Clinical trials: Intestinal Transplantation
Renal Transplant
Characterization Of the Intestinal Microbiome Evolution After Kidney Transplant Donation or Receipt
This is a hypothesis-generating pilot study. The intent is to model the impact of perioperative practices on the intestinal microbiome and possibly associate these conditions with the final microbiome status (e.g., number of…
- Trial name
- COMET-DR (NCT03043339)
- Testing
- Stool Specimen Collection, Anal Swab Sampling, Short Diet Assessment (SDA)
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Emory University
Ulcerative Colitis, Irritable Bowel Syndrome
Fecal Microbiota Transplantation for Health Improvement (TFM3)
Search for mechanisms of the effect of fecal transplantation on a healthy organism and various nosological forms.
- Conditions
- Ulcerative Colitis, Irritable Bowel Syndrome, Crohn Disease, Irritable Bowel
- Trial name
- TFM3 (NCT04011943)
- Testing
- Fecal Microbiota Transplantation
- Where
- Russia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Federal Research and Clinical Center of Physical-Chemical Medicine
Biliary Atresia
Gut Microbiome in Biliary Atresia
The investigator will investigate the gut-microbiome and liver elasticity of the Biliary Atresia (BA)-patients before and after Kasai operation.
- Trial name
- NCT04260503
- Testing
- Monitoring of the gut-microbiome and ultrasound elasticity., Monitoring of the gut-microbiome, Monitoring of the gut-microbiome.
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Morbid Obesity, Metabolic Syndrome
FMT in Obesity: RYGB vs. LEAN vs. Autologous FMT
This double-blinded proof-of-concept study is proposed to explore the effects of fecal microbiota transfer (FMT) in human subjects.
- Conditions
- Morbid Obesity, Metabolic Syndrome, Diabetes, PreDiabetes
- Trial name
- DACH (NCT06268990)
- Testing
- Fecal microbiota transplantation
- Where
- Austria
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Wiebke Kristin Fenske
Fecal Microbiota Transplantation, Crohn Disease
Microbial Restoration in Inflammatory Bowel Diseases
This is a prospective, two-centre, double-blind, parallel-arm, randomised, placebo-controlled trial evaluating the impact of FMT on patients with active Crohn's disease.
- Conditions
- Fecal Microbiota Transplantation, Crohn Disease, Inflammatory Bowel Diseases, Microbiome
- Trial name
- MIRO II (NCT04970446)
- Testing
- Antibiotics, Dietician designed diet, FMT
- Where
- Australia
- Volunteers
- 120 people
- Sponsor
- St Vincent's Hospital Melbourne
Lung Cancer, Lymphoma
Vandetanib and Bevacizumab in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: Vandetanib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as bevacizumab, can block cancer growth in different ways.
- Conditions
- Lung Cancer, Lymphoma, Lymphoproliferative Disorder, Small Intestine Cancer
- Trial name
- NCT00734890
- Testing
- bevacizumab, vandetanib, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Irritable Bowel Syndrome (IBS)
Safety and Efficacy of Lyophilized Faecal Microbiota Transplantation Via Capsules in Treatment of Irritable Bowel Syndrome
The goal of this clinical trial is to learn if oral capsules containing lyophilized fecal microbiota transplantation (FMT) can safely and effectively treat refractory irritable bowel syndrome (IBS) in adults aged 18-65 years.
- Trial name
- LYO-IBS (NCT07481422)
- Testing
- FMT capsule
- Where
- Croatia
- Volunteers
- 70 people
- Sponsor
- University of Rijeka
Inflammatory Bowel Disease, Ulcerative Colitis Type
A Multicenter Clinical Trial: Efficacy, Safety of Fecal Microbiota Transplantation for Inflammatory Bowel Disease
There are many limitations in the current treatments of Inflammatory bowel disease(IBD). Some patients have no or little reaction to the traditional drugs.
- Trial name
- NCT04521205
- Testing
- fecal microbiota capsule
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhongshan Hospital Xiamen University
Ulcerative Colitis
Impact of Fecal Microbiota Transplantation in Ulcerative Colitis
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease. UC pathogenesis remains poorly understood but involves an inappropriate immune response toward an unbalanced gut microbiota (called dysbiosis) in…
- Trial name
- REBALANCE-UC (NCT03483246)
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission
Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies
This pilot phase II trial studies how well giving vorinostat, tacrolimus, and methotrexate works in preventing graft-versus-host disease (GVHD) after stem cell transplant in patients with hematological malignancies.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q)
- Trial name
- NCT01789255
- Testing
- vorinostat, tacrolimus, cyclosporine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Pulmonary Arterial Hypertension
Microbiota Transplant With Antibiotic Preconditioning and Fiber Supplementation in PAH.
