal Transplantation
Non-alcoholic Fatty Liver Disease
Intestinal Microbiota Transplantation for Nonalcoholic Fatty Liver Disease
In China, with the improvement of living standards, there is a significant increase in the rate of prevalence of type 2 diabetes and hyperlipidemia, associated with Non-alcoholic fatty liver disease（NAFLD） which has gradually…
- Trial name
- NAFLD (NCT03648086)
- Testing
- intestinal microbiota transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhongshan Hospital Xiamen University
Chronic Heart Failure
Intestinal Microbiota Transplantation in Patients With Chronic Heart Failure
The purpose of this study is to determine whether people with CHF, who often have different gut bacteria from healthy, would benefit from replacing their gut bacteria with healthy donor bacteria (also known as Intestinal…
- Trial name
- IMT (NCT07490054)
- Testing
- MTP-101-C encapsulated Microbiota, Vancomycin, Neomycin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Melana Yuzefpolskaya, MD
Microsporidiosis Intestinal, Heart Transplant Infection
Intestinal Microsporidiosis in French Heart Transplant Recipients (CARMIC)
The investigators propose to carry out a national retrospective study to collect epidemiological, biological, clinical and therapeutic data on microsporidiosis among heart transplant patients.
- Trial name
- CARMIC (NCT06986980)
- Where
- France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Clermont-Ferrand
Ulcerative Colitis
Transplantation of Faeces in Ulcerative Colitis; Restoring Nature's Homeostasis
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) of the colon. Complaints such as abdominal pain, cramps and bloody diarrhoea usually start in early adulthood and lead to life-long substantial morbidity.
- Trial name
- TURN (NCT01650038)
- Testing
- treatment with faecal transplantation (donor faeces), treatment with faecal transplantation (own faeces)
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chronic Widespread Pain
Fecal Microbiota Transplantation for Patients With Chronic Widespread Pain
This study aims to explore the effect of Fecal Microbiota Transplantation (FMT) on the clinical symptomatology in Chronic Widespread Pain (CWP), to assess the acceptability, tolerability, and safety of FMT in patients with CWP…
- Trial name
- NCT05700331
- Testing
- Fecal Microbiota Transplantation, Sigmoidoscopy
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
Diarrhea Caused by Drug, Clostridium Difficile Infections
Faecal Bacteriotherapy for Postantibiotic Diarrhoea in Critically Ill Patients
Rationale: Postantibiotic diarrhoea in critically ill patients is common, often prolonged and currently there is no effective treatment of it.
- Trial name
- FEBATRICE (NCT05430269)
- Testing
- Faecal bacteriotherapy (FBT), standard-of-care protocolised treatment of postantibiotic diarhea
- Where
- 2 sites in Czechia
- Volunteers
- 36 people
- Sponsor
- Charles University, Czech Republic
Anorexia Nervosa
A Study on the Effects of Combined FMT on Gut Microbiota and Eating Disorder Symptoms in AN
The goal of this clinical trial is to determine if Fecal Microbiota Transplantation (FMT) is effective in treating Anorexia Nervosa (AN). The study will also explore how FMT works. The main questions it aims to answer are: 1.
- Trial name
- NCT06744751
- Testing
- Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Mental Health Center
Transplant; Intestine, Transplant; Complication, Rejection
The Endoscopic Assesment of Intestinal Grafts
The study validates prospectively a new endoscopic scoring system (Gothenburg Intestinal Transplant Endoscopy Score, GITES) designed to summarize and stratify the abnormal ileal endoscopic findings after intestinal…
- Conditions
- Transplant; Intestine, Transplant; Complication, Rejection, Transplant; Failure, Bowel, Enteritis
- Trial name
- INTEGRATE (NCT03444675)
- Where
- 4 sites in United States, Argentina and 2 more
- Volunteers
- 80 people
- Sponsor
- Sahlgrenska University Hospital
Premature Birth
Effect of Intake in Bioactive Molecules From Natural or Pasteurised Milk on Gut Maturation in Very Premature Newborns
It seems important to correlate real consumption in bioactives molecules of natural milk versus pasteurized with gut maturation in very preterm infants during small enteral feeding protocol.
- Trial name
- NCT01177475
- Testing
- blood samples , feces samples, blood samples, feces samples
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Inflammatory Bowel Disease, Crohn's Disease (CD)
Standardized Fecal Microbiota Transplantation for Crohn&Apos;s Diseases
The gut microbiota is considered to constitute a "microbial organ" which has pivotal roles in the intestinal diseases and body's metabolism.
- Trial name
- NCT01793831
- Testing
- FMT
- Where
- 2 sites in China
- Volunteers
- 800 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Ulcerative Colitis
Fecal Microbiota Transplantation for Ulcerative Colitis
Fecal microbiota therapy (FMT) is an emerging treatment for gastrointestinal disorders marked by an imbalance in the intestinal microbial flora (dysbiosis).
- Trial name
- NCT01742754
- Testing
- Fecal Microbiota Transplantation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Washington
Pouchitis
Safety and Efficacy of Fecal Microbiome Transplantation (FMT) in the Treatment of Antibiotic Dependent Pouchitis (ADP)
Antibiotic dependent pouchitis (ADP) is predestined to benefit from FMT, since bacterial dysbiosis, which can only be controlled with antibiotics, appears to be the major driver of the clinical symptoms.
- Trial name
- NCT02782325
- Testing
- Active FMT, then open label FMT
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of North Carolina, Chapel Hill
Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes
Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC
This is a data collection study that will examine the general diagnostic and treatment data associated with the reduced-intensity chemotherapy-based regimen paired with simple alemtuzumab dosing strata designed to prevented graft…
- Conditions
- Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes, Inherited Metabolic Disorders (IMD), Hereditary Anemias
- Trial name
- PRO-RIC (NCT04528355)
- Testing
- data collection
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Paul Szabolcs
Graft-versus-host Disease Prevention
Fecal Transplant +/- Gut Decontamination in Preventing Acute Graft Versus Host Disease in Patients Given Broad-Spectrum Antibiotics
This phase II trial studies how well a fecal microbiota transplant with or without total gut decontamination works in preventing graft versus host disease in patients exposed to broad-spectrum antibiotics.
- Trial name
- NCT03862079
- Testing
- Best Practice, Fecal Microbiota Transplantation, Nystatin
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Renal Transplant
Influence of the Intestinal Microbiota on the Clinical Course of Renal Transplantation
ACKGROUND: The development of new molecular techniques, in recent years, has increasing the knowledge of the composition and functionality of the intestinal microbiota.
- Trial name
- NCT04874896
- Testing
- Microbiota autotransplantation, Control
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Cancer Metastatic to the Liver, Hepatocellular Carcinoma
A Study to Assess PV-10 Chemoablation of Cancer of the Liver
This open-label study will evaluate the safety, tolerability, pharmacokinetics and effect on tumor growth following a single intralesional injection of PV-10 in subjects with either (a) hepatocellular carcinoma (HCC) that is not…
- Conditions
- Cancer Metastatic to the Liver, Hepatocellular Carcinoma, Metastatic Melanoma, Metastatic Ocular Melanoma
- Trial name
- NCT00986661
- Testing
- PV-10 (10% rose bengal disodium)
- Where
- 5 sites in United States
- Volunteers
- 78 people
- Sponsor
- Provectus Biopharmaceuticals, Inc.
Diabetes, Insulin Resistance
Measurement of the Pancreas Function in Patients With More Than One Pancreas After Liver and Small Bowel Transplantation
Under chronic immunosuppressive and corticosteroid therapy, transplant patients have a tendency to develop in the long-term diabetes.
- Conditions
- Diabetes, Insulin Resistance, Liver/Small Bowel Transplant
- Trial name
- NCT01621516
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Irritable Bowel Syndrome
FMT for Post-infectious IBS
Considering that PI-IBS is brought on by infection and gut microbiota may be associated with the onset of symptoms, the modification of altered gut microbiota with nonabsorbable antibiotics such as rifaximin-α or probiotics is…
- Trial name
- NCT05461833
- Testing
- Fecal transplantation, OTILONII BROMIDUM, multi-strain probiotic
- Where
- 2 sites in Ukraine
- Volunteers
- 59 people
- Sponsor
- Bogomolets National Medical University
Anal Cancer
Host Genome Methylation: a Screening Tool in Anal Cancer Detection
In January 2023, the first recommendations for anal cancer screening were issued by the French National Society of Coloproctology (SNFCP).
- Trial name
- AMethysT (NCT06792604)
- Testing
- Anal self-sampling (smear), HPV questionnaire
- Where
- 9 sites in France
- Volunteers
- 770 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Pancreatitis, Severe Acute Pancreatitis
Fecal Microbiota Transplantation (FMT) in Patients With Moderate to Severe Acute Pancreatitis
This study is a randomized, double-blind and placebo-controlled study. The purpose of this study is to evaluate the efficacy and safety of FMT in patients with moderate to severe acute pancreatitis.
- Trial name
- NCT07153809
- Testing
- FMT
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Changhai Hospital