Clinical trials: Intestinal Transplantation
IBS - Irritable Bowel Syndrome
Fecal Transplantation in Patients With IBS
The study will characterize the biology of FMT in the context of IBS prior to wider clinical application of the method. Given the ethical concerns of unknown and long-term adverse effects of FMT therapy, the study will include…
- Trial name
- NCT03333291
- Testing
- fecal suspension
- Where
- Norway
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Ileus
Interventions to Decrease the Impact of Post-OPerative Ileus After Liver Transplant or Resection Surgery
This is a randomized controlled trial to assess ways to address post-operative ileus (POI) in adult patients on the liver transplant service undergoing either liver transplant or resection surgery.
- Trial name
- NCT01156129
- Testing
- stool softener, Arm B: Acupressure bracelet, sugar free gum
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Nebraska
Chronic Functional Constipation, Intestinal Bacteria Flora Disturbance
Fecal Microbiota Transplantation for Chronic Functional Constipation
Chronic functional constipation is a common digestive system disease, the incidence is increasing in recent years.It is reported that the occurrence and development of chronic functional constipation is closely related to…
- Conditions
- Chronic Functional Constipation, Intestinal Bacteria Flora Disturbance, Fecal Microbiota Transplantation
- Trial name
- FMTFCFC (NCT03018613)
- Testing
- Fecal Microbiota Transplantation, Normal Saline
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Chengdu Medical College
Sickle Cell Disease, Chronic Kidney Diseases
Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions
The purpose of this study is to test the efficacy of a peer support coaching intervention to improve activated chronic illness self-management versus an attention control group in 225 adolescents and young adults with childhood…
- Conditions
- Sickle Cell Disease, Chronic Kidney Diseases, Systemic Lupus Erythematosus, Childhood Cancer
- Trial name
- PiCASO (NCT03938324)
- Testing
- PiCASO Intervention Group
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Duke University
Pancreas-kidney Transplantation, Kidney Transplantation
Bile Acids and Incretins in Pancreas Kidney Transplant Patients
Pancreas Kidney Transplantation (PKT) is the prominent treatment for type 1 diabetic patients with chronic kidney disease and improves patients' outcome.
- Trial name
- ITABI (NCT02234349)
- Testing
- pancreas kidney transplantation, kidney transplantation
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma
RATIONALE: Giving high doses of chemotherapy drugs, such as busulfan and cyclophosphamide, before a donor bone marrow transplant helps stop the growth of cancer cells.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Monoblastic Leukemia (M5a)
- Trial name
- NCT01177371
- Testing
- busulfan, cyclophosphamide, allogeneic bone marrow transplantation
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Case Comprehensive Cancer Center
Primary Sclerosing Cholangitis, Inflammatory Bowel Diseases
FAecal Microbiota Transplantation in primaRy sclerosinG chOlangitis
FARGO is a randomised, phase IIa, multi-centre, placebo-controlled trial to compare Faecal Microbiota Transplant (FMT) with placebo in patients with primary sclerosing cholangitis (PSC) and concomitant inflammatory bowel disease.
- Trial name
- FARGO (NCT06286709)
- Testing
- Faecal Microbiota Transplant
- Where
- 5 sites in United Kingdom
- Volunteers
- 58 people
- Sponsor
- University of Birmingham
Fecal Microbiota Transplantation, Clostridium Difficile Infection
Fecal Microbiota Transplant National Registry
A national data registry of patients receiving fecal microbiota transplantation (FMT) or other gut-related-microbiota products designed to prospectively assess short and long-term safety and effectiveness
- Conditions
- Fecal Microbiota Transplantation, Clostridium Difficile Infection, Gut Microbiome
- Trial name
- FMT (NCT03325855)
- Testing
- None - Observational
- Where
- 53 sites in United States, Canada
- Volunteers
- 4,000 people
- Sponsor
- American Gastroenterological Association
Carcinomas, Amyloidosis
B-Receptor Signaling in Cardiomyopathy
We hope to determine the importance of different genes (including B receptors) in anthracycline-induced cardiomyopathy. This has important benefits to patients exposed to anthracyclines, as this could help determine whether…
- Conditions
- Carcinomas, Amyloidosis, Anal Cancer, Anemia
- Trial name
- NCT01135849
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Daniel Bernstein
Clostridium Difficile Infection Recurrence, Ulcerative Colitis (UC)
Real-World Study on Fecal Microbiota Transplantation: Long-Term Effectiveness and Safety Statistics
This is a large-scale observational study aiming to evaluate the long-term effectiveness and safety of Fecal Microbiota Transplantation (FMT).
- Conditions
- Clostridium Difficile Infection Recurrence, Ulcerative Colitis (UC), Crohn Disease (CD), Irritable Bowel Syndrome (IBS)
- Trial name
- NCT07261826
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Chen QiYi
Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
Immune Reconstitution After Autologous Hematopoietic Stem Cell Transpl for High-Risk Lymphoma
RATIONALE: Vaccines may help the body build an effective immune response to kill cancer cells. Giving vaccine therapy after an autologous stem cell transplant may kill any cancer cells that remain after transplant.
- Conditions
- Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Small Intestine Cancer
- Trial name
- NCT00569309
- Testing
- Streptococcus pneumoniae, laboratory correlative studies, quality-of-life assessment
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Kidney Disease
Effects of Dexmedetomidine on Microcirculation of Kidney Transplant Recipient
The microcirculation is altered in acute kidney injury and chronic kidney disease. The microcirculation is poor in end-stage renal disease patients receiving hemodialysis.
- Trial name
- NCT02707809
- Testing
- Dexmedetomidine
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Aging
Ecosystem Nourishment for Gut Restoration After Fecal Transplantation
The purpose of this study is to test whether young-donor fecal microbiome transplantation (FMT) and a fermented, plant-rich high-fiber, microbiome rejuvenating diet (MRD) reduce inflammatory and biological aging markers.
- Trial name
- ENGRAFT (NCT07826793)
- Testing
- Fecal Microbiota Transplant Capsules, Microbiome Rejuvenating Diet
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stanford University
Irritable Bowel Syndrome
Fecal Microbiota Transplantation to Relieve Symptoms of Irritable Bowel Syndrome With Constipation
Irritable bowel syndrome (IBS) is a complex multifactorial functional disorder, whose pathophysiology is largely associated to an impairment of the intestinal microbiota composition, namely dysbiosis.
- Trial name
- TRAMIR-S (NCT05803993)
- Testing
- Fecal microbiota transplantation (FMT) Single FMT infusion
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Crohn Disease
Fecal Microbiota Transplantation in Crohn's Disease as Relay After Anti-TNF Withdrawal
Crohn's disease (CD) is a chronic inflammatory bowel disease. CD pathogenesis remains poorly understood but involves an inappropriate immune response toward an unbalanced gut microbiota in predisposed hosts.
- Trial name
- MIRACLE (NCT04997733)
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ulcerative Colitis
The Effect of Fecal Microbiota Transplantation in Ulcerative Colitis
7 patients with active Ulcerative Colitis are treated with 25 multi-donor FMT Capsules daily for 50 days.
- Trial name
- NCT03711006
- Testing
- Fecal Microbiota Transplantation Capsules
- Where
- Denmark
- Volunteers
- 7 people
- Sponsor
- Alice Højer Christensen
Autism Spectrum Disorder
WMT for Autism Spectrum Disorder (ASD)
Autism Spectrum Disorder (ASD) is a group of serious neurodevelopmental disorders. A significant comorbidity exists between ADHD and ASD: 30%-50% of individuals with ASD exhibit ADHD symptoms, and two-thirds with ADHD show ASD…
- Trial name
- NCT06030752
- Testing
- Washed Microbiota Transplantation
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Exacerbation of Ulcerative Colitis, Ulcerative Colitis, Active Severe
Manipulating the Microbiome in IBD by Antibiotics and FMT
the etiology of Inflammatory Bowel Diseases (IBD) is closely associated with the gut microbiome. The results of previous studies on the effectiveness of antibiotics and fecal macrobiota transplantation (FMT) are contradicting.
- Conditions
- Exacerbation of Ulcerative Colitis, Ulcerative Colitis, Active Severe, Crohn's Colitis
- Trial name
- FMT (NCT02033408)
- Testing
- AB (antibiotics), CS (corticosteroids) Only
- Where
- 12 sites in Canada, Finland and 4 more
- Volunteers
- 28 people
- Sponsor
- Shaare Zedek Medical Center
Ulcerative Colitis, Crohn Disease
Efficacy of Fecal Microbiota Transplantation for Inflammatory Bowel Disease
The gut microbiota is determined to constitute a "microbial organ" which has pivotal roles in the intestinal diseases and body's metabolism.
- Conditions
- Ulcerative Colitis, Crohn Disease, Constipation (Excl Faecal Impaction)
- Trial name
- NCT02575040
- Testing
- Fecal microbiota transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Colorectal Cancer, Liver Metastases
The Swedish Study of Liver Transplantation for Non-resectable Colorectal Cancer Metastases
To evaluate if the addition of liver transplantation primarily utilizing liver grafts from extended criteria donors not utilized for approved indications to conventional treatment of non-resectable/ non-abatable colorectal liver…
- Conditions
- Colorectal Cancer, Liver Metastases, Colorectal Liver Metastases
- Trial name
- SOULMATE (NCT04161092)
- Testing
- Liver transplantation Ltx, Best alternative care
- Where
- 2 sites in Sweden
- Volunteers
- 45 people
- Sponsor
- Vastra Gotaland Region