This pilot clinical trial analysis will evaluate the initial safety, feasibility, and pharmacokinetics of microbiota transplant therapy (MTT) with antibiotic pre-conditioning and fiber supplementation vs.
- Trial name
- NCT07751120
- Testing
- MTT with antibiotic preconditioning + fiber supplementation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Minnesota
Graft Rejection, Transplantation
Regenerative Cellular Therapies, Physiology, Pathology and Developmental Biology
This study aims to use tissue from deceased organ donors to investigate organ physiology, developmental biology, as well as the development of future regenerative cellular therapies.
- Conditions
- Graft Rejection, Transplantation, Diabetes Mellitus
- Trial name
- RCT (NCT02469207)
- Testing
- Removal of tissue post-mortem
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma
Panobinostat in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
Panobinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. This phase II trial is studying how well panobinostat works in treating patients with relapsed or refractory non-Hodgkin…
- Conditions
- Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue
- Trial name
- NCT01261247
- Testing
- panobinostat, laboratory biomarker analysis, western blotting
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Liver Cirrhosis
A PROspective Faecal MIcrobiota tranSplantation Trial to Improve outcomEs in Patients With Cirrhosis
A feasibility trial called PROFIT has previously shown that FMT administered endoscopically into the jejunum in patients with cirrhosis is safe and feasible and have identified some potential mechanisms of action that warrant…
- Trial name
- PROMISE (NCT06461208)
- Testing
- Encapsulated FMT
- Where
- 23 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- King's College London
Crohn's Disease
Autologous Stem Cell Transplant for Refractory Crohn's Disease
Crohn's disease is an 'auto-immune' disorder of the gut. In this condition the body's own immune system is fighting its gut and causing inflammation and other symptoms.
- Trial name
- NCT02676622
- Testing
- mobilization of stem cells to prepare for Leukapheresis, Leukapheresis- Collection of stem cells, Preparative regimen 4-6 weeks after Leukapheresis
- Sponsor
- Nationwide Children's Hospital
Crohn Disease
Fecal Transplant for Crohn's Disease
To determine the efficacy and safety of serial FMT at inducing and maintaining clinical and endoscopic response in patients with mild to moderate Crohn's disease
- Trial name
- NCT03078803
- Testing
- Fecal Microbiota Transplant (FMT)
- Where
- 3 sites in Canada
- Volunteers
- 38 people
- Sponsor
- University of Alberta
Hematologic Neoplasms, Gastrointestinal Symptoms
Effects of Synbiotic Supplementation on Gastrointestinal Symptoms, Appetite, and Nutritional Recovery in Patients After Autologous Bone Marrow Transplant
Patients undergoing autologous bone marrow transplantation (ABMT) receive high-dose chemotherapy and routine prophylactic antibiotics, which often disrupt the gut microbiome (dysbiosis).
- Conditions
- Hematologic Neoplasms, Gastrointestinal Symptoms, Malnutrition, Loss of Appetite
- Trial name
- NCT07845669
- Testing
- Tri-component Synbiotic Supplement
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
Crohn Disease, Pediatric Crohns Disease
PediCRaFT: Pediatric Crohn's Disease Fecal Transplant Trial
The objective of this study is to assess the feasibility of a novel colonic and oral fecal microbiota transplantation protocol for the treatment of active pediatric Crohn's disease (CD).
- Conditions
- Crohn Disease, Pediatric Crohns Disease, Inflammatory Bowel Diseases, Colitis
- Trial name
- PediCRaFT (NCT03378167)
- Testing
- MICROBIOTA
- Where
- 2 sites in Canada
- Volunteers
- 17 people
- Sponsor
- McMaster Children's Hospital
Faecal Microbiota Transplantation, Crohn Disease
FMT in Inflammatory Bowel Disease
This is a prospective observational cohort study, over 52 weeks, evaluating the the use of faecal microbiota transplantation amongst patients with Inflammatory Bowel Disease and Microscopic Colitis
- Conditions
- Faecal Microbiota Transplantation, Crohn Disease, Ulcerative Colitis, Microscopic Colitis
- Trial name
- NCT03477032
- Testing
- Faecal Microbiota Transplantation
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- St Vincent's Hospital Melbourne
Allogeneic Hematopoietic Stem Cell Transplant (Allo-HSCT)
Enteral Nutrition Versus Standard of Care in Allogeneic Hematopoietic Stem Cell Transplantation
This is a randomized controlled phase II trial which will enroll 112 patients with a diagnosis of a blood cancer or a serious blood disorder who plan to undergo an allogenic hematopoietic stem cell transplant using any…
- Trial name
- NCT07315165
- Testing
- Enteral Nutrition
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Nebraska