Clinical trials: Intestinal Transplantation
Chronic Myeloproliferative Disorders, Leukemia
Non-Ablative Allo HSCT For Hematologic Malignancies or SAA
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy…
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00006379
- Testing
- anti-thymocyte globulin, graft-versus-tumor induction therapy, cyclophosphamide
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Case Comprehensive Cancer Center
Colorectal Cancer
Partial Liver Segment 2/3 Transplantation Study
The patients will receive hepatectomy as a 2 stage procedure. In the first surgical procedure liver segments 2-3 are removed and liver donor segments 2-3 inserted.
- Trial name
- NCT02215889
- Testing
- Liver transplantation
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Adults With Ulcerative Colitis
Evaluation the Safety and Efficacy of Lyophilized Fecal Microbiota Transplantation Administered Orally for Prevention of Relapse or Intestinal Inflammation in Adults With Ulcerative Colitis
The purpose of the study is to evaluate the efficacy and safety of lyophilized PRIM-DJ2727 capsules given orally in subjects with ulcerative colitis at remission stage.
- Trial name
- NCT04373473
- Testing
- PRIM-DJ2727
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- The University of Texas Health Science Center, Houston
Clostridium Difficile
Transplantation of Cultured Gut Microflora to Repeat Antibiotic-induced Diarrhea Due to Clostridium Difficile
Patients who have received antibiotics and thereafter developed diarrhea are investigated for presence of Clostridium difficile toxin. Primary treatment is given with oral metronidazole/vancomycin.
- Trial name
- NCT02857582
- Testing
- Cultured human intestinal microbiota, Vancomycin, Metronidazole
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Per Hellström
Liver Diseases, Liver Cancer
Liver Transplantation for Unresectable GIST Liver Metastases
Liver Transplantation for Unresectable GIST Liver Metastases
- Conditions
- Liver Diseases, Liver Cancer, Liver Metastases, Liver Neoplasms
- Trial name
- TRANSGIST (NCT04825470)
- Testing
- Liver Transplantation
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Secondary Malignant Neoplasm of Retroperitoneum, Secondary Malignant Neoplasm of Peritoneum
Intestinal & Multivisceral Transplantation for Unresectable Mucinous Carcinoma Peritonei (TRANSCAPE)
The goal of this prospective phase 2 study is to assess the efficacy and safety of intestinal or multivisceral transplantation for participants with PMP not amenable to other curative-intent treatments.
- Conditions
- Secondary Malignant Neoplasm of Retroperitoneum, Secondary Malignant Neoplasm of Peritoneum, Pseudomyxoma Peritonei
- Trial name
- TRANSCAPE (NCT06084780)
- Testing
- Intestinal, Multivisceral or Modified Multivisceral Transplantation, Alemtuzumab, Tacrolimus
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Case Comprehensive Cancer Center
Ulcerative Colitis, Intestinal Bacteria Flora Disturbance
Fecal Microbiota Transplantation for Ulcerative Colitis
Ulcerative colitis is a common digestive system disease, the incidence is increasing in recent years.It is reported that the occurrence and development of ulcerative colitis is closely related to imbalance of intestinal flora…
- Conditions
- Ulcerative Colitis, Intestinal Bacteria Flora Disturbance, Fecal Microbiota Transplantation
- Trial name
- FMTFUC (NCT03016780)
- Testing
- Fecal Microbiota Transplantation, Normal Saline
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Chengdu Medical College
Pitt Hopkins Syndrome
Microbiota Transfer Therapy for Children and Adults With Both Pitt Hopkins Syndrome and Gastrointestinal Disorders
The investigators propose to investigate Microbiota Transfer Therapy (MTT) for treating patients with Pitt-Hopkins Syndrome (PTHS) and gastrointestinal problems (constipation, bloating, abdominal pain).
- Trial name
- NCT06321796
- Testing
- MTP-101P, Vancomycin, Magnesium Citrate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Gut-Brain-Axis Therapeutics Inc.
Kidney Transplant; Complications, Drug Interaction Food
Drug Interaction With Envarsus XR and Grapefruit Juice
Transplant patients must take lifelong immunosuppression in order to prevent rejection of their organ. Tacrolimus is the most widely used immnosuppressive agent.
- Trial name
- NCT03916380
- Testing
- Grapefruit Juice
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Shirley M. Tsunoda
Pediatric Ulcerative Colitis in Remission
Oral Fecal Microbiota Transplantation in Pediatric Ulcerative Colitis
The purpose of this study is to evaluate whether FMT by frozen stool capsules in pediatric UC patients in remission after corticosteroid treatment, can modify their dysbiotic gut microbiota by increasing the richness of their…
- Trial name
- T-FORE (NCT05202990)
- Testing
- Fecal Microbiota Transplantation by Stool capsules, Fecal Microbiota Transplantation by Intra-rectal enemas
- Where
- 3 sites in France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stem Cell Transplant Complications, Graft Versus Host Disease, Acute
Fecal Microbiota Transplantation for Steroid Resistant and Steroid Dependent Gut Acute Graft Versus Host Disease
The investigators hypothesize that perturbations in the intestinal microbiota following allogeneic hematopoietic stem cell transplantation (HSCT) are essential for the development and propagation of acute graft-versus-host…
- Conditions
- Stem Cell Transplant Complications, Graft Versus Host Disease, Acute, Fecal Microbiota Transplantation
- Trial name
- NCT03214289
- Testing
- Fecal Microbiota Transplantation
- Where
- Israel
- Volunteers
- 4 people
- Sponsor
- Sheba Medical Center
Allogeneic Hematopoietic Stem Cell Transplantation
A Dose-Finding Study of Vedolizumab for Treatment of Steroid-Refractory Acute Intestinal Graft-Versus-Host Disease (GvHD) in Participants Who Have Undergone Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT)
The purpose of this study is to assess the initial activity, tolerability, safety and to identify a recommended dose and regimen of vedolizumab intravenous (IV) administered for treatment of steroid-refractory acute intestinal…
- Trial name
- NCT02993783
- Testing
- Vedolizumab
- Where
- 15 sites in United States, Belgium and 3 more
- Volunteers
- 17 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Irritable Bowel Syndrome
Efficacy of Fecal Microbiota Transplantation (FMT) in Irritable Bowel Syndrome (IBS)
The goal of this clinical trial is to determine efficacy of FMT via rectal enema and encapsulated FMT in patients with IBS in Thailand.
- Trial name
- NCT06201182
- Testing
- FMT via rectal enema, FMT capsules
- Where
- Thailand
- Volunteers
- 45 people
- Sponsor
- Thammasat University
Ulcerative Colitis
A Pilot and Feasibility Study of Fecal Microbiota Transplantation for Ulcerative Colitis
The investigators are conducting an open-label study of fecal microbiota transplantation (FMT) for adult patients with mildly-moderately active ulcerative colitis.
- Trial name
- NCT02058524
- Testing
- fecal microbiota transplantation
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Ankylosing Spondylitis
The Effect of Fecal Microbiota Transplantation in Ankylosing Spondylitis (AS) Patients.
Ankylosing spondylitis (AS) patients often have subclinical gut wall inflammation. Gut dysbiosis has been associated with both AS and Crohn disease, both of which have several features in common.
- Trial name
- ASGUT (NCT03726645)
- Testing
- Fecal microbiota transplantation
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Hospital District of Helsinki and Uusimaa
Obesity, Morbid, Insulin Resistance
Stool Transplantation for Treatment of Insulin Resistance in Morbidly Obese Patients
More and more people in Canada and around the world are severely (morbidly) obese, and this is associated with a high risk for poor blood sugar control (insulin resistance, IR) and diabetes.
- Trial name
- NCT02970877
- Testing
- Fecal filtrate from 150 g stool from healthy lean donors, Fecal filtrate from 150 g of the recipient's own stool
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Johane Allard
Epstein-Barr Virus (EBV) Infections, Lymphoproliferative Disorders
Expanded Access Protocol for Tabelecleucel for Patients With Epstein-Barr Virus-Associated Viremia or Malignancies
The primary objective of this protocol is to provide expanded access to tabelecleucel to participants with Epstein-Barr virus-associated diseases and malignancies for whom there are no other appropriate therapeutic options, and…
- Conditions
- Epstein-Barr Virus (EBV) Infections, Lymphoproliferative Disorders, EBV+ Associated Lymphoma, EBV+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD)
- Trial name
- NCT02822495
- Testing
- tabelecleucel
- Sponsor
- Atara Biotherapeutics
Crohn Disease, Microbial Substitution
Fecal Microbial Transplantation and Vedolizumab Treatment of Crohn's Disease
The investigators postulate that by determining a patient's baseline microbiome and manipulating it through fecal microbial transplantation (FMT) may improve response rates to vedolizumab in Crohn's disease (CD) patients.
- Trial name
- NCT04328922
- Testing
- Fecal microbial transplantation
- Where
- 2 sites in Israel
- Volunteers
- 80 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Chronic Disease, Immunocompromised
Integrating Vaccination Into Hospital Care Pathways for Vulnerable Patients
AMBU-VAX is a prospective, single-center observational study designed to develop and implement an organizational model for delivering recommended vaccinations within a hospital setting.
- Conditions
- Chronic Disease, Immunocompromised, HIV Infection, Chronic Kidney Disease
- Trial name
- AMBU-VAX (NCT07391046)
- Testing
- Hospital-Based Vaccination Pathway
- Volunteers
- 1,500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ulcerative Colitis Chronic Mild, Inflammatory Bowel Diseases
Effectiveness of Fecal Microbiota Transplantation as add-on Therapy in Mild-to-moderate Ulcerative Colitis
Ulcerative colitis (UC) is a chronic immune-mediated inflammatory bowel disease (IBD) that almost always affects the rectum and often extends to the more proximal colon.
- Trial name
- NCT05538026
- Testing
- Mesalazine, Fecal transplantation
- Where
- 2 sites in Ukraine
- Volunteers
- 53 people
- Sponsor
- Bogomolets National Medical